lecture 7 - musculoskeletal

Upload: destareda

Post on 30-May-2018

218 views

Category:

Documents


0 download

TRANSCRIPT

  • 8/14/2019 Lecture 7 - Musculoskeletal

    1/120

    Review of Human SkeletalReview of Human SkeletalAnatomyAnatomy

    Mark Anthony R. Rivera, MD RN CST

    Lecturer, College of Nursing

    Our Lady of Fatima University

  • 8/14/2019 Lecture 7 - Musculoskeletal

    2/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    3/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    4/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    5/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    6/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    7/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    8/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    9/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    10/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    11/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    12/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    13/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    14/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    15/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    16/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    17/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    18/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    19/120

    Assessment of the

    Musculoskeletal SystemMusculoskeletal System

  • 8/14/2019 Lecture 7 - Musculoskeletal

    20/120

    The Body Axis

    The body is made up of the skull, vertebralcolumn, ribs, and coccyx (tailbone)

    Skull is made up of the cranium, which

    protects the brain, and the face. Vertebral column is the backbone. It has

    33 vertebrae

    Vertebrae are small, rigid bones thatstack together

    The ribs protect the heart and lungs. Thereare 12 pairs.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    21/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    22/120

    Arm

    At the tips of your fingers are the phalanges.

    Long, slender, lightweight.

    Phalanges are connected to metacarpal bones.

    Metacarpals are framework of the palm.

    Metacarpals branch off from the carpal bones.

    8 of them; pebble-ish

    The carpal bones are below the ulna and the radius.

    If your palm is face-up and your arm extended, your elbow

    is your ulna. The ulna and the radius are connected to the humerus.

    The humerus in turn connects to the scapula.

    The scapula is held in place by muscles.

    The scapula is then connected to the clavicle, or collarbone.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    23/120

    Legs

    At the tips of your toes are the phalanges.

    These connect to the metatarsals.

    Which in turn connect to the tarsals.

    7 tarsals, only 1 is heel.

    Connected to the tarsals are the tibia and fibula.

    Tibia is the shin bone.

    At the knee, the tibia and fibula are separated from the femur by a large section of cartilage.

    On this cartilage rests the patella. The femur is then connected to the coxal bone, which is

    connected to the sacrum

    Femur is the largest bone in the body.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    24/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    25/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    26/120

    Skeletal System

    Bone types Bone structure Bone function

    Bone growth and metabolism

    affected by:1. calcium and phosphorous,2. calcitonin,3. vitamin D,4. parathyroid hormone,5. growth hormone,6. glucocorticoids,7. estrogens and androgens,8. thyroxine, and

    9. insulin

  • 8/14/2019 Lecture 7 - Musculoskeletal

    27/120

    Bones

    Support the body and anchor muscles.

    Ligaments link bones to other bones.

    Tendons link bones to muscle

    Two types of bones Compact Bone

    Spongy Bone

    Inside bones is a central shaft. This is the marrowcavity where fat is stored.

    Bone matrixes contain the bones proteins andminerals. These heal bone and maintain healthiness.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    28/120

    2 Major Types of Bone

    Compact

    Has few and very smallspaces inside.

    Made of osteons.

    Spongy

    Has many largespaces. It contains redmarrow where redblood cells are made.

    Made of trabeculae.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    29/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    30/120

    Joint types

    Ball and socket

    Pivot

    Saddle

    Ellipsoid

    Hinge

    Plane

    Arm

    Neck

    Thumb

    Knuckles

    Knee

    Ankle

  • 8/14/2019 Lecture 7 - Musculoskeletal

    31/120

    http://images.google.com/imgres?imgurl=http://www.yflyer.org/CYFYRA/images/Maple%2520Leaf.jpg&imgrefurl=http://www.yflyer.org/CYFYRA/&h=245&w=200&sz=11&tbnid=NOHXrxXrkoMJ:&tbnh=105&tbnw=85&hl=en&start=2&prev=/images%3Fq%3Dmaple%2Bleaf%26svnum%3D10%26hl%3Den%26lr%3D%26rls%3DGGLD,GGLD:2004-07,GGLD:en%26sa%3DN
  • 8/14/2019 Lecture 7 - Musculoskeletal

    32/120

    MUSCULAR SYSTEMMUSCULAR SYSTEM

  • 8/14/2019 Lecture 7 - Musculoskeletal

    33/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    34/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    35/120

    Muscular System

    Structure

    Function

    Supporting structures

    Musculoskeletal changes associated with aging

    Cultural considerations

    Movements to

    know!

    Know aging changes vs.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    36/120

    List of major muscles

    Biceps brachiiInner armTriceps brachiiBack of armDeltoidUpper armTrapeziusBase of neckScientific NameCommon Name

    Biceps femorisBack part of the upper legSartoris and Rectus femorisFront part of the upper legGluteus maximusButtAbdominal musclesStomachLatissimus dorsiBack

  • 8/14/2019 Lecture 7 - Musculoskeletal

    37/120

    Muscles

    In humans with hard skeletons, muscles arein antagonistic pairs

    e.g. shin and calf muscles

    The skeletal muscles are muscles that areattached to bones. These move the skeleton.

    Made of muscle fibers, multi-nuclei cells.

    The plasma membranes enclose longbundles called fibrils.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    38/120

    Muscles Cont.

    They work by shortening (contracting) andlengthening (flexing)

    The energy is supplied my mitochondria in

    the fibrils. Muscle contraction is called Sliding

    Filament Mechanism, where filaments incells slide past each other.

    Cardiac muscle is electrically connected.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    39/120

    Different Types

    Smooth

    Found in hollowbody organs likedigestive tractand bloodvessels.

    Have 1 nucleus.

    Skeletal

    Composed of long fibers.

    Controlsvoluntary

    movement.

    Cardiac

    Central nuclei.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    40/120

    Muscle energy

    The Immediate Energy System is a quick blast of muscle power. This uses fast-twitch fibers.

    The Glycotic Energy System splits glucose byglycolysis in the muscles.

    The Oxidative Energy System (Aerobic Energy System)is for prolonged muscle use, like marathons. This usesslow-twitch fibers.

    Slow-twitch fibers are packed with mitochondriaand myoglobin.

    Fast oxidative-glycolytic muscle fibers are moderatelypowerful and last for a moderate amount of time.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    41/120

    Assessments

    Family history and genetic risk

    Personal history

    Dietary history

    Socioeconomic status and ability to afford food

    Current health problems including obesity

  • 8/14/2019 Lecture 7 - Musculoskeletal

    42/120

    Physical Assessment

    General inspection

    Posture

    Abnormality in gait such as antalgic gait or lurch

    Goniometer, which provides a measure of ROM Head and neck: evaluate the temporomandibular joints

    Spine: lordosis, scoliosis

    Upper extremities Lower extremities

    )

  • 8/14/2019 Lecture 7 - Musculoskeletal

    43/120

    Diagnostic Assessment

    Laboratory tests: serum calcium andphosphorus, alkaline phosphatase, serummuscle enzymes

    Radiographic examinations: standardradiography, tomography and xeroradiography,myelography, arthrography, and CT

    Other diagnostic tests: bone and muscle biopsy

  • 8/14/2019 Lecture 7 - Musculoskeletal

    44/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    45/120

    Arthroscopy

    Fiberoptic tube is insertedinto a joint for directvisualization.

    Client must be able to flexthe knee; exercises areprescribed for ROM.

    Evaluate theneurovascular status of

    the affected limbfrequently.

    Analgesics areprescribed.

    Monitor for complications.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    46/120

    Other Tests

    Bone scan

    Gallium or thallium scan

    Magnetic resonance imaging

    Ultrasonography

  • 8/14/2019 Lecture 7 - Musculoskeletal

    47/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    48/120

    Osteoporosis

    Metabolic disease, in which bone demineralizationresults in decreased density and subsequent fractures

    Osteopenia (low bone mass), which occurs when thereis a disruption in the bone remodeling process

  • 8/14/2019 Lecture 7 - Musculoskeletal

    49/120

    Classification of Osteoporosis

    Generalized osteoporosis occurs mostcommonly in postmenopausal women and menin their 60s and 70s.

    Secondary osteoporosis results from anassociated medical condition such ashyperparathyroidism, long-term drug therapy,long-term immobility.

    Regional osteoporosis occurs when a limb isimmobilized.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    50/120

    Health Promotion/Illness Prevention

    Ensure adequate calcium intake.

    Avoid sedentary life style.

    Continue program of weight-bearing exercises.Unchangeable risk factors for osteoporosis include female

    gender, older age, small or thin body size, Caucasian and Asian

    ethnicity, and family history of fractures.

    Modifiable risk factors include a diet low in calcium and vitamin

    D, use of certain medications, an inactive lifestyle or extended

    bed rest, cigarette smoking, and excessive alcohol

    consumption.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    51/120

    Assessment

    Physical assessment

    Psychosocial assessment

    Laboratory assessment

    Radiographic assessment

  • 8/14/2019 Lecture 7 - Musculoskeletal

    52/120

    Drug Therapy

    Hormone replacement therapy Parathyroid hormone

    Calcium and vitamin D

    Bisphosphonates

    Selective estrogen receptor modulators

    Calcitonin Other agents used with varying results

  • 8/14/2019 Lecture 7 - Musculoskeletal

    53/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    54/120

    Fall Prevention

    Hazard-free environment

    High-risk assessment through programs such asFalling Star protocol

    Hip protectors that prevent hip fracture in case of a fall

  • 8/14/2019 Lecture 7 - Musculoskeletal

    55/120

    Flexibility and Strength

    Chronic Health Conditions-HTN

    Cardiac Arrhythmiasperipheral neuropathies

    FallContributors

    Uneven surfacesNo HandrailsBad lighting

    Slick Surfaces

    Outdoors

    Poor LightingClutter

    Extension CordsUnstable Handrails

    Scatter rugsPetsIndoors

    Medications

    HealthConditions

  • 8/14/2019 Lecture 7 - Musculoskeletal

    56/120

    Others

    Exercise

    Pain man agement

    Orthotic devices

    http://depts.washington.edu/bonebiohttp://depts.washington.edu/bonebiohttp://depts.washington.edu/bonebio
  • 8/14/2019 Lecture 7 - Musculoskeletal

    57/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    58/120

    Osteomyelitis

    Osteomyelitis is an acute or chronic inflammatory processof the bone and its structures secondary to infection withpyogenic organisms.

    Infection of bone with rich vascular supply frombacteremia, UTI, long term IV caths, Salmonella from GI,poor dental hygiene, MRSA

    Trauma admits bacteria such as Pseudomonas directly.

    Acute -> high temp, swelling, bone pain

    Chronic -> skin ulceration, sinus tract, local pain, drainage

    AB Tx IV, Infection control, > 3 months, surg debridementor bone grafts, amputation.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    59/120

    Padgets Disease

    Metabolic disorder of bone remodeling in whichbone deposits are weak, enlarged anddisorganized.

    2nd most common bone disease in elderly.

    Cause unknown but may be latent viralappearing > 80 yrs.

    80% asymptomatic; affects bone in skull,

    vertebrae, long bones, hip joint etc. Tx- symptomatic for pain- NSAIDS, calcitonin,

    Fosamax.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    60/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    61/120

    Classification of Fractures

    A fracture is a break or disruption in the continuityof a bone.

    Types of fractures include:

    Complete

    Incomplete

    Open or compound

    Closed or simple

    Pathologic (spontaneous) Fatigue or stress

    Compression

  • 8/14/2019 Lecture 7 - Musculoskeletal

    62/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    63/120

    Stages of Bone Healing

    Hematoma formation within 48 to 72 hr after injury

    Hematoma to granulation tissue

    Callus formation

    Osteoblastic proliferation

    Bone remodeling

    Bone healing completed within about 6 weeks;up to 6 months in the older person

  • 8/14/2019 Lecture 7 - Musculoskeletal

    64/120

    Acute Compartment Syndrome

    Serious condition in whichincreased pressure withinone or more compartmentscauses massivecompromise of circulation tothe area

    Prevention of pressurebuildup of blood or fluidaccumulation

    Pathophysiologic changessometimes referred to asischemia-edema cycle

  • 8/14/2019 Lecture 7 - Musculoskeletal

    65/120

    Emergency Care

    Within 4 to 6 hr after the onset of acutecompartment syndrome, neuromuscular damageis irreversible; the limb can become uselesswithin 24 to 48 hr.

    Monitor compartment pressures.

    Fasciotomy may be performed to relievepressure.

    Pack and dress the wound after fasciotomy.

    P ibl R lt f A t C t t

  • 8/14/2019 Lecture 7 - Musculoskeletal

    66/120

    Possible Results of Acute CompartmentSyndrome

    Infection

    Motor weakness

    Volkmanns contractures

    Myoglobinuric renal failure, known asrhabdomyolysis

  • 8/14/2019 Lecture 7 - Musculoskeletal

    67/120

    Other Complications of Fractures

    Shock Fat embolism syndrome: serious complication

    resulting from a fracture; fat globules arereleased from yellow bone marrow intobloodstream

    Venous thromboembolism

    Infection

    Ischemic necrosis Fracture blisters, delayed union, nonunion,

    and malunion

  • 8/14/2019 Lecture 7 - Musculoskeletal

    68/120

    Musculoskeletal Assessment

    Change in bone alignment Alteration in length of extremity

    Change in shape of bone

    Pain upon movement Decreased ROM

    Crepitation

    Ecchymotic skin Subcutaneous emphysema with bubbles under the skin Swelling at the fracture site

  • 8/14/2019 Lecture 7 - Musculoskeletal

    69/120

    Special Assessment Considerations

    For fractures of the shoulder and upper arm,assess client in sitting or standing position.

    Support the affected arm to promote comfort.

    For distal areas of the arm, assess client in asupine position.

    For fracture of lower extremities and pelvis,

    client is in supine position.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    70/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    71/120

    Casts

    Rigid device that immobilizes the affected body part whileallowing other body parts to move

    Cast materials: plaster, fiberglass, polyester-cotton

    Types of casts for various parts of the body: arm, leg,brace, body

    Cast care and client education

    Cast complications: infection, circulation impairment,peripheral nerve damage, complications of immobility

  • 8/14/2019 Lecture 7 - Musculoskeletal

    72/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    73/120

    Operative Procedures

    Open reduction with internalfixation (ORIF)

    External fixation

    Postoperative care: similar to thatfor any surgery; certain

    complications specific to fracturesand musculoskeletal surgeryinclude fat embolism and venousthromboembolism

  • 8/14/2019 Lecture 7 - Musculoskeletal

    74/120

    Procedures for Nonunion

    Electrical bone stimulation

    Bone grafting

    Bone banking

  • 8/14/2019 Lecture 7 - Musculoskeletal

    75/120

    Acute Pain

    Interventions include: Reduction and immobilization of fracture

    Assessment of pain

    Drug therapy: opioid and nonopioid drugs

    Complementary and alternative therapies: ice,heat, elevation of body part, massage, baths,back rub, therapeutic touch, distraction, imagery,music therapy, relaxation techniques

  • 8/14/2019 Lecture 7 - Musculoskeletal

    76/120

    Risk for Infection

    Interventions include: Apply strict aseptic technique for dressing

    changes and wound irrigations.

    Assess for local inflammation Report purulent drainage immediately to

    health care provider.

    Assess for pneumonia and urinary tractinfection.

    Administer broad-spectrum antibioticsprophylactically.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    77/120

    Impaired Physical Mobility

    Interventions include: Use of crutches to promote mobility

    Use of walkers and canes to promote mobility

    Imbalanced Nutrition: Less Than Body

  • 8/14/2019 Lecture 7 - Musculoskeletal

    78/120

    Imbalanced Nutrition: Less Than BodyRequirements

    Interventions include: Diet high in protein, calories, and calcium,

    supplemental vitamins B and C

    Frequent small feedings and supplements of high-protein liquids

    Intake of foods high in iron

  • 8/14/2019 Lecture 7 - Musculoskeletal

    79/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    80/120

    Fractures of the Hip

    Intracapsular or extracapsular Treatment of choice: surgical repair, when possible, to allow the

    older client to get out of bed

    Open reduction with internal fixation

    Intramedullary rod, pins, a prosthesis, or a fixed sliding plate

    Prosthetic device

    NNormal --------------------------------- Fracture-------------------------- ORIF

  • 8/14/2019 Lecture 7 - Musculoskeletal

    81/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    82/120

    Fractures of the Pelvis

    Associated internal damage the chief concern infracture management of pelvic fractures

    Nonweight-bearing fracture of the pelvis

    Weight-bearing fracture of the pelvis

  • 8/14/2019 Lecture 7 - Musculoskeletal

    83/120

    Compression Fractures of the Spine

    Most are associated with osteoporosis rather than acute spinal injury.

    Multiple hairline fractures result when bone

    mass diminishes. Nonsurgical management includes bedrest,

    analgesics, and physical therapy.

    Minimally invasive surgeries are vertebroplastyand kyphoplasty, in which bone cement isinjected.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    84/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    85/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    86/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    87/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    88/120

    Prostheses Devices to help shape and

    shrink the residual limb andhelp client readapt

    Wrapping of elasticbandages

    Wrap residual limb in afigure eight pattern, nota circular one. Wrappingin a circular pattern willcut off the blood flowand cause harm.

    The goal of wrapping is

    to form a cone-shapedresidual limb. To do this,apply more pressure tothe bottom end of theresidual limb, and lesspressure to the topportion.

    Individual fitting of therosthesis s ecial care

  • 8/14/2019 Lecture 7 - Musculoskeletal

    89/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    90/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    91/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    92/120

    Knee Injuries, Ligaments

    When the anterior cruciate ligament is torn, asnap is felt, the knee gives way, swelling occurs,stiffness and pain follow.

    Treatment can be nonsurgical or surgical.

    Complete healing of knee ligaments after surgery can take 6 to 9 months.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    93/120

    Tendon Ruptures

    Rupture of the Achilles tendon is common inadults who participate in strenuous sports.

    For severe damage, surgical repair is followed

    by leg immobilized in a cast for 6 to 8 weeks. Tendon transplant may be needed.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    94/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    95/120

    Strains

    Excessive stretching of a muscle or tendonwhen it is weak or unstable

    Classified according to severity: first-, second-,

    and third-degree strain Management: cold and heat applications,

    exercise and activity limitations, anti-inflammatory drugs, muscle relaxants, and

    possible surgery

  • 8/14/2019 Lecture 7 - Musculoskeletal

    96/120

    Sprains

    Excessive stretching of a ligament Treatment of sprains:

    first-degree: rest, ice for 24 to 48 hr,compression bandage, and elevation

    second-degree: immobilization, partial weightbearing as tear heals

    third-degree: immobilization for 4 to 6 weeks,possible surgery

  • 8/14/2019 Lecture 7 - Musculoskeletal

    97/120

    Rotator Cuff Injuries

    Shoulder pain; cannot initiate or maintainabduction of the arm at the shoulder

    Drop arm test

    Conservative treatment: nonsteroidal anti-inflammatory drugs, physical therapy, slingsupport, ice or heat applications during healing

    Surgical repair for a complete tear

  • 8/14/2019 Lecture 7 - Musculoskeletal

    98/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    99/120

    Rheumatology

    Connective tissue disease (CTD) is a major focus of rheumatology.

    Rheumatic disease is any disease or condition

    involving the musculoskeletal system. Arthritis means inflammation of one or more

    joints.

    (Continued)

  • 8/14/2019 Lecture 7 - Musculoskeletal

    100/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    101/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    102/120

    Collaborative Management of OA

    History Physical assessment and clinical manifestations

    Joint involvement

    Heberden's nodes

    Bouchards nodes

    Joint effusions Atrophy of skeletal muscle

  • 8/14/2019 Lecture 7 - Musculoskeletal

    103/120

    Assessments of OA

    Psychosocial Laboratory assessment of erythrocyte

    sedimentation rate and C-reactive protein (maybe slightly elevated)

    Radiographic assessment

    Other diagnostic assessments

    MR imaging CT studies

  • 8/14/2019 Lecture 7 - Musculoskeletal

    104/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    105/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    106/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    107/120

    Connective Tissue

  • 8/14/2019 Lecture 7 - Musculoskeletal

    108/120

    or Rheumatic Diseases

    Rheumatoid Arthritis (RA) joint deformity

    Lupus Erythematosis (SLE) - skin, heart, kidneys

    Scleroderma - skin

    Sjogrens Syndrome - dry mouth, dry eye -> systemic

    Raynauds Disease- blood vessels

    Inflammation of synovial joints due to an immune response withdegeneration as a secondary process. Blood vessels, heart, skinand kidneys may also be affected.

  • 8/14/2019 Lecture 7 - Musculoskeletal

    109/120

    Lab Studies

    Creatinine ESR inflammation

    RBC - RA and SLE

    WBC SLE

    Antinuclear Antibody (ANA) all

    Rheumatoid Factor - > 80%

    h d h

  • 8/14/2019 Lecture 7 - Musculoskeletal

    110/120

    Rheumatoid Arthritis

    A most common connective tissue disease andthe most destructive to the joints

    Chronic, progressive, systemic inflammatoryautoimmune disease primarily affecting thesynovial joints

    Autoantibodies (rheumatoid factors) formed thatattack healthy tissue

    Affects synovial tissue of any organ or bodysystem

  • 8/14/2019 Lecture 7 - Musculoskeletal

    111/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    112/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    113/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    114/120

    RA M di ti

    Immunosuppressive

    Methotrexate gold

  • 8/14/2019 Lecture 7 - Musculoskeletal

    115/120

    RA Medications

    ASA NSAIDS

    Antimalarials - visualchanges

    Plaquenil Aralen

    Gold administer withNSAIDS. Stomatitis,

    diarrhea, proteinuria maybe a problem

    Sulfasalazine

    Penicillamine

    gstandard for RA, usedalso in SLE

    Imuran Cytoxan

    Cyclosporin

    Arava

    Enbrel

    Remicade

    Corticosteroids

    Prednisone

    Prednisolone

    Hydrocortisone

    Topical

    Capsaicin

  • 8/14/2019 Lecture 7 - Musculoskeletal

    116/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    117/120

  • 8/14/2019 Lecture 7 - Musculoskeletal

    118/120

    A t f L

  • 8/14/2019 Lecture 7 - Musculoskeletal

    119/120

    Assessments for Lupus

    Psychosocial results can be devastating. Laboratory

    Skin biopsy (only significant test to confirmdiagnosis)

    Anti-Ro (SSA) test

    Complete blood count

    Body system functions

  • 8/14/2019 Lecture 7 - Musculoskeletal

    120/120