lesson 1 introduction to human anat and cell structure
TRANSCRIPT
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Introduction to Human Anatomy and Cell biology
Dr. Obimbo MMMBChB, MSc. Dip Felasa C, PhD (c)
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Anatomical Etymology
• Anatomy- Science of the structure of body
• Greek ‘anatome’- ana – up, tome – cutting
• Latin ‘dissecare’ – dis – asunder, secare – cut (dissection)
• Anatome = dissecare
• Study of Anatomy introduces students to greater terminology
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Anatomy is to Physiology, as Geography is to History
Emphasis should be placed on the Anatomy of living body ◦ Surface Anatomy
◦ Radiological Anatomy
Major divisions of Anatomy◦ Gross
◦ Microscopic
◦ Embryology
◦ Neuroanatomy
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• Anatomy may be studied systematically or regionally (topographical)
• Body systems
– Name??
• Body topography
– ??
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Rules Guiding etymology• 1. Each structure shall be designated by one term
• 2. Every term in official list shall be in Latin
• 3. The term shall primarily be for memory signs
• 4. No usage of eponyms
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Anatomical Position and Direction
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• The body standing erect, facing forward, feet together, toes pointed slightly apart, hands at one’s side, palms facing forward.
• Once the body is in this position (or imagined to be in this position,) the positional terms can be used correctly.
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Terms• Medial/ lateral – nearer/away median plane
• Anterior/posterior – near front/near the back
• Superior/inferior – nearer the head/toe
– (cf, cranial/caudal/rostral)
• Proximal/ distal – limbs
• Internal and external – nearer/away from center of an organ (cf, middle)
• Superficial/deep
• Supine/prone
• Ipsilateral/contralateral
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Terms of body movement
FLEXION: reduces the angle of the joint from the anatomical position. Flex elbow
EXTENSION: movement that returns you to anatomical position. Extend elbow.
◦ All these terms refer to either a body part or a joint. HYPEREXTENSION: extension beyond anatomical
position; wrist, neck. Some terms relate only to certain areas, such as the
ankle: DORSIFLEXION: lift up toes PLANTARFLEXION: move toes down INVERSION: when sole of foot points inward EVERSION: sole of foot points outward. ABDUCTION: move body part away from midline;
arm, fingers, thumb ADDUCTION: bring back to midline; arms, fingers,
thumb
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ROTATION: pivot on an axis; shake head “no”; can rotate head and shoulder
CIRCUMDUCTION: to draw a circle with body part; shoulder, head
PRONATION (to lie prone is on stomach). Turn hands downward.
SUPINATION: refers to arms; want a bowl of soup, supinate
PROTRACTION: to move anteriorily; shoulders, mandible
RETRACTION: to move part posteriorly; shoulders
ELEVATION: to raise part superiorly; shoulders
DEPRESSION: to lower part; open mouth.
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Main areas to be studied• Osteology and arthrology
• Myology
• Angiology
• Neurology
• Splanchnology
• Surface marking/ anatomy
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Cell Structure and Function
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Chapter Outline
• Cell theory
• Properties common to all cells
• Cell size and shape – why are cells so small?
• Eukaryotic cells
– Organelles and structure in all eukaryotic cell
• Cell junctions
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History of Cell Theory
• mid 1600s – Anton van Leeuwenhoek– Improved microscope, observed many living cells
• mid 1600s – Robert Hooke – Observed many cells including cork cells
• 1850 – Rudolf Virchow– Proposed that all cells come from existing cells
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Cell Theory
1. All organisms consist of 1 or more cells.
2. Cell is the smallest unit of life.
3. All cells come from pre-existing cells.
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Observing Cells
• Light microscope– Can observe living cells in true color
– Magnification of up to ~1000x
– Resolution ~ 0.2 microns – 0.5 microns
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Observing Cells
• Electron Microscopes– Preparation needed to kill the cells
– Images are black and white – may be colorized
– Magnifcation up to ~100,000
• Transmission electron microscope (TEM)
– 2-D image
• Scanning electron microscope (SEM)
– 3-D image
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SEM
TEM
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Cell Structure
• All Cells have:
–an outermost plasma membrane
–genetic material in the form of DNA
–cytoplasm
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Cell Structure
• All Cells have:
–an outermost plasma membrane
• Structure – phospholipid bilayer with embedded proteins
• Function – isolates cell contents, controls what gets in and out of the cell, receives signals
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Cell Structure
• All Cells have:
–genetic material in the form of DNA
• Eukaryotes – DNA is within a membrane (nucleus)
• Prokaryotes – no membrane around the DNA (DNA region called nucleoid)
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Cell Structure
• All Cells have:
–cytoplasm with organelles
• Cytoplasm – fluid area inside outer plasma membrane and outside DNA region
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Eukaryotic Cells
• Structures in all eukaryotic cells– Nucleus
– Ribosomes
– Endomembrane System • Endoplasmic reticulum – smooth and rough
• Golgi apparatus
• Vesicles
– Mitochondria
– Cytoskeleton
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CYTOSKELETON
MITOCHONDRION
CENTRIOLES
LYSOSOME
GOLGI BODY
SMOOTH ER
ROUGH ER
RIBOSOMES
NUCLEUS
PLASMA
MEMBRANE
Fig. 4-15b, p.59
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Nucleus
• Function – isolates the cell’s genetic material, DNA
– DNA directs/controls the activities of the cell
• DNA determines which types of RNA are made
• The RNA leaves the nucleus and directs the synthesis of proteins in the cytoplasm
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Nucleus
• Structure
–Nuclear envelope
• Two Phospholipid bilayers with protein lined pores
–Each pore is a ring of 8 proteins with an opening in the center of the ring
–Nucleoplasm – fluid of the nucleus
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Nuclear pore bilayer facing cytoplasm Nuclear envelope
bilayer facing nucleoplasm
Fig. 4-17, p.61
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Nucleus
• DNA is arranged in chromosomes
–Chromosome – fiber of DNA and the proteins attached to the DNA
–Chromatin – all of the cell’s DNA and the associated proteins
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Nucleus
• Structure, continued
–Nucleolus
• Area of condensed DNA
• Where ribosomal subunits are made
– Subunits exit the nucleus via nuclear pores
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Endomembrane System
• Series of organelles responsible for:
–Modifying protein chains into their final form
– Synthesizing of lipids
–Packaging of fully modified proteins and lipids into vesicles for export or use in the cell
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Endomembrane System
• Endoplasmic Reticulum (ER)
–Continuous with the outer membrane of the nuclear envelope
– Two forms - smooth and rough
• Transport vesicles
• Golgi apparatus
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Endoplasmic Reticulum
• Rough Endoplasmic Reticulum (RER)
• Network of flattened membrane sacs create a “maze”
• Ribosomes attached to the outside of the RER make it appear rough
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Endoplasmic Reticulum
• Function RER
• Where proteins are modified and packaged in transport vesicles for transport to the Golgi body
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Endomembrane System
• Smooth ER (SER)
– Tubular membrane structure
– Continuous with RER
– No ribosomes attached
• Function SER
– Synthesis of lipids (fatty acids, phospholipids, sterols..)
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Endomembrane System
• Additional functions of the SER
– In muscle cells, the SER stores calcium ions and releases them during muscle contractions
– In liver cells, the SER detoxifies medications and alcohol
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Golgi Apparatus
• Golgi Apparatus
– Stack of flattened membrane sacs
• Function Golgi apparatus
– Completes the processing substances received from the ER
– Sorts, tags and packages fully processed proteins and lipids in vesicles
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Golgi Apparatus
– The proteins and lipids are modified as they pass through layers of the Golgi
– Molecular tags are added to the fully modified substances
• These tags allow the substances to be sorted and packaged appropriately.
• Tags also indicate where the substance is to be shipped.
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Transport Vesicles
• Transport Vesicles
– Vesicle = small membrane bound sac
– Transport modified proteins and lipids from the ER to the Golgi apparatus (and from Golgi to final destination)
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Endomembrane System
• Putting it all together
–DNA directs RNA synthesis RNA exits nucleus through a nuclear pore ribosome protein is made proteins with proper code enter RER proteins are modified in RER and lipids are made in SER vesicles containing the proteins and lipids bud off from the ER
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Endomembrane System
• Putting it all together
ER vesicles merge with Golgi body proteins and lipids enter Golgi each is fully modified as it passes through layers of Golgi modified products are tagged, sorted and bud off in Golgi vesicles …
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Endomembrane System
• Putting it all together
Golgi vesicles either merge with the plasma membrane and release their contents OR remain in the cell and serve a purpose
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Vesicles
• Vesicles - small membrane bound sacs
– Examples
• Golgi and ER transport vesicles
• Peroxisome
– Where fatty acids are metabolized
– Where hydrogen peroxide is detoxified
• Lysosome
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Lysosomes
• The lysosome is an example of an organelle made at the Golgi apparatus.
– Golgi packages digestive enzymes in a vesicle. The vesicle remains in the cell and:
• Digests unwanted or damaged cell parts
• Merges with food vacuoles and digest the contents
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Mitochondria (4.15)
• Function – synthesis of ATP
– 3 major pathways involved in ATP production
1. Glycolysis
2. Krebs Cycle
3. Electron transport system (ETS)
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Mitochondria
• Structure:
– ~1-5 microns
– Outer membrane
– Inner membrane - Highly folded
• Folds called cristae
– Intermembrane space (or outer compartment)
– Matrix
• DNA and ribosomes in matrix
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Mitochondria
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Cytoskeleton (4.16, 4.17)
• Function
– gives cells internal organization, shape, ability to move and polarity
• Structure
– Interconnected system of microtubules, microfilaments, and intermediate filaments
• All are proteins
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Cytoskeleton
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Cell Junctions
• Plasma membrane proteins connect neighboring cells - called cell junctions
– Plant cells – plasmodesmata provide channels between cells
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Cell Junctions (4.18)
• 3 types of cell junctions in animal cells
1. Tight junctions
2. Anchoring junctions
3. Gap junctions
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Cell Junctions
1. Tight junctions – membrane proteins seal neighboring cells so that water soluble substances cannot cross between them
• Seen between stomach cells
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Cell Junctions
2. Anchoring junctions – cytoskeleton fibers join cells in tissues that need to stretch
• See between heart, skin, and muscle cells
3. Gap junctions – membrane proteins on neighboring cells link to form channels
• This links the cytoplasm of adjoining cells
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Gap junction
Anchoring
junction
Tight junction
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Cell specializationSpecialized cell Function Modification
Muscle cell Contraction Myofilaments
Pancreatic acinar cell Synthesis and secretion of
enzymes
RER
Kidney tubular cells Ion transport Basal membrane infoldings
Macrophages Intracellular digestion Lysosomes
Sensory cells Transformation of stimuli
into nerve impulses
Membrane receptors
Leydig Testicular cells Synthesis and secretion of
testosterone
SER
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Tissues
• Tissues are collection of cells that subserve specific function
• Four fundamental types:
– Epithelial
– Supporting
– Propulsion
– Nervous
– Composed of cells, intercellular matrix and tissue fluid
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Scope of microscopic Anatomy
• Cytology
• Histology
• Organology
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The end....
• “ No man should marry until he has studied anatomy and dissected at least one woman”
Honore de Balzac
Thank you!!