lipids function and structure
DESCRIPTION
Lipid Function and StructureTRANSCRIPT
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Lipid 1
Lipids Function and Structure
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I. THE MOLECULAR STRUCTURE OF LIPIDS
Unlike the proteins, nucleic acids, and polysaccharides, lipids are not polymers
They are quite small molecules. The predominance of hydrocarbon chains (-
CH2-CH2-CH2--) in their structure, lipids have a hydrophobic, which explain why they are insoluble or only poorly soluble in water
They are readily solible in non polar solvent solvent such as ether, chloroform, and benzene
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Lipid 3
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Lipid 4
123
cis
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Lipid 5
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Lipid 6
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Lipid 7
DEFINISI
composed of carbon, hydrogen, and oxygen but have many more hydrogens than oxygens. Different types of lipids include the neutral lipids ( fats and oils ), the phospholipids, steroids, and waxes.
Kelompok heterogen senyawa yang memiliki sifat tidak larut dalam air; larut dalam senyawa non polar (eter, kloroform, benzene)
lemak, minyak, wax, dll
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Lipid 8
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Lipid 9
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Lipid 10
Berdasarkan muatan
Neutral LipidTGKolesterol/ester
Polar lipid
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Lipid 11
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Lipid 12
A. CLASSIFICATION There are many different methods of classifying
lipids. In this chapter used classification of lipids and
the biologic functions FATTY ACIDS TRIACYLGLYCEROL (triglyceride) KETONE BODIES PHOSPHOGLYCERIDES (Phospholipid) SPHINGOLIPIDS EIOCOSANOID (Prostaglandins,Thromboxanes,
Leucotrienes) CHOLESTEROL STEROID HORMONES
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Lipid 13
FATTY ACIDS
A. Nature and Nomenclature Fatty acids are water-insoluble long-chain hydrocarbon with one carboxyl group at the end/beginning of the chain, which may be saturated or unsaturated (Table 10.1 list some biologically important fatty acids)
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Lipid 14
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1. Saturated fatty acids (SFA) do not have double bonds in the chain Nomenclature.
The systematic name gives the number of carbons, with the suffix –anoic (IND=ANOAT).Palmitic acid, for example, has 16 carbons and has the systematic name hexadecanoic acid
Structure
The general formula of saturated fatty acids is CH3-(CH2)n-COOH Where n specifies the number of methylene groups between the methyl and carboxyl carbons
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2. Unsaturated Fatty acids have one or more double bonds
Nomenclature. The most commonly used system for designating the position of double bonds in an unsaturated fatty acid is the delta (Δ) numbering system.(1). The terminal carboxyl carbon is designated carbon number 1, and the double bond is given the number of the carbon atom on the carboxyl side of the double bond.For example:Palmitoleic acid has 16 carbons and has a double bond between carbons 9 and 10. It is designated as 16:1 Δ 9 or 16 : 1 :9
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(2) The systematic name gives the number of carbon atoms,the number of double bonds, and bears thesuffic –enoic
Palmitoleic acid is cis- Δ9-hexadecenoic acid; linoleic acid, which has 18 carbons and two double bonds, is (i.e, all double bond are cis) cis- Δ9- Δ12
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Lipid 18
Structure.
Double bonds in naturally occurring Fatty acids are always in a cis
CH2 C C CH2
H H
cis
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Lipid 19
B. SOURCES Non essential Fatty acids Essential fatty acids
The melting point of fatty acids is related to chain length and degree of unsaturation. The longer the chain length, the higher the melting point, and the greater the number of double bonds the lower the
melting point
C. PHYSICAL PROPERTIES
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Lipid 20
TRIACYLGLYCEROLS : FATS Structure
Triglycerides or triacylglycerols are triesters of glycerol and three fatty acids.The general formula is shown here
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Lipid 21
FunctionThe long hydrocarbon chains of fatty acids are extraordinarily efficient for energy storage. In fact, storage of fatty acids in organism is largely in the form of triacylglycerols, or fats.
Fatty acids are converted to triglycerides for transport between tissues and for storage of metabolic fuel.
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Lipid 22
a. The main stores are the fat deposit in fats cells (adipocytes)
b. Triglycerides have several advantages (1) Triglycerides are light (less than water). They
complete combustion to CO2 and water release 9 kcal/g as opposed to 4 kcal/g for carbohydrate.
(2)Triglycerides present no osmotic problems to the cell even when stored in large amounts, because they are water insoluble.
c.Utilization of fatty acids. The fatty acids are used by most tissues, with the exeption of the brain .
Utilization of glycerol. The glycerol, which cannot be used by adipose tissue cells, is picked up by the liver as a substrate for gluconeogenesis.
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Lipid 23
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Lipid 24
KETONE BODIES
Keton bodies are small, water soluble, potential units of acetate: acetone, acetoacetate and β-Hydroxybutirate, all of which are formed from fatty acids (and amino acid catabolism):
1. Synthesis of ketone bodies are limited, for example, in fasting and in
starvation
2. During starvation, keton bodies are the source of fuel
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Lipid 25
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Lipid 26
PHOSPHOLIPIDS
A. FUNCTION Phospholipids are the major lipid constituent of cellular membranes and occur in high concentration in the lipids of glandular organs, blood plasma, egg yolk.40 % of the lipids in the erythrocyte membraneover 95 % of the lipids in the inner mitochondrial membrane, only about 20% the inner mitochondrial membrane are cardiolipin, a phosphoglyceride
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B. STRUCTURE OF PHOSPHOGLYCERIDE
Phosphoglycerides are triesters of glycerol 3-phosphate
O CH2 – O – C – R1
OR2 – C – O – CH
O CH2 – O – C – R3
O
CH2 – O – C – R1
O
R2 – C – CH O
CH2 – O – P – OH
OH
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Lipid 28
O
CH2 – O – C – R1
O
CH – O – C – R2 O
R3 – O – P – O – CH2
OH
Glycerophospholipid Structure
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Lipid 29
C CLASSIFICATION OF PHOSPHOGLYCERIDE
1. Phosphatidylcholine (lecithin)
2. Phosphatidylethanolamine (a cephalin)
3. Phosphatidylserine
4. Phosphatidylinositol5. Cardiolipin
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Lipid 30
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Lipid 31
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Lipid 32
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Lipid 33
D. PROPERTIES OF PHOSPHOGLYCERIDES
1. Amphipatic
Phosphoglycerides possessing both hydrophilic and hydrophobic groups
2. Amphoteric
Phosphoglycerides bering both negatively charged and positively charged groups
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SPHINGOLIPIDS
The greatest concentration of sphingolipids is found in the CNS, particularly in white matter
Types of sphingolipids: sphingomyelin and the glycosphingolipids.
All sphingolipids are derived from sphingosine.
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Lipid 35
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Lipid 36
A. SPHINGOMYELIN
Function. Sphingomyelin are the major phospholipid component of membranes in neural tissue
Structure. Sphingomyelin are the only sphingolipids that contain phosphate and have no sugar moiety
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Lipid 37
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OH O
CH3 – (CH2)12 – CH = CH – C – CH – NH – C – R
CH2
O
O = P – OH
O – CH2 – CH2 – N(CH3)3
+
Fatty acid
Phosphic acid
Cholin
Sphingosin
Sphingomyelin
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Lipid 39
B. GLYCOSPHINGOLIPID Sphingolipids that contain carbohydrate
moieties are known as glycosphingolipids have been distinguished : cerebrosides and Ganglioside
1. Cerebrosides are ceramides monohexosides, the most important being galactocerebroside and glucocerebroside. Cerebrosides are found in neural tissue membrane, particularly the myelin sheath . 2. Gangliosides are ceramide oligosaccharides, they contain one or more neuraminic residue
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Lipid 40
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Lipid 41
Sia
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Lipid 42
C. SPHINGOLIPIDOSES
There are a number of inherited genetic disorders referred to as lipid storage diseases in which there is a deficiency of an enzyme.
For example : Gaucher’s disease, Niemann-Pick disease and Tay-Sachs
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Lipid 43
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Lipid 44
EICOSANOIDS
Eicosanoids are products of the metabolism of the 20-carbon-poliunsaturated fatty acid arachidonic acid
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Lipid 45
A. PROSTAGLANDINS
1.Structure .
Prostaglandins are analogs of prostanoic acids
Prostaglandin E1
COOH
OH
O
OH
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Lipid 46
2. Functiona. Prostaglandins are widely distributed in tissues, but their role is not yet fully understood .
At very low concentrations prostaglandins have been shown biologic activies, including:
(1) Smooth muscle contraction and relaction(2) Gastric secretion(3) Platelet aggregation(4) Inflamatory response(5) Response to trophic hormone (FSH & LH)(6) Sodium and water retention by kidney tubules
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Lipid 47
B THROMBOXANES
1. Structure.
Thromboxanes are also analogs of prostanoic acids, but they possess a six-membered, oxygen containing ring
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Lipid 48
2. Function
Thromboxane A2 (TX2) is produced by
platelets; it causes contraction of arteries and platelet aggregation.
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Lipid 49
STEROIDS
Steroids are lipids that contain four fused carbon rings that form the steroid nucleus cyclopentanoperhydrophenantrene
A. Sterol are a class of steroid in the human body
1. A hydroxyl group at carbon 3 (C-3)
2. An aliphatic chain of at least eight carbons at C-17
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Lipid 50
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Lipid 51
B. Cholesterol is the mayor sterol in the human body.
1. It is a structural component of cell membranes and plasma lipoprotein
2. It is precursor from wich steroid hormones and bile acids are synthesized
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a. Steroid hormones
(1) The steroid hormones produced in humans are formed and secreted by the adrenal cortex, the testis, the ovary, and the placenta.
In addition, the steroid compound, 1,25-dihydroxycholecalciferol is form in the kidney.
The structures are………
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Lipid 53
(2) The adrenal cortex produces hormones with two kind of physiologic activities.
(a) The zona fasciculate of the adrenal cortex primarily produces cortisol in humans, they are glucocorticoid and cortisol
(b) The zona glomerulosa produces mineralocorticoid, that is aldosteron, which controls the reabsorption of Na+ in the kidney.
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(3). Gonadal steroids
(a)Testis produced testosterone
O
CH3
CH3
OH
Testosterone
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Lipid 55
b. Bile acids
The predominant bile acids in humans are cholic, chenodeoxycholic, deoxycholic, and lithocholic acids (Figure 8-5)
1. Structure a) The bile acids are C-24 steroids and are
derived from cholesterol (a C-27 steroid) by scissor of the side chain, which leaves:
(i) A C-24 carboxyl group with the loss of
three carbons
(ii) Saturation on Δ5 double bond of cholesterol
(iii) Hydroxylation of the steroid nucleus
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Lipid 56
b) Cholic and chenodeoxycholic acids are formed in the liver from cholesterol and are the primary bile acids.
Deoxycholic acids and lithocholic acids are known as the secondary bile acids because they are formed from the primary bile acids
c). The bile acids are conjugated to glycine or taurine in the liver to form glycol or taurocholate
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2. Function.
Continuos conversion of cholesterol to bile acids prevents the excessive accumulation of cholesterol in tissues.
Bile acids are secreted with faeces
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Lipid 58
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Lipid 59
1. storage form of metabolic fuel
2. transport form of metabolic fuel3. part of the outer coat between the body of
the organism and the environment, providing protection in bacteria, plants, insects and vertebrates
4. structural components of membranes n neural system
5. Precursor of vitamins, hormons6. Cell cignaling
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Lipid 60
SELESAI