kuliah histologi - muthmainah, dr., mkes
TRANSCRIPT
![Page 1: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/1.jpg)
dr. MUTHMAINAH, dr. MUTHMAINAH, MKesMKes
![Page 2: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/2.jpg)
EPIDERMISEPIDERMIS
(JE. SKUAMOUS (JE. SKUAMOUS KOMPLEKS DG KOMPLEKS DG KORNIFIKASI)KORNIFIKASI)
DERMISDERMIS JP. LONGGARJP. LONGGAR JP. PADAT IREGULERJP. PADAT IREGULER
![Page 3: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/3.jpg)
![Page 4: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/4.jpg)
![Page 5: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/5.jpg)
STR. KORNEUM / LAP. TANDUKSTR. KORNEUM / LAP. TANDUKSTR. LUSIDUM / LAP. BENINGSTR. LUSIDUM / LAP. BENING
STR. GRANULOSUM / LAP. BERBUTIRSTR. GRANULOSUM / LAP. BERBUTIR
STR. SPINOSUM / LAP. TAJUSTR. SPINOSUM / LAP. TAJU
STR. BASAL / LAP. BENIHSTR. BASAL / LAP. BENIH
EPIDERMIS EPIDERMIS
STR. MALPHIGISTR. MALPHIGI
![Page 6: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/6.jpg)
EPIDERMISEPIDERMIS
![Page 7: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/7.jpg)
![Page 8: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/8.jpg)
SELAIN SEL KERATINOSIT :SELAIN SEL KERATINOSIT :
SEL MELANOSITSEL MELANOSIT
SEL SEL LANGERHANSLANGERHANS
SEL MERKELSEL MERKEL
SEL LIMFOSITSEL LIMFOSIT
![Page 9: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/9.jpg)
Badan sel bulat dg tonjolan sitoplasma panjang.
Terletak diantara sel-sel stratum basal.
Menghasilkan pigmen melanin.
MELANOSITMELANOSIT
![Page 10: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/10.jpg)
SINTESIS MELANIN SINTESIS MELANIN
TIROSIN TIROSIN
DOPA DOPA
DOPAQUINONDOPAQUINON
MELANIN MELANIN
TIROSINASETIROSINASE
![Page 11: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/11.jpg)
SINTESIS MELANIN SINTESIS MELANIN
![Page 12: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/12.jpg)
Morfologi mirip melanosit (tetapi tidak menghasilkan pigmen melanin).
Terutama ditemukan pd stratum spinosum.
Pengecatan “emas klorida” sel tampak hitam & btk stelat sangat jelas.
Berfungsi dlm aktivitas imun (merupakan makrofag) Fagositosis & sebagai sel penyaji antigen (APC).
SEL LANGERHANS
(LANGHAN)
SEL LANGERHANS
(LANGHAN)
![Page 13: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/13.jpg)
Morfologi mirip sel epitel epidermis (tetapi sitoplasmanya mengandung granula-granula kecil & padat).
Pada umumnya terdpt pd lapisan basal epidermis kulit yg tebal.
Pada dasar sel-sel ini melekat ujung-ujung saraf bebas “corpusculum merckeli” (merupakan mekanoreseptor sensoris).
SEL MERKELSEL MERKEL
![Page 14: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/14.jpg)
Sebagian besar berupa limfosit T imatur.
Maturasi lanjutan terjadi di epidermis dg bantuan sel keratinosit.
Bersama dg sel langerhans & sel keratinosit sistem imunologi kulit (SALT / Skin Associated Lymphoid Tissue).
LIMFOSITLIMFOSIT
![Page 15: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/15.jpg)
LAPISAN PAPILER (JP. longgar; terdpt anchoring fiber)
LAPISAN RETIKULER (JP. padat ireguler)
Terdpt: pembuluh darah, limfe, saraf dan derivat kulit.
DERMISDERMIS
![Page 16: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/16.jpg)
K U L I TK U L I T
![Page 17: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/17.jpg)
SUBKUTAN(JP. LONGGAR)
SUBKUTAN(JP. LONGGAR)
HIPODERMIS (Sel lemak sedikit)
SUBKUTAN PROPRIA (Sel lemak banyak / corpus adiposum)
![Page 18: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/18.jpg)
Arteri (2 pleksus): antara lap. papiler & retikuler; antara dermis & subkutan.
Vena (3 pleksus): 2 pleksus sama dg pd arteri, 1 pleksus terletak pd pertengahan dermis.
Pembuluh limfe terletak pd tempat yg sama dg arteri.
PEMBULUH DARAH& PEMBULUH LIMFE
PEMBULUH DARAH& PEMBULUH LIMFE
![Page 19: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/19.jpg)
TANPA KAPSUL BERKAPSUL
C. MERCKELIC. MERCKELI
C. VATER PACINIC. MEISSNERC. RUFFINIC. KRAUSE
C. VATER PACINIC. MEISSNERC. RUFFINIC. KRAUSE
![Page 20: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/20.jpg)
Ujung saraf bebas melekat pada sel-sel merckel.
Pada epidermis
Rangsang sentuhan / raba & tekanan.
C. MERCKELI C. MERCKELI
![Page 21: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/21.jpg)
Lonjong spt bawang.
Akhir serat saraf dg kapsul berlamel-lamel konsentris.
Kapsul : serabut kolagen & sel pipih spt endotel.
Pd subkutan.
Rangsang getaran & tekanan.
C. VATER PACINI
C. VATER PACINI
![Page 22: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/22.jpg)
Silindris.
Akhir serat saraf bercbg2, berkapsul.
Kapsul : JP. tipis & sel pipih transversal.
Pd papila dermis.
Rangsang sentuhan/raba & diskriminasi 2 titik yang berdekatan.
C. MEISSNERC. MEISSNER
![Page 23: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/23.jpg)
Silindris (< C. Meissner). Akhir serat saraf bercbg spt
pancaran (Spray-like), berkapsul.
Kapsul : JP. tipis. Pd dermis. Rangsang sentuh / raba,
tekanan & suhu panas.
C. RUFFINIC. RUFFINI
![Page 24: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/24.jpg)
Bulat / sferis.
Akhir serat saraf bercabang-cabang, berkapsul.
Kapsul : JP. tebal.
Pada dermis.
Rangsang sentuh / raba, tekanan & suhu dingin.
C. KRAUSEC. KRAUSE
![Page 25: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/25.jpg)
RAMBUTRAMBUT
![Page 26: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/26.jpg)
RAMBUTRAMBUT
![Page 27: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/27.jpg)
RAMBUTRAMBUT
![Page 28: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/28.jpg)
RAMBUT RAMBUT
![Page 29: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/29.jpg)
KUKUKUKU
![Page 30: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/30.jpg)
KEL. ASINER BERCBG SIMPLEKS
& KEL. HOLOKRIN
![Page 31: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/31.jpg)
KELENJAR SUDORIFERAKELENJAR SUDORIFERA
2 TIPE2 TIPE
SEJATI(EKRIN)
SEJATI(EKRIN)
BESAR(MODIFIKASI)
BESAR(MODIFIKASI)
![Page 32: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/32.jpg)
KELENJAR KERINGAT
SEJATI
KELENJAR KERINGAT
SEJATI
KEL. TUBULER BERGELUNG SIMPLEKS
KEL. MEROKRIN
![Page 33: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/33.jpg)
PARS SEKRETORIUSPARS SEKRETORIUS
PARS EKSKRETORIUSPARS EKSKRETORIUS
![Page 34: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/34.jpg)
> Besar
Subkutan
Biasanya bermuara pd folikel rambut
Sekret > kental
Apokrin
Contoh : kel. aksilla, mammae & areola mammae.
![Page 35: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/35.jpg)
Bloom W and Fawcett D.W. 1971. A. Textbook of Histology. Ninth edition. Igaku Shoin Ltd. Tokyo.
di Fiore M.S.H. 1974. Atlas of Human Histology. Fourth edition. Lea & Febiger. Philadelphia.
Junqueira L.C and Carneiro J. 2003. Basic Histology Text and Atlas. Tenth edition. Mcgraw-Hill Companies. New York.
REFERENSIREFERENSI
![Page 36: Kuliah Histologi - Muthmainah, Dr., MKes](https://reader033.vdocument.in/reader033/viewer/2022061602/55cf9ace550346d033a37c39/html5/thumbnails/36.jpg)
TERIMA KASIH TERIMA KASIH