Labile or stable: opposing consequences for memory when reactivated during waking

and sleep

Susanne Diekelmann, Christian Büchel, Jan Born & Björn Rasch

Feng Jingyu

Memory Consolidation

Consolidation is defined as a time-dependent stabilization process that leads eventually to the permanent storage of newly acquired memory

Reactivation & Reconsolidation

Memories are not consolidated, or stabilized, just once: they can return to a labile state and need to be reconsolidated, or restabilized, when reactivated

Experimental procedures

1.Participants learned object-location task in presence of the experimental odor2.One group of subjects stayed awake.The other group of subjects went to sleep3.learned an interference object-location task4.Recall of the original object-location task was tested 30 min after interference learning

(Each participant was also tested in a control condition in which, instead of odor, odorless vehicle was presented during waking and SWS, respectively)

Results

Results

Conclusion

Reactivation during waking destabilized memory traces, returning them to a labile state, The same odor-cued reactivation stabilized memory traces when induced during SWS

Neuronal correlates of reactivation during waking

Activememory

Oldmemory

New situations

Reconsolidated memory

Overwritten memory

Retrival Rminder

Neuronal correlates of reactivation during waking

Neuronal correlates of reactivation during SWS

To be continued Reactivation during SWS

stablization

Newly encoded memory

or

transient destabilization

fast restabilization

Strengthenedmemory

Thank you