Vision Science Theme

Lana J. NagyUniversity of Rochester

High Tech Maui Industry Education Exchange

March 2005

Goals of Vision Science

•Advance Vision Science

•Demonstrate value of Adaptive Optics (AO) to eye care

•Increase accessibility of Adaptive Optics to scientists and clinicians

•Develop novel ophthalmic instruments

•Education

Anatomy of the Eye

Ganglion cellsAmacrine cells Rods

Cones

Aberrations in Lens and Cornea Distort Wave front

Deformable MirrorCorrects Wavefront

Sharp Image in Camera

Wavefront SensorMeasures Wavefront

Courtesy of David Williams

Principle of AO

Without adaptive optics (single image)

With adaptive optics(single image)

1 deg retinal eccentricity

With adaptive optics(many images)

AO and Retinal Imaging

Courtesy of David Williams

AO Ophthalmoscope

Human Trichromatic Cone MosaicRoorda, A. and Williams, D.R. (Nature, 1999),

Heidi Hofer (2003)

NC-DeuteranopeHas L and M genes, but M gene defective

Joe Carroll (2004)

University of RochesterMissing Photoreceptors

AO Scanning Laser Ophthalmoscope (SLO)

Austin Roorda

Nerve fiber layer

Blood vessel just below nerve

layer

Photoreceptor layer

University of HoustonConfocal capabilities allow for:

•Sectioning through retinal layers

•Monitoring of real time dynamics

Flood Illuminated Retinal AO Camera

Indiana University

24μm

Registered stack of 120 images 30 Hz images rate0.8o Field of view1.4o retinal ecc.

•Real time imaging of photorecptoractivity

•Working to combine AO with optical coherence tomography to produce high resolution 3-D retinal views

Juntae Rha, Ravi Jonnal, Yan Zhang, Don Miller

AO Phoropter

Lawrence Livermore National Laboratories

Deformable mirror

Wavefrontsensor

Vision Science in the

Center for Adaptive Optics

Thank You!

Keck TelescopeMauna Kea, Hawaii