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Kopyrrol (Pyrrolidino diamino pyrimidine oxide)

An enlivening hair growth active

� Rejuvenates hair follicle

� Increases the growth of hair

� Protects against hair loss

� Favors a better hair anchoring

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Worldwide, 85% of Men (15% women) suffer from hair loss. Day by day, the number of hair loss

sufferers is increasing in number and is more than doubled between 2008 to 2010. The importance

of hair in our lives cannot be overstated. Whether men or women lose their hair, they lose much

more than their natural, youthful appearance. People also lose their self-esteem and self-

confidence associated with healthy looking hair. The scalp and hair requires an optimal amount of

nutrients that is not always provided by the daily nutritional intake leading to Hair. Hair growth

actives have a strong presence in our everyday lives and are integrated to help prevent hair loss

and nurture hair regrowth.

KOPYRROL recovers weak follicle cells by supplying the nutrition which hair needed for growth and

increase the growth of hair and increases the volume of hair in the growth stage by working on the

deep structure of the roots. Through the bloodstream, KOPYRROL works at the level of the hair

root, which is responsible for a healthy scalp and beautiful hair. KOPYRROL is used in hair cosmetics

to combat hair loss due to premature exhaustion of the hair root.

Product Specification

Trade Name KOPYRROL

INCI Name Pyrrolidinil diaminopyrimidine oxide

Chemical Name 6-pyrrolidino 2,4-diaminopyrimidine 3-oxide

Molecular Formula C8H13N5O

CAS NO 55921-65-8

Harmonized Tariff No. 2932.00

Appearance Pale White crystalline powder

Assay by HPLC (on dried basis) NLT 99%

Solubility 2% solution in ethanol/water (70:30)

Clear & Colourless

Suggested use level 0.1-5%

Storage Preserve in well closed container

Kumar Organic Products Pvt Ltd

At Kumar Organic Products, we are committed to develop and deliver our valued customers who are in

pharmaceutical and personal care industries with superior quality products at most competitive prices.

N

N

N NH2

NH2

O

Molecular Structure

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Mechanism of Hair Growth Cycle The scalp has at an average 100,000 hairs. A healthy scalp sheds hair continuously and new hair replaces them.

Hair growth follows a series of cycle. Each cycle includes a growth phase (anagen), a transitional phase

(catagen), and a resting phase (telogen). Any changes to the normal hair growth cycle would result in hair loss. It

occurs when the old hairs are shed and no new hair is growing from beneath to replace it. However, when the

scalp is not able to produce new hair to replace the shed hair, baldness develops and the condition is

scientifically called as alopecia.

The most common type of hair loss is androgenetic alopecic (AGA) both in men (Male pattern baldness)

and women (Female pattern hair loss) and is caused by heredity hormones and genetics.

* Everyday around 100 old hairs are shed before new hair replaces them. Average hair growth rate is upto 1cm per

month

Mechanism of KOPYRROL on stimulating hair growth

Altered Hair Growth Cycle

Decrease A: T

• Miniaturization of follicles

• Gradually Shorter Anagen Phase &

longer telogen phase

• Empty follicles- Disruption of hair cycle

Normal Hair Growth Cycle

Normal A: T (80:20)

Return to Anagen: The

hair follicle re-enters

the growth phase. The

older hair is shed, and

then replaced by a new

one.

Multiplication of group of

cells at the base of the

hair. Typically lasts from 2

to 6 years.

The growth in the hair

follicles stops and

degeneration begins. This

phase lasts about 2 to 3

weeks.

The hair rests and no growth

is experienced which lasts 2

to 3 months.

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Hair Growth Activity

Efficacy of KOPYRROL

Hair Growth Activity

Efficacy of KOPYRROL

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TOXICOLOGICAL INFORMATION

Acute Toxicity:

LD50 Oral rat 820mg/kg

LD50 Oral mouse 780mg/kg

LD50 Cutaneous Rat >2000mg/kg

Chronic Exposure:

Primary irritation skin rabbit : not irritant

Primary irritation eye rabbit : not irritant

Primary irritation skin Guinea pig : not irritant

Mutagenicity:

Animal cellule ‘in vitro’ negative

Cytotoxicity:

“Salmonella Typhimurium”

Range: 100mcg/dishes – 10000 mcg/dishes negative

ECOLOGICAL INFORMATION

No information is available about the potential of this product to produce adverse

environmental effects. Local regulations and procedures should be consulted prior to

environmental release.

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Features & Benefits

Features Benefits

Potassium channel opener Transition from telogen to anagen phase of the

hair cycle. Maintains the anagen phase for a long

period of time.

Nourish the hair follicles Dilates blood vessels and increases nutrients and

oxygen supply to the hair root.

Increases matrix cell proliferation Strengthens hair from root to tip by strong

anchoring of the hair root. Works on crown of the

scalp in certain, usually younger, men.

Known for its efficacy Safe and Effective for Both Men and Women.

RECOMMENDED DOSAGE AND APPLICATIONS

Regulatory Status*:

Not approved by FDA

Europe : Allowed for personal care application

USA : Allowed for personal care application

Japan : Allowed in selected product category

Rest of world : Allowed for use in most of the Asian countries

*Consult your regulatory authority for use level and restrictions.

Recommended dosage: The compound generally used in the proportion of between 0.001 and 10% w/w and

preferably in the concentration of 0.1 -5% w/w.

Applications:

-Hair Tonic -Hair Cream

-Scalp Treatment -Hair Gel

-Hair Shampoo -Hair Conditioner

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Formulation guidelines:

• Charge 5%w/w of KOPYRROL into the vessel and add all other ingredients(50 wt% Propylene

Glycol, 15 wt% Ethanol, 15 wt% Benzyl Alcohol, QS to 100 wt% Distilled water, 0.25 wt%

Perfume and 0.50 wt% Tween 20) one by one with stirring in the order mentioned. Continue

stirring until KOPYRROL dissolves and forms a clear solution.

• Typical use level of KOPYRROL: 0.001-1.5 wt% of finished formulation

• The finished product should be protected from prolong exposure to heat and light.

References:

• Won Seok Park et. al. Hair growth activity of cosmetic diaminopyrimidine oxide

compound invitro and in murine anagen induction. Amore pacific corporation.

• A.G.Messenger and J .Rundegren. Minoxidil: Mechanisms of action on hair growth.

British Journal of Dermatology 2004; 150: 186–194.

• Davies GC et.al., Novel and established potassium channel openers stimulate hair

growth invitro: Implications for their mode of action in hair follicles. J Invest Dermatol

2005. 124: 686-94.

Disclaimer:

The information given and the recommendations made herein are based on literature search and are believed to be accurate but no guarantee of

their accuracy is made. Information is supplied upon the condition that the receivers will make their own determination as to its suitability for their

purposes prior to use. In no event will KUMAR ORGANIC PRODUCTS LTD be responsible for the damage of any nature whatsoever resulting from the

use of or upon reliance of the information