kshivets o. cancer, synergetics, computer sciences and alive supersystems

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  • Early Detection and Phase Transitions in System Malignancy-Human OrganismOleg Kshivets, M.D., Ph.D.Siauliai Cancer Center, LithuaniaAACR Special Conference: The Biology and Genetics of Early Detection & Chemoprevention of CancerMiami, Florida, The USA, 1999

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  • Abstract: EARLY DETECTION AND PHASE TRANSITIONS IN SYSTEM MALIGNANCY-HUMAN ORGANISM Oleg Kshivets Siauliai Cancer Center, Siauliai, Lithuania Purpose: This research studied homeostasis parameters, typical for two extreme states of phase transition: early malignancy (strategic purpose of early detection) and invasive cancer (C). Methods: Basis of this research was the data of 1524 cancer patients (CP) with pathologic stage (T1-4N0-2M0-1G1-4): 655 gastric CP (GCP), 525 lung CP (LCP) and 344 bladder CP (BCP) operated and monitored in clinic 1970-1998. All CP had preoperation examination including peripheral blood count, biochemical tests of venous blood using usual unified methods, clinical, anthropometric, X-ray examination, endoscopy, sonography, electrocardiography and also doctors examination, if required, computed tomography and radioisotope scanning. After operations the data of intraoperational investigation, information on character of surgery, complications, morphologic C characteristics (size, TNMG, growth, histology, etc.) was registrated. Representativeness of samplings was reached by means of randomization based on unrepeated random selection. Multiple correspondence analysis (A), clustering, A of variance, confirmatory factor A, structural equation modeling and Monte Carlo simulation were used to determine any significant overall regularities between malignancy and CP organism. Results: Using complex system analysis, simulation modeling in terms of synergetics, evoinformatics, statements from theories of Hopf, Landau, Turing and Marchuk it was discovered that system C-patients homeostasis consecutively passed through three phase transitions: 1) phase transition norm--oncobackground; 2) phase transition oncobackground--early malignancy; 3) phase transition early malignancy--invasive C. If diagnosis of first two phase transitions depended on outcomes of early detection and diagnosis, identification of third phase transition resulted in effectiveness of treatment process and 5-year survival of CP. It was also verified that most important figure of this transition for human was quantity of C cell population in organism and average critical threshold of this population was 4.189e+9 per human organism. Below such value there was a temporal dynamic equilibrium between C and patients homeostasis and 5-year survival of radically operated CP tended to be 100%. Excess over this threshold resulted in irreversible consequences when effectiveness of treatment went down up to 10-15%. It was discovered that phase transition of early malignancy into invasive C of any localization significantly depended on: 1) input level of blood cell circuit; 2) ratio of C cell population quantity to blood cell subpopulations in integral CP organism (cell ratio factors); 3) C characteristics (C cell population quantity in CP organism, TNMG); 4) some blood biochemical factors; 5) anthropometric data.

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  • Samplings:Lung Cancer Patients (T1-4N0-2M0-1).525Gastric Cancer Patients (T1-4N0-2M0-1).655Bladder Cancer Patients (T1-4N0-2M0-1)344In All ......1524

    Patients with Non-Malignant Pathology.3977 Practically Healthy Old People...1464

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  • Prognostic Role of Cancer Diameter

    EMBED STATISTICAGraph

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  • Main Problem of Analysis of Living Supersystems: Phenomenon of Combinatorial ExplosionAverage Number of Routine Blood Parameters: 28Number of Possible Combination for Random Search:.... n!=28!=3.049e+29 Computer Operation Time of The 7G Teracomputer (1000TFLOPS) (The 21st Century) 9.7 Million Years

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  • BasisNP RP P n! n*n*2(e+n) or n log n n AI CSA+S+B SM

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  • Model Cancer Cells(Cr)--Human Killer Cells(Kl)r=Cr(1-KlCr/Kl);l=(KlCr/Kl)[25Cr/(4.189++2.5Cr)-Cr-1];

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  • Regularities between Dynamics Cancer Cell Population and Patient's Survival Rate

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  • Phase Transitions in System Homeostasis-Malignancy

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  • The Three Phase Transitions in the System Malignancy-Humans Organism

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  • Phase Transition Early Malignancy into Invasive Cancer

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  • Role of Cell Ratio Factors in Phaze Transition Erly Cancer into Invasive Cancer

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  • Regression Models (Lym/CC--Life Span of GCP, n=224; BCP, n=120 and LCP, n=162; 18th Degree Polynomial Fit): y=a+bx+cx2+dx 3+...

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  • Cell Ratio Factors in Prognosis5-Year Survival Cancer Patients

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  • Results of Monte Carlo Simulation

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  • Results of Structural Equotion Modeling

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  • Early and Differential Diagnosis of Malignancies

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  • The Results of Multiple Correspondence and Claster Analysis of Blood Indexes in Oncoscreening

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  • Interdependencies between Blood Parameters, Indexes and Cancer Cell Population

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  • Interdependencies between Blood Indexes and Immune System of Cancer Patients

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  • Networks Between Phase Transition Early Cancer-Invasive Cancer, Life Span and Homeostasis Data

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  • Superoncoscreeng-1.0

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  • Superoncodiagnos-1.0

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  • Superoncodiagnosis of Metastasazing-1.0

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  • Superoncoimmunology-1.0

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  • Superoncoprognosis-1.0

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  • Total Monitoring System

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  • Conclusions:1. System Cancer-patients homeostasis consecutively passed through three phase transitions: norm-oncobackground; oncobackground-early malignancy; early malignancy-invasive cancer. 2. Most important figure of this transition for human was quantity of cancer cell population in organism and average critical threshold of this population was 4.189e+9 per human organism. 3. Phase transition of early malignancy into invasive cancer of any localization significantly depended on: input level of blood cell circuit; ratio of cancer cell population quantity to blood cell subpopulations in integral cancer patients organism (cell ratio factors); malygnancy characteristics (cancer cell population quantity in organism, TNMG); some blood biochemical factors and anthropometric data.

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  • Patents:1. Kshivets O.M. Method of Screening and Differential Diagnosis of Malignant Neoplasms// Patent from 27.04.92.-N2045072.-28pp.. 2. Kshivets O.M. Method of Prognosis of Survival Rate of Radically Operated Oncopatients// Patent from 10.02.94.-N2101704.-24pp. .3. Kshivets O.M. Method of Prognosis of Survival Rate of Non-Radically Operated Oncopatients// Patent from 14.03.94.-N2104536.-10pp. .4. Kshivets O.M. Method of Early and Differential Immunodiagnosis of Malignancies// Patent from 24.10.95.-N2107290.-12pp. .5. Kshivets O.M. Method of Immunodiagnosis of Distant Metastases of Oncopatients// Patent from 06.10.95.-N2107295.-8pp. .6. Kshivets O.M. Method of Immunodiagnosis of Generalization of Oncopatients// Patent from 09.10.95.-N2107294.-12pp. .7. Kshivets O.M. Method of Immunodiagnosis of Early and Invasive Oncopathology for Patients// Patent from 04.05.95.-N2107293.-14pp. .8. Kshivets O.M. Method of Differential Diagnosis of Oncopathology and Pre-Cancer or Non-Malignant Pathology// Patent from 08.11.94.-N2114431.-18pp.

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  • Patents:. 9.Kshivets O.M. Method of Measuring the Size of Malignant Neoplasms and Total Quantity of Malignant Cells in Oncopatients Organism Based on the Homeostasis Parameters// Application for Patent from 04.05.95.-N95107201/012623.-8pp. (Positive Decision)..10. Kshivets O.M. Method of Diagnosis of Distant Metastases of Oncopatients// Application for Patent from 03.11.95.-N95118236/032006.-12pp. (Positive Decision)..11. Kshivets O.M. Method of Diagnosis of Generalization of Oncopatients// Application for Patent from 20.10.95.-N95117904/031312.-12pp. (Positive Decision)..12. Kshivets O.M. Method of Diagnosis of Early and Invasive Oncopathology for a Single Patient// Application for Patent from 06.10.95.-N95117338/029690.-13pp. (Positive Decision)..13. Kshivets O.M. Method of Diagnosis of Malignant Neoplasms Metastasizing in Regional Lymphatic Nodules of a Concrete Patient// Application for Patent from 29.09.95.-N95116510/028981.-10pp. (Positive Decision)..14. Kshivets O.M. Method of Measuring the Size of the Malignancy and Total Quantity of Malignant Cells in the Oncopatients Organism Based on the Immunogram// Application for Patent from 04.05.95.-N95107200/012622.-9pp. (Positive Decision)..15. Kshivets O.M. Method of Immunodiagnosis of Regional Metastases of Oncopatients// Application for Patent from 06.10.95.-N95117049/029707.-9pp. (Positive Decision).

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  • Address: Oleg Kshivets, M.D., Ph.D. Thoracic Surgeon Department of Surgery Siauliai Cancer CenterTilzes:42-16, Siauliai, LT78206, LithuaniaTel. (37041)[email protected] [email protected]//:myprofile.cos.com/Kshivets

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