klinisk strålebiologi - normalvev
DESCRIPTION
Klinisk strålebiologi - normalvev. Tidlig reaksjon. Sen reaksjon. teleangiectasi. Basis for dose-respons-kurver. Stigetallet for dose-responskurven. Gaussian distribution of radiation sensitivity. Gaussian distribution of technical and dosimetrical factors. - PowerPoint PPT PresentationTRANSCRIPT
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Klinisk strålebiologi - normalvev
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Tidlig reaksjon
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teleangiectasi
Sen reaksjon
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Basis for dose-respons-kurver
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Stigetallet for dose-responskurven
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Gaussian distribution of radiation sensitivity
Dose response curve
Uniquely described by two parameters: - gradient at 50% response
levelD50% - dose to achieve 50%
response
Gaussian distribution of technical and dosimetrical
factors
biolo > clin Pettersen M et al Radiotherapy and Oncology 2008
Clinical dose response curve
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Uniquely described by two parameters: - gradient at 50% response
levelD50% - dose to achieve 50%
response
is linked to the standard deviation, , of the Gaussian distribution by:
21
Pettersen M et al Radiotherapy and Oncology 2008
22bioldoseclin ),( bioldoseclin f and ),( bioldoseclin f
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Steepness of clinical dose-response curve is depending of the dose variation
Pettersen M et al Radiotherapy and Oncology 2008
Roué et al 2004ESTRO-Equal external audit102 centres, 235 beams in France3% beams had deviations > 5%24 centres had deviations > 5%
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Design of a randomised clinical study
• The null hypothesis is that the two treatment options produce no different outcome
• To prove a difference, the null hypothesis has to be rejected
• The number of patients needed is linked to , the difference in response (R), the level of significance () and the power ()
= 0.2 = 0.05
Pettersen M et al Radiotherapy and Oncology 2008
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The number of patients required
Conclusions:To keep the number of patients
required for RCT as low as possible, the standard deviation of the
dosimetry should be kept below 5%.
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Volumeffet for rektumblødning
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Strandqvist plot
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-kill
-kill
LQ-formelverket
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