key competitors in the dental stem cell storage …...introduction dental pulp is the soft living...
TRANSCRIPT
The Market for Dental Stem Cell Storage | BioInformant.com
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1. Introduction
Dental pulp is the soft living tissue inside a tooth that
contains mesenchymal stem cells (MSCs). The ideal
time to harvest dental stem cells is when children lose
their deciduous (baby) teeth, either through natural
loss or extraction. While MSCs from dental pulp stem
cells are only being used only in laboratory settings
now, there is huge potential for the cells to be used in
regenerative applications in the future, as MSCs from
other sources are being explored in more than 600
clinical trials worldwide.1
Five different types of dental stem cells exist,
including:
• Dental pulp stem cells (DPSCs)
• Dental follicle progenitors cells
• Stem cells from apical papilla
• Periodontal ligament stem cells
• Stem cells from human exfoliated deciduous teeth (SHED)
While the dental stem cell storage market is an early-stage market, new competitors are entering
it on a global basis, with the United States, the UK, and India leading the way for industry
competition. The largest competitor within the global dental stem cell market is BioEden.
BioEden is the world’s first international biobank company to collect, assess, and cryogenically
store living stem cells from deciduous baby teeth. The company began offering tooth stem cell
storage as early as 2006, making it one of the earliest known providers of dental stem cell
storage. Over the past decade, BioEden has continued to be one of the most dominant
competitors in this space, controlling an estimated 50% of market share within the dental stem
cell storage market.
1 Search of ClinicalTrials.gov. Search terms: "mesenchymal stem cell" OR "mesenchymal stem cells". Executed October 4, 2017.
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2. Overview of Dental Stem Cell Storage
There are two types of dental stem cell banks:
1. Those that specialize exclusively in dental stem cell storage
2. Those that are diversified biobanks offering dental stem cell storage in addition to other
types of stem cell storage (most often, umbilical cord blood and tissue banking)
Cord blood banking is the collection, processing, and long-term storage of cord blood and tissue
under sterile conditions. It can either be publicly donated at no-cost or privately stored for a fee.
While cord blood banking is an entire global industry, approximately 2-3% of cord blood banks
worldwide now offer dental stem cell storage as a service offering.
Like cord blood storage, dental stem cell banking involves tissue collection, processing, and
long-term storage. Specifically, dental stem cell storage involves the preservation of dental pulp
tissue, because the stem cells contained within it may be valuable for future medical use. Dental
pulp is the soft living tissue inside a tooth that contains mesenchymal stem cells (MSCs).
The ideal time to harvest dental stem cells is when children lose their deciduous (baby) teeth, either
through natural loss or extraction. Stem cells harvested from the dental pulp within teeth have
many advantages over other types of stem cells. First, they are not limited to the amount
collected from the tooth, because they can be expanded within a laboratory. Additionally, they
can differentiate into many other cell types, including bone, heart muscle, skeletal muscle,
cartilage, adipose (fat) and nerve cells. Dental
stem cells embryologically originate from the
cranial neural crest, so their use in
neurodegenerative applications is particularly
exciting.
Cells harvested from baby teeth are also harvested
when they are young, healthy, and have
high functionality. Finally, harvesting from the
tooth provides the only non-invasive method of
collecting stem cells, because no medical or
dental intervention is required since the tooth can
be exfoliated naturally.
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3. Leading Dental Stem Cell Companies
The following are the leading companies offering dental stem cell storage.
Cord blood banks offering dental stem cell storage as a service offering include:
• Precious Cells Group (London, UK) – In addition to being its own independent
dental stem cell storage company, Precious Cells entered into a strategic alliance to
undertake all processing, laboratory and regulatory undertakings on behalf of
BioEden in the UK.
• Future Health Biobank (Nottingham, UK)
• GeneCell International (Miami, FL)
• VAULT SC Inc (Palm Coast, FL)
• Transcell Biologics Pvt Ltd (Hyderabad, India)
• ReeLabs (Mumbai, India)
• Dentcell, offered by Cryoholdco (Mexico)
In addition, specialty companies also exist that focus exclusively on dental stem cell storage.
Specialty companies offering dental stem cell storage include:
• National Dental Pulp Laboratory (Marlborough, MA)
• StemSave (New York, NY)
• BioEden (Austin, TX)
• “Store-A-Tooth” run by Provia Laboratories, LLC (Littleton, MA)
• Tooth Bank (Brownsburg, IN)
• Stemade (Mumbai, India)
• Bank a Tooth, a Singapore incorporated company specializing in dental stem cell
banking, is a product of Prolife Biobank (Singapore)
While there are other small companies providing dental stem cell storage services, the companies
listed above account for the clear majority the market, according to BioInformant estimates that
integrate data from Google Search, Google Trends, company filings, and
importantly, interviews with company representatives, including the CEO of the world’s largest
dental stem cell storage company, Tony Veverka of BioEden.2
2 Hildreth, Cade. (2017). Interview with Tony Veverka, Chief Group Executive of BioEden - How Dental Stem Cells Will Impact Our Future. [online] BioInformant. Available at: https://.bioinformant.com/how-dental-stem-cells-will-impact-our-future-qa-with-bioeden-executive-tony-veverka/ [Accessed 22 Sep. 2017].
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4. Timeline of Events in the Dental Stem Cell Storage Market
BioEden began offering tooth stem cell storage as early as 20063,
making it one of the earliest known providers of dental stem cell
storage.
A couple years ago, Precious Cells entered a strategic
alliance with BioEden to provide all processing, laboratory
and regulatory undertakings on behalf of BioEden in the
UK. Although it entered a strategic partnership, Precious
Cells remained a separate company and provides direct services to its own clients.
The National Dental Pulp Laboratory launched shortly thereafter in
2007.4
According to Stemade, it is the first and largest private dental stem cell storage company in
India.5 The company has also served areas of Asia since
2013.6 Stemade licenses their dental storage technology from Institut
Clinident Biopharma, which it describes as “offering a technical
solution to the collection and preservation of the dental pulp, rich in
adult stem cells”.7 The Institut Clinident Biopharma also licenses its technology to European
companies.
There is also ReeLabs, which a major enterprise for stem cell storage in
India, banking cells from over ten human sources.8
Clearly, the regions most active in offering dental stem cell storage services are:
• United States
• India
• United Kingdom
3 Us.bioeden.com. About BioEden Inc | Stem cells | Tooth stem cell storage bank. [online] Available at: http://us.bioeden.com/about/ Web. 22 Sept. 2017. 4 Ndpl.net,. ‘National Dental Pulp Laboratory | Preserving Dental Stem Cells’. N.p., 2015. Web. 221 Sept. 2017. 5 Stemade.com,. “Stemade – India’s First & Largest Dental Stem Cell Bank”. N.p., 2015. Web. 1 Sept. 2017. 6 Biospectrumasia.com,. “Asia’S First Dental Stem Cell Bank Is Here”. N.p., 2015. Web. 22 Sept. 2017. 7 Stemade.com/about/partners,. “Stemade Partner”. N.p., 2015. Web. 7 Oct. 2017. 8 Reelabs.com,. “Stem Cell Banking & Therapy In India | Reelabs”. N.p., 2015. Web. 11 Sept. 2017.
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5. Key Competitors in the Dental Stem Cell Storage Market
The exact number of market participants offering dental stem cell storage depends on whether
subsidiaries of the same company are counted as one company or multiple companies.
Additionally, companies often serve multiple regions. For example, Stemade serves both India
and Asia. Furthermore, the same company may market its services under multiple names for
branding or language purposes.
In addition, the actual storage service sometimes has a different name than the company offering
it, as is the case with the “Store-a-Tooth” program run by Provia Laboratories, LLC.
Finally, there are cord blood banks that will store the deciduous teeth of clients on a “by request”
basis, but they do not publicly market the service.
The table on the following page presents the leading competitors within the dental stem cell
market. It contains both specialty companies offering dental stem cell storage services and cord
blood banks that have expanded to offer dental stem cell storage as an additional product
offering.
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TABLE. Companies Offering Dental Stem Cell Storage
Company Location Description
(Diversified vs. Specialized) Link
BioEden Austin, TX, USA
Specialty dental storage company and the first company to offer dental storage (2006).
http://us.bioeden.com/why-store-stem-cells/
Dentcell (Owned by Cryoholdco)
Huiquilucan, Mexico
Cryoholdco is a holding company that owns multiple cord blood banks in Latin America. It also owns Dentcell, a dental stem cell storage provider.
http://dentcell.com.mx/contacto/
Future Health Biobank Nottingham, UK
Diversified stem cell bank. Also offers cord blood, cord tissue, adipose storage, and more.
http://www.futurehealthbiobank.com/tooth-stem-cells
GeneCell International Miami, FL, USA
Diversified stem cell bank. Also offers cord blood, cord tissue, adipose storage, and more.
http://www.genecell.com/dental-pulp-banking/
National Dental Pulp Laboratory (NDPL)
Marlborough, MA, USA
A specialty dental storage company, started in 2007. However, it is a subsidiary of parent company New England Cryogenic Center (opened in 1970’s) and a sister company to New England Cord Blood Bank. Therefore, the larger organization is diversified.
http://www.ndpl.net/
Precious Cells Group London, UK Diversified stem cell bank. Also offers cord blood, cord tissue, adipose storage, and more.
http://www.precious-cells.com/services/tooth-stem-cells/
ReeLabs Mumbai, India Diversified stem cell bank that stores stem cells from more than ten human sources.
http://www.reelabs.com/
Stemade Biotech Private Ltd.
Mumbai, India Specialty dental storage company offering services in India and Asia.
http://www.stemade.com/
StemSave New York, NY, USA
Specialty dental storage company. http://www.stemsave.com/
“Store-a-Tooth” (run by Provia Laboratories, LLC
Littleton, MA, USA
Specialty dental storage company. http://www.store-a-tooth.com/
Tooth Bank Brownsburg, IN, USA
Specialty dental storage company. www.toothbank.com
Transcell Biologics Pvt. Ltd
Hyderabad, India
Diversified stem cell bank. Also offers cord blood, cord tissue, adipose tissue, and bone marrow storage. It is the only known Indian company to offer the service.
http://transcell.in/tooth-scell.html
VAULT SC, Inc. Palm Coast, FL, USA
Diversified stem cell bank. Also stores fat tissue and bone marrow aspirate.
www.vaultstemcell.com
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6. Trends in the Scientific Literature
An important way to gauge innovation and progress within the dental stem cell storage market is to
consider trend rate data for scientific publications over a trailing ten-year period.
PubMed is a service of the U.S. National Library of Medicine and the National Institutes of Health
(NIH) that contains citations from MEDLINE and a collection of other life science journals. The data
presented in this section was generated using the PubMed database, because it is the largest, most
comprehensive, and most up-to-date global meta-database available for scientific publications.9 It is
also the most versatile tool for screening by multiple criteria.
For purposes of this analysis, the following search terms were searched simultaneously:
• Teeth + “Stem Cells”
• Tooth + “Stem Cells”
• Dental + “Stem Cells”
• “Dental Follicle Progenitors Cells”
• “Stem Cells” + “Apical Papilla”
• “Periodontal Ligament Stem Cells”
• “Stem Cells” + SHED
The goal of these search terms was to:
1. Capture terms and synonyms descriptive of dental stem cells
2. Capture results in which the word order may vary – For example, searching for
(“Dental” + “Stem Cells”) allows us to capture phrases that include: “Dental Pulp Stem
Cells,” “Dental Stem Cells,” “Stem Cells from Dental Pulp,” etc.
3. Capture long-tail searches, in which our terms of interest appear within longer,
contextual descriptions
While these terms listed above likely do not capture every single result in the scientific literature
pertaining to dental stem cells, they do capture the clear majority of them, thereby revealing
valuable trend data.
9 Ncbi.nlm.nih.gov, (2014). Home - PubMed - NCBI. [online] Available at: http://www.ncbi.nlm.nih.gov/pubmed [Accessed 30 Sept 2017].
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TABLE. Number of Dental Stem Cell Scientific Publications by Year (PubMed.gov)
*The Full-Year (FY) 2017 figures are estimates based on data for Jan. 1 – Sept. 30, 2017.
Clearly, scientific publication data reveals growing interest in dental stem cells over the past ten
years.
0
50
100
150
200
250
300
350
2006 2008 2010 2012 2014 2016 2018
# of Dental Stem Cell Scientific Publications by Year (PubMed.gov)
Year # of Scientific Publications
2007 52
2008 81
2009 93
2010 116
2011 141
2012 172
2013 195
2014 250
2015 271
2016 259
YTD 2017* 232
FY 2017* 309
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7. BioEden, Leading Provider of Dental Stem Cell Storage Services
BioEden was the world’s first company to collect, assess, and cryogenically store living stem
cells from deciduous baby teeth. In 2003, dentist and researcher Dr. Sontago Shi discovered stem
cells within the pulp of his daughter’s naturally shed baby tooth. He wrote about this, which
caught the interest of several parties.
Shortly thereafter, he met Mike Byrom, the current Chief Science Officer (CSO) at BioEden,
during a stem cell lecture tour in the United States. Mr. Byrom had read various articles about
this discovery, but as a result of the meeting, developed a commercial process for harvesting
stem cells from teeth that was later commercialized into BioEden’s technologies.
In 2006, BioEden became the world’s first dental pulp stem cell bank, forming its headquarters
in Austin, TX. Since that time, the market has gathered momentum and other entrants have
joined the industry around the world. BioEden’s current CEO, Tony Veverka, became involved
with BioEden and dental stem cell banking in 2014 when he invested in the business and joined
the board as CEO.
As the world’s first tooth cell bank, BioEden is a leading specialist in the field of dental stem cell
banking. BioEden holds a patent on the process in the U.S. and has more samples under storage
by a significant margin than any other provider. For this reason, BioEden is widely considered
the industry-leader in dental stem cell storage.
All BioEden samples are stored in duplicate in separate
locations for the purpose of creating additional security
and safety. Additionally, BioEden tests all units for
viable stem cells prior to cryopreservation to ensure
cell functionality, so it is known that dental stem cells
will be useful for therapeutic intervention should
they be required in the future.
Finally, BioEden has more pricing plans than any other
provider, offering a greater degree of flexibility to
potential clients.
Today, BioEden operates in 25 countries and has members in over 60 countries. It also has
laboratories in the US (Texas), Europe (UK), and Asia (Thailand).
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In addition to these hubs, its primary markets are10:
• Latin American
• Europe (where it has announced a significant strategic alliance with the major medical
group, Medicover)
• Asia (where its service recently launched in India)
10 Hildreth, Cade. (2017). Interview with Tony Veverka, Chief Group Executive of BioEden - How Dental Stem Cells Will Impact Our Future. [online] BioInformant. Available at: https://.bioinformant.com/how-dental-stem-cells-will-impact-our-future-qa-with-bioeden-executive-tony-veverka/ [Accessed 22 Oct. 2017].
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