lecture 12 august 26, 2005 lehninger (4 th edition), chapter 17
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Lecture 12
• August 26, 2005
• Lehninger (4th Edition), Chapter 17
FATTY ACID DEGRADATION (OXIDATION)
LNC Chapter 17
LNC 10-1
LNC 10-6
LNC 10-8
LNC 10-15
LNC 10-16
UPTAKE and DISTRIBUTION in Mammals
LNC 17-1
LNC 21-40
ADIPOSE TISSUE
LNC 17-2
Chylomicron
LNC 21-39a
Structure of an LDL particle
LNC 21-39b
Breakdown/Oxidation of Fatty Acids
-Oxidation
Activation
LNC 17-5
LNC 17-6
C14 fatty acid 7 acetyl CoA
6 rounds of oxidation
LNC 17-7
LNC 19-8
LNC 17-9
How to deal with unsaturated fatty acids:
cis 3 - ordouble bond between
LNC 17-10
LNC 17-11
How to deal with a fatty acid
containing an
uneven number of carbons
C3
C4
LNC box 17-1
LNC box 17-2
catalase
Degradation ofvery long chainfatty acids in the
peroxisome
LNC 17-12
Glyoxalate Cycle inPlants
LNC 17-13
Ketone Bodies
LNC Fig 17-18
Conditions favoringketone body formation:
depletion of OAfor gluconeogenesis
acetyl-CoA becomesavailable forketone body synthesis
Metabolic Biochemistry
FATTY ACID SYNTHESIS
LNC Chapter 21
LNC Fig. 21-1
the enzyme has threefunctional regions:
- biotin carrier protein- biotin carboxylase- transcarboxylase
acetyl-CoA + CO2 ==> malonyl-CoA
LNC Fig. 21-4
acyl carrier protein
LNC Fig. 21-2
End of lecture 12
August 26, 2005