lecture 12: introduction to protein structure; structure ......courtesy of wenqing xu et al. and...
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Courtesy of Wenqing Xu et al. and RCSBProtein Data Bank. Used with permission. Courtesy of Macmillan Publishers Limited. Used with permission.
Source: Barabási, Albert-László, Natali Gulbahce, et al."Network Medicine: A Network-based Approach to Human Disease."Nature Reviews Genetics 12, no. 1 (2011): 56-68.
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© Cold Spring Harbor Laboratory Press. All rights reserved. This content is excluded from our CreativeCommons license. For more information, see http://ocw.mit.edu/help/faq-fair-use/.
Source: Pavletich, Nikola P., Kristen A. Chambers and Carl O. Pabo. "The DNA-binding Domain of p53
Contains the Four Conserved Regions and the Major Mutation Hot Spots." Genes & Development 7, no.
12b (1993): 2556-64.
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© American Association for the Advancement of Science. All rights reserved. This content is excludedfrom our Creative Commons license. For more information, see http://ocw.mit.edu/help/faq-fair-use/.
Source: Cho, Yunje, Svetlana Gorina, et al. "Crystal Structure of a p53 Tumor Suppressor-DNA
Complex: Understanding Tumorigenic Mutations." Science 265, no. 5170 (1994): 346-55.
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© Jens Meller. All rights reserved. This content is excluded from our CreativeCommons license. For more information, see http://ocw.mit.edu/help/faq-fair-use/.
Courtesy of Kjaergaard on wikipedia. Courtesy of MartinSaunders on wikipedia.
Photograph in the public domain. Photograph in the public domain.
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Challenges of Structural Bioinformaticscourtesy of Russ Altman & Jonathan Dugan
in Structural Bioinformatics, Philip E. Bourne & Helge Weissig, editors
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Source: Figure 11.18 in Zvelebil, Marketa J., and Jeremy O. Baum. "Understanding Bioinformatics." Garland Science, 2008.
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© Annual Reviews. All rights reserved. This content is excluded from our Creative Commonslicense. For more information, see http://ocw.mit.edu/help/faq-fair-use/.Source: Orengo, Christine A., and Janet M. Thornton. "Protein Families and their Evolution--AStructural Perspective." Annual Review Biochemistry 74 (2005): 867-900.
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Source: Dill, Ken A., and Hue Sun Chan. "From Levinthal to Pathways to Funnels."
Nature Structural Biology 4, no. 1 (1997): 10-9.
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Source: Kuszewski, John, Angela M. Gronenborn, et al. "Improvements and Extensions
in the Conformational Database Potential for the Refinement of NMR and X-ray Structures
of Proteins and Nucleic Acids." Journal of Magnetic Resonance 125, no. 1 (1997): 171-7.
Courtesy of Elsevier, Inc., http://www.sciencedirect.com. Used with permission.
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license. For more information, see http://ocw.mit.edu/help/faq-fair-use/.
Source: Mendes, Joaquim, António M. Baptista, et al. "Improved Modeling of Side‐chains
in Proteins with Rotamer-based Methods: A Flexible Rotamer Model." Proteins: Structure,
Function, and Bioinformatics 37, no. 4 (1999): 530-43.Courtesy of Jane S. Richardson. License: CC-BY.
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Source: Kuszewski, John, Angela M. Gronenborn, et al."Improvements and Extensions in the Conformational
Database Potential for the Refinement of NMR and X-ray
Structures of Proteinsand NucleicAcids." Journal of
Magnetic Resonance 125, no. 1 (1997): 171-7.
53
Courtesy of Elsevier, Inc., http://www.sciencedirect.com.Used with permission.
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© The estate of the authors. All rights reserved.
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Commons license. For more information, see
http://ocw.mit.edu/help/faq-fair-use/.
Source: Pauling, Linus, Robert B. Corey, and Herman R.Branson. "The Structure of Proteins: Two Hydrogen-bonded Helical Configurations of the Polypeptide
Chain." Proceedings of the National Academy ofSciences 37, no. 4 (1951): 205-211.
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http://ocw.mit.edu/help/faq-fair-use/.
Source: Pauling, Linus, Robert B. Corey, and Herman R.Branson. "The Structure of Proteins: Two Hydrogen-bonded Helical Configurations of the Polypeptide
Chain." Proceedings of the National Academy ofSciences 37, no. 4 (1951): 205-211.
Source: Ramachandran, G. N., C. T. Ramakrishnan, et al. "Stereochemistry of Polypeptide
Chain Configurations." Journal of Molecular Biology 7, no. 1 (1963): 95-9.
© source unknown. All rights reserved. This content is excluded
from our Creative Commons license. For more information,
see http://ocw.mit.edu/help/faq-fair-use/.
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Source: Chou, Peter Y., and Gerald D. Fasman. "Conformational Parameters
for Amino Acidsin Helical, β-sheet, and Random Coil Regions Calculated from
Proteins." Biochemistry 13, no. 2 (1974): 211-22.
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Courtesy of Nature Publishing Group. Used with permission.Source: Dill, Ken A. and Hue Sun Chan. "From Levinthal to Pathways to Funnels."
Nature Structural Biology 4, no. 1 (1997): 10-9.
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7.91J / 20.490J / 20.390J / 7.36J / 6.802J / 6.874J / HST.506J Foundations of Computational and Systems BiologySpring 2014
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