The North Of England

Life Sciences Overview

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Executive Overview

Low workforce costs - between 15 and 20% lower than greater London area

Highly strategic location - central UK with fast, easy access to mainland Europe links

Superb transport infrastructure, including international airports with many direct links to North America, Europe and the rest of the UK

A high quality of life and the highest level of professional support for inward investing businesses.

Business Environment - the North England Proposition

The North of England (NoE) has the scale, skills, diversity, strength of economy and transport links to provide the perfect base needed to reach key markets throughout Europe

Profile of North England:

15 highly ranked Universities in addition to colleges of higher education dedicated to specific skills in Life Sciences

42% of new European biopharmaceuticals are developed in the UK and more than 30% of those are developed in North England

Home to world-class Bio-Medical companies including:

Astra-Zeneca/MedImmune (largest R&D Center in the world)

Novartis/Chiron

Eli Lilly

GSK

BMS

Merck

Thermo Fisher

Millipore

Sanofi-Aventis

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A Skilled labor force leads the UK

Business Environment – Life Sciences

North England is home to over 600 Life Sciences companies which operate in a collaborative environment integrating industry, academia and government

With 1.7 million science and technology workers you will find the expertise you need

• NOE has a workforce of over 4.3 million, which is larger than Scotland, N. Ireland and Denmark combined

• Our pool of 1.7 million science and technology workers is available to support advanced technologies

Recruit from a large pool of highly qualified students and professionals

• NOE has over 100,000 students enrolled in graduate and undergraduate life science programs and more than 25,00 graduate each year

• NOE has almost 6,000 postgraduates in medicine allied subjects

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A robust infrastructure driven by research One example - Wellcome Trust Clinical Research Facility

• Pharmaceutical companies in North England benefit from vigorous Government commitment, a receptive regulatory environment and a comprehensive network of support services offering a broad range of outsourcing opportunities.

• Wellcome Trust Clinical Research Facility (http://www.mhs.manchester.ac.uk/wtcrf/) in Manchester allows pre-clinical and clinical trials of tissue engineered products and tissue regeneration reagents

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UK Center for Tissue EngineeringUK Centre for Tissue Regeneration (UKCTR) – www.ukcte.org/index.htm

• UKCTR has developed from a research collaboration in Tissue Engineering in the University of Manchester and the University of Liverpool.

• Research of the UKCTR aims to develop and manufacture a variety of tissues for potential therapeutic use including: Cartilage, Intervertebral Disc, Material Engineering

• Underpinning these themes is research into cell phenotypes, genetic engineering, biodegradable materials, 3D scaffolds, host integration, immune response and generic research.

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National Biomanufacturing CenterNational Biomanufacturing Centre (NBC) http://www.biomanufacturing.co.uk/

• The NBC is a government funded initiative (£34 million), developed as part of the Bionow portfolio, owned by NWDA and run by a commercial operator, Eden Biodesign

• The NBC delivers much needed design expertise and manufacturing capability to early stage biotechnology companies and product development programs

• Provides the full range of services necessary to take a novel biopharmaceutical from proof of concept through to cGMP manufacture for clinical trials

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Manchester Cancer Research Centre - Creating a world leader in the fight against cancer

MCRC

Faculty of Life Sciences

(Cancer Studies)

Faculty of Life Sciences

(Cancer Studies)

Paterson Institutefor CancerResearch

Paterson Institutefor CancerResearch

Faculty of Medical & Human Sciences(School of Cancer

& Imaging)

Faculty of Medical & Human Sciences(School of Cancer

& Imaging)

Christie Hospital NHSFoundation Trust

(Research & Development)

Christie Hospital NHSFoundation Trust

(Research & Development)

Engineering

Chemistry

Pharmacy

ComputerSciences

Other NHSTrusts

Cancer Research – Christie Hospital NHS Trust and MCRC

The Christie Hospital NHS Trust is the largest and most complex cancer referral network in the UK.

Together with the Manchester Cancer Research Center (MCRC), the Paterson Institute and the Wolfson Medical Imaging Centre, it represents the largest comprehensive cancer center in Europe.

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Cancer Imaging Research: Manchester Strengths

Wolfson Medical Imaging Institute

Imaging Biomarkers PET (WMIC)MRI (ISBE/ WMIC)CT (Christie)

CRUK DrugsSmall Mol Drug DevBiologicals/ AbCell therapy

Pharma

Tissue/ SerologicalBiomarkers Clin. Exp. Pharmacol.Tissue BankProteomics

Phase I/IIDerek Crowther UnitExp. Cancer Medicine Centre

ImagingBiomarkerDevelopmentPreclinicalClinical

Image AnalysisImaging PhysicsInformatics

Target IdentificationPaterson Inst. Cancer ResearchPreclinical ImagingFluorescence Imaging3D imaging and reconstruction

Christie Hospital14,000 pts/year

Manchester Cancer Research Centre

Imaging Biomarkers PET (WMIC)MRI (ISBE/ WMIC)CT (Christie)

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Bionow – Northwest England’s Biocluster Development Organizationwww.bionow.co.uk/

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Bionow – Technology Transfer and Commercialization

MerseyBIO Incubator exists to promote and support the transition of quality bioscience research into new business enterprises in Merseyside in conjunction with the University of Liverpool.

The University of Liverpool Business Gateway, helps commercial and public sector organizations access the cutting edge knowledge and expertise available from the University.

The University of Manchester Incubator Company Limited (UMIC) is The University's Incubator Facilities include Europe's first dedicated campus based Manchester Bioscience Incubator, The Core Technology Facility and the North Campus IT Incubator.

The University of Manchester Intellectual Property Limited (UMIP) is the university's technology transfer and intellectual property commercialization company. It has been formed by the merger of two very successful companies, UMIST Ventures and Manchester Innovation.

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CELS – Centres of Excellence in Life Sciences

CELS, the Biocluster Organization for the North East of England (http://www.celsatlife.com/)

• CELS acts as a catalyst to develop distinct strengths in research, science and technology within a selected number of specific Life Sciences fields to create an engine for growth for the regional healthcare economy.

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N8 Centre for Translational Regenerative Medicine (regeNer8)

• N8 is an innovative partnership between the North's eight most research-intensive universities, (Durham, Lancaster, Leeds, Liverpool, Manchester, Newcastle, Sheffield, and York) that accelerates the development of regenerative therapies and bring them through to clinic and market.

• The North of England is uniquely positioned in Europe as a centre of basic research excellence in regenerative medicine. A collaborative regional approach has the potential to add considerable value to this emergent sector.

• The N8 Centre for Translational Regenerative Medicine Within the N8 universities there are over 150 post-doctoral scientists with research expertise extending across stem cell biology, materials science, bio-processing and tissue engineering.

• In addition to basic research excellence, the N8 has a track record in forming commercial partnerships and taking ideas through from concept into clinic.

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North East England Stem Cell Institute (NESCI)

• NESCI draws together the North-East's Universities and NHS Trusts, the Centre for Life and the Regional Development Agency (ONE NorthEast) in a unique interdisciplinary collaboration to convert stem cell research and technologies into cost effective, ethically robust 21st century health solutions to ameliorate degenerative diseases, the effects of ageing and serious injury.

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NorthEast England Stem Cell Institute (NESCI)

• NESCI researchers draw from a number of disciplines to develop and commercialize leading stem cell therapies and diagnostics

• NESCI conducts leading edge research with Somatic, Embryonic and Cord Blood Stem Cell

• A close association with Clinical Research Hospitals and surgical centers of excellence accelerates the development of cellular therapies and diagnostics

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Newcastle Biomanufacturing Facility

The Newcastle Bio-Manufacturing Facility was designed and built to enable the production of stem cells and derived cellular products to a clinical standard

• The facility provides high specification room space, equipment infrastructure and air-handling capabilities that when combined with the process management requirements of EU cGMP, will ensure biologics are produced for safe use in human applications

• The facility was designed as a two suite model to enable the separation of work involving somatic and embryonic stem cells. Commercial clients will have exclusive access to up to seven separate Grade B (Class 100, ISO grade 5) and two Grade C (Class 10,000, ISO grade 7) rooms together with additional space for QA/QC and storage. Expert Quality Assurance and Control staff are available at the facility

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Notable Companies in Regenerative Medicine, Tissue Engineering and Cellular Biology

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North England OverviewThe North of England Consulting Services

The NoE IIA is available to help plan and execute your business expansion and relocation strategy, objectively, confidentially and free of charge

Our team can work closely with you and provide the information you require, including:

Market feasibility studies

How to set up a legal entity in the UK

UK and region specific economic and market information

Site Selection

Local supply chain development

Personnel recruitment and training

Availability of Government Financial Assistance

Introductions to private avenues of funding

Introductions to public and private sector networks of professionals

Logistics and communications information

Legal/customs and taxation information

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ContactScott Kozak

North England Investment AgencyVice President of Life Sciences

8 Faneuil Hall Market Place3rd Floor

Boston, MA 02109

Tel: (617) 973-5023 Fax: (617) 973-6406

Email: scott.kozak@northengland.com

Website: www.northengland.com