lecture series 1 introduction to cellular and molecular ... · and molecular biology 205. reading...
TRANSCRIPT
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Lecture Series 1Introduction to Cellular
and Molecular Biology 205
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Reading AssignmentsReading Assignments
•• Read Chapter 1Read Chapter 1•• Review Chapter 2Review Chapter 2
(I am assuming you know this stuff!)(I am assuming you know this stuff!)
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A. Evolutionary MilestonesA. Evolutionary Milestones
•• A major theme in evolution is increasingly A major theme in evolution is increasingly diverse ways of capturing external energy diverse ways of capturing external energy for biologically useful reactions.for biologically useful reactions.
•• This means many different ways to make This means many different ways to make ATP! Especially considering relatively ATP! Especially considering relatively recent discovery of microbial diversity.recent discovery of microbial diversity.
•• Microbiology is the original cell biology.Microbiology is the original cell biology.
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An introduction to energy flow and energy transformation in an eAn introduction to energy flow and energy transformation in an ecosystemcosystem
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Chemosynthesis:Chemosynthesis:Hydrothermal VentsHydrothermal Vents
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A. Evolutionary MilestonesA. Evolutionary Milestones
•• All living organisms contain the large All living organisms contain the large moleculesmolecules——carbohydrates, lipids, carbohydrates, lipids, proteins, and nucleic acids.proteins, and nucleic acids.
•• Ordered Ordered ““bags of biochemistrybags of biochemistry”” insulated insulated from the chaos of the environment. from the chaos of the environment. NotNot a a closed system.closed system.
•• Storage, transfer and expression of Storage, transfer and expression of genetic information.genetic information.
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DNADNA
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Languages of the cellLanguages of the cell
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A. Evolutionary MilestonesA. Evolutionary Milestones
•• Life arose from Life arose from nonlifenonlife about 3.8 to 4.0 about 3.8 to 4.0 billion years ago.billion years ago.
•• This process occurred over only a couple This process occurred over only a couple hundred million years! Not 2 billion.hundred million years! Not 2 billion.
•• Now all cells come from cellsNow all cells come from cells……..why?..why?
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A. Evolutionary MilestonesA. Evolutionary Milestones
•• Photosynthetic singlePhotosynthetic single--celled organisms celled organisms released oxygen, allowing oxygenreleased oxygen, allowing oxygen--based based metabolism of large cells and eventually metabolism of large cells and eventually multicellularmulticellular organisms.organisms.
•• Oxygen began getting released very early Oxygen began getting released very early on, but only accumulated in atmosphere on, but only accumulated in atmosphere after after ““Rust the CrustRust the Crust”” and movement onto and movement onto land occurred only after an Ozone shield.land occurred only after an Ozone shield.
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StromatolitesStromatolites
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BIFsBIFs aka Banded Iron Formationsaka Banded Iron Formations
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A. Evolutionary MilestonesA. Evolutionary Milestones
•• Complex eukaryotic cells evolved from Complex eukaryotic cells evolved from bacterial cells. Eukaryotic cells developed bacterial cells. Eukaryotic cells developed into into multicellularmulticellular organisms whose cells organisms whose cells became modified for specific functions. became modified for specific functions.
•• The evolution of sexual reproduction The evolution of sexual reproduction enhanced the ability of organisms to adapt enhanced the ability of organisms to adapt to changing environments.to changing environments.
•• Adaptation to environmental change is the Adaptation to environmental change is the result of evolution by natural selection, the result of evolution by natural selection, the filter for innate variability.filter for innate variability.
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Structural organization of Eukaryotic and Prokaryotic cellsStructural organization of Eukaryotic and Prokaryotic cells
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•• The evolutionary view of life came into sharp The evolutionary view of life came into sharp focus in 1859 when Charles Darwin published focus in 1859 when Charles Darwin published On On the Origin of Species by Natural Selectionthe Origin of Species by Natural Selection
•• The Origin of SpeciesThe Origin of Speciesarticulated two main articulated two main pointspoints
Descent with Descent with modificationmodificationNatural selectionNatural selection
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Natural selectionNatural selection
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Descent with modificationDescent with modification
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B. The Hierarchy of LifeB. The Hierarchy of Life
•• Biology is organized into a hierarchy of Biology is organized into a hierarchy of levels. Each has levels. Each has ““emergent propertiesemergent properties””not found at lower levels.not found at lower levels.
•• Emergent properties are where the sum Emergent properties are where the sum is greater than the parts.is greater than the parts.
•• Basic unit of biology is the Basic unit of biology is the ““cellcell””, we go up , we go up or down from there.or down from there.
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•• The cell iThe cell is the lowest level of organization that s the lowest level of organization that can perform can perform allall activities required for lifeactivities required for life
25 µm
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•• Some emergent properties of lifeSome emergent properties of life
(c) Response to the environment
(a) Order
(d) Regulation
(g) Reproduction(f) Growth and development
(b) Evolutionary adaptation
(e) Energy processing
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B. The Hierarchy of LifeB. The Hierarchy of Life
•• Domains Domains vsvs KingdomsKingdoms……etc.etc.•• Species are classified into the Domains Species are classified into the Domains
ArchaeaArchaea, Bacteria, and , Bacteria, and EukaryaEukarya. . ArchaeaArchaeaand Bacteria consist of prokaryotic cells. and Bacteria consist of prokaryotic cells. EukaryaEukarya contain the contain the protistsprotists and the and the kingdoms kingdoms PlantaePlantae, Fungi, and , Fungi, and AnimaliaAnimalia..
•• Crown Groups all require Crown Groups all require endosymbiosisendosymbiosis!!
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Classifying lifeClassifying life
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The first The first endosymbioticendosymbiotic jumpjump
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The second The second endosymbioticendosymbiotic jumpjump
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Complexity results in Complexity results in bags within bagsbags within bags
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The Big TreeThe Big Treeof Lifeof Life
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The Big TreeThe Big Treeof Lifeof Life
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Complexity and Complexity and MulticellularityMulticellularity
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Protozoan DiversityProtozoan Diversity
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Examples of the three Domains of lifeExamples of the three Domains of life
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Unity underlying the diversity of life: the architecture of EukaUnity underlying the diversity of life: the architecture of Eukaryotic ciliaryotic cilia
9 + 29 + 2
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Complexity: Size isnComplexity: Size isn’’t everything!t everything!
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C. Fundamental Concepts Used C. Fundamental Concepts Used Throughout BiologyThroughout Biology
•• Evolution unites all of biology. ItEvolution unites all of biology. It’’s s mechanism is Natural Selection.mechanism is Natural Selection.
•• Emergent PropertiesEmergent Properties•• Hierarchical OrganizationHierarchical Organization•• MulticellularityMulticellularity accomplished by accomplished by ““terra terra
formingforming””•• Hypothesis Testing/Deductive ReasoningHypothesis Testing/Deductive Reasoning
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Idealized version of the scientific methodIdealized version of the scientific method
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Life on Life on EuropaEuropa??
AstrobiologyAstrobiology
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