PAULA HAMMONDKoch Professor of Engineering Department Head of Chemical Engineeringkoch institute of integrative cancer research Massachusetts Institute of Technology

march 20, 2019

William G. Lowrie LectureshipHonors and Awards Banquet

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PAULA HAMMONDKoch Professor of Engineering

Department Head of Chemical Engineeringkoch institute of integrative cancer research

Massachusetts Institute of Technology

Professor Paula T. Hammond is the David H. Koch Chair Professor of Engineering at the Massachusetts Institute of Technology, and the Head of the Department of Chemical Engineering. She is a member of MIT’s Koch Institute for Integrative Cancer Research, the MIT Energy Initiative, and a founding member of the MIT Institute for Soldier Nanotechnology, whose mission is to help design more functional technology for the nation’s soldiers. She is the co-founder and member of the Scientific Advisory Board of LayerBio, Inc. and a member of the Scientific Advisory Board of Moderna Therapeutics.

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2019 WILLIAM G. LOWRIE LECTURES

Research

Professor Hammond’s research interests include the nanoscale design of biomaterials, macromolecular design and synthesis, and directed assembly using surface templates. The core of her work is the use of electrostatics and other complementary interactions to generate functional materials with highly controlled architecture.

Her research in nanotechnology encompasses the development of new biomaterials to enable drug delivery from surfaces with spatio-temporal control. She also investigates novel responsive polymer architectures for targeted nanoparticle drug and gene delivery, and self-assembled materials systems for electrochemical energy devices.

She has designed multilayered nanoparticles to deliver a synergistic combination of siRNA or inhibitors with chemotherapy drugs in a staged manner to tumors, leading to significant decreases in tumor growth and a great lowering of toxicity.

Dr. Hammond has published over 320 papers, and over 20 patent applications.

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Awards and Honors

Professor Paula Hammond was elected into the National Academy of Engineering in 2017, the National Academy of Medicine in 2016, and the 2013 Class of the American Academy of Arts and Sciences. She is also the recipient of the 2013 AIChE Charles M. A. Stine Award, which is bestowed annually to a leading researcher in recognition of outstanding contributions to the field of materials science and engineering, and the 2014 Alpha Chi Sigma Award for Chemical Engineering Research.

In 2013, Professor Hammond was selected to receive the Department of Defense Ovarian Cancer Teal Innovator Award, which supports a single visionary individual from any field principally outside of ovarian cancer to focus his/her creativity, innovation, and leadership on ovarian cancer research.

During her sabbatical in 2013, she was a visiting scientist at the Dana-Farber Cancer Institute, and a visiting professor at the Nanyang Technological University in Singapore, in the Chemical Engineering Department.

Professor Hammond continues to serve as an Associate Editor of the American Chemical Society journal, ACS Nano. As a part of the Year of Chemistry in 2011, she was one of the Top 100 materials scientists named by Thomson-Reuters, a recognition of the highest citation impact in the field over the past decade (2001-2011).

She was named a Fellow of the American Physical Society, the American Institute of Biological and Medical Engineers, and the American Chemical Society Polymer Division. Professor Hammond’s work on multilayer tattoos for transdermal DNA vaccines was recently featured on the PBS Nova program, “Making Stuff” with David Pogue, and she was also featured in the Chemical Heritage Foundation’s Catalyst Series: Women in Chemistry.

PAULA HAMMOND

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Lecture I: Nanolayered Particles for Tissue Targeted TherapiesWednesday, March 20, 2019Reception: 11:00 am, Physics Research Building LobbyLecture: 11:30 am - 12:30 pm, 1080 Physics Building

Layer-by-layer assembly provides an approach that allows complementary secondary interactions to generate a stable thin film coating which can contain a broad range of molecular and macromolecular systems. It can be applied to a range of nanomaterials that are of interest for cancer therapies, from solid nanocrystals that can act as imaging systems to nanometer scale drug containers such as liposomes or polymeric nanoparticles. This kind of approach offers the promise of delivery of a cascade of drugs in sequence, thus allowing for optimized combination therapy of synergistic drugs with therapeutic molecules such as proteins and siRNA.

The generation of LbL nanoparticles that can directly target specific tissues such or key organs is dependent on the nature of the outer LbL layer, and its net surface charge, degree of hydration, and type of polyelectrolyte bilayer pair that is adsorbed as the final layers on the nanoparticle. Recent work in which these nanoparticle systems are designed for optimized uptake by advanced serous ovarian cancer cells will be discussed, and the use of these approaches to deliver combination siRNA/chemotherapy or drug inhibitor combination therapies or to generate imaging systems and theranostic nanoparticles will be addressed.

The potential to target other tissues using designed nanoplex systems is discussed, in particular for the case of targeting cartilage to address the early stages of post-traumatic osteoarthritis. The manipulation of outer surface charge and polymer chain functionality, as well as the ability to design these layered nanoscale complexes to respond to micro-environment cues to achieve controlled biodistribution and uptake to targeted cells in vivo will be described.

2019 WILLIAM G. LOWRIE LECTURES

Lecture II: Research and Life Matters: Seeking Passion and Sanity in CareerThursday, March 21, 2019Reception: 11:00 am, CBEC LobbyLecture: 11:30 am - 12:30 pm, 130 CBEC

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2019 LOWRIE AWARDS PROGRAM

I. LOWRIE LECTURESHIP AWARD PRESENTATION

PAULA HAMMOND

II. SPECIAL STUDENT AWARDS & RECOGNITIONSUNDERGRADUATEAIChE Poster CompetitionsVasiliki Kolliopoulos First Prize-2018 Food, Pharmaceutical and Biotechnology Division. Vasiliki also received an honorable mention for a 2018 National Science Foundation Graduate Research Fellowship and a two-year, fully-funded NIH Fellowship called the Chemistry-Biology Interface Training Program for 2018-20 at University of Illinois at Urbana-Champaign. (Castro)

Nathaniel Olson Third Prize-2018 AIChE Poster Competition, Catalysis and Reaction Engineering. Also selected for a NASA Space Technology Research Fellowship for 2018-19 at University of Illinois Urbana-Champaign. (Brunelli)

Benjamin Rudzinski First Prize-2018 AIChE Catalysis and Reaction Engineering. Also won Second Place in the 2018 COE Undergraduate Research Forum, Engineering-Chemical & Environmental. (Ozkan)

Michael Petrecca First Prize-2018 AIChE Fuels, Petrochemical and Energy Division. (Fan)

ChemE Car 2018 National CompetitionOhio State ChemE Car Team 2018 Sportsmanship Award. (Tomasko)

2018 Denman Undergraduate Research ForumIvan Pires First Place, Engineering-Chemical & Environment (Palmer)Lucas Watson Second place, Engineering-Chemical & Environmental (Zakin, Maxson)Emma Garber Third Place, Engineering-Chemical & Environmental; also won the Sustainability Competition in Climate Change sponsored by the Office of Energy and Environment. (Fan)

Future Leaders in Chemical Engineering SymposiumIvan Pires 2018 participant in the highly selective Future Leaders in Chemical Engineering Symposium at North Carolina State. 2017 and 2018 representative, 25th and 26th Annual SIICUSP Undergraduate Research Meeting, Sao Paulo, Brazil. (Palmer)

COE Undergraduate 2018 Summer Research FundingTaylor Fitzgerald (Ozkan); Yu Gu, Aashika Katapadi, Chase Kayrouz, Ivan Pires (Palmer), Qianxia Zhang.

Office of Undergraduate Research and Creative Inquiry Summer FundingDavid Allen, Ivan Pires. (Palmer)

For contributions to the understanding and use of self-assembly to guide material structure at surfaces and in solution.

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2019 LOWRIE AWARDS PROGRAM

GRADUATEAIChE AwardsDonald Belcher First Prize-2018 AIChE Divisional Student Poster Competition. (Palmer)

Nitish Deshpande 2018 AIChE Travel Award. (Brunelli)

Yang Han 2018 AIChE Separations Graduate Student Award, Membrane Separations Area. (Ho)

National Science Foundation Graduate Research FellowshipsMichael Charles. Michael was also a representative at the 2017 UN Climate Negotiations in Bonn, Germany and was a keynote speaker/research award winner at the 2017 AISES National Conference. (Bakshi)

Blaise Kimmel. (Fan) Blaise is currently working on a Ph.D. at Northwestern University.

2017 grads Jacob Paul Martin and Hopen Kaichi Yang (former advisor: Wood) won honorable mentions. Hopen is the son of faculty ST Yang.

North American Membrane Society Kai Chen 2019 NAMS Elias Klein Founders’ Travel Supplement Award. (Ho)

Yang Han 2019 NAMS Young Membrane Scientist Award; 2018 NAMS Poster Award; 2018 NAMS Elias Klein Founders’ Travel Award (Ho)

Process Systems Engineering InternationalTapajyoti Ghosh 2019 Process Systems Engineering International Symposium Young Researcher Travel Award (Bakshi)

Ohio State University Office of Student Academic Success-Undergraduate Research & Creative InquiryMandar Kathe 2019 Excellence in Undergraduate Research Mentoring Award. (Fan)

2018 CBE Graduate Research Symposium AwardsDonald Belcher Oral PresentationAbhilasha Dehankar Oral Presentation, Poster PresentationKayane Dingilian Poster PresentationYang Han Poster PresentationDeeksha Jain Poster PresentationJames Kim Poster PresentationYan Liu Poster Presentation

Ohio State University 2018 Institute of Materials Research AwardsSaurabh Ailawar IMR Poster Award. (Ozkan)Deeksha Jain IMR Poster Award. (Ozkan, Co) Sourabh Nadgouda IMR Poster Award. (Fan)Aamena Parulkar IMR Three-Minute Thesis Award Runner-Up. (Brunelli)

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III. STUDENT LEADERSHIP RECOGNITION

Chemical Hygiene Committee (CHYCOMM)

Society for Petroleum Engineering

President: Stiphany Tieu Internal Vice President: Mike PetreccaExternal Vice President: Leah SoppiSecretary: Julie GemmelTreasurer: Taylor CochranEvents Coordinator: Jacob BeldingSocial Events Coordinator: Siena VeurinkMentorship Chair: Matt GreenwaldtMarketing Chair: Jessica SrailIntramural Chair: Bryce Bridges

Fundraising Chair: Alex KrumelChem-E Car Liason: Spencer KrebsFreshman Outreach: Anjali TewariWebmaster: Josie MillerE-Council Representative: Rebecca DunneSo. Class Representative: Bryce PemberJr. Class Representative: Luke MorricalSr. Class Representatives: Yara Mohamad, Eman Jallaq(Advisor: Endres, Rathman)

President: Joe GruberVice President: Ben WatersTreasurer: Daniel BiblerSecretary: Steve LinPressure Lead: Josh GoetzeBattery Lead: Jack Thomas Design Lead: Dave LendlSafety Lead: Kovid Mosicka

Co-Chairs: Mariah Whitaker,Committee Members: Deeksha JainDishari BasuSaurabh AilawarDeven BaserPinaki Ranadive

Academic Officer: Elizabeth JergensBusiness Officer: Archit Datar Facilities Officer: Mitch WeigandRecruitment Officer: Nick Liesen

Social Officer: Vance GustinGraduate Research Symposium Officer: Anagha Hunoor(Advisor: Bennett)

ChemE Car Officers

GRADUATECEGC Officers

Graduate Research Symposium Officers

UNDERGRADUATE AIChE Student Chapter Officers

Ashwin KaneVedant ShahTapajyoti GhoshMitchell WeigandAbhilasha Dehankar

Utkarsh ShahArchit DatarAnagha Hunoor

Dhruba Jyoti Deka

President: Yiwen GongVice President: Stuart SvetlakAssociate Vice President: Talia AbedonTreasurer: Martin NguyenEvent Coordinator: Izwan Zhuqairy Bin Iskander ZulqaranainClass Representative: Yu Zhang(Advisor: El-Monier)

Chair: Saurabh AilawarVice-Chair: Donald BelcherYu Yen ChenRoss ChongsonAndrew DengKayane DingilianYang HanRichard Hickey

Deeksha Jain Elizabeth JergensAshwin KaneFaiz KhanJames KimJackelyn Miozzi

Junjie PanKevin ShenJoao Vinicius Ribeiro Leite SilvaVyom Thakker

2019 LOWRIE AWARDS PROGRAM

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2019 LOWRIE AWARDS PROGRAM

IV. STUDENT AWARDS

AIC (American Institute of Chemists) Foundation AwardsOutstanding Undergraduate Award: Ivan Susin Pires (Palmer)Outstanding Graduate Student Award: Eun Hyun Cho (Lin)Outstanding Postdoctoral Student Award: Lang Qin (Fan)

AIChE Chapter AwardsCentral Ohio Section Outstanding Student Award: Julie Gemmel Donald F. Othmer AIChE Sophomore Academic Excellence Award: Matthew Polatas

AIChE Student Chapter AwardsExemplary Service and Leadership Award: Jessica MalesOutstanding Community Outreach Award: Kyle LangmackOutstanding Support of Undergraduate Education Award: Mason Lilja

CBE Undergraduate Patents/Publishing AwardThomas Porter (Winter)

Michael Petrecca (Fan)Samantha Thobe (Swindle-Reilly)

CBE Outstanding Undergraduate Award for Research Excellence

CBE Outstanding Graduate Award for Academic Achievement

CBE Outstanding Post-Doc Award for Research Excellence Ruizhi Pang (Ho)

CBE Chemical Hygiene Committee Awards (CHYCOMM)Department-Wide Excellence in Safety Award: Ozkan Group Outstanding Lab Safety Awards: Palmer Group, Wood Group

Deeksha Jain (Ozkan)Tapajyoti Ghosh (Bakshi)

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-1996 Lecturer- John F. Davidson, University of Cambridge

-1997 Lecturer- William R. Schowalter, University of Illinois at Urbana-Champaign

-1998 Lecturer- James Wei, Princeton University

-1999 Lecturer- Judson King, University of California, Berkeley

-2000 Lecturer- Robert Langer, MIT

-2001 Lecturer- Roy Jackson, Princeton University

-2002 Lecturer- Alexis T. Bell, University of California, Berkeley

-2004 Lecturer- John H. Seinfeld, California Institute of Technology

-2005 Lecturer- Charles A. Eckert, Georgia Tech

-2006 Lecturer- Alice P. Gast, Massachusetts Institute of Technology

-2007 Lecturer- Greg Stephanopoulos, Massachusetts Institute of Technology

-2008 Lecturer- Carol K. Hall, North Carolina State University

-2009 Lecturer- Gabor A. Somorjai, University of California, Berkeley

-2010 Lecturer- Rakesh K. Jain, Harvard Medical School

-2011 Lecturer- Frank S. Bates, University of Minnesota

-2012 Lecturer- Pablo G. DeBenedetti, Princeton University

-2013 Lecturer- Mark E. Davis, California Institute of Technology

-2014 Lecturer- William F. Banholzer, University of Wisconsin-Madison

-2015 Lecturer- Enrique Iglesia, University of California, Berkeley

-2016 Lecturer- Nicholas Peppas, University of Texas at Austin

-2017 Lecturer- Eric W. Kaler, University of Minnesota

-2018 Lecturer- Matthew Tirrell, University of Chicago

Previous Recipients of the Lowrie Lectureship

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The William G. Lowrie Lectureship was established in the department of chemical engineering at The Ohio State University on October 1, 1995 to honor distinguished alumnus William G. Lowrie.

The lectureship is awarded anually to an individual who has made outstanding contributions to fundamental or applied research in the field of chemical engineering.

Thank you for attending!

William G. Lowrie Department of Chemical and Biomolecular Engineering

Koffolt Laboratories151 West Woodruff AvenueColumbus, OH 43210-1350

(614) 292-7907www.cbe.osu.edu