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TRANSCRIPT
�}UHN Krembil
• Brain Institute• • • • •
I . • I • •
THE 19th ANNUAL
VIRTUAL TATOR -TURNBULL SPINAL CORD INJURY SYMPOSIUM
Frtday, 2:00 - 4:00 PM EDT
FEATURING:
-Keynote Address from Dr. Tetzlaff
-Barbara Turnbull Tribute
-All Day Poster Session
From Diet to Cells: Preclinical
Strategies for Spinal Cord Injury
•-� .,
REGISTER
HERE
Dr. Wolfram Tetzlaff Director, ICORD
Professor, Dept of Surgery and Dept of Zoology
University of British Columbia
SPINAL CORD INJURY ONTARIO
LESIONS MEDULLAIRES ONTARIO
Fondation Brain Canada Foundation
Attendance is FREEi
ORGANIZED BY:
Dr. Michael G. Fehlings
Ontario Neurotrauma Foundation
Fondation ontarienne de neurotraumatologie
Co1laborative Program In euroscience (CPIN) lnteligex ' UNIVERSITY OF TORONTO FoJ�dat,o,n
For further information, contact Anoushka Singh - [email protected]
Keynote / Visi,ng Professor??
We are delighted to welcome you to the 19th Annual Tator-‐Turnbull Spinal Cord Injury Symposium. While this year’s mee,ng takes on a different format due to the COVID-‐19 pandemic, we are excited that our new virtual format while allow us to engage individuals beyond the Greater Toronto Area community. This event aims to bring informa,on about cuPng edge spinal cord injury research to the wide community of those interested in the area, with special aQen,on to including those living with an injury, as well as their friends and families.
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THE TATOR-TURNBULL SYMPOSIUM
ARer being shot at the age of 18 during a convenience store robbery, which leR her paralyzed from the neck down, Barbara Turnbull went on to become a journalist and a ,reless advocate and research ac,vist for those living with spinal cord injury. Dr. Charles Tator, who treated Barbara when she came into the ER aRer the shoo,ng, has a legacy which includes establishing the first dedicated spinal cord injury unit in Ontario, providing excellence in the care of individuals with spinal cord injury, direc,ng an interna,onally acclaimed basic and clinical research program, leading efforts aimed at preven,ng brain and spinal injuries, and also as a teacher and mentor to countless neurosurgeons and researchers.
Barbara Turnbull Dr. Charles Tator
Dr. Michael Fehlings
Dr. Michael Fehlings hosts and organizes The Charles H. Tator-‐Barbara Turnbull Spinal Cord Injury Symposium each year to honour Charles Tator and Barbara Turnbull, who shared a special doctor-‐pa,ent friendship. The event recognizes their enormous contribu,on, energy and drive in the area of spinal cord injury research. The symposium is an excellent pla\orm for researchers, students, as well as members of the community to come together and exchange ideas that con,nue to advance the field of spinal cord injury pa,ent management.
Keynote / Visi,ng Professor??
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AGENDA WELCOME REMARKS 14.00 Michael Fehlings & Albert Yee – Co-‐Chairs of the UofT Spine Program
Gelareh Zadeh – Chair of Neurosurgery, UofT James T. Rutka – Chair of the Department of Surgery, UofT Zhong-‐Ping Feng – Director of the Collabora,ve Program in Neuroscience, UofT
SPEAKER SESSION I 14.18 Overview of the UofT Spine Program & Krembil Brain InsTtute SCI Research
Michael Fehlings, MD, PhD, FRCSC, FACS 14.35 Overview of Lyndhurst SCI Rehab Program
Cathy Craven, BA, MD, FRCPC, MSc 14.40 Opening of NominaTons for the 2020 Turnbull-‐Tator Award – Brain Canada
Viviane Poupon, PhD 14.45 IntroducTon of the E-‐Poster Presenters
Michael Fehlings, MD, PhD, FRCSC, FACS 14.50 Break SPEAKER SESSION II 15.00 TATOR-‐TURNBULL SYMPOSIUM KEYNOTE ADDRESS / CPIN DISTINGUISHED LECTURE
From Diet to Cells: Preclinical Strategies for Spinal Cord Injury Wolfram Tetzlaff, MD, PhD
15.35 Discussion 15.45 TRIBUTE TO BARBARA TURNBULL
Charles Tator, OC, MD, PhD, FRCSC, FACS Barbara Turnbull Family Members
15.55 Closing Remarks
Michael Fehlings
Each year a dis,nguished individual is invited to give the Tator-‐Turnbull keynote address. The speaker is a scien,st or advocate in the spinal cord injury field that has made a significant contribu,on to addressing challenges for those living with this injury. This individual demonstrates leadership in the field and a commitment to finding a cure; quali,es synonymous with Charles Tator and Barbara Turnbull.
Dr. Wolfram Tetzlaff, MD, PhD Director, ICORD Professor, Dept of Surgery and Dept of Zoology University of Bri,sh Columbia
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2019 Dr. Brian Kwon, University of Bri,sh Columbia 2018 Dr. Mark Tuszynski, The University of California -‐ San Diego 2017 Dr. Dalton Dietrich, The Miami Project to Cure Paralysis, University of Miami 2016 Dr. Claes Hultling, Karolinska Ins,tute, Sweden 2015 Dr. Jan Schwab, Ohio State Wexner Medical Center 2014 Dr. Ole Kiehn, Karolinska Ins,tute, Sweden 2013 Drs. Derek van der Kooy, Cindi Morshead, and Andras Nagy, University of Toronto 2012 Dr. Susan Harkema, University of Louisville 2011 Dr. Armin Curt, University of Zurich 2010 Dr. V. Reggie Edgerton, Brain Research Ins,tute, UCLA 2009 Dr. James FawceQ, Cambridge University Centre for Brain Repair, United Kingdom 2008 Dr. Jerry Silver, Case Western Reserve University 2007 Dr. Serge Rossignol, University of Montreal 2006 Dr. Arthur Prochazka, University of Alberta 2005 Dr. John Steeves, Interna,onal Collabora,on On Repair Discoveries (ICORD), Bri,sh Columbia 2004 Prof. Eva Sykova, Ins,tute of Experimental Medicine, Czech Republic 2003 Dr. Lars Olson, Karolinska Ins,tute, Sweden 2002 Mr. Rick Hansen, Rick Hansen Ins,tute, Bri,sh Columbia
KEYNOTE SPEAKER
Past Keynote Speakers
Dr. Tetzlaff is the Director of ICORD and a Professor in the Departments of Zoology and Surgery at the University of Bri,sh Columbia. He also holds the Rick Hansen Man in Mo,on Chair in Spinal Cord Research. He obtained his MD at the University of Essen, completed his Dr. Med. at Ruhr-‐University Bochum and his PhD at the University of Calgary. Dr. Tetzlaff is currently focused on two dis,nct areas of research. The first focuses on early strategies that will assist in protec,ng against secondary damage aRer SCI, termed neuroprotec,on. His second area of research is focused on repair, since you cannot protect against all injury. Currently, Dr. Tetzlaff is using approaches such as gene manipula,on to enhance the regenera,ve poten,al of nerve fibers. He is also working on remyelina,on strategies, which involves the construc,on of new myelin sheathes to replace those lost from the nerve fibers due to injury. His ul,mate vision is to combine mul,ple strategies to encourage nerve cells to grow and enhance recovery aRer SCI.
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SPEAKER BIOGRAPHIES
Michael G. Fehlings received his MD degree from the University of Toronto (UofT) in 1983, and completed his general surgical training at Queen’s University. Upon returning to UofT, he completed his neurosurgical training as well as PhD, and received his Fellowship of the Royal College of Surgeons of Canada. He is currently Professor and Vice Chair of Research in the Department of Surgery at UofT, a McLaughlin Scholar in Molecular Medicine, Senior Scien,st at the McEwen Centre for Regenera,ve Medicine, Co-‐Director of the UofT Spine Program, Neurosurgeon at Toronto Western Hospital and Halbert Chair in Neural Repair and Regenera,on. Dr. Fehlings combines an ac,ve clinical prac,ce in complex spinal surgery with a transla,onally oriented research program focused on discovering novel treatments for the injured spinal cord.
Dr. Fehlings has received numerous awards including the Gold Medal in Surgery from the Royal College of Physicians and Surgeons, the Olivecrona Award from the Karolinksa Ins,tute, and the Golden Axon Leadership Award. In 2013, Dr. Fehlings was recognized with the Queen Elizabeth II Diamond Jubilee Medal presented to him by the Honourable Stephen Harper, and In 2014 he was elected to the Fellowship of the Royal Society of Canada and to the Canadian Academy of Health Sciences. He was awarded the Regional Mentor of the Year award in 2016 from the Royal College of Physicians and Surgeons of Canada for his significant impact on the career development of medical residents and fellows. In 2017, he was awarded the Dave Lostchuck People’s Choice Award for outstanding SCI Scien,st, and he was recently awarded the pres,gious Ryman Prize as well as the Vilhelm Magnus Medal. He is currently President of the Interna,onal Neurotrauma Society and Chair of the AO Clinical Inves,ga,on and Documenta,on Advisory CommiQee.
Cathy Craven is the Toronto Rehabilita,on Ins,tute / University of Toronto Chair in Spinal Cord Injury SCI Rehabilita,on and a Professor in the Division of Physical Medicine and Rehabilita,on, Department of Medicine with cross appointments in the Ins,tutes of Health Policy Management and Evalua,on and Rehabilita,on Sciences at the University of Toronto. Dr. Craven is a Senior Scien,st at KITE and leads the field with her clinical and research exper,se in the preven,on and management of osteoporosis and health service innova,on for individuals living with spinal cord injury. Dr. Craven has published extensively on related topics. External to UHN, Dr. Craven is a Fellow of the American Spinal Injury Associa,on, Co-‐Chair of the 1-‐9th Na,onal SCI Conference, Chair of the Canadian Spinal Cord Injury – Rehabilita,on Associa,on (CSCI-‐RA), and a Member of the Osteoporosis Canada Scien,fic Advisory Board.
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SPEAKER BIOGRAPHIES
Zhong-‐Ping Feng is Professor and a Graduate Coordinator in the Department of Physiology, the Director for Interna,onal Development at the Ins,tute of Medical Science, and the Director of the Collabora,ve Program in Neuroscience. She completed her MD at Zhongshan Medical College, Residency in Peking Union Hospital, China, her MSc at the University of Alberta, and her PhD at the University of Calgary. Professor Feng’s lab inves,gates the biophysical and pharmacological proper,es of ion channels and calcium-‐dependent regulatory mechanisms of neurodevelopment and neural plas,city, in order to iden,fy poten,al drug targets for neurodevelopmental and neurological disorders. She has published over 120 peer-‐reviewed research ar,cles and reviews, and given numerous invited lectures at interna,onal/na,onal conferences or universi,es. Her work has been funded by CIHR and NSERC. Professor Feng has served on a number of interna,onal (i.e. China, France, Netherlands, US), and na,onal (i.e. CIHR, NSERC) grant review commiQees as well as ins,tu,onal program review commiQees.
Vivianne Poupon is President and Chief Execu,ve Officer of the Brain Canada Founda,on. Previously, she held the posi,on of Director, Scien,fic Development and Partnerships at The Neuro, the Montreal Neurological Hospital Ins,tute of McGill University. As such, she oversaw the development of new major research ini,a,ves and alliances, including interna,onal ini,a,ves, and led the transforma,on of The Neuro into an open science ins,tute. She also served as COO of the Tanenbaum Open Science Ins,tute. Previously, she held the posi,on of Deputy Director, Scien,fic Affairs at the Quebec Health Research Fund (FRSQ) where she oversaw the management of scien,fic programs and acted as an interlocutor with provincial, federal and interna,onal scien,fic funding organiza,ons. She advised the funding agency on governance, organiza,onal restructuring and change management during a
restructuring during which she was appointed Interim Scien,fic Director and member of the Board of Directors. A graduate of the École normale supérieure-‐Paris, Viviane Poupon holds a doctorate in immunology from the Pierre and Marie Curie University in Paris.
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SPEAKER BIOGRAPHIES
James Rutka assumed his appointment in the Department of Surgery, Division of Neurosurgery in 1990, and has been on the surgical staff at the Hospital for Sick Children in the Division of Pediatric Neurosurgery since that ,me. He has served a Co-‐Director of the Arthur and Sonia LabaQ Brain Tumor Research Centre at the University of Toronto since 1998. From 1999-‐2010, Dr. Rutka held the Dan Family Chair in Neurosurgery at the University of Toronto, leading the world's largest neurosurgical training program. In 2011, he was selected as the R.S. McLaughlin Chairman of the Department of Surgery at the University of Toronto. Dr. Rutka has also served as the President of the American Associa,on of Neurological Surgeons (2010-‐2011), President of the American Academy of Neurological Surgery (2011-‐2012), and in 2013 he was appointed as the seventh Editor-‐in-‐Chief of the Journal of Neurosurgery, the first Canadian neurosurgeon to
hold this pres,gious role. Dr. Rutka's primary research and clinical interests relate to the science and surgery of human brain tumors. His laboratory interests lie in the molecular biology of human brain tumors -‐ specifically in the determina,on of the mechanisms by which brain tumors grow and invade.
Albert Yee is the Holland Bone and Joint Program Chief and the Head of the Division of Orthopaedic Surgery at Sunnybrook Health Sciences Centre, where he holds the Marvin Tile Chair in Orthopaedic Surgery. Dr. Yee is an Orthopaedic Spine Surgeon at Sunnybrook Health Sciences Centre, an Associate Scien,st (Physical Sciences Pla\orm) at Sunnybrook Research Ins,tute and a Consultant in Surgical Oncology, Bone Metastasis Clinic, OdeQe Cancer Centre. He is a Full Professor at the University of Toronto in the Ins,tute of Medical Sciences with a cross appointment in the Ins,tute of Biomaterials and Biomedical Engineering. He is the Vice Chair of Research in the Division of Orthopaedic Surgery and Co-‐Director of the University of Toronto’s Department of Surgery Spine Program.
Dr. Yee is the Past President of the Canadian Orthopaedic Research Society, President-‐Elect of the Canadian Spine Society and Co-‐Chair of Bone & Joint Canada. He is the Canadian Lead for the Young Inves,gators Ini,a,ve (YII) of Bone & Joint Canada, and the US Bone & Joint Ini,a,ve, a grant mentorship and career development program. Dr. Yee has over 100 peer reviewed publica,ons and has received academic honours including the American Bri,sh Canadian (ABC) Interna,onal Travelling Fellowship (American Orthopaedic Associa,on / Canadian Orthopaedic Associa,on, 2013), the Charles H. Tator Surgeon-‐Scien,st Mentoring Award (2012), and the Canadian Orthopaedic Founda,on J. Edouard Samson Award (2011). Dr. Yee’s laboratory focuses on transla,onal orthopaedic research u,lizing pre-‐clinical surgical models to evaluate novel minimally invasive vertebral metasta,c therapies (e.g. Photodynamic Therapy, Radiofrequency Abla,on). His work has led to firsts in human clinical trials and FDA approval with commercializa,on of new minimally invasive spine technology. He has interest in understanding mechanisms of disease in cancer invasiveness to bone with an aim towards iden,fying poten,al new promising therapeu,c targets.
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SPEAKER BIOGRAPHIES
Gelareh Zadeh is an Associate Professor at the Department of Surgery University of Toronto and Chair of Neurosurgery at University Health Network (UHN). She is a Neurosurgeon-‐Scien,st at Toronto Western Hospital, UHN and was most recently appointed as the Wilkins Family Chair in Brain Tumor Research. Her clinical prac,ce focuses on Skull Base Neuro-‐oncology, with dedicated general brain tumour clinic and many mul,disciplinary clinics that she has established and is ac,vely involved with such as skull base, pituitary, brain metastases, gamma knife and neurofibromatosis clinic. She is ac,vely involved with and is dedicated to the goal of advancing surgical clinical trials. Her research laboratory is focused on studying the molecular mechanisms of glioma angiogenesis and molecular regulators of tumour metabolism. Specifically inves,ga,ng the role of bone marrow derived cells in suppor,ng tumour vasculature in gliomas and how differen,a,on into macrophage and microglia popula,on plays a role in escape mechanisms of evading an,-‐angiogenic therapy. A second focus of the laboratory, on tumour metabolism, explores the interplay between altered metabolism in response to an,-‐angiogenic therapy. She also has a transla,onal program, dedicated to establishing the genomic landscape of menigniomas and schwannomas.
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TURNBULL-TATOR AWARD
The Turnbull-‐Tator Award, presented in partnership by the Barbara Turnbull Founda,on for Spinal Cord Research and the Brain Canada Founda,on, recognizes an outstanding publica,on by a Canadian researcher in the field of spinal cord and brain injury research. The Turnbull-‐Tator Award was originally established in 2001 in honour of Barbara Turnbull, and known as the Barbara Turnbull Award for Spinal Cord Research, in recogni,on of Barbara’s ,reless efforts to raise awareness about spinal cord injuries, and her advocacy for excellence in research done in Canada in this field.
This award aims to recognize an outstanding publica,on by a Canadian researcher in the field of spinal cord and brain injury research (including concussion) in the last two years. The winning publica,on includes novel and ground-‐breaking results that represents a major advancement for the research area and has the poten,al to generate new hypotheses. The award is open to all ac,ve inves,gators in any phase of their career, graduate students, and postdoctoral fellows conduc,ng research at a Canadian ins,tu,on. You can learn more about Brain Canada here.
The Barbara Turnbull Foundation for Spinal Cord Research
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E-PostersPosters will be available for viewing on VoiceThread throughout the day
To access posters, click on the link below
hQps://voicethread.com/myvoice/browse/threadbox/4225
Genome Engineering Human Neural Precursor Cells for Closed-‐Loop DegradaTon of Scar Tissue Presenter: William Luong – Fehlings Lab Using Me`ormin to AcTvate Endogenous Precursor Cells in the Spinal Cord Presenter: Emily Gilbert – Morshead Lab Drug Repurposing: Delayed AdministraTon of High Dose Human Immunoglobulin G for Treatment of TraumaTc Cervical Spinal Cord Injury Presenter: Jonathon Chon Teng Chio –Fehlings Lab The Effect of SynapTc AcTvity on DifferenTaTon and IntegraTon of Transplanted Neural Progenitor Cells and FuncTonal Recovery Acer Spinal Cord Injury Presenter: Gokce Ozdemir – Fehlings Lab ProspecTve Randomized Control Pilot Study to Compare the Role of InjecTon Cerebrolysin in Operated Cases of DegeneraTve Cervical Myelopathy Presenter – Nandan Marathe – Fehlings Lab A Review of DXA Methodologies to Assess Knee Region Bone Density in Individuals with Neurologic Impairment Presenter-‐ Lindsie Blencowe – Craven Lab ResumpTon of AcTvity and Community ParTcipaTon Post-‐Fracture: An OT PerspecTve Presenter: Emily Newton –Craven Lab Central Recruitment: A novel system for recruiTng inpaTents with spinal cord injury/disease (SCI/D) for research studies at Toronto RehabilitaTon InsTtute Presenter: Julia Rybkina – Craven Lab Remote Ischemic PrecondiToning Ameliorates Ischemia Reperfusion Injury Associated With Decompression Surgery For DegeneraTve Cervical Myelopathy Presenter: James Hong – Fehlings Lab
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E-PostersPosters will be available for viewing on VoiceThread throughout the day
To access posters, click on the link below
hQps://voicethread.com/myvoice/browse/threadbox/4225
Myelin Basic Protein Interacts with the Spinal Cord Niche to Regulate ProliferaTon of Endogenous Neural Stem Cells in the Adult Mammalian CNS Presenter: Nishanth Lakshman – Morshead Lab Biasing Neural Progenitor Cells Toward an Oligodendrogenic Fate Presenter: Katarzyna Pieczonka – Fehlings Lab Regional IdenTty of Neural Progenitor Cells is Maintained Throughout the in vitro Culturing Process Presenter: William BreN McIntyre – Fehlings Lab Bioengineered Smart Human Neural Stem Cells to degrade Scar and Enhance RegeneraTon in Chronic Spinal Cord Injury Presenter: Chris Ahuja – Fehlings Lab Neural Progenitor Cells Expressing Herpes Simplex Virus-‐thymidine Kinase for AblaTon have DifferenTal ChemosensiTvity to Brivudine and Ganciclovir Presenter: Zijian Lou – Fehlings Lab
Organizer:
Michael G. Fehlings, MD, PhD, FRCSC, FACS, FRSC, FCAHS Professor of Neurosurgery
Vice Chair Research, Department of Surgery Co-‐Director, Spine Program
University of Toronto
Halbert Chair in Neural Repair and Regenera,on Senior Scien,st, Krembil Research Ins,tute
Toronto Western Hospital, University Health Network T: 416-‐603-‐5085 F: 416-‐603-‐5298
drfehlings.ca TwiQer: @DrFehlings