2005-2006A N N U A L R E P O R T

Ophthalmology Insight

The Long ViewUCSF’s Basic Scientists Chart the Course

Dr. Creig HoytHonored withEndowed Chair

Annual Report

Cordes Connection:Dr. Robert Kim

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Patient’s Point of View:Crewe andPaige Hutson

Dr. Stephen D. McLeod,New Chair of UCSFOphthalmology

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A P E E K I N S I D E :

Dear Friends,

This fall issue of VISIONS, with our annual report, is dedicated to thelong view.Two thoughts motivate the theme: one relates to the timerequired for basic scientists tounderstand biological processes,fundamental to discovery and itsapplications; the other honors ourcontributors who share our need forendowments.These funds are investedin perpetuity, providing an essentialstream of financial support impactingall aspects of our work.

This being the 35th anniversary of That Man May See, supportfoundation for UCSF Ophthalmology,we are grateful for the insight of itsfounders and the many gifts that have resulted from the generosityencouraged through TMMS.

Building a preeminent center focusedon eye disease and its preventiontakes a gifted faculty with muchdiversity of viewpoint and experience.With this issue, we salute our facultyand our newest residents and fellows,welcoming them into our family.

Thank you for your support of our vision.

Sincerely,

Stephen D. McLeod, MDTheresa M. and Wayne M.Caygill, MD, Chair inOphthalmology

Professor and Chair,UCSF Ophthalmology

Within UCSF Ophthalmology, apreeminent group of researchersdevote all of their effort tolaboratory work in pursuingdiscoveries at the Koret VisionResearch Laboratory.These “basicscientists” strive to understand the pure science that potentiallyunderlies glaucoma, cornealdisease, cataract and lens biology,cellular pharmacology, ocularoncology, amblyopia, visual

development, retinal physiology,ophthalmic genetics, retinal growthfactors, retinitis pigmentosa, andmacular degeneration.

These basic scientists aremotivated by a belief that progressrequires elemental understanding.

The discoveries of these basicscientists fuel innovative research,including studies of the mechanism

publications, on articles by thosesame clinician scientists; and theycreate an enduring bond withThat Man May See and the entireDepartment of Ophthalmology.Ensuring the long-term strengthof UCSF Ophthalmology has beena priority for That Man May See

as far back as its founding 35years ago.

Thanks to loyal contributors who take the long view, thedepartment is able to establishdistinguished professorships and

Continued on page 4

Focal Point

Annual Report Issue Fall 2006Koret Vision Institute + Beckman Vision Center + Department of Ophthalmology

of – and potential new treatmentsfor – glaucoma; evaluation ofnew diagnostic and therapeuticmodalities for ocular tumors;and investigations of the basicmechanisms of vision, includingthe molecular biology and cellbiology of visual process.They areengaged in an effort to understandand overcome prevalent blindingdiseases that have been historically

University of California San Francisco + That Man May See

Caygill, Kimura, Shearing,Steel, and Stock arefamiliar names at UCSFOphthalmology.They areetched on crystal plaques;

they appear on the letterhead ofindividual faculty members and in peer-reviewed international

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Continued on page 3

Driven strongly by curiosity,scientists ask deeply

technical questions.Their answersexpand our knowledge, uncovermolecular mechanisms, and laythe groundwork for possibletreatments and clinicalapplications.These initial effortsto discover fundamental biologicalprocesses are part of the longview required for the preventionand cure of disease.

Envision the FutureEndowment Donors Go the Distance

First-Year ResidentsUCSF Ophthalmology

2 Fall 2006

Dr. Stephen D. McLeod New Chair of UCSF Ophthalmology

Distinguished Education and Background

Dr. McLeod was born in Jamaica and spent his childhood there and the United Kingdom.He first came to the United States as an undergraduate at Dartmouth College, where hecompleted an AB in biology, graduating magna cum laude. He obtained his medical degreefrom Johns Hopkins University School of Medicine and went on to internship in internalmedicine at the Beth Israel Medical Center in New York, followed by residency inophthalmology at the Illinois Eye and Ear Infirmary of the University of Illinois, Chicago.Dr. McLeod then completed a fellowship in cornea, external disease, and refractive surgeryat the Doheny Eye Institute of the University of Southern California.

Dr. McLeod returned to the Illinois Eye and Ear Infirmary as director of refractive surgery,where he initiated the university’s excimer laser refractive surgery program. He was recruitedto the Department of Ophthalmology at UCSF in 1998, where he initially served as co-director of the Division of Refractive Surgery and vice chairman for clinical affairs.

He and his wife, artist Marion Faymonville, reside in San Francisco and Healdsburg, wherethey have planted a vineyard. •

An interview with Robert Kim, MD, is a part of theongoing series focused on residency graduates and formerfellows of UCSF Ophthalmology.

As Chief Clinical Scientist, OphthalmicMedicine, at Genentech, Inc., Robert Kim,

MD, shepherded the Phase III development ofLUCENTISTM, a drug to halt vision loss from age-related macular degeneration (AMD) (See story,page 1).When Dr. Kim isn’t in the laboratories of the South San Francisco biotech company, heand his wife, Elizabeth, might be found swimmingfrom Alcatraz to the San Francisco Bay. He has racedfrom Angel Island to Tiburon (Raccoon Straits) andholds a 2nd degree black belt in taekwondo.All ofhis family pursue the discipline – Dr. Kim, his wife,who works at Sun Microsystems, and their twodaughters, Katie and Carolyn. His wife and eldestdaughter also hold black belts.

Routine Eye Exam Led to Lifelong Fascination

with Vision

Dr. Kim’s family came to the U.S. from Korea. Hisfather was on the faculty of UCSF in the area ofgastrointestinal research and care. Born in NewYork, the younger Dr. Kim was 12 when he had aroutine eye exam that detected an abnormality onthe optic nerve.An evaluation by William Hoyt,

CordesDr. Robert Kim

C O N N E C T I O N SCordes

C O N N E C T I O N S

MD, at UCSF Ophthalmology, began a lifelongfascination with eyes and ocular disease and cures.

“I didn’t have the tumor everyone was worriedabout,” says Dr. Kim. Instead it was little dischemorrhages common in Asian myopics.

Following undergraduate and medical degreesfrom Brown University in a special seven-yearprogram, Dr. Kim came to San Francisco for his internship at St. Mary’s Medical Center andthen residency at UCSF Ophthalmology. Hecompleted a three-year postdoc at the NationalEye Institute and a two-year retina fellowship at Moorfields Eye Hospital in London. Hismentors at UCSF became Dr. Hoyt,Alex Irvine,MD, and Jorge Alvarado, MD. His advice to ourresidents today:“Make the most of your time atUCSF.Ask all the questions you can think of. It’sa special group of people, and they will be therefor you when you leave.”

According to Dr. Kim, taking part in theLUCENTISTM project has had greater impactthan anything he could have imagined.“Eventoday, I think of former patients.What excites memost is the opportunity to work on a potentiallycutting-edge new therapeutic that targets diseasewith a huge unmet need.” •

he University of California, San Francisco, School of Medicine named StephenMcLeod, MD, chair of the Department of Ophthalmology. Dr. McLeod has been on thefaculty since 1998, and has been interim chair of the department since January, when CreigHoyt, MD, retired after working 36 years at the school.

David Kessler, MD, vice chancellor for medical affairs and dean of the School of Medicine,oversaw a national and international search and said,“This is a great department; it was agreat search; and you have a great leader.” He praised Dr. McLeod for earning the respectand admiration from his own faculty and from other departments on campus while servingas interim chair, emphasizing the “overwhelming and unanimous recommendation for Dr.McLeod.”

New Vision for UCSF Ophthalmology

“This is truly one of the world’s great departments of ophthalmology, and it is a privilegeto be able to lead such an impressive group of researchers, educators, and clinicians whoshare a dedication to understanding, preventing, and treating visual disorders," said Dr. McLeod.

“Our strategic vision is attracting the brightest and best minds to tackle the most challengingclinical and scientific issues.”

Highlighting the department’s mission of excellence in research, patient care, and teaching,Dr. McLeod emphasized,“We provide world-class care for our patients by investigating andadvancing emerging technologies. Our researchers create a dynamic, collaborativeenvironment that fosters creativity and groundbreaking discoveries.We train the finestophthalmologists of the future whom we can look to for the next great advances inaddressing blindness and visual discovery.”

Dr. McLeod’s research bridges the disciplines of cornea and external disease, cataract, andrefractive surgery, and includes the diagnosis and management of infectious keratitis, thedevelopment of materials for the artificial cornea (keratoprosthesis), and the development ofintraocular lens devices that restore accommodation for dynamic change in focus aftercataract surgery.

He has published extensively in these areas, and serves as a consultant to the FDA ophthalmicdevices panel. He is co-editor of the online edition of the Archives of Ophthalmology andserves on the editorial board of the Journal of Refractive Surgery. He has served the AmericanAcademy of Ophthalmology in many roles and is currently chairman of the PreferredPractice Patterns Refractive Surgery Panel charged with setting the academy’s standards forrefractive surgery.

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3Fall 2006

The Long ViewContinued from page 1

The specificity and ability to localize thisanti-VEGF drug holds much promise fortreating AMD.“We have to think carefullyabout how to treat eye disease,” says Dr.Kim,“as eyes are such a delicate part of the body.With wet AMD, we are dealingwith an older population already at risk forcardiovascular disease, and we wouldn’twant to put the individual at risk for other diseases.”According to Dr. Kim,LUCENTISTM addresses the specific needsfor treating eye disease by gently shuttingdown abnormal blood vessels in the eyeusing doses of LUCENTISTM administeredlocally to the eye that are very lowcompared to doses of other monoclonalantibodies administered intravenously totreat systemic diseases such as cancer.

The approval of LUCENTISTM for thetreatment of AMD culminates over 50years of basic research, applied research,engineering, and clinical trials.Thesuccessful development of this drugexemplifies the need to take the long view of research and treatment of disease.Dr. Folkman in 1971 could not haveenvisioned that his study of tumor cellswould lead to a treatment for AMD.

How UCSF and Genentech Work

Together to Treat Disease

UCSF’s overall mission is education,research, and public service – notessentially the development of products.Yet, university researchers play a significant role in working with industry to collaborate on research, generate new knowledge, and engage with trials and applications.The development ofLUCENTISTM reveals the connection not only between basic scientists at UCSFbut with clinical scientists as well.

“It takes multiple minds,” says DawnKalmar, spokeswoman at Genentech.“It takes a lot of smart people thinkingfrom different angles to come up with a product.”

“We routinely seek out expert advice,”says Dr. Kim.“Academics provide highlyspecialized expertise.”

In particular, UCSF’s Robert Bhisitkul,MD, PhD, engaged in the trials to workwith Dr. Kim on these studies. OtherUCSF clinical faculty were involved aswell:Walter Stern, MD; H.R. McDonald,MD; J. Michael Jumper, MD; Craig Leong,MD; Dan Brinton, MD; and their partnersand staffs, just to name a few.

Nisha Acharya, MD, served as a Genentechfellow before recently joining the Francis I.Proctor Foundation at UCSF, an organizedresearch unit closely aligned with UCSFOphthalmology. (See story on page 7.)

“Dr.Acharya was critical to helping usmaintain scientific momentum while wewere focusing on our application forLUCENTISTM to the FDA,” says Dr. Kim.“It was wonderful to have her here. Shehad a background in statistical methodsfrom her work with Tom Lietman, MD,at UCSF’s Proctor Foundation that shebrought to the LUCENTISTM team,enabling her to work closely with one of our statisticians to mine data while we prepared our application. It was anopportunity for her and a real benefit to Genentech – a win-win for all.”

Dr. Kim cites additional connections atGenentech to UCSF:Art Levinson, PhD,Genentech CEO, was once a postdoctoralfellow at UCSF. Co-founder of Genentech,Herb Boyer, PhD, was a UCSF professor.Genentech has been a strong financialsupporter of many UCSF researchprograms and the training of graduate and medical students. •

incurable, such as macular degenerationand other inherited and acquired retinaldiseases.

The Long View – Hope for Age-

Related Macular Degeneration

This is a story of how a basic scientist atUCSF played a pivotal role in discovery of a growth factor that became the basisfor the development of an innovative newdrug offering hope to individuals sufferingfrom age-related macular degeneration(AMD). It’s a story of how UCSFOphthalmology plays a role in helping to bring novel treatments from thelaboratory to the clinic.

But first, it’s a story about the long view and why it can take over 50 yearsfrom initial discovery of fundamentalbiological processes to eventual human use and treatment.

On June 30, 2006, the Food and DrugAdministration (FDA) approvedLUCENTISTM (ranibizumab injection) forthe treatment of neovascular (wet) AMD.The availability of this drug culminatesseveral decades of basic and appliedresearch.AMD is a major cause of painlesscentral vision loss and is a leading cause of blindness for people over the age of 55.The National Eye Institute estimates thatthere are 1.6 million people with AMD inthe United States alone and that thisprevalence will grow to nearly 3 million by 2020.AMD occurs in two forms: dryand wet.The dry form is associated withatrophic cell death of the central retina ormacula, which is required for fine visionused for activities such as reading, driving,or recognizing faces.The wet form iscaused by growth of abnormal bloodvessels under the macula.These vessels leakfluid and blood and cause scar tissue thatdestroys the retina.While the dry formaccounts for 80%–90% of AMD, the wetform accounts for 80%–90% of the legalblindness from AMD.

Uncovering Vascular Endothelial-

Derived Growth Factor Paved Way for

Treatment of AMD

In 1971, Judah Folkman, MD, at Harvarddiscovered a novel soluble factor releasedby cultured cancer cells that stimulated thegrowth of blood vessels. Over the next 20years, improved biochemical techniquesenabled scientists in many differentlaboratories to isolate other “factors” thathad similar angiogenic properties. One ofthese, fibroblast growth factor (FGF), wasstudied by Dr. Denis Gospodarowicz, thena UCSF professor.A young physician in Dr. Gospodarowicz’s lab, NapoleoneFerrara, PhD, moved to nearby Genentech,Inc., in South San Francisco, where hecontinued to look for new angiogenicfactors. Dr. Ferrara’s efforts at Genentechcumulated in two reports describing thediscovery and DNA sequence of a novelangiogenic factor, vascular endothelialgrowth factor (VEGF), in 1989, using thetechnology pioneered by Watson andCrick, the discoverers of the structure ofDNA in the early 1950s, to identify thecomplete DNA structure of VEGF DNA.This discovery sparked a whole field of

research into the properties of VEGF.Since 1981, over 15,000 separate studieshave been published on VEGF in thescientific literature.

To block abnormal blood vessel growth in AMD as well as in tumors, it was notenough to understand VEGF. Moreresearch had to be done to develop actualdrugs to inhibit VEGF functions.A majorbreakthrough was the development ofengineered antibodies that could be usedto “tie up,” or bind, free-floating VEGFthat stimulated blood vessel growth, as well as leakage from blood vessels.Genentech, a biotech company with strong connections to UCSF, was in anideal position to develop a drug that might arrest new blood vessels in the eye.Genentech received FDA approval for thefirst monoclonal antibody for a therapeuticpurpose in 1997. Using the expertise of Dr. Ferrara, a vascular biologist atGenentech, and many other basic andclinical scientists, the effort to develop and get approval for a method to treatAMD accelerated. Ranibizumab(LUCENTISTM), a humanized monoclonalantibody antigen-binding fragment (FAB)directed against VEGF, was the result ofthese efforts.

Once the drug had been designed andengineered in the laboratory, it was testedin a series of Phase I and Phase I/II trialsinvolving 27, 32, and 64 patients todetermine whether the drug was safe todeliver by injection into the eye and todetermine what dose and regimen toexplore in pivotal Phase III trials.The final Phase III program involved a total of 1,139 subjects in two trials to establishwhether it was safe and effective. RobertKim, MD, a former resident and currentclinical faculty member in the Departmentof Ophthalmology at UCSF, was the firstophthalmologist hired at Genentech in2003. He shepherded the pivotal Phase IIIprogram required for approval.

UCSF Ophthalmology basic scientists: JenniferLaVail, PhD; Hilary Beggs, PhD; Erik Ullian,PhD; David Copenhagen, PhD; JonathanHorton, MD, PhD; David Sretavan, MD, PhD;Julie Schnapf, PhD; Jeanette Hyer, PhD; andDouglas Gould, PhD.

The Long ViewToday’s Basic Scientists Make Way for Tomorrow’s Breakthroughs

We asked each of UCSF Ophthalmology’s current basic science faculty members to tell us what they do.Three questions included:

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What do you do every day –

what is your project at hand?1How could what you are working on

today be applied – what is the potential

application or increased understanding?

What is your dream?

Hilary Beggs, PhD:We are taking a multifaceted approach tostudy a crucial signaling pathway that utilizesfocal adhesion kinase (FAK) in the eye.

David Copenhagen, PhD:Our two immediate projects are the discoveries andcharacterization of essential molecules required for the normaldevelopment of the retina after birth and for the “transmission”of visual signals, generated by rods and cones, to the brain. Inaddition to mentoring, my daily tasks include grant reviewing,reading the scientific literature, reviewing journal articles, andtrying to deal with the bureaucracy while still maintaining asense of humor.

Doug Gould, PhDI am currently in the process of establishing my lab andstrategic plan of how to best develop my research program.

Jonathan Horton, MD, PhD:With my lab members, I’m seeking tounderstand how visual perception occursin the human brain.

Jeanette Hyer, PhD:My lab works on the development of the anterior portion ofthe eye (the iris, ciliary body, lens, and cornea), how thatcomplicated structure forms, and what has gone wrong when itdoesn't form correctly.

David Krizaj, PhD:My project consists of studying two complementary questions:How do retinal photoreceptors regulate calcium? And, what isthe functional role for glutamate-glutamine interactions in theretina? This involves experimental work, as well as supervisionof postdoctoral students, interactions with colleagues, andpresenting our work to the wider community of scientists.

Understanding how this kinase signaling pathway worksnormally, how it produces lens and retinal disease whenperturbed will: a) not only lead us towards fundamentalbiological insight, but b) towards possible therapeuticintervention.

The techniques we develop and use and the discovery offundamental biological processes will enable future scientistsand clinicians to assess how therapeutic approaches work andpoint to ways to manipulate biological pathways to aiddevelopment of the visual system and to offset degenerativeprocesses of aging.

The goal of my work is to understand theprecise biological processes that lead fromgenetic mutations to human ocular diseases,ranging from ocular dysgenesis, to glaucoma,and to age-related macular degeneration.

Our research is focused on two common visual disorders:amblyopia and strabismus. If we can learn how the processingof visual signals is disrupted in these conditions, we may beable to offer better treatments for patients.

Since there is still no real understanding about how thedifferent tissues interact with each other to create the wholestructures, we don't know how to apply what we have learnedabout the genetics behind glaucoma and other developmentalsyndromes; we hope to provide that link.

The mechanisms we study represent a fundamental problem inretinal biology: most, if not all, photoreceptor degenerations areassociated with pathological increases in intracellular calciumconcentration, which ultimately makes the retina go blind bykilling rods and cones.We characterized a number of novelpathways and mechanisms that both act to increase intracellularcalcium in dying cells (calcium channels) and protect cells frompathological increases (calcium transporters).

The elegance of this approach is that – because pathologicalcalcium is the final common pathway leading to celldegeneration – blocking/manipulating calcium levels may helpus treat MOST, if not all, eye diseases originating fromphotoreceptor degeneration (such as retinitis pigmentosa).

Deletion or dysfunction of FAK produces retinaldysplasia/degeneration, microphthalmia, and lens degradation.We would like to figure out WHY FAK doesn’t work andHOW we might fix it. My dream would be to identify a wayto rescue this gene or inhibit its deleterious actions when it isnot working correctly.

My dream is that the discoveries we make and that thestudents and fellows trained in my laboratory impactpositively how eye disease is ultimately cured and howthe workings of the visual system are understood andrevealed.

My dream is to prevent or treat diseases using genetic medicine.For example, once we understand the genetics behind, andpathogenic mechanisms of,AMD, one could potentiallydetermine the genetic profile of each patient and provide“individualized therapy,” in which each patient is treated in amanner targeted for his or her specific genetic profile.

Newton observed that scientists are like dwarfs perched on theshoulders of giants. My dream is to advance the cause ofmedical science by seeing a little further than my predecessors.Perhaps at some point in the future my research will spareothers from the wantonness of Nature.

An understanding of how these tissues originally form willaid us in learning how they might be reformed andreengineered in the future, perhaps using an individual’sown retinal stem cells (strikingly, stem cell populationshave been found within both the iris and corneal tissue).

The Dream . . . The basic idea is to see the cell as a livingbeing that is trying to make sense of its world and that isresponding to (healthy or pathological) stimuli in a way thatresolves a question posed by its environment. If Ianthropomorphize this teleology a bit – it is to look at a livingcell with respect.This involves understanding of not onlymechanisms but also interactions between these mechanisms inorder to understand what makes a cell such as a photoreceptoralive.What IS life? How do our cells interpret health, and whatmakes them give it up?

(newly arrived at UCSF Ophthalmology):

chairs and encourage research projects and fellowships,using a portion of the interest from invested funds tokeep the department on the leading edge.

“Distinguished professorships and chairs allow us toattract and support an excellent faculty,” according toStephen D. McLeod, MD, chair of ophthalmology andholder of the Theresa M. and Wayne M. Caygill, MD, Chairin Ophthalmology.“Absent the freedom this allows ourfaculty who are supported by these endowments, wewould be challenged to remain among the finestinstitutions in the country.”

The Jane and Marshall Steel, Jr.,Endowment Fund for Vision Research

Endowment Donors Go the DistanceContinued from page 1

recently played a critical role in helping to attract adedicated young scientist to UCSF. Douglas B.Gould, PhD (see interview on page 8), was sought after by several major universities, as hisgroundbreaking research shows great promise in

areas of glaucoma and stroke.

Several factors went into Dr. Gould’s decision to come toUCSF, including the opportunity to work collaboratively

with some of the best minds in the world addressing thecauses and cures for disease from a variety of

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Thank you to loyal contributors TerryCaygill and Pearl Kimura for fundingendowed chairs in ophthalmologythrough That Man May See.

Fall 2006

5Fall 2006

Jennifer LaVail, PhD:I solve puzzles about research, how to teach optimally, and how to support and mentor my research staff so they aresatisfied with their work.The project at hand is to figure out how to block the spread of human herpes virus from the eye to the brain.

Matthew LaVail, PhD:We currently have about 13 different studiesongoing in our lab. Our experiments are directed toward developingexperimental therapy for inherited and age-related retinal degenerations.

Julie Schnapf, PhD:I do electrophysiological research on the retina, teach graduatestudents and postdocs, write research grants, attend scientificmeetings, and review papers in professional journals. For ourresearch, we study how photoreceptors interact with each otherthrough gap-junctions.

David Sretavan, MD, PhD:We have a number of different projects in the laboratory at themoment.They are linked by a fundamental interest in theprocesses of nerve cells called axons.Axons are key toinformation processing in the eye and in the brain, and axonaldamage from injury or disease has serious irreversibleconsequences for vision. Specific studies include basicmechanisms of retinal ganglion cell axon damage in glaucoma,and novel methods using micro- and nanoscale devices foraxon micro-repair.

Erik Ullian, PhD:We are working on several genetic and signaling mechanismsthat regulate retinal neuron survival, morphology, and function.I spend time discussing experiments and data with graduatestudents and postdocs in the lab. I also spend time applying forgrant money from public and private foundations, teachinggraduate students and medical students, and traveling tomeetings to discuss our work and its significance.

We have identified a protein that appears to be required fortransfer of herpes viral DNA to the brain.This protein is apotential target for therapy to block viral encephalitis.

Most of our studies are in the category of applied, or targeted,research. Since we are working with animal models of humanblinding diseases, the findings may be directly applicable tohuman diseases.A number of our current projects could lead tohuman clinical trials similar to a recently completed Phase 1clinical trial of a growth factor called CNTF.

We think that gap-junctions may be involved in the progress ofdisease in retinitis pigmentosa.We would like to know howgap-junctions are regulated naturally in the retina and whatrole they may play in disease processes of the retina.

We believe that our projects are potentially quite clinicallyapplicable.A deeper understanding of how and why opticnerve axons die in glaucoma patients can lead to new avenuesfor diagnosis and treatment. Nerve injuries anywhere in thenervous system have devastating effects on the patient’s qualityof life. Unlike many diseases where significant therapeuticinroads have been made, nerve injuries represent one area ofmedicine where there is as yet no beneficial therapeuticintervention that can be offered to patients.

We want to understand the basic biological mechanisms thatregulate neuronal function and survival.This work is relevant toa variety of diseases and conditions where neurons become sickor do not function normally, such as with glaucoma.

My dream is to confirm that this protein is thesignal that tells neuron motor molecules tocarry the viral DNA into the brain.Then Ihope to develop agents to block its function.

I would hope that our studies will lead to therapy forheretofore untreatable blinding diseases of the retinitispigmentosa category, as well as for the dry form (and, perhaps,the wet form) of age-related macular degeneration.We are veryencouraged by the initial CNTF trials for retinal degenerativediseases.An approach that came from our earlier work showedefficacy of CNTF in slowing retinal degenerations in animalmodels of eye disease.

The dream is to discover pharmacologicalagents that alter gap-junctions in humanpatients and that halt retinal degeneration.

My hope is that these projects will ultimately make an impactin people’s lives. Every once in a while, we receive e-mails orletters from patients who have learned of our research onlineor by word of mouth.Although we cannot offer them a newmedicine or therapy today, hearing directly from people whoselives are affected by these diseases provides everyone in thelaboratory, students, fellows, and research associates, with anextra degree of encouragement and motivation.

My dream is to uncover fundamental rulesgoverning retinal neuron function andsurvival.We believe that understandingthese rules will allow us to attack retinaldiseases with novel tools and approaches. •

What do you do every day –

what is your project at hand?

How could what you are working on

today be applied – what is the potential

application or increased understanding?

What is your dream?

perspectives.The Steel Prize gave Dr. Gould a running starton his research as soon as he arrived in San Francisco.Thisprestigious award of funds is an example of how privatephilanthropy fosters excellence in the face of progressinglimitations from state funds and other government sources.

Building an endowment requires that the organization, aswell as its major funders, go the distance.

The endowment for UCSF Ophthalmology is comprisedlargely from funds raised through That Man May See –given by donors in their lifetimes as well as created fromestate-planned gifts.These funds are invested at the UCSFFoundation and the Board of Regents of the University of

Continued on page 15

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What does the basic scientist do?

New Donation OpportunityTransfer Your IRA to That Man May See

The Pension Protection Act of 2006 allows individuals who are at least 701/2 years ofage to make direct transfers from traditional IRAs and rollover IRAs of otherwise

taxable dollars to certain charities without federal tax consequences.That Man May See isa qualified recipient of such funds.The transfers can be made only in 2006 and 2007 andare limited to $100,000 per individual per year.

For further information, please contact That Man May See, support foundation for UCSFOphthalmology, at 415.476.4016. •

Patient’sP O I N T O F V I E W

Crewe and Paige Hutson

he Paige and Kirby Hutson familybecame intimately involved with UCSFOphthalmology two years ago, whenyoung son, Crewe, needed immediateattention from a doctor who understandsretinoblastoma.“We were on a ski trip toTahoe when we noticed that Crewe’s lefteye was severely dilated,” describes Paige.

A rush to the emergency room and a callto UCSF Ophthalmology brought thefamily together with Joan O’Brien, MD,renowned ocular oncologist, whoperformed surgery and has guided Creweand the Hutsons through a series of stepsneeded to survive the cancer. Dr. O’Brienhas become one of Crewe’s best friends.

Retinoblastoma is a life-threateningchildhood cancer that develops in theretina of the eye and can rapidly spread,up the optic nerve to the brain. It is a fast-growing and dangerous form of cancer.However, if detected early and treatedeffectively, it is survivable.This disease isone of the few cancers that can affect veryyoung children, even newborns. It isalmost always diagnosed before the age offive and accounts for over 12% of infantcancers.Yet a cure for retinoblastoma canhelp lead to cures for all cancers, as Dr.O’Brien’s research illuminates thesimilarity in pathways for retinoblastomaand cancer in general.

An intelligent and especially diligentmother, Paige has become a spokespersonfor the disease. She joined the board ofThat Man May See last year and becamethe co-chair, with Tom Bird from Napa, ofthe Visual Center for the Child at UCSFOphthalmology.

Paige and Tom participated in a site visitthat ultimately resulted in a $2 milliongrant from the Wayne and Gladys ValleyFoundation as a lead gift for the newcenter, a place dedicated to children andfamilies with serious eye issues. Funding

from the Valley Foundation willaccelerate Dr. O’Brien’s search for acure.The capital portion of the grantwill build a family-friendly space fordiagnosis and treatment, including newequipment especially configured forchildren. Doug Fredrick, MD, and Dr.O’Brien are the lead physicians indeveloping the new center, which willinclude an endowment for pediatricophthalmology, the current focus offundraising for the project.

Paige and Dr. O’Brien have developededucational materials at UCSF forfamilies to better understand resourcesavailable when this frightening tumoremerges.

For Crewe, this has been a life-changingexperience that he counts as one of hisblessings.“I’m the first in our family tosurvive cancer, aren’t I, Mommy?” heproudly asked, as he learned the valueof firsts in our world.“I’m so proud ofCrewe and everything he teaches us,but this is one ‘first’ I wish we couldhave avoided,” says Paige. Crewe’s twosisters, Sonja and Summer, support theview that their brother is indeed aspecial child. •

Hutson family helping seek a curefor retinoblastoma.

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6 Fall 2006

Dr. Nancy McNamaraInvestigates Eye Disease at the Clinical and Molecular Levels

‘‘became interested in helping patients

with corneal disorders during mycontact lens residency and decided Iwanted to better understand some ofthese disorders at the molecular level,as well as provide vision care,” saysAssistant Professor of Anatomy Nancy A.McNamara, OD, PhD. In January,Dr. McNamara joined the faculty at theFrancis I. Proctor Foundation to studythe molecular mechanisms of dry eyedisease, and to provide screening andcomprehensive vision care to patientswho need glasses or contact lenses.

Trained as an optometrist and cornealresearcher, Dr. McNamara will combinepatient studies with molecular biology toinvestigate the mechanisms of squamousmetaplasia (benign, noncancerouschanges) in dry eye.The work issupported by a five-year RO1 grantfrom the National Eye Institute. She waspreviously a research biologist in theUCSF laboratory of the late Professor

Carol Basbaum, PhD, studying the role ofinnate immunity in protecting cells fromenvironmental injury.The lab was first todemonstrate a role for specialized receptorson the cell surface (nucleotide ATPreceptors) that communicate the presenceof bacteria outside the cell with the cellnucleus where it can affect geneexpression.

Helping People with Corneal Injury

and Disease

“So many patients who have cornealdisorders from scarring, postsurgery, andinjury have difficulty with glasses andcontacts,” Dr. McNamara says.“Afterpracticing as an optometrist in Michigan, Icame to UC Berkeley to get specializedtraining to help people with corneal injuryand disease.”

Born in Grand Rapids, Michigan, Dr.McNamara graduated from Michigan StateUniversity, and received her optometry degreeat Michigan College of Optometry in Big

Rapids, Michigan, in 1991. Moving to UC Berkeley that year, she completed aresidency in cornea and contact lenses,and then earned a PhD in vision sciencein 1997, with an emphasis on cornealphysiology, biostatistics, and clinical trials.She also studied physiological changes inpatients with diabetes at the Mayo Clinicin Rochester, Minnesota, working withexperts in the field.

Today, she and her husband, NicholasPittler, an attorney specializing in

international aircraft leasing, live in San Francisco.

“Science is my passion, but my childrenare my life,” says Dr. McNamara, whosetwin daughters are six and attend St.Brendan’s School in San Francisco; a sonaged three attends UCSF Preschool inLaurel Heights.Their family loves skiingat Tahoe, and spends summers with alarge, extended family in Glen Arbor, asmall town on Lake Michigan. •

Dr. Nancy McNamarastudying the molecularmechanisms of dry eyedisease.

ProctorP E R S P E C T I V E

I

7

Treatment for Traumatic InjuryDr. Timothy McCulley Bridges Oculoplastics and

Neuro-Ophthalmology

With an interest in two important subspecialties –oculoplastics and neuro-ophthalmology – Assistant

Professor Timothy McCulley, MD, is busy providingclinical care and pursuing research that bridges the twofields. He joins the faculty at UCSF from Stanford, wherehe was assistant professor of ophthalmology and wasawarded the Joint Commission of Allied HealthProfessionals in Ophthalmology Teaching Award in 2004.

“My initial interest was in neurology, and I had an affinityfor surgery,” says Dr. McCulley.“By combining these twospecialties in ophthalmology, I was able to pursue both.”He will serve as the direcor of ophthalmic plastic andreconstructive surgery, teach and mentor residents andfellows, in addition to patient care and research activities.

“I consider it a privilege to be part of the topophthalmology program on the West Coast,” he says.

Research and Treatment for Traumatic Injury“Anyone who is hit in the head hard enough can lose hisor her sight, and there is no effective treatment,” explainsDr. McCulley regarding the importance of research on thebiomechanics of traumatic optic neuropathy.“We areexamining the mechanisms of the injury to the optic nerveto better define where to look next, in terms of treatment.”

Treatment for another traumatic injury, orbitalhemorrhage, generally requires surgery. Dr. McCulley isalso investigating the effectiveness of the standard of carefor that injury – a small procedure that detaches the lateralcanthal tendon from the eyelid.This research will evaluatethe accuracy of intraocular pressure in reflecting orbitalpressure and will determine to what degree the standardsurgery lowers orbital pressure.

A Family Tradition of OphthalmologyLike his father, University of Texas OphthalmologyProfessor James McCulley, who has been chairman of theDepartment of Ophthalmology at UT Southwestern forover 20 years, Dr.Timothy McCulley has extensivetraining in medicine and ophthalmology.

UCSF’s Dr. McCulley was born in Boston and graduatedfrom the Claremont Colleges outside of Los Angeles,receiving his medical degree at Washington UniversitySchool of Medicine in St. Louis. He completed hisinternship, an integrated transitional residency, at theUniversity of Hawaii School of Medicine in Honolulu,and a residency in ophthalmology at Stanford. He alsocompleted a fellowship in neuro-ophthalmology atBascom Palmer Eye Institute in Miami, and a clinical andresearch fellowship in ophthalmic plastic and reconstructivesurgery at Cincinnati Eye Institute.

He is a member of the American Academy of Ophthalmologyeditorial board, and serves on two committees of theNorth American Neuro-Ophthalmology Society.

Currently ensconced south of San Francisco, Dr.McCulley is house-hunting in the city proper.“I’ve alwayswanted to return to San Francisco,” he says. •

Fall 2006

Welcome New Faculty

‘‘

ControllingInfectious EyeDiseaseDr. Nisha Acharya Named Uveitis

Service Director

The entire field of medicine is moving towardsevidence-based patient care, and there is a tremendous

need for randomized clinical trials that can guide treatmentfor our patients with uveitis (inflammation of the inner eyestructures),” says the new co-director of the Uveitis Serviceat the Francis I. Proctor Foundation, Nisha Acharya, MD, MS.

“There are a multitude of potential therapies for infectiousand inflammatory eye diseases, but we don’t always knowwhat treatment is best for which patient,” Dr.Acharya says,explaining her clinical and translational research in thefield of ocular infectious and inflammatory disease.

Multidisciplinary Interests“I was really intrigued by the diversity of patients inophthalmology, and the multidisciplinary approach totreatment for inflammatory eye disease,” says Dr.Acharya.“Conditions that affect the eye can affect the entire body,and we often work with rheumatologists, infectious diseasespecialists, and dermatologists to care for our patients.”

“I have an extremely interesting uveitis clinic at the ProctorFoundation, and it’s wonderful working with eager residentsand fellows,” she says.“We see patients who have seriousinflammatory or infectious diseases of the eye, referredfrom all over the Bay Area. Often we are their last resort.”

Research and TreatmentWith a background in epidemiology and health care services.Dr.Acharya has focused her research on clinical trials.

She is participating in a study that is evaluating whether addingsteroids to the treatment of corneal ulcers will improve clinicaloutcomes.The principal investigator of this NIH trial isAssociate Professor Tom Lietman, MD, of the ProctorFoundation.The major enrollment site for this multicenterstudy is Aravind Eye Hospital in South India. Dr.Acharya hasan NIH/UCSF Career Development Award to study whetherbacterial subtypes and antibiotic resistance factors will affecttreatment outcomes in this corneal ulcer trial. Her mentorsfor this grant are Dr. Lietman, Dr.Todd Margolis, director ofthe Proctor Foundation, and Dr. George Rutherford, directorof the Institute for Global Health at UCSF.

From Musician to MedicineDr.Acharya was a serious violinist who toured with theChicago Youth Symphony. Only when she was anundergraduate at Stanford did she realize her greatestpassion was medicine.

She earned her medical degree at UCSF in 2000, followedby an ophthalmology residency at Harvard’s MassachusettsEye and Ear Infirmary.

Dr.Acharya also completed a research fellowship atGenentech in 2005-2006, working with chief clinicalscientist in ophthalmic medicine, Robert Kim, MD, togain additional expertise in clinical trials in ophthalmology.(See story on Dr. Robert Kim, page 2.)

Dr.Acharya and her husband, Mintu Turakhia, MD, met inmedical school at UCSF, where he is completing afellowship in cardiology with a subspecialty inelectrophysiology. •

‘‘

Focus on Resident EducationDr. Cynthia Chiu Named Assistant

Resident Director

Iwas a student at UCSF and have always thought of thisas the ivory tower of medicine. Now I’ll be working

with residents as a preceptor, guiding them in the clinicand the operating room, and supervising their inpatientconsultations at UCSF, San Francisco General Hospital,and Veterans Administration Medical Center,” says Assistant Professor Cynthia Chiu, MD, who joins thefaculty as assistant residency director this fall. She will also work with Residency Director Doug Fredrick,MD, to reorganize the resident curriculum and optimizeoutcomes for accomplished young residents learning new surgical techniques.

“My motivation is to help residents learn as much as they can for the benefit of the patient,” she says.“This is a three-year opportunity for residents to take advantage of an extraordinary faculty, to learn from their patients,and to read.We owe it to our patients to be as well-rounded and as well educated as possible.”

As a clinician and researcher, Dr. Chiu will see patientsand pursue research on inflammation of the ocular bloodvessels in temporal arthritis that can cause blindness andheart attack.

Coming Home to CaliforniaBorn in Salt Lake City, Utah, Dr. Chiu moved to Danvilleas a teenager. She graduated from Stanford University andcompleted her medical degree at UCSF in 2000, beforecompleting a residency in ophthalmology at Harvard’sMassachusetts Eye and Ear Infirmary.

Dr. Chiu and her fiancé,Annjoe Wong-Foy, PhD, are nowreturning to California from Manhattan, where she wasassistant professor of ophthalmology at Weill MedicalCollege of Cornell University and New York-PresbyterianHospital, and he worked as a physicist, studying photonics(using light to power computers and microchips).

“We’re a pretty nerdy couple,” she says, adding that theyplan to collaborate on projects to help patients with no vision.

They look forward to exploring the restaurants of SanFrancisco (as they’ve been exploring the restaurants of New York), and taking dance lessons.

“Everyone deserves a good quality of life,” Dr. Chiu says.“You have to be studious, in order to take good care of patients and to have the privilege of doing surgery.You also have to set aside time on a daily basis to enjoy your life.” •

8 Fall 2006

role model for his academic aspirations, afather who had been a science teacher.

“I did an extensive job search,” says Dr.Gould, who was completing a fellowship.“My goal was to find a strong, supportiveenvironment for young faculty. Anintellectual atmosphere is extremelyimportant for me.” He will find the Bay Areaan ideal place to also enjoy his avocations,rock climbing, music, and sports.

Dr. Gould received a doctorate in medicalgenetics from the University of Alberta inCanada, where he studied eye developmentand how it relates to glaucoma. Hecontinued studying eye development andglaucoma during his postdoctoral fellowship.

He began to study a particular genemutation (COL4A1 – a type of collagen)that affects eye development but that alsopredisposes mice to brain hemorrhages – acondition that exists in humans as well.COL4A1 is expressed in every organ ofthe body including the vasculature whereit wraps a sheath around blood vessels toafford them greater strength. He noticedthat on the day of birth, some mouse pupswith the mutation were dying with severecerebral hemorrhage, perhaps caused by acombination of the weakened blood vesselsand the trauma of natural birth. Deliveringthe pups by Cesarean section buffered theeffects of COL4A1 mutation and birthcanal stress, but each mutant adult mousecontinued to develop small hemorrhages,and about 20% had cavities in their brains,a condition called porencephaly.

Dr. Gould made another kind of search –one for human families who might sufferfrom porencephaly. He found six: fourDutch, one Italian, and one French, allcarriers of the mutation in COL4A1. Histeam’s results were published in The NewEngland Journal of Medicine, reporting onthe French family, which has experiencedtwo deaths due to cerebral hemorrhage:one adult suffered a head injury at work;the other died while on anticoagulanttherapy.The results of this work could be aprevention of stroke for those who carrythis gene, COL4A1.

The researchers believe this gene’s effectsmight be even greater, extending beyondinfantile stroke and porencephaly to smallvessel disease, responsible for about 30% ofhemorrhagic strokes and sometimes

leading to cognitive impairment in theelderly. It also can cause anteriorsegment dysgenesis (ASD) of the eye,a strong risk factor for developingglaucoma, according to Dr. Gould.

He dreams big.This research is aimed atreducing the risk of hemorrhagic strokeand glaucoma, but Dr. Gould also seesramifications for treatment and preventionof age-related macular degeneration(AMD).As this gene is expressed in everyorgan of the body, mutations couldunderlie many other diseases that are acombination of genetic makeup andenvironmental influences.“Very little isknown yet about the underlyingmechanisms and biological processes ofAMD,” asserts Dr. Gould.“Once youunderstand, it makes it easier to developtherapeutics.” His collaborators at UCSFOphthalmology will be Jacque Duncan,MD; Matthew LaVail, PhD; Hilary Beggs,PhD; and Erik Ullian, PhD. Dr. Gouldalso has a cross appointment with anatomyand will collaborate with neurology.

Many awards and honors already havebeen bestowed on the young Dr. Gould.Receipt of the prestigious Steel Prize, acash award made possible by the Janeand Marshall Steel, Jr., Endowment Fundfor Vision Research, accompanied hiswelcome to UCSF.“I deeply appreciatethese funds so this research can continueimmediately,” says Dr. Gould.“In thecurrent funding climate, securing federalresearch grants is increasingly moredifficult. Organizations like That ManMay See (through which the Steel fundswere given) make it easier to domeaningful and sometimes more creativeresearch, ultimately leading to faster andmore effective treatments for patientswith blinding diseases.” •

Dr. Douglas B. Gould How Genetics Contributes to Human Disease

he development of his line ofresearch is a telling story of insight,tenacity, and sheer brilliance,” saidStephen D. McLeod, MD, on the arrivalof Douglas B. Gould, PhD, at UCSFOphthalmology.“Dr. Gould hasestablished a remarkable career for oneso early in the field, and we are delightedto welcome him to our faculty,” says Dr. McLeod.

Dr. Gould moved to San Francisco inmidsummer from Bar Harbor, Maine,where he was a postdoctoral fellow withthe Howard Hughes Medical Instituteand The Jackson Laboratory. Raised on afarm near Alberta, Canada, in a village of700 people, Dr. Gould had an excellent

The Jane and Marshall Steel, Jr.,Endowment Fund for Vision Researchhelped to attract Dr. Gould.

football game. He played thetrombone,“as in The Mikado,” hesays, citing the Gilbert andSullivan operetta, with his typical,wry sense of humor. He lovesclassical music, especially opera, aswell as hiking in the mountainsand reading.

His passion for internationalophthalmology started early.He and Naomi joined the PeaceCorps for two years after collegeand went to the West Indies,working with 500 volunteers.“The Peace Corps had aprofound impact on my life,”says Dr. Stamper.

A research position at UCLAbrought him to California andalso opened up the world ofmedical research.“I like to look

at new things, but tempered withthe knowledge that some thingssound good but don’t work out,”he says. Dr. Stamper has a widerange of research and clinicalinterests – including early andbetter diagnostic modes forglaucoma.“Diagnostics andmonitoring are a key to savingsight,” he says. Dr. Stamper workson the evaluation of newtechnologies in an effort to findbetter therapeutics to find a curefor glaucoma, one of the majorcauses of blindness today. Hereceived his medical degree fromthe State University of New Yorkand completed residency and a fellowship at WashingtonUniversity in St. Louis.

Glaucoma affects over twomillion Americans. Dr. Stamper’sresearch has taken several tracks:finding new, simpler, and betterways to make diagnosis early;

Dr. Robert L. Stamper

On the door to Robert L.Stamper, MD’s office at

UCSF Ophthalmology, youwill find pictures of his grand-children. In vivid color – allsmiling faces and tousled heads,four offspring in all. Once insidethe door, look beyond thepaperwork on his desk to theblack and white photos byworld-famous photographers:Roman Vishniac, RuthBernhard, Elliott Erwitt, andJudy Dater, a part of his collectionamassed over the years.

Dr. Stamper, the MichalVilensky Endowed Chair forResearch in Ophthalmology,professor of clinical ophthalmology,and director of the UCSFglaucoma service, met his wife,Naomi, at a Harvard-Cornell

finding better ways to monitorfor glaucoma progression; andassessing new pharmacologicaland surgical ways to preventvision loss.

“I like all three aspects of mywork,” says Dr. Stamper, whichincludes taking care of patients,teaching residents and medicalstudents, and conductingresearch to fight blindness.

Dr. Stamper admires world-renowned photographers andenjoys caring for patients.

“Mostly, I like to take care ofpatients – in all age groups.”With glaucoma, a doctor forms a long-term relationship withpatients.“Ophthalmology is veryrewarding,” says Dr. Stamper.“You can help a lot of peoplemost of the time.” •

FacultyP R O F I L E

ResearchP R O F I L E

‘‘T

9

2005-2006A N N U A L R E P O R T

Dear Friends of That Man May See,

Directors and OfficersMarilyn M. Pratt*Chair

Kathleen L. Rydar*President

Daniel Benatar*Vice President

Creig S. Hoyt, MD*Vice President

W. Scott Thomas*Secretary

Ann G. Golson*Treasurer

Richard L.Abbott, MDThomas J. BirdDavid BulferJackson BuschEdward B. Collins J. Brooks Crawford, MDBruce E. Crocker*John F. de BenedettiJanet L. DinsmoreRonald DrabkinEmily H. FineFrançoise G. Fleishhacker*Thomas D. Follett*Douglas R. Fredrick, MDDavid GlotzerPaul L. Gomory, Jr.*Larry HaimovitchJohn E. Hall IIIOssama Hassanein, PhD

Paige HutsonAngus L. MacLean, Jr.*Gerry MarshallThomas R. Mazzocco, MDStacy R. Mettier, Jr., MDRosanne B. OglesRichard J. Olsen*J. Frederick Riedel, MDAlbert R. SchreckIsabel P. SchuchardtStephen S. Smith*Robert L. Stamper, MDR. M.“Terry”ThomasDavid T.TraitelJohn P.Whitcher, MD, MPHA. Sydney Williams, MDAndrew Yau

Directors EmeritiPearl T. KimuraJames P. Livingston

Distinguished Honorary BoardTheresa M. Caygill

Honorary BoardBrook H. ByersAnn Jones CarlsonRoger S. CarlsonJ. Hallam DawsonMargaret DuflockReed FreyermuthMaurice Galante, MDWilliam H. GreenArthur O. HarperCharles W. HomerH. Dunbar Hoskins, Jr., MDThomas F. Kostic

William C. KuehneJack LinkletterPeter H. MattsonNan Tucker McEvoyHerbert P. Moore, Jr.J. Fraser Muirhead, MDAllen S. MusikantowWalter S. NewmanJames R. Powell, MDStanley Powell, Jr.Patricia Lute RobinsonStephen S. Seiff, MDRobert N. Shaffer, MDJon B. ShastidSteven P. Shearing, MDJohn P. StockJames B. SwinertonDexter C.TightAlejandro A. Zaffaroni, MD

Past ChairsStephen S. SmithPeter H. MattsonAngus L. MacLean, Jr.Dexter C.TightRichard J. OlsenBrook H. ByersStacy R. Mettier, Jr., MDJames P. LivingstonWilliam H. Green

Past PresidentsWalter S. NewmanStacy R. Mettier, Jr., MDCrowell Beard, MDSamuel J. Kimura, MD

*Executive Committee

Board of DirectorsThat Man May See, Inc.2005-2006

Clinical/Research FacultyStephen D. McLeod, MDChair

Richard L.Abbott, MDNisha Acharya, MDJorge A.Alvarado, MDRobert B. Bhisitkul, MD, PhDCynthia S. Chiu, MDJ. Brooks Crawford, MDEugene de Juan, Jr., MDMichael V. Drake, MDJacque L. Duncan, MDAllan J. Flach, MD, PharmDDouglas R. Fredrick, MDJonathan C. Horton, MD, PhDEdward L. Howes, MDDavid G. Hwang, MDThomas M. Lietman, MDShan C. Lin, MDTodd P. Margolis, MD, PhDTimothy J. McCulley, MDNancy A. McNamara, OD, PhDAyman Naseri, MDJoan M. O’Brien, MDDaniel M. Schwartz, MDRobert L. Stamper, MDJay M. Stewart, MDErich C. Strauss, MDJohn P.Whitcher, MD, MPHIra G.Wong, MD

Research ScientistsHilary E. Beggs, PhDDavid R. Copenhagen, PhDKeith G. Duncan, PhDDouglas B. Gould, PhDJeanette Hyer, PhDDavid Krizaj, PhDJennifer H. LaVail, PhDMatthew M. LaVail, PhDJulie L. Schnapf, PhDDavid W. Sretavan, MD, PhDErik M. Ullian, PhD

Faculty Emeriti and RecallCreig S. Hoyt, MDAlexander R. Irvine, MDStuart R. Seiff, MD

Faculty EmeritiChandler R. Dawson, MDWilliam F. Hoyt, MDG. Richard O’Connor, MDJohn A. Stanley, MD

FacultyUCSF Department ofOphthalmologyKoret Vision InstituteBeckman Vision Center

Fall 2006

We all feel fortunate to have UCSF Ophthalmology as a resource in our community.

At That Man May See (TMMS), it has been one of our best years of support for this outstanding department. Our faculty and

TMMS are committed to the elimination of eye disease, thereby giving hope to future generations. We could not do this

without you.

One of our greatest pleasures as a board is our role in introducing new friends to this talented faculty. We also enjoy thanking

those who have supported us for so long – 35 years in all.

When we meet these clinician scientists firsthand, we begin to appreciate how special these dedicated people are – an internationally

renowned group demonstrating clinical, surgical, and research expertise every day to make a difference in the lives of others. The complex

ophthalmic challenges confronting us require the finest minds and the funding to help them succeed with their ideas.

Thank you for supporting excellence in patient care, vision research, and physician education through your generosity to That Man May See.

Sincerely,

Marilyn M. Pratt

Chair of the Board

That Man May See, Inc.

Donors

2005-A N N U A L

10 Fall 2006

DISTINGUISHED CONTRIBUTORSThe following exceptional contributors have madegifts that total $1,000,000 or moreArnold & Mabel Beckman Foundation*Theresa M. and Wayne M. Caygill, MDPaul L. and Lois M. Fahrney TrustsFoundation Fighting Blindness*Mrs. Pearl T. KimuraKoret Foundation*Mrs. Jeannik M. LittlefieldDr.Thomas and Mrs.Yvonne MazzoccoBernard A. Newcomb Fund at Peninsula

Community FoundationHelen Pritchard EstateResearch to Prevent Blindness*Shirley Reich EstateMr. and Mrs.Walter Rosenberg Robert Henry Sanborn Estate*Mr. and Mrs. Marshall Steel, Jr.Wayne and Gladys Valley Foundation

Benefactors – ($500,000+)Alexander Family TrustThe Lincy FoundationMrs. Jeannik M. LittlefieldShirley Reich Estate

Visionaries – ($100,000+)Allergan PharmaceuticalsTheresa M. CaygillRichard H. Chartrand Eye Research FoundationFrannie FleishhackerFoundation Fighting Blindness*The Thomas J. Long FoundationMarch of Dimes Birth Defects Foundation*Donald and Judy McCubbinBernard A. Newcomb Fund at Peninsula

Community FoundationThe Bernard Osher FoundationResearch to Prevent Blindness*

Entrepreneurs – ($50,000+)Alcon Laboratories, Inc.David Bulfer and Kelly PopeJeanne CopelandDoris S. and Theodore B. LeeEdmund and Jeannik Littlefield FoundationMr. and Mrs. Charles D. MillerThe John and Lisa Pritzker Family FundThe Sandler Family Supporting FoundationStephen S. and Paula K. Smith Family Foundation

Investors – ($25,000+)AnonymousTom, Jan,Tommie & Christopher BirdHellman Family Philanthropic FundMrs. Pearl T. KimuraDr.Thomas and Mrs.Yvonne MazzoccoNina Pera EstateJoan and David Traitel

Director’s Council – ($10,000+)AnonymousThe Bellini FoundationDaniel and Jeanne BenatarMr. and Mrs. Daniel G. CookEyetis FoundationOssama R. Hassanein, PhDHerst Family FoundationThe Joan Leidy Foundation, Inc.Mr. and Mrs. James P. LivingstonLumenisThe Mattson Family Conservation Foundation Inc.MellonDr. and Mrs. Stacy R. Mettier, Jr.Ivan, Maris, and Harry MeyersonMarilyn and David PrattRobert and Karen Rishwain Family FoundationJeanne and Sanford Robertson FundThe Robinson FoundationThe Schreck FamilyWalter H. ShorensteinLaurence L. SpittersThe Gloria Jean Stefani TrustJohn P. Stock

Luminaries – ($5,000+)Sylvia and Buck BreiholzSuzanne and Bruce CrockerThe de Benedetti Charitable FundJanet and Bill DinsmoreMark Feldberg and Emilyn PageAnn and Charles GolsonSusan and Robert GreenLarry and Carie HaimovitchCharles W. HomerJean-Claude KaminsKoret FoundationChong-Moon Lee FoundationMr. and Mrs.Angus L. MacLean, Jr.McKesson Foundation, IncWalter J. and Patsy R. PartonPayne Family FoundationFrank & Denise Quattrone FoundationSaints and Sinners FundAnn,Aline and David SinaiSkaer Family FoundationEric Zankman and Pamela KaufmannSusan Carter, MD, and Marco A. Zarbin, MD, PhD

Dream Makers – ($2,500+)Mary and Phil AndersonMr. and Mrs. Jeff BleichDavid and Victoria ChangMr. and Mrs. Norman E. CimaKimberly P. Cockerham, MD, FACSEdward and Margaret CollinsMr. and Mrs. Donald W. DavisMarilynn and John FultonMr. and Mrs. Milo S. GatesJames and Julie GrazianiJulie and Walter J. Haas FundKomes FoundationDr. Shiu and Mrs.Wai Wah KwokShan C. Lin, MDMichael and Alexandra MarstonRosanne and Michael OglesToni and Arthur RockKathleen L. RydarDr. and Mrs. Steven P. ShearingRobert and Naomi StamperJacqueline and Robert Young

Innovators – ($1,000+)Anonymous (2)William W.AbrahamDorothy and Richard AnnesserInga and Bryant BennettArthur Berliner Philanthropic FundPaula and Joel BlankMr. and Mrs. Robert N. BlochMr. and Mrs. Johnson S. BogartLeslie and Michael BraunJack Busch and Patty Hagen-BuschC.M. Capital FoundationJohn E. and Helen K. Cahill Fund

Johnson and Selina ChaDr. Shi-Hwa William and Therese ChangJerry and Geraldine ColeEleanore Compagno EstateJoseph V. Costello, Jr.Dr. and Mrs. J. Brooks CrawfordDr. and Mrs. Emmett T. Cunningham, Jr.Peter D’Alena, MDRosalind Gray Davis and Robert M. DavisJohn de Benedetti and Nina SrejovicSue and John DiekmanAnnette DobbsMarilyn and John DougeryDr. and Mrs. James E. DowlingLeonard J. Shustek and Donna DubinskyRobert Eberle and Mary CarryerDr. and Mrs. James F. EggertElaine A. EklundEmily H. FineDr.Allan and Teri FlachTom and Gunilla FollettFrances W. Garron TrustGrant and Austra GaugerMr. and Mrs. Michael R. GaulkePaul and Béatrice Gomory

William V. Good, MDLorrie and Richard GreeneGrimm Family FundDr. and Mrs. Plato J. GrivasPauline L. HaddadArthur and Shirley HarperChristine HarrisThe Hartless FoundationCharlene HarveyKenneth G. Hausman and Ellyn LazarusJonathan and Lidia HortonEdward L. HowesPaige and Kirby HutsonAlexander Irvine, MDMargaret M. JacobsenDr.Arthur and Mrs. Peggy JampolskyJoan and Paul KaufmannElizabeth H. KemsleyRobert L. KnoxBurton and Dale KushnerBabette LevingstonLocal Independent CharitiesAngiolina MartiniStephen D. McLeod, MD, and Marion FaymonvilleRichard and Virginia MichauxPeter and Lela MoulthropLary Lynn and Anthony MullerAyman Naseri, MD, and Alejandra G. de Alba,

MD, MPHCameron Parsa, MDCyril M. and Roma C. PeletzVelimir and Ming PetrovicMrs. Joan PlattDan PoratWalter T. RaineriCharles J. RobelJohn W. and Barbara H. RosstonSan Francisco Chinatown Lions CaliforniaJohn and Diane SavageIsabel P. SchuchardtDaniel M. Schwartz, MDDr. and Mrs. Stuart R. Seiff and FamilyMary and Marshall SmallPierre and Dorothy SpearMichael H. StaffMr. and Mrs. Dexter C.TightChristopher and Lori ToomeyMichel and Masako VacheronKatherine and Mark ValentineSylvia B.Vicknair*William D. and Mary Jane WalshJack and Marilyn WhitcherRuth S.WhiteA. Sydney Williams, MDDrs. Myra and Burton Wise

Supporters – ($500+)AnonymousRobert Bhisitkul, MD, PhD, and Sara MacPhersonMarcus and Elaine BitterDr. and Mrs. Edwin E. BoldreyDr. and Mrs. Blaine S. BoydenBunker & Company, LLPGene L. Campbell and Lee Devereaux CampbellArnett Carraby, MDDenis and Anne CarrollMrs. Olive CookPeter and Lisa CracknellChandler and Paula DawsonEmma Dong, MD, and Harry Chong, MDDr. and Mrs. Francisco A. GarciaGolden Road Motor Inn, Inc.R.Thomas HarrasCynthia Sperry HarrisDean and Debra HirabayashiCharles and Alice HoffnerDr. and Mrs.Thomas C. Hoyle, IIIDr. Man and Grace KimBarbara and Robert LeeThomas and Linda LeonDan and Meta LightfootTodd and Nina MargolisBrian R. Matas, MDPaul S. NadlerRichard and Susan Olness

Peerless LightingJames Pickrel and Carolyn WoolleyGeorge and Karen RathmanFred and Judy RiedelSue J. SiegelMr. and Mrs. Dean W. SkanderupJim and Mary SmithMary Ann Milias St. PeterJudith Good StearnsMrs.Ann C. SteppanJohn and Peggy StockRoselyne C. SwigWendy and David TeplowAlexander S.WalkerMrs. Laverne M.WalshMichael L.Wang, MD, FACSTerry and Madeline WelshMr. and Mrs. Hulton B.WoodPeggy and Lee Zeigler

Patrons – ($250+)Cecilia and Richard AbbottTerry Pink AlexanderJoe Franklin Arterberry, MD, FACSCharles J.Astrue, Jr.Von Joseph BarsottiAnne and David BaudlerDepartment of Ophthalmology and the Pacific Vision

Foundation at California Pacific Medical CenterRachel and Andrew BerlinerRaymond and Marian ChristensenSally Collins and Chris WarthBen Colloff, MDJudge and Mrs. John S. CooperJoyce and David CopenhagenSusan H. Day, MDThelma de SouzaBettye Poetz Ferguson FoundationMichael E. FoleyPete Greco, Jr., and Nancy K. GrecoChristine Miller HighThe Honorable and Mrs. George W. KennedyLeonard E. KingsleyMatthew LaVail, PhD, and Katelin Ryan-LaVailBen LefflerChi-Chun and Anna LiaoTodd and Stacey MelcherGeorge Nissen and Peter NissenRichard NormanOwen Oakley, Jr.Mr. and Mrs.Walter H. ObermeyerG. Richard O’Connor, MDMary Alice and Tom O’MalleyA. David Parnie, Esq.Genelle RelfeEdwin A. Seipp, Jr.Lata Krishnan Shah and Ajay ShahBradley ShoreDr. and Mrs. Lionel W. SorensonPearl TalbotUnited Way of the Bay AreaMaxine Wanner

Friends – ($100+)Jorge and Jean AlvaradoRobert C.AreggerB. H. BallardJoan and John BarkanElaine G. BauerC. H. BaumhefnerHilary Beggs, PhD, and Thomas BarbashMr. and Mrs. Ronald BenvenisteRolf M. and Pamela BondelieKatherine M. BonniciFred Borg and Susan HorstDaphne BranstenNewman and Joanne BuckleyNieca D. Caltrider, MDRic Charlton and Barbara Charlton

Endowed Professorships and ChairsProfessorships and chairs providesustained support for research andclinical faculty.Jean Kelly Stock Distinguished

ProfessorshipThomas W. Boyden Endowed Chair in

OphthalmologyTheresa M. and Wayne M. Caygill, MD,

Chair in Ophthalmology*

William F. Hoyt, MD, Chair inOphthalmology

Pearl T. and Samuel J. Kimura, MD, ChairSteven G. Kramer, MD, PhD, Endowed

Chair in OphthalmologySteven P. Shearing, MD, Chair in

OphthalmologyMichal Vilensky Endowed Chair for

Research in OphthalmologyRose B.Williams Chair for Research in

Corneal Disease

Thank You for EndowmentsThank you to our

generous friends; you add

inspiration to the work

of our dedicated faculty.

Kathleen L. RydarPresidentThat Man May See

2005-2006

-2006 R E P O R T

Catherine E. ChiltonFrederick A. ChristiansenJ. Hallam Dawson and Mary McVeyDr. and Mrs. John T. DawsonRaymond and Joyce De MatteiJanet Tashima DeboskeySandra and Conrad DonnerRosalind and Sanford DorbinCarl E. Drake, Jr., MD, PhDMark H. Elias, MDLouise and Robert ElliottJohn T. Flynn, MDKenneth Frangadakis, DDSDr. Douglas and Mary Pat FredrickJoyce and Jay FriedrichsKaren K. FuArdette L. FultonVyvien M. GearDr. Lee Goldman and the UCSF Department

of MedicineLinda and Lou GolmAnn and Don GralnekJeanne S. GressensJohn Hall and Rebecca DerringtonRobert C. HarrisMrs. Jennie HenderRobert HermanA. Joan HolstiusDr. and Mrs. George K. HortonH. Dunbar Hoskins, Jr., MDJane and David JacksonWilliam E. and Corinne J. JensenConstance L. JohanssonDr. Ronald A. KalaytaJo KennedyDr. and Mrs. J.W. KohlTerry and Bill KrivanScott R. Lambert, MDJanet B. LandauerJennifer H. LaVail, PhDVernon F. Lightfoot, MDD.F. Lucey and FamilyJames J. Ludwig and Eileen D. Ludwig FoundationDavid MacKenzie and Patricia GarrettJohn M. MahoneyMargaret E. MalloryV. David ManahanPatricia and Joseph ManciniVeronica J.B.D. MastersonPaul and Joan McKnightJohn R. McManus and Rhonda RossiT. Neal McNamaraGeorge W. McNelly and B. Louise McNellyBonnet J. MeihoeferClarence and Joan MiguelRobert and Bee Gee MillinichThomas F. Minas, MDBarbara and John MiragliaJanet MiyataJacob L. MobergBarbara J. MonieHerbert P. Moore, Jr.Kay J. MooreNeil Cummins Elementary SchoolNew United Motor Manufacturing, Inc.Joseph J. O’BrienMrs. Florence C. PauliKim-Lien and Frederick PeckRenaldo and Ellen PepiRose PeraDr. and Mrs. Edward C. PersikeVibeke H. Petersen-JensenSusan and George PfauCeleste and Roger PhillipsTerri-Diann Pickering, MDMr. and Mrs. John PientaJulia J. PonSenator William J. RaggioDr. and Mrs. J. Earl Rathbun

Wilma Reichard and Gordon HowieRichard and Marianne ReynoldsDouglas RiggBenson B. Roe, MDEdith and Morris RubesinJoel and Sylvia SaldingerAriah Schwartz, MD, and Pauline Schwartz, PhDDr. and Mrs. Norman F. Schwilk, Jr.Richard L. SegalBeth and Kurt SeibertMrs. Rosalie SetonJohn and Barbara ShaferDr. and Mrs. Robert N. ShafferJoseph Peter SiminiDr. and Mrs. Richard SlavinJeanette and Steven SmithVictoria C. SmithNorman and Masa SoskinDr. and Mrs. Stuart B. StephensTracy and Charles StephensonRobert E. SwingleyDr. Scott and Mrs. Jennifer SykesSeiji, Masuko, and Judy TakanoStephen C.Tanaka, MDLarry TeagueRosemary E.ThakarMr. and Mrs. J.R.ThallKathleen ThielDenise and Terry ThomasBarbara Ann ThompsonJohn and Jane ThrelkeldR. Douglas Wayman, MDRichard and Joyce WeismannRichard H.Whitten, MDKathryn D.WilliamsNancy B.WilsonIan and Margaret WishartSusan Wong, MDWoodburn and WedgeElsie WrightKathleen Ouchi Yamaguchi, MDLucy and Peter Yang

ContributorsAnonymousLorita D.AaronsAbdul R.Al-Shamma, MDBernice BiedermanJohn R. BlackmanThomas and Margaret BowmanNorma M. BrinerKate Doyle BrownPatricia L. BrownIsabel M. BucklesBarton and Patsy ByersMuriel S. CalegariLloyd and Gloria CarlsonLisa ChangThe Chavez FamilyThe Chubb CorporationJoan G. CogenDavid B. Cooper, Kate Mitchell, and Daniel CooperMrs. George CostelloCarmen V. CritchlowSharon A. DanielWilma DanielDr. and Mrs.William A. DanzJack R. and Claire L. DavisDeogracias de la RosaJudith Del TrediciNorman & Laura Dianda, Mike & Julie Dianda and

Chris DiandaJacque and Keith DuncanMarta B. DuntonJeremy N. EgenbergerNetta F. and Michael F. FedorD. M. FigleyColleen FraserRobert C. Frates, Jr., DDS, and Patricia A. FratesNancy B. FromEdward A. GallagherIda GearyJames GeeCraig L. GerlachMr. and Mrs. Harold J. Giebler

Howard and Lenore GoodmanThomas and Judith GrubeW.W. GudmundsonWilliam W. HalprinWanda R. HambyDonald and Barbara HendersonMr. and Mrs. John F. HenshawStanley HertzDiana HicksMarcia T. HillMr. and Mrs. Roy E. Hills, IIIRuth HiltsRosemarie HirschlerJill J. HorowitzRobert and Anne JohnsonHyuenchung J. JongDr. and Mrs. John D. KasterLev KatsnelsonDaniel W. KingRobert and Marilyn KlingerLillian and Eugene KodaniMonica KomivesWanara KumalaDonna Lee LampertMargit LandesmanDavid and Judith LayneCharles, Rosemary, and Bridget LeachTammy R. Lewis, ODKermit Lipez and Nancy ZieglerBarbara LivingstonCora C. LohseRay and Mary LopezPatricia M. LuceyCarole and Bruce MacPhailMarjorie MahoneyJoseph ManciniDennis and Susan MarMassucco Family TrustJudge and Mrs. John S. McInernyWinifred A. McKinnonDr. and Mrs. Eugene B. McLaurinRoy and Loraine MichaelJan M. MillerMelvin and Mildred MogulofClara MonroeEleanor C. MoorePamela and Mark MooreMary NicolaisenJan W. Olsen and Teresa L. Kangas-OlsenToni J. PascucciJohn H. PinskiEugene PlockiGrace PrienPaul and Christine PrusinerBarbara S. PughPauline Leveille QuiliciBernard and Florence RechtschaffenH.T. and Marguerite RichterJoanne RobertsElaine RosenfeldEmanuel and Miriam RozentalHelen Almazan RudnickNancy J. RuppMargaret RussellWilliam and Wilma RyanRuth M. SakaiRoseann and Edwin ScottLarry and Dona ShaidnagleLeila and Everett ShockleyJoseph ShouaTony Zackin and Katharine SilvermanMaxine SimontacchiRobert E. SpivockSharon StaleyDora Lou and Charles SticeMarjorie C. StockettMargery H. StrassC. Coe SwobeWayne L.TaylorMr. and Mrs. Edwin H.TierneyDiana ToomajianBernard J.Vogel, Jr.William and Camele WanatTimothy and Jennifer WelshHenry S.Wiencek and Donna Lucey Wiencek

Marjorie J.WilcoxJohn Williams IIIMr. and Mrs. Philip C.WoodsMrs. Harry YaglijianYing Chuen Yip

Gifts in KindThomas J. BirdJessica and James FlemingDr.Thomas and Mrs.Yvonne Mazzocco

VISIONARY SOCIETYThose who have chosen to include That Man MaySee, Inc., in their estate plansMs. Lillian AlbertsenMrs. Helen E.AmmenMs. Elaine G. BauerMrs. Clyde CarringtonMrs. Sarah Carroll-HirschTheresa M. CaygillMr. Ralph CechettiniMr. and Mrs. Ralph A. CoddeMs. Jeanne CopelandJoan E. Diblin, PhDJanet and Bill DinsmoreDavid and Adeline EdwardsMs. Denise B. EvansMrs. Janet GolnerJohn E. Hall III Mr.Arthur O. HarperMrs. Mildred B. HartMr. and Mrs.William G. HoffmanCreig Hoyt, MDMs. Marjorie JacksonClare & Gordon Johnson Charitable TrustMrs. Clarence K. JonesMrs. Elizabeth KennedyMrs.Walter KesslerMrs. Pearl T. KimuraMr. and Mrs. Sigmond A. Kriegsman, Jr.David and Mary Jane LaityMr. and Mrs. Harold LillardJames P. LivingstonMr. and Mrs. McKay MarlerMs.Angiolina A. MartiniStacy R. Mettier, Jr., MDPeter and Lela MoulthropBoris D. Nahlovsky, PhDMrs. Marjorie A. NolteJ. Frederick Riedel, MDMiss Emily B. RievaulxKathleen L. RydarMr. Jon B. ShastidMrs. Branna SisenwienMrs.Arthur T. SkaerMrs. Marshall Steel, Jr.Mr. John P. StockMr. Daniel E. StoneMs. Carol StraussMr. Dexter C.TightMrs. George A.WatsonMr. and Mrs. Richard M.WeismannMr. Ronald P.WinikerEleanor and Ira G.Wong, MD, Family Foundation

BEQUESTSRealized bequests benefiting the UCSF Departmentof OphthalmologyAlexander Family TrustEleanore Compagno EstateFrances W. Garron TrustNina Pera Estate*Shirley Reich EstateThe Gloria Jean Stefani Trust

* Gifts received via the UCSF Founation or Board of Regents

11Fall 2006

Endowed Research FundsResearch funds support innovativeresearch.The Dawn Society EndowmentHeleanor Campbell Foerster Ophthalmic

Pathology Endowment*Samuel J. Kimura, MD, Endowment FundRobert H. Sanborn Research Fund*Jane and Marshall Steel, Jr., Endowment

Fund for Vision ResearchDexter C.Tight Macular Degeneration

Endowed Research Fund

Endowed Education FundsEducations funds provide permanentfunding for academic lectures.George and Rosalie Hearst Fellowship in

Ophthalmology*Amy S. McNamara Endowed Fund*Francis I. Proctor Lecture Fund*Transamerica Visiting Professorship in

Vision Science

General Endowed FundsThese endowments are appliedwherever the need is greatest.Frances W. and Levon K. Garron

EndowmentMichael J. Hogan, MD, Endowment FundCharles Taylor Reeve Endowed Fund*Agnes M.Welsh Eye Fund*

Endowed funds raised by That Man May See are managed by the UCSFFoundation.

* UC Regents endowments. Others are held bythe UCSF Foundation.

2005-2006A N N U A L R E P O R T

Received and Influenced by Gifts Committed by 6/30/06 to BeTMMS FY Ending 6/30/06* Received in FY 2006-2007 Total

Board Gifts $846,498 $23,000 $869,498

Individual Gifts $2,579,833 $292,750 $2,835,573

Bequests $2,785,573 $50,000 $2,835,573

Corporations, Foundations, Other $2,047,131 $2,140,000 $4,187,131

Total $8,259,035 $2,505,750 $10,764,785

*Some gifts are processed through the UCSF Foundation and Board of Regents, primarily as bequests.

TMMS – Sources of Private Support

Clinical Revenue $8,394,924

National Institutes of Health $3,213,662

Private Sources of Funds $4,670,252

Endowment Income $923,671

State Funds $955,599

Total $18,158,108

UCSF Department of Ophthalmology Source of Funds

� Clinical Revenue � National Institutes of Health � Private Sources of Funds � Endowment Income � State Funds

Faculty/Clinical Fellows $6,293,478

Research & Administrative Staff, Supplies & Equipment $7,277,681

Patient Care & Clinical Expenses $3,919,065

Institutional Taxes & Fees $667,884

Total $18,158,108

UCSF Department of Ophthalmology Use of Funds

� Faculty/Clinical Fellows � Research & Administrative Staff, Supplies & Equipment� Patient Care & Clinical Expenses � Institutional Taxes & Fees

12 Fall 2006

July 1, 2005, to June 30, 2006

Select Patient Care and Education Awards Eugene de Juan, Jr., MD Equip and Upgrade Research LaboratoryDouglas Fredrick, MD Residency Education FundJonathan Horton, MD, PhD Neuroscience Program Seminar SeriesDavid Hwang, MD Support for Fellow from Japan for Dr. David Hwang’s Human Cornea ProjectStephen McLeod, MD UCSF Ophthalmologic Epidemiology and Clinical Trials Center

Select Research AwardsJorge Alvarado, MD Cytokines Released by Trabecular Meshwork Endothelial CellsJacque Duncan, MD High Resolution Retinal Imaging in Patients with Inherited

Retinal DegenerationsDavid Krizaj, PhD Calcium Overload and Photoreceptor Death Jennifer LaVail, PhD Role of Tegument Protein US9 in Anterograde Delivery of Herpes Simplex

Virus Nuclecapsids to the AxonMatthew LaVail, PhD Animal Models and Therapeutic Studies on Retinal Degenerative DiseasesThomas Lietman, MD Mycotic Ulcer Treatment TrialTodd Margolis, MD, PhD Medical Discovery in the Field of Infectious Eye DiseaseJoan O’Brien, MD High-Throughput Screening for Retinoblastoma Gene Mutations and Retinoblastoma

Mutation Database – International DevelopmentJulie Schnapf, PhD Signal Processing in RetinaDaniel Schwartz, MD Novel Techniques for Imaging and Treating Bruch’s Membrane Lipid DepositsDavid Sretavan, MD, PhD Microdevices for Minimally Invasive Glaucoma SurgeryErik Ullian, PhD Role of Micro-RNAs in Retinal Ganglion Cell Development

and Disease

Seed Funding for ResearchThat Man May See Awards to the Department of Ophthalmology: $4,160,306

Dr. David Sretavan Receives Lew R.

Wasserman Award

avid Sretavan, MD, PhD, is one ofonly seven this year granted a Lew R.Wasserman Merit Award by Research toPrevent Blindness (RPB). Dr. Sretavan isamong 85 scientists at 37 institutions whohave been honored with this prestigiousaward over the past eleven years.

Recognized as an expert in the field ofdevelopmental neuroscience with specialinterest in optic nerve formation andregeneration, Dr. Sretavan is professor ofophthalmology and physiology at UCSFOphthalmology.

Dr. Sretavan will use this award to supportglaucoma research on the molecularmechanisms of retinal ganglion cell(RGC) axon damage. Glaucoma is a major cause of vision loss worldwide andis expected to become an increasinglyserious health issue as the generalpopulation ages.Although it is clear thatelevated intraocular pressure is a major riskfactor for glaucoma, the molecular eventsthat lead to RGC death are not known.Dr. Sretavan’s laboratory will investigatewhether specific receptor tyrosine kinasesthat have been detected at the optic nervehead of animals with glaucoma contributeto the progression of the disease.Ultimately, this work could lead to specific pharmacologic treatments thatdelay the onset or slow the progression of the disease.

Established in 1995, the Research toPrevent Blindness Lew R.WassermanMerit Award provides unrestricted supportto mid-career MD and PhD scientists whohold primary positions within departmentsof ophthalmology, and who are activelyengaged in eye research at medicalinstitutions in the U.S.

Dr. Erich Strauss Presented with

James S. Adams Award

Assistant Professor Erich Strauss, MD, hasreceived the James S.Adams Scholar Awardfrom Research to Prevent Blindness.Theaward is part of RPB’s Special Scholarprogram, which supports outstandingyoung scientists conducting research ofunusual significance and promise.

A specialist in immune and inflammatoryeye disease, Dr. Strauss is director of thePearl and Samuel J. Kimura OcularImmunology Laboratory at the Francis I.Proctor Foundation at UCSF, which isdedicated to research and training ininfectious and inflammatory oculardiseases. He is also an assistant professor ofophthalmology at the UCSF Departmentof Ophthalmology and a visiting scientistat the UCSF Gladstone Institute ofVirology and Immunology.

Immune and inflammatory ocular surfacedisease may result in blindness, and patientswith these diseases currently have limitedtreatment options available. Dr. Strauss’slaboratory-based research program is

focused on the molecular mechanismsmediating sight-threatening inflammatoryand autoimmune disease of the ocularsurface.

Based on his clinically relevant modelsystems, Dr. Strauss’s investigations promiseto provide a fundamental understanding ofthe molecular signaling pathways promotingocular surface immuno-inflammatorydisorders.This research is aimed atidentifying novel targets for therapeuticintervention.

RPB Announces Career Development

Award for Dr. Erik Ullian

Neurobiology researcher,AssistantProfessor Erik Ullian, PhD, has beengranted a four-year Career DevelopmentAward by Research to Prevent Blindnessto support eye research in the field of glaucoma.

The RPB Career Development Award was established in 1990 to attract youngphysicians and basic scientists to eyeresearch.This marks the seventh time that UCSF Ophthalmology has receivedthis award.

Glaucoma is the second leading cause ofblindness in the U.S. One promisingavenue for the treatment of this and otherdiseases or injuries is replacement ofthe retinal ganglion cells that die.For this treatment to work,progenitor or stem cells mustdifferentiate into theappropriate cell type andthen become integrated intothe synaptic circuitry of theretina and brain. Dr. Ullian’swork explores the process bywhich this synaptic integrationoccurs in the visual system.

To facilitate regenerationof active retinal cellsthat would allow theinjured eye to “see,”Dr. Ullian hasidentified some of

the signals and cell types that are requiredto form synaptic connections.As withother neurons generated from stem cells,these retinal ganglion cells do not initiallybecome activated or integrated in retinalcircuitry when they are formed. He iscurrently aiming to explore these signalsfurther, to understand the molecularmechanisms that lead to integration intoretinal circuitry, so that future therapiesusing stem cells would allow retinalganglion cells to be made and to function fully.

RPB Provides Critical Unrestricted

Support to the Department

Research to Prevent Blindness has awardedan unrestricted grant to the Departmentof Ophthalmology to support researchinto the causes, treatment, and preventionof blinding diseases.The research will bedirected by the department chair, ProfessorStephen McLeod, MD.

Funding from RPB provides criticalunrestricted support for a wide range of programs at UCSF Ophthalmology,developed by a faculty of basic and clinical scientists.

Basic science programs supported by RPBfunding include the study of the neuralmechanisms of amblyopia; fundamental

cellular processes in retinalfunction; the relationship

between retinal signalingand human visualperception; axonalguidance systems; retinalsynapse development; andthe molecular biology of

lens development.

RPB funding also supports a vibranttranslational program in ophthalmology atUCSF that includes ophthalmic devicedevelopment, such as the next-generationof accommodative and adjustableintraocular lenses; novel drug deliverydevices; and optical retinal imaging devicesadapted to the study of degenerativeretinal disease.Additional RPB fundingsupports translational projects includingmolecular mechanisms of ocular surfaceinflammatory disease and dry eye andrelated therapeutic targets; moleculardiagnostics for ocular tumors; and novel cellular targets for the treatment of glaucoma.

To date, RPB has awarded grants totaling$4,904,656 to UCSF Ophthalmology andthe Proctor Foundation. •

Research to Prevent Blindness Awards

David Sretavan, MD, PhD, andErich Strauss, MD.

D

13Fall 2006

Celine Bouquet, PhD

Postdoctoral Fellow: Lens and Retina Lab: Hilary Beggs, PhDBorn: Lyon, FranceCollege: École Normale Supérieure de

Lyon, FranceGraduate Degree: PhD, Neuroscience, Pierre

and Marie Curie University,Paris

Wesley Chang, PhD

Postdoctoral Fellow: Neurosciences Lab: David Sretavan, MD, PhDBorn: San Jose, CaliforniaCollege: UC BerkeleyGraduate Degree: PhD, Mechanical

Engineering, UC Berkeley

Clifton Dalgard, PhD

Postdoctoral Fellow: Ocular Oncology Lab: Joan O’Brien, MDBorn: San Francisco, CaliforniaCollege: UC BerkeleyGraduate Degree: PhD, Neuroscience,

Uniformed ServicesUniversity of the HealthSciences, Bethesda, Maryland

Tigwa Davis, PhD

Postdoctoral Fellow: Neurodevelopment Lab: Erik Ullian, PhDBorn: Lansing, MichiganCollege: Morehouse College,Atlanta,

GeorgiaGraduate Degree: PhD, Pharmacy, University

of Michigan

Juan Du, MD, PhD

Postdoctoral Fellow: GlaucomaLab: David Sretavan, MD, PhDBorn: Xifeng, ChinaCollege and Medical School: MS and MD, Norman

Bethune University ofMedical Sciences, ChangChun, China

Graduate Degree: PhD,Vision Science, PekingUniversity Health ScienceCenter

John Economides, PhD

Postdoctoral Fellow: Neuro-Ophthalmology Lab: Jonathan Horton, MD, PhDBorn: Lawrence, KansasCollege: University of Kansas,

LawrenceGraduate Degree: PhD, Neuroscience,

University of Texas MedicalBranch, Galveston

Postdoc: Postdoctoral Researcher,Emory University,Atlanta

Juliette Johnson, PhD

Postdoctoral Fellow: Developmental Neurosciences Lab: David Copenhagen, PhDBorn: CaliforniaCollege: UC DavisGraduate Degree: PhD,Anatomy and Cell

Biology, UCLA

Research Fellows 2006–2007Accomplished Scientists Join UCSF Research Labs

Fumie Kagaya, MD, PhD

Postdoctoral Fellow: CorneaLab: David Hwang, MDBorn: JapanMedical School: MD, University of Akita

School of Medicine, JapanGraduate Degree: PhD, Ophthalmology,

University of TokyoResidency: Tokyo University HospitalProfessional Appointment: Assistant Professor,

Ophthalmology, IchiharaHospital,Teikyo University

Xiaorong Liu, PhD

Postdoctoral Fellow: Developmental Neurosciences Lab: David Copenhagen, PhDBorn: Shijiazhang, ChinaCollege: Peking UniversityGraduate Degree: PhD, Biology, University of

Virginia

Sarah Moseley, PhD

Postdoctoral Fellow: Neuro-OphthalmologyLab: Hilary Beggs, PhDBorn: Great BritainCollege: University of East Anglia,

Norwich, England Graduate Degree: PhD, Molecular, Cellular, and

Developmental Biology, UCSanta Cruz

Petras Ongen, MD

Postdoctoral Fellow: Ocular Oncology Lab: Joan O’Brien, MDBorn: CroatiaCollege: BS, BA, Honors, University of

Illinois, Champaign-UrbanaMedical School: MD, University of Illinois,

ChicagoResidency: Internal Medicine, University

of Illinois Hospital, ChicagoPostdoc: Visiting Postdoctoral Scholar,

UCSF

Luciano Pereira, MD

Hearst Fellow: Oculoplastics and Neuro-Ophthalmology

Lab: Timothy McCulley, MD Born: São Paulo, BrazilCollege and Medical School: MD, Federal University of

Uberlândia, Minas Gerais,Brazil

Residency: Santa Casa Misericórdia deSão Paulo, São Paulo, Brazil

Jose Perez, PhD

Postdoctoral Fellow: Ocular Oncology Lab: Joan O’Brien, MDBorn: Manila, PhilippinesCollege: BA, Biology, ColumbiaPostgraduate studies, Molecular Biology, NYUProfessional Appointment: Research Assistant,

Rockefeller UniversityMedical School: PhD, Biochemistry, Rutgers,

University of Medicine andDentistry of New Jersey

Postdoc: Postdoctoral Research Fellow,NYU Howard HughesMedical Institute; PostdoctoralScientist, Sugen, Inc.

Jan Verweij, PhD

Postdoctoral Fellow: Retina Lab: Julie Schnapf, PhDBorn: Huizen,The NetherlandsCollege: BS, University of Utrecht,

The NetherlandsGraduate Degree: PhD, University of

Amsterdam,The Netherlands

Wiwan Sansanayudh, MD

Proctor Research Fellow: Cornea and External DiseaseBorn: Bristol, United KingdomMedical Degree: MD, Srinakarinwiroth

University, Bangkok,ThailandInternship: Anandamahidol Hospital,

Lopburi,ThailandResidency: Ophthalmology,

Pramongkutklao Hospital,Pramongkutklao School ofMedicine, Bangkok

Other Fellowships: Cornea and RefractiveSurgery Fellowship,Ramathibodi Hospital,Mahidol University, Bangkok •

he most talented, capable physician scientists and PhD graduates join UCSF vision research laboratories each year as research fellows, priorto obtaining appointments in academia or in commercial laboratories.

The research fellows at UCSF this year are making significant contributions to ophthalmology research.

T

14 Fall 2006

California.“Our endowmentdonors greatly strengthen the department,” says KathleenL. Rydar, president of That Man May See.“Thanks to thegrowth of these funds over the past decades, we are able todemonstrate the value of placing this trust in UCSF.”

This past year,TMMS developed funds for three newchairs: one from the estate of the late Shirley Reich,another from the estate of the late Edward and EstelleAlexander, and another from a collection of gifts fromcolleagues and friends of the recently retired chair ofophthalmology, Creig S. Hoyt, MD, and his wife, Debbie.

“Our goal is to have an endowed chair for each of ourprofessors and associate professors,” explains Dr. McLeod.“And, we hope someday that our generous contributorswill support new distinguished professorships to anchoreach of our research and clinical divisions.This is what setsa university apart and provides distinction for holders ofindividual chairs and professorships, as well as a legacy ofcontribution for our donors.”

That Man May See and UCSF Ophthalmology salute and thank the generous individuals and foundations whocontributed to the current endowments. •

ENDOWED PROFESSORSHIPS AND CHAIRS

Professorships and chairs provide sustained support

for research and clinical faculty.

Eugene de Juan, Jr., MD, holds the Jean Kelly StockDistinguished Professorship

Stephen D. McLeod, MD, holds the Theresa M. andWayne M. Caygill, MD, Chair in Ophthalmology*

Jonathan C. Horton, MD, PhD, holds the William F.Hoyt, MD, Chair in Ophthalmology

Joan M. O’Brien, MD, holds the Pearl T. and Samuel J.Kimura, MD, Chair

Douglas R. Fredrick, MD, holds the Steven G.Kramer, MD, PhD, Endowed Chair in Ophthalmology

Michael V. Drake, MD, has held the Steven P. Shearing,MD, Chair in Ophthalmology, until his recentappointment as chancellor of the University ofCalifornia at Irvine

Robert L. Stamper, MD, holds the Michal VilenskyEndowed Chair for Research in Ophthalmology

Richard L.Abbott, MD, holds the Thomas W. BoydenEndowed Chair in Ophthalmology

Todd P. Margolis, MD, PhD, holds the recentlyestablished Rose B.Williams Chair for Research inCorneal Disease

New chairs currently being established and

awaiting the university’s official approval include:

Edward and Estelle Alexander Chair for Vision Research

Deborah Hoyt and Creig S. Hoyt, MD, Chair inPediatric Ophthalmology

Shirley Reich Chair in Ophthalmology

Faculty AwardsFunding forRetinalDegenerationCenter

The Foundation Fighting Blindness,Baltimore, MD, awarded the Kearn Family

Center for the Study of Retinal Degenerationwithin the UCSF Department of Ophthalmology,with a five-year renewal for highly collaborativeresearch efforts.The Kearn Center, headed byMatthew LaVail, PhD, is called the “CenterWithout Walls,” and includes basic researchersJohn Flannery, PhD, of UC Berkeley, and DouglasVollrath, MD, PhD, of Stanford.The presentrenewal will fund Dr. LaVail’s therapeutic studiesfor retinal degenerations in mice and rats and twoimportant added modules: (1) Jacque Duncan,MD, will head a clinical module, which will helpestablish UCSF Ophthalmology as a key clinicalcenter for retinal degenerationsin northern California andsupport Dr. Duncan’sclinical research;(2) Michael Danciger,PhD, of LoyolaMarymount University,was recentlyadded to the group. •

Endowment Donors Go the DistanceContinued from page 5

* UC Regents endowments. Others are invested by the UCSF Foundation.

Shelley Day, MD

Born: IllinoisCollege: Harvard, History and ScienceMedical School: HarvardInternship: UCSF, Medicine

Ying Han, MD, PhD

Born: Xi’an, ChinaMedical School: Nanjing Medical University, ChinaPhD: UC Berkeley,Vision ScienceInternship: Oakland Kaiser, Internal Medicine

IsabellaT. Phan, MD

Born: Columbus, MississippiCollege: UCLA,AnthropologyMedical School: UCSFInternship: CPMC, Internal Medicine

Soraya Rofagha, MD, MPH

Born: Columbus, OhioCollege: Ohio State Univiversity,

Political ScienceMPH Johns Hopkins School of

Public HealthMedical School: Ohio State UniversityInternship: Riverside Methodist Hospital,

Columbus, Ohio,TransitionalMedicine

Michelle J.Trager, MD

Born: Washington, DCCollege: Stanford, Biological SciencesMedical School: UCSFInternship: Cabrini Medical Center/Mt.

Sinai, New York City,Preliminary Medicine •

UCSF Department of OphthalmologyFirst-Year Residents 2006–2007

15Fall 2006

Five new residentshave joined UCSFOphthalmology –selected from 350new, young medicaldoctors, all of whomare in the top 5% ofthe country’s finestmedical schools.

The newest member of the influential AmericanOphthalmological Society (AOS), Department Chair

and Professor Stephen McLeod, MD, joins prominentUCSF faculty and alumni who play a leading role in theorganization.“Our faculty are among the leaders in thefield who are part of this prestigious organization inophthalmology,” says Professor Brooks Crawford, MD, whowas editor and associate editor of the AOS Journal for adecade, and served as AOS president in 2005.

It is an honor to be nominated to the AOS, and membersmust demonstrate a body of work that contributes toeducation, research, or leadership in the field ofophthalmology. Prospective members also submit a 50- to 100-page thesis, based on original research, forevaluation by AOS editors.

The oldest specialty society in the U.S., the AOS wasfounded in 1863, just 13 years after Helmholtz inventedthe ophthalmoscope that allows ophthalmologists to lookinside a person’s eye.The society was one of three thatestablished the American Board of Ophthalmology in theearly 1900s, which sets the standards for ophthalmologyeducation in the U.S. (the others are the AmericanAcademy of Ophthalmology and Otolaryngology

and the American Medical Association Section onOphthalmology).

Exemplifying Excellence

Dedicated to promoting excellence in patient care,education, and research in ophthalmology,The AmericanOphthalmological Society holds annual meetings onquestions of major importance in the field.“Theseprograms are designed to address essential issues thatwould be applicable in ophthalmology and other fields of medicine, as well,” says Dr. Crawford.

Recent AOS programs include symposia on TissueBioengineering and Regenerative Medicine;TargetedDrug Delivery in Ophthalmology; and Ocular Genetics,which featured a presentation on Current Research inRetinoblastoma by Professor Joan O’Brien MD.

Honors and Leadership

Six UCSF faculty have received the highest recognition an ophthalmologist can obtain, with the presentation ofthe AOS Lucien Howe Medal for distinguished service to ophthalmology.The late Professor Crowell Beard, MD,received the honor in 2002 for his work in oculoplasticsurgery, just short of his 90th birthday; and former

Department Chair Michael J. Hogan, MD, was honored in 1975. Other faculty recipients include Robert Shafer,MD (1985), as well as the late faculty members PhillipsThygeson, MD (1949), David Harrington, MD (1981),and William Spencer, MD (1995).

Four UCSF faculty have served as president of the AOS:Former Department Chair Fredrick Cordes, MD, in 1957;Robert Shafer, MD, in 1984;William Spencer, MD, in1995; and J. Brooks Crawford, MD, in 2005. •American Ophthalmological Society

UCSF Faculty Leaders

Richard Abbott, MDJorge Alvarado, MDJ. Brooks Crawford, MDAllan Flach, MD, PharmDJonathan Horton, MD, PhDAlexander Irvine, MDStephen McLeod, MDAriah Schwartz, MD*Daniel Schwartz, MDRobert Shaffer, MD*Gilbert Smolin, MD*Robert Stamper, MD

alented clinicians and researchers pursue advancedstudies and research projects in partnership with renownedUCSF Ophthalmology faculty at the Koret VisionResearch Laboratory, Beckman Vision Center, and FrancisI. Proctor Foundation.These are skilled physicians whohave completed their residency and internships, andprovide patient care as well as develop research projects for publication.

Matilda Chan, MD, PhD

Proctor Fellow in Cornea and External DiseaseBorn in Oakland, California, Dr. Chan earned her BA inmolecular and cell biology from UC Berkeley in 1994.After completing her MD and PhD at the University ofSouthern California Keck School of Medicine in 2002,she interned at UC San Diego. She completed herresidency in 2006 at the University of RochesterDepartment of Ophthalmology.

Julie Freidlin, MD

Proctor Fellow in UveitisBorn in Moscow, Dr. Freidlin has a BS in electricalengineering and mathematics, summa cum laude, from theUniversity of Maryland, College Park. She earned her MDat the Johns Hopkins University School of Medicine in2002. She completed her internship at Greater BaltimoreMedical Center in 2003, and her residency at theUniversity of Illinois, Chicago, Department ofOphthalmology and Visual Sciences, in 2006.

Jenny Hong, MD

Oculoplastics and Neuro-Ophthalmology FellowDr. Hong was born in Seoul,South Korea, and earned her BA in biology and East Asian studies at Harvard University in 1995.She was awarded an MD at Columbia University College of Physicians

& Surgeons in 2001. She completed her internship ininternal medicine at New York University Medical Centerin 2002, and a residency at Massachusetts Eye and EarInfirmary in 2005.

Thomas Hwang, MD, PhD

Oculoplastics and Neuro-Ophthalmology FellowBorn in Narberth, Pennsylvania, Dr. Hwang received his BA in engineering sciences at HarvardUniversity in 1992, and his PhD in biomedical sciencesfrom UCSF in 2000. He attended medical school at theUniversity of Pittsburgh and received his MD at StanfordUniversity in 2002.After his internship at Kaiser Permanentein Santa Clara, Dr. Hwang completed his residency atStanford University Hospital in 2006.

Shane Kim, MD

Proctor Fellow in Cornea and External DiseaseDr. Kim was born in Korea, and earned his BA inchemistry, magna cum laude and Phi Beta Kappa, in 1997at Franklin and Marshall College in Lancaster,Pennsylvania, where he was also an NSF NationalResearch Scholar. He earned his MD at New YorkUniversity in 2001, and completed his residency at ScheieEye Institute in Philadelphia in 2005.

Har Hiu Dawn Lam, MD, PhD

Retina FellowDr. Lam grew up in Hong Kong. She earned a BS inbiomedical engineering and psychology at Johns HopkinsUniversity in 1995, and completed a PhD in neuroscienceat Cambridge University 1998. She received her MD atStanford University in 2002, where she interned in 2003.She completed her residency at USC Doheny EyeInstitute in 2006.

Sharon McCaffery, MD

Ocular Oncology FellowBorn in Pasadena, California, Dr. McCaffery earned a BAin communication studies at UCLA, a BS in biologicalsciences at UC Irvine, and completed her MD at UCSF in2000.After an internship at Mayo Clinic Hospital in 2002,she completed a residency at St. Louis at Barnes-JewishHospital at Washington University Medical Center in 2005.

Judy Ou, MD

Proctor Fellow in Cornea and External DiseaseBorn in Taiwan, Dr. Ou earned her BA in human biology with honors at Stanford University in 1997.She subsequently received her MD from UCSF in 2002,where she was awarded the UCSF Dean’s Fellowship forResearch in 2001 and the UCSF School of Medicinetravel grant to England’s Moorfields Eye Hospital in 2002. She completed her residency at Stanford in 2006.

Bryan Seiff, MD, MS

Oculoplastics and Reconstructive Surgery FellowDr. Seiff was born in New York City and earned his BA in psychology at Cornell University, and an MS inphysiology at Georgetown University. He received his MDfrom the University of Medicine and Dentistry of NewJersey in 2002. Following an internship at Mount SinaiMedical Center in New York City, Dr. Seiff completed hisresidency at New York Presbyterian Hospital in 2006.

Gloria Wang, MD

Glaucoma FellowDr.Wang was born in Santa Monica, California. She receivedher BS in biology at Massachusetts Institute of Technologyin 1997, followed by an MD at UC San Diego in 2001.After an internship at Scripps Mercy Hospital in San Diego,Dr.Wang began residency at the University of Illinois,Chicago, in 2003, and completed her residency at Stanford University in 2006. •

Prominent Faculty Role in Prestigious Society

Clinical Fellows 2006–2007Patient Care and Research

Cordes Alumni

Taylor Asbury, MDDevron Char, MDWilliam Good, MDRobert Weinreb, MDMarco Zarbin, MD

*UCSF Clinical Faculty

T

16 Fall 2006

New clinical fellows who are pictured include (fromleft to right) Thomas Hwang, MD, PhD; Julie Freidlin,MD; Matilda Chan, MD, PhD; Har Hiu Dawn Lam, MD,PhD; Judy Ou, MD; and Shane Kim, MD.

17Fall 2006

Faculty NewsRichard L. Abbott, MDAppointments: Lifetime Achievement Award,American Academy of OphthalmologyHonors: Who’s Who in America, 61st EditionAppointments: American Academy of Ophthalmology: Chair, Maintenance ofCertification (MOC) Review Course; Eye Care Work Group, Physician Consortium forPerformance Improvement; Global Education CommitteeInvited Lectures: How to Select the Most Effective Antibiotic to Prevent Infection in Cataract andRefractive Surgery and The Value of Preferred Practice Patterns in Clinical Practice, ChineseNational Congress,Annual Meeting, Beijing; Diagnosis and Management of Corneal Trauma,Osaka University, Japan; Clinical Pearls in the Management of Corneal Trauma, University ofUdine, Italy; Maintenance of Certification for the Ophthalmologist, AAO MOC ReviewCourse, Rosemont, Illinois; Quality Based Initiatives from the AAO and Their Effect on OurProfession, American Society of Oculoplastic and Reconstructive Surgery,Annual Meeting,Banff, Canada; The Consequences of Medical Errors and Their Effect on Our Profession, MansourF.Armaly, MD, Distinguished Lectureship, University of Iowa,Annual Meeting, Iowa City;Evidence-Based Decisions in Choosing Antibiotics, Asia Pacific Academy of OphthalmologyAnnual Meeting, Singapore; LASIK Related Microbial Keratitis, Practical Tips in theManagement of Corneal and Scleral Trauma, Clinical Rationale in Choosing and Using Antibioticsfor Cataract and Refractive Surgery, Korean Ophthalmological Society,Annual Congress,Pusan, Korea; The Challenge of Providing Valid and Accessible Educational Materials to Physiciansin Practice,The Development and Use of Evidence-Based Preferred Practice Patterns, Keratoconus:Reviewing the Association to Local and Systemic Conditions,The Clinically Relevant Curriculum forInternational Use, Ocular Allergic Manifestations of Dermatologic Disease, Incorporating PreferredPractice Pattern into Your Practice to Improve Quality of Care, Clinical Pearls in the Management ofMicrobial Keratitis,The Role of the Pan American Foundation in Latin America, WorldOphthalmology Congress, São Paulo, Brazil; Clinically Relevant Curriculum for OphthalmologyResidents:An Educational Tool, Association of University Professors in Ophthalmology,Annual Meeting, Sarasota, Florida; Update on Quality of Care Measures for Ophthalmology,Santen, Inc. Meeting, Napa, California

Robert B. Bhisitkul, MD, PhDInvited Lectures: Anti-VEGF Therapy: Setting a New Standard for AMD Treatment,Eyetech/Pfizer Webcast Program for Professional Education; The VISION Study: Safety of aSecond Year of Macugen Treatment for Neovascular AMD, Retina Society Meeting, Coronado,CA; Update on Anti-VEGF Therapies in Age-Related Macular Degeneration; Orange CountyMedical Association, Orange, CA; Anti-VEGF drugs: Clinical Applications, and New therapiesin Age Related Macular Degeneration, Course Coordinator, XXV Pan-American Congress ofOphthalmology, Santiago, Chile; Anti-VEGF Therapies – from Clinical Trials to Practice,Asociación de Retina de Occidente, Guadalajara, Mexico; Update on Anti-VEGF Therapiesin Macular Degeneration, Pacific Coast Oto-Ophthamologic Society (PCOOS),Vancouver,Canada; Retinal Vein Occlusion: Evidence-Based Management, Systemic Considerations withAnti-VEGF Therapies, Retinal Manifestation of HIV/AIDS, New Approaches to DiabeticRetinopathy, Second Annual Symposium in Systemic Diseases in Ophthalmology, Riyadh,Kingdom of Saudi Arabia; Anti-VEGF Therapies in 2005, King Khaled Eye Hospital,Retinal Division Conference, Riyadh, Kingdom of Saudi Arabia; Management of VenousOcclusive Diseases, World Ophthalmology Congress, São Paulo, Brazil

Allan J. Flach, MD, PharmDAppointments: Chair, Pharmacology Section, Ophthalmology Basic Science Course,Stanford UniversityAwards: Jerome W. Bettman Service Award, Prevent Blindness, Northern CaliforniaInvited Lectures: Ophthalmology and Non-Steroidal Anti-Inflammatory Drugs, 2006 AsburyLecture, University of Cincinnati College of Medicine, Cincinnati; Nutrition andOphthalmology, Grand Rounds, Cincinnati Society of Ophthalmology; Ocular Pharmacologyand Toxicology, Pharmacology Section, Ophthalmology Basic Science Course given atStanford University; Pharmacology of Cataract Surgery, Pearls of Ocular Therapy Conference,University of California, San Diego/LaJolla; Emerging Trends in NSAID Therapy, 9th AnnualOcular Drug and Surgical Therapy Update, Dana Point, California

Douglas R. Fredrick, MDHonors: Elected to the Haile T. Debas Academy of Medical Educators at UCSF Invited Lectures: Vision Development, Bay Area Ophthalmology Course

Jennifer H. LaVail, PhDInvited Lectures: The US9 Tegument Protein of HSV-1 Is Necessary for Efficient AnterogradeAxonal Transport of Capsid and DNA in Neurons in Vivo, 2006 International HerpesvirusWorkshop, Seattle,Washington; Herpetic Infections of the Eye:A Hitchhiker's Guide to the Cell,Bay Area Ophthalmology Course, Foundations of Clinical and Visual Science, StanfordMedical School

Matthew M. LaVail, PhDAppointments: Co-Organizer, XII International Symposium on Retinal Degenerations,San Carlos de Bariloche,ArgentinaInvited Lectures: Neuroprotective Therapy for Retinal Degenerations, Symposium for GrandOpening of John A. Moran Eye Center, Department of Ophthalmology, University ofUtah; Current Status of Neuroprotective Therapy Clinical Trials for Retinal Degenerative Diseases,14th Retina International Conference, Rio de Janeiro, Brazil; Neuroprotection and ClinicalTrials for Retinal Degenerations, Bressler Symposium,The Jewish Guild for the Blind, NewYork City; Neuroprotective Therapy for Retinal Degenerations, Macula Vision ResearchFoundation Conference, Santa Fe, New Mexico; Unexpected Effects of Neuroprotective Agents,W.K. Kellog Eye Center, University of Michigan; Neuroprotective Therapy for RetinalDegenerations: Current Status, Save Sight Sunday, Foundation Fighting Blindness;Experimental Neuroprotective Therapies for Retinal Degenerative Diseases, OphthalmologyDepartment,Vanderbilt University

Shan C. Lin, MD Invited Lectures: The Role of the Cytoskeleton in Outflow Obstruction of POAG, Wills EyeHospital in Philadelphia, PA; Phaco-Chopping Techniques, Harvard Medical School CataractSurgical Training Conference, Boston, MA; San Francisco Chinese Eye Study, Frederick C.Cordes Eye Society; Neuro-protection in Glaucoma Therapy:Are We There Yet, UltrasoundBiomicroscopy:The Latest Developments, Pacific Coast Oto-Ophthalmological Society, CaboSan Lucas, Mexico; Trabecular Meshwork Physiology, Basic Science Course in Ophthalmology,Stanford University; Taking High Frequency to the Next Level – Come and See What’s Next,Asian Pacific Academy of Ophthalmology (APAO); New Developments in EndoscopicCyclophotocoagulation, Glaucoma Grand Rounds, National Taiwan University,Taipei,Taiwan; New Developments in Ultrasound Biomicroscopy, Glaucoma Teaching Session, NationalTaiwan University,Taipei,Taiwan; New Developments in Endoscopic Cyclophotocoagulation,Glaucoma Neuro-Protection:Are We There Yet?, Glaucoma Grand Rounds,Tri-Service GeneralHospital,Taipei,Taiwan

Todd P. Margolis, MD, PhDInvited Lectures: Stat1 Regulates Outcomes of HSV-1 Infection, ICP0 Antagonizes Stat1-Dependant Repression of Herpes Simplex Virus: Implications for the Regulation of Viral Latency,and Differences in the LAT Coding Region Are Responsible for Differential Latent Infection withHerpes Simplex Virus (HSV) Type 1 and Type 2, 2006 International Herpes Virus Workshop,Seattle,Washington; Invited Lecturer, Emory Medical School;Thomas H. Pettit Lecturer,UCLA, Jules Stein Eye Institute; Harvard Medical School, Department of Ophthalmology;Harvard Medical School,Visiting Professor for Cornea Rounds

Stephen D. McLeod, MDInvited Lectures: Update on the Visiogen Synchrony Dual Optic Accommodative IOL,Department of Ophthalmology, University of Washington, Seattle; Clinical Decision Makingin Infectious Keratitis, Department of Ophthalmology, Boston University

Timothy J. McCulley, MDAppointments: AAO Editorial for Basic and Clinical Science Course: Orbit, Eyelids, andLacrimal System; Patient Education Committee, North American Neuro-OphthalmologySociety; Judge:The Eye Institute-Pfizer Research PrizesInvited Lectures: Botox in Ophthalmology, Ophthalmology at the Crossroads: Controversies andEvidence-Based Knowledge at the Cutting Edge, University of Texas, Southwestern MedicalCenter, Dallas,Texas; Lacrimal Drainage System, Orbital Osteology, Nuclear and InternuclearExtraocular Motility, Orbital and Nasal Anatomy, Bay Area Ophthalmology Course,Foundations of Clinical and Visual Science, Stanford Medical School; Eyelid and Orbital SoftTissue Trauma, Orbital Trauma,The Lacrimal Drainage System, The Osler OphthalmologyBoard Review Course, San Francisco

Joan M. O’Brien, MDInvited Lectures: Invited Mentor, 2006 Heed Ophthalmic Foundation Resident Retreat;Differential Diagnosis of Choroidal Melanoma,The Dilemma of Small Melanocytic Lesions of theChoroid, Genetics of Retinoblastoma,Treatment Options for Retinoblastoma, Melanosis andMalignant Melanoma of the Conjunctiva, Surgical Management of Conjunctival Tumors, Updates inOphthalmic Oncology, Continuing Education Series, Department of Ophthalmology,University of North Carolina

Julie L. Schnapf, PhDInvited Lectures: Electrical Signals of Rods and Cones in Primate Retina, Gap-JunctionalCoupling of Macaque Photoreceptors, Stanford and Joan Alexander Lecturer in Ophthalmology,University of Texas, Houston; How Do Photoreceptors Work? Keynote Speaker at the Centerfor Adaptive Optics Annual Meeting,Arrowhead, CA; Electrical Coupling of Photoreceptors,FASEB Conference on the Biology and Chemistry of Vision,Tucson

David W. Sretavan MD, PhDHonors: Lew R.Wasserman Research Award, Research to Prevent Blindness

Robert L. Stamper, MDHonors: Who’s Who in America, 61st EditionInvited Lectures: Innovative Surgery for Glaucoma, Keynote Address, and A SimplifiedApproach to Express Implantation, Israeli Eye Microsurgery Society Annual Meeting; EarlySurgical Outcome of Ex-Press™ Mini Shunt, International Congress of Glaucoma Surgery,Toronto, Canada; New Diagnostic Approaches in Glaucoma and New Surgical Treatments forGlaucoma, The George Washington University School of Medicine Annual AlumniMeeting,Washington, DC •

18 Fall 2006

Faculty Presentations at 2006 ARVO MeetingWorld’s Largest Vision Research Society

UCSF Ophthalmology faculty presented research findings at theAssociation for Research in Vision and Ophthalmology (ARVO)Annual Meeting on Building International Collaboration in FortLauderdale, Florida, April 30-May 4, 2006.

Matthew M. LaVail, PhD

The C57BL/6-c2J Albino Background Reduces theSeverity of Light-Sensitive rd3 Disease but Not by Meansof the RPE65 Met450 Variant; Mechanisms of CNTF-Mediated Neural Protection in the P216L rds TransgenicMouse; Rapid and Stable Knockdown of the EndogenousNeuroprotective Factor bFGF in the Retina in Vivo UsingViral Vectors; BDNF Confers Long-Term Protection fromthe Retinal Toxicity of Verteporfin PDT;Visual Thresholdsand ERG Amplitudes Are Impaired by IntraocularDelivery of CNTF; Relationship of Retinal VasculatureDevelopment and Photoreceptor Degeneration in MutantRhodopsin Transgenic Rats.

Thomas M. Lietman, MD

The Probability of Finding the Pathogen of PresumedMicrobial Keratitis with Repeat Cultures After a NegativeCulture at the F.I. Proctor Foundation; HookwormInfestation as a Risk Factor for Mooren’s Ulcer in SouthIndia;Analysis of Digital Images of Corneal Ulcers in thePilot Study for the Steroid Corneal Ulcer Trial (SCUT);Steroids for Corneal Ulcers Treatment – SCUT PilotStudy Results; Complete Local Elimination of InfectiousTrachoma from a Severely Affected Community; Is ThereA Herd Protective Effect Associated with Annual MassAntibiotic Distributions for Trachoma?; EliminatingInfectious Trachoma with Antibiotics: Report from theTEF II Study in Ethiopia;TEF I: Is More Frequent MassTreatment Necessary for Elimination of InfectiousTrachoma?; Clinical Grading of Trachoma fromPhotographs.

Shan C. Lin, MD

Efficacy of Different Selective Laser TrabeculoplastyTreatment Area Parameters;Time Dependent Changes inCentral Corneal Thickness in the Ocular HypertensionTreatment Study (OHTS); Dynamic Contour Tonometryand Ophthalmic Pulse Amplitude in Patient with NormalTension Glaucoma, Pseudo-Exfoliative Glaucoma, andPrimary Open-Angle Glaucoma; San Francisco ChineseEye Study; Isolation, in Vitro Culture, and Characterizationof Putative Fetal Trabecular Meshwork Cells; Efficacy of Diabetic Retinopathy Screening Using Mobile EyeServices among Different Races; Effect of Hypertensionand Diabetes on Progression of Optic Nerve Damage inNormal Tension Glaucoma Suspects;The Effect of Statinsand Aspirin on Glaucomatous Visual Field Progression;Effect of Statin Drugs and Aspirin on Progression of OpticNerve Parameters in POAG Suspects; Usefulness of TwoCre-Expressing Transgenic Lines for Conditional Deletionof Genes in the Retina.

Stephen D. McLeod, MD

Magnification Induced by Single Optic Intraocular Lenses Compared to a Dual Optic AccommodativeIntraocular Lens Design; Comparison of Corneal Levels of Moxifloxacin After Subconjunctival Versus TopicalApplication; Steroids for Corneal Ulcers Treatment –SCUT Pilot Study Results.

Timothy J. McCulley, MD

The Relationship between Orbital Pressure andIntraocular Pressure Following Orbital Hemorrhage:An Experimental Model;The Effect of LateralCanthotomy and Cantholysis on Orbital and IntraocularPressure Following Orbital Hemorrhage:An ExperimentalModel;A Novel Mechanism for Indirect Traumatic OpticNeuropathy; Cranial Nerve Visualization with FlowImaging Using Steady Acquisition (FIESTA) Sequences.

Todd P. Margolis, MD, PhD

Differences in the LAT Coding Region Are Responsiblefor Differential Latent Infection with Herpes SimplexVirus (HSV) Type 1 and Type 2.

Joan M. O’Brien, MD

Expression of Truncated Mutant pRB in Retinoblastoma;Selective Inhibition of Calcineurin/Nuclear Factor ofActivated T-cells Signaling by the Cell Permeable Peptide11R-VIVIT Is Insufficient for Induction of Apoptosis inRetinoblastoma Cells;Tumor Volume Assessment ofChoroidal Melanoma by High-Resolution Reformattable3D MRI Improves Proton Beam Radiotherapy Planning;Subconjunctival Topotecan in Fibrin Sealant in theTreatment of Murine Retinoblastoma; COG / NCIRetinoblastoma Clinical Trials; Research Advances inOcular Oncology: Focus on Translational Applications.

Julie L. Schnapf, PhD

Spectral and Spatial Properties of Rod and ConeResponses in Macaque Retina.

Daniel M. Schwartz, MD

Novel Corneal Implant Materials.

Stuart R. Seiff, MD

Efficacy of Diabetic Retinopathy Screening Using MobileEye Services Among Different Races.

Robert L. Stamper, MD

Efficacy of Different Selective Laser TrabeculoplastyTreatment Area Parameters; Effect of Statin and AspirinUse on Primary Open-angle Glaucoma Progression;Ophthalmology, Epidemiology and Biostatistics; DynamicContour Tonometry and Ophthalmic Pulse Amplitude in Patients with Normal Tension Glaucoma, Pseudo-exfoliative Glaucoma, and Primary Open-angle Glaucoma; Effect of Hypertension and Diabetes onProgression of Optic Nerve Damage in Normal TensionGlaucoma Suspects.

John P.Whitcher, MD, MPH

TEF I: Is More Frequent Mass Treatment Necessary for Elimination of Infectious Trachoma?; EliminatingInfectious Trachoma with Antibiotics: Report from the TEF II Study in Ethiopia; Is There a Herd Protective Effect Associated with Annual Mass Antibiotic Distributions for Trachoma?; Complete Local Elimination of Infectious Trachoma from a SeverelyAffected Community; Hookworm Infestation as a RiskFactor for Mooren’s Ulcer in South India;The Probabilityof Finding the Pathogen of Presumed Microbial Keratitiswith Repeat Cultures after a Negative Culture at the F. I.Proctor Foundation; Correlation of Corneal ScrapingSmear Examination and Presence of Hypopyon toMicrobial Culture Results in Suspected InfectiousKeratitis; Steroids for Corneal Ulcers Treatment – SCUT Pilot Study Results. •

Richard L. Abbott, MD

Vertical Optokinetic Nystagmus and Smooth Pursuit inParkinson’s Disease.

Nisha R. Acharya, MD

Randomized, Controlled Phase III Study of Ranibizumab(LUCENTISTM) for Minimally Classic or OccultNeovascular Age-Related Macular Degeneration:Two-Year Safety Results of the MARINA Study; Steroids forCorneal Ulcers Treatment – SCUT Pilot Study Results;Biologics and Ocular Inflammatory Disease:The Presentand Future.

Jorge A. Alvarado, MD

Multifocal Electroretinography Evaluation inNormal–Tension Glaucoma Patients.

Cynthia S. Chiu, MD

Dietary Carbohydrate Intake and Glycemic Index inRelation to Cortical and Nuclear Lens Opacities in theAge-Related Eye Disease Study.

Kimberly P. Cockerham, MD, FACS

Comparison of Electric Stimulation of Patients with Acuteand Chronic Facial Nerve Palsy at Multiple Locations ofthe Orbicularis Oculi; Creation of a Functional Blink inRabbits with Denervated Orbicularis Oculi with anImplanted Stimulation Chip Based on Micro ElectroMechanical Systems (MEMS) Technology; ProspectiveComparison of 1-Day vs. 1-Hour Pre-OperativeMoxifloxacin Prophylaxis for Intraocular Surgeries.

Jacque L. Duncan, MD

Expression and Function of High-Affinity CalciumTransport at the Photoreceptor Synapse;Adaptive OpticsImaging of Macular Photoreceptors Reveals Differences in Patients with Retinitis Pigmentosa and Cone-RodDystrophy;Visual Thresholds and ERG Amplitudes AreImpaired by Intraocular Delivery of CNTF; BDNFConfers Long-Term Protection from the Retinal Toxicityof Verteporfin PDT.

Allan J. Flach, MD, PharmD

Amiodarone Induced Cataracts:A 22-Year Follow-Up.

Douglas B. Gould, PhD

Mice with a COL4A1 Mutation Have PhenotypesRelevant to Human Age-Related Macular Degeneration.

Jonathan C. Horton, MD, PhD

Radiation Treatment of Optic Nerve Sheath Meningioma:Visual Improvement Can Begin Before Radiotherapy Ends.

David G. Hwang, MD

Rigid Gas Permeable Contact Lens Use as a Risk Factorfor LASIK Retreatment; Retinal Function AssessmentFollowing Intravitreal Injection of Erythropoietin in Rats:A Dose-Toxicity Study.

Jennifer H. LaVail, PhD

A Comparison of the Roles of HSV Tegument ProteinsVP22 and US9 in Corneal Cell-Cell Spread and RetinalAnterograde Transport.

S I G H T I N G S

Distinguished speakers from Londonand Japan joined their U.S.

colleagues and UCSF Ophthalmologyalumni and faculty at a wide-rangingscientific program for practicingophthalmologists at the Frederick C.Cordes Eye Society Scientific Meeting,March 31 to April 1. Former CordesSociety President Brien Seeley called it“the best meeting in years.”

The Hogan lecturer, Mr. Richard Keeler,the son of the founder of the world-famous Keeler Instrument Company, andhonorary fellow of the Royal College,England, gave an authoritative lecture on

the history of the ophthalmoscope, whichwas invented 150 years ago and yet stillallows ophthalmologists to convenientlysee inside the eye in their offices everyday. He is the author of a famous atlas onthe ophthalmoscope, and noted that theUCSF Department of Ophthalmology hasone of the most important collections ofhistoric ophthalmoscopes in the UnitedStates.

Shigeaki Ohno, MD, chair of theDepartment of Ophthalmology and VisualSciences at Hokkaido University GraduateSchool of Medicine, and vice president ofthe University Hospital, graciously returned

to San Francisco to deliver the HearstLecture for the second time. He delivereda scholarly lecture about Behçet’s diseaseand the Vogt-Koyanagi-Harada's syndrome,which has been his special interest eversince he was a Hearst Fellow with SamuelKimura, MD, in the 1970s.

J. Earl Rathbun, MD, of Santa Rosadelivered the Williams Lecture on “APerspective on Oculoplastics.” He gave acomplete review of the personalitiesinvolved in the evolution of this subspecialtyin Northern California and at UCSFduring the time of his residency and hisyears of practice since finishing his

fellowship at UCSF. He will be retiringthis year.

The program was hosted by A. SydneyWilliams, MD, 2006 president of theCordes Society.The society was namedin honor of Frederick C. Cordes, MD,who was ophthalmology chair at UCSFfor 25 years.The Cordes Society hasnearly 300 members internationally,including former UCSF ophthalmologyresidents and fellows and ophthalmologyfaculty.The 2006 meeting was organizedby Cordes Society Vice President RezaVagefi, MD, a senior resident, andCordes Secretary Kelly Stone. •

Cordes Society Scientific MeetingNew Insights in Ophthalmology from the U.S. and Abroad

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Board member Andrew Yau, and Cecilia Yau, fromBangkok, Thailand, with David Sretavan, MD, PhD, atThat Man May See’s annual Vision Awards Dinner.

Matt LaVail, PhD, with board member John deBenedetti , with Ginny MacLean, and board members AngusMacLean and Emily Fine.

The Vision Awards Dinner was held at the FranciscaClub. Peg Gomory, mother of board member Paul Gomory,and Béatrice Gomory.

Chita Abbott with husband, Richard Abbott, MD, boardmember of That Man May See and UCSF Ophthalmologyfaculty member.

Marilyn Pratt, new chair of the board for That ManMay See, with Dan Benatar, board member, and spouse,Jeanne Benatar.

Tom Bird, board member from Napa, with spouse, JanBird.

Thomas Mazzocco, MD, confers with Ajay Singh, MD,from India. Dr. Singh was the recipient of the HearstInternational Fellowship for 2005-2006.

Jim Livingston, generous long-time supporter of ThatMan May See, receiving status as emeritus board member,from Steve Smith, who served as chair from 2003-2005.

Steve Smith congratulates Patsy Schuchardt, boardmember, with the Shirley Reich Award.

Steve Smith, outgoing board chair, loyal supporter, andlong-term board member with commemorative plaquedesigned by Teri Flach – salute to a golfer!

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19Fall 2006

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