Company Confidential

Copyright © 2013 Eli Lilly and Company

Patient-at-the-Centerof Clinical Trials Workshop

Lilly’s Patient Centric Engagement Overview

14 November 2013

Tom Krohn

What if patients…

• were viewed as collaborators in drug development, not sources of data?

• considered of clinical studies as part of their healthcare treatment options?

• could bring their own data and in real-time determine if they were a match for study eligibility?

• could explore what it was like to be in a study, BEFORE they visited the site?

• received study information in a form that was easy to understand – in THEIR context?

• were viewed as the real heroes of clinical research?

Today’s environment

Patients• Have choice• Are becoming empowered• Are knowledgeable about their disease• Have unmet needs• Often view clinical trials as last resort• Are willing to engage in research, but often do know how

Sponsors (Lilly)• Is committed to innovation• Is targeting unmet needs and therapeutic areas with innovation• Thinks, processes and communicates through a scientific perspective• Primarily reaches patients through investigator sites

Lilly’s Patient-Centric Engagement Strategy

• Voice of patient in development• Patient-centric communication• Enabling marketplace for trial matching• Targeted/Tailored Therapeutics• Patient simulation of study for deep understanding• Patient Experience – before, during and after study

1

Patient-CentricDesign

PatientVoice

2

Patient-Centric Communication & Design Input

Study Representation

Informed ConsentDocumentCt.Gov

Study Design

Open

Platform

Patients

Finding a trial for me

OPENAPI

?

Enabling marketplace for trial matching

Open

Platform

Patients

api.lillycoi.com

Daily Updates

Open Web

RESTAPI

Patient Study“Target Profiles”

Study Sponsors

Patient & Communities

Personal ElectronicMedical Records

MatchProcess

Consentto

Match

April 2014 POC

Targeted/Tailored Therapeutics

Personalized

Medicinegenome

phenotypebiomarkers

quantified self

Lilly’s Patient-Centric Engagement Strategy

• Voice of patient in development• Patient-centric communication• Enabling marketplace for trial matching• Targeted/Tailored Therapeutics• Patient simulation of study for deep understanding• Patient Experience – before, during and after study

Patient Experience

Informed Consent Study mobile app

Streamlined visits Continuity of care

Lilly’s Patient-Centric Engagement Strategy

• Voice of patient in development• Patient-centric communication• Enabling marketplace for trial matching• Targeted/Tailored Therapeutics• Patient simulation of study for deep understanding• Patient Experience – before, during and after study

Breakout Group Themes

• Understanding clinical trials (pre-trial)• Joining a clinical trial (consent)• Support while in a CT• CT Integration into patient lifestyle

• Other?