life science, what? products which serve human health care product’s source is asian herbal...
TRANSCRIPT
Life Science, what?Products which serve human health careProduct’s source is Asian herbal traditional
medicineHerbs extractThe extract is marketed to end-stage
companies in the pharmaceutical, cosmetic or food supplement market
unique technology
Products95% pure extract from the leaves of the
Ginkgo biloba tree; GinkgoTerp®R&D:
Immune stimulatorsAnti-oxidizing agentsAnticancer steroïds
GinkgoTerp®Because of the different constituents, this extract
can affect various systems in the human bodyIn general, GinkgoTerp® is a perfect prophylaxis
for the body under strain or where the body is decreasingly able to recover from it, such asSportsStressAgeing
Atherosclerosis Memory impairment Alzheimer’s disease Parkinson’s disease
Bioactivity: flavonoïds and terpenelactonesFlavonoïds are free-radical scavengers. Since
flavonoïds are also available in dietary products, the additional effect of the amount in the normal extract is considered to be not significant.
Terpene trilactones are known to block three receptors (GABA -, Glycine – and Platelet Activating Factor receptors) and act on mitochondria throughout the whole body. Effects of GBE are largely attributed to these compounds
Mode of actionAlzheimer’s diseaseParkinson’s diseaseMood/anxietyCancer progression
Cognitive functionNeuronal damage
CardiovascularAtherosclerosisErectile dysfunction
GABA
GLY
PAFGk A+B
GkB
Bil
BilGkA
mito
chon
dr
ia
Disappointing results of Ginkgo studiesGinkgo shows a clear positive effect on vascular
disorders with 240mg a dayIntermittent claudationVascular dementia
No positive results from clinical studies regarding Alzheimer’s diseaseAn inadequate dosage regimen could be the cause
Estimation of the correct dosage regimen is a must!
Dosage regimen(1)Tablets/capsules have to be taken 0.5h
before the meal to obtain a desired blood-level
Tablets/ capsules have to be taken at two or three different time points per day
Tablets/capsules have to be non-enteric coated
Dosage regimen(2)Based on the pharmacology of the active constituents, following doses are advised:
vascular disorders: 120/7.5 mg, twice a day*memory impairment: 240/15 mg, twice a day*neurodegenerative diseases: 360/22.5 mg, thrice a
day*
* EGb761/GinkgoTerp®
GinkgoTerp® vs. EGb76195%
terpenelactonesNO flavonoids5% undefined7.5 mg extract to
achieve effect
6% terpenelactones
24% flavonoids70% undefined120 mg extract to
achieve effect16 times less
Why are we the best?Competitors produce a 30% pure product,
GinkgoTerp® is a 95% pure product of the active compounds
Based on terpenelactones-content, we produce 16 times purer extract than competitors
bilobalide
ginkgolides
flavonoidglycosides
variable and/or to bedetermined
SGBE-T
49%45%
5%1%bilobalide
ginkgolides
flavonoidglycosides
variable and/or to bedetermined
GinkgoTerp®
EGB 761
24%
70%
3%3%
Competitors
Co-formulationsSince GinkoTerp® is added in much less mg’s as
competitive extracts, co-formulation is an excellent option
For instance with:Sports: Magnesium, Potassium, ZincStress/Concentration: Vitamin B1 and 3Ageing: Vitamins (B1,3,9, C, E)
Principle of productionExcellent quality of raw material
continuity, method of harvesting and drying
A unique production process for extract with high purity level
What’s in it for you?A 16x purer extract/new formula means:You get your money’s worth
95% instead of 6% terpenelactones-content
Competitive price setting which creates a win-win situation
Less side effectsless undefined compounds, 5% vs. 70% undefined
Smaller dose needed in formulation 16 times less mg’s needed e.g. 7.5mg GinkgoTerp® vs. 120mg EGb761
Increasing convenience for consumersmaller tablets/capsules; easier to swallow
Excellent to use in co-formulations16 times less mg’s needed
No colorizationsnow-white appearance