lipid metabolism
TRANSCRIPT
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LIPID METABOLISMLIPID METABOLISM
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LIPID METABOLISM
Free fatty acids
Monoglycerides
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Fatty Acid Metabolism
Fatty Acids
LIPIDS
Acetyl - CoAAcetyl - CoA
TCAC
Lipoproteins
CholesterolCholesterol
Bile saltsBile salts
Ketone bodiesKetone bodies
Steroid hormonesSteroid hormones
NADH
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LIPID METABOLISM
Synthesis of fatty acids
Ketogenic amino acids
Excess dietary carbohydrates
Exported as VLDL
Converts fatty acids to ketone bodies during fasting.
Synthesis of cholesterol derivatives.
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METABOLISM
STAGE 3
Production of ATP
STAGE 2
Conversion of subunits to Acetyl CoA
STAGE 1
Hydrolysis of macromolecules
to subunits
FOOD
GLYCOLYSIS
PYRUVATE
ACETYL CoA
CITRIC ACID
CYCLE
CARBOHYDRATES
MONOSACCHARIDES
PROTEINS
AMINO ACIDS
FATS
FATTY ACIDS + GLYCEROL
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FATTY ACID DEGRADATION
– Oxidation
Breakdown of fatty acids to acetyl CoA
REACTIONS
Activation
Oxidation
Hydration
Oxidation
Cleavage
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OHCH3 C
O
CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2
CoACH3 C
O
CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2
CoACH3 C
O
CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH CH2
OH
CoACH3 C
O
CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH CH2
O
CH2CoAC
O
CH3 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH
O
CoA
CoACH3 C
O
CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2 CH2
NADH
FADH
2
2 ATP
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SUMMARY OF ENERGY YIELD
PROCESSATP
USEDENERGY
YIELDATP
EQUIVALENT
ACTIVATION2
OXIDATION FADH2 2 ATPs
OXIDATION NADH 3 ATPs
CITRIC ACID CYCLE
Acetyl CoA 12 ATPs
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SUMMARY OF ENERGY YIELD
PROCESSATP
USEDENERGY
YIELDATP
EQUIVALENT
ACTIVATION2
OXIDATION 5 FADH2 10 ATPs
OXIDATION 5 NADH 15 ATPs
CITRIC ACID CYCLE
6 Acetyl CoA 72 ATPs
TOTAL 95 ATPs
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EXERCISE
Compute for the energy yield of the complete oxidation of
palmitic acid (16 carbon)
stearic acid (18 carbon)
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PALMITIC ACID
PROCESSATP
USEDENERGY
YIELDATP
EQUIVALENT
ACTIVATION2
OXIDATION 7 FADH2 14 ATPs
OXIDATION 7 NADH 21 ATPs
CITRIC ACID CYCLE
8 Acetyl CoA 96 ATPs
TOTAL 129 ATPs
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STEARIC ACID
PROCESSATP
USEDENERGY
YIELDATP
EQUIVALENT
ACTIVATION2
OXIDATION 8 FADH2 16 ATPs
OXIDATION 8 NADH 24 ATPs
CITRIC ACID CYCLE
9 Acetyl CoA 108 ATPs
TOTAL 146 ATPs
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KETOGENESIS
Production of ketone bodies from acetyl CoA
–hydroxybutyrate
acetone
acetoacetate
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METABOLISM
Energy
Metabolism
Amino acids
Carbohydrates Lipids
CELLULAR FUNCTION