lipids store energy in a fat cell part of membranes serve as chemical messengers
Post on 22-Dec-2015
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Lipids
• Store Energy in a Fat Cell
• Part of membranes
• Serve as chemical messengers
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Energy Storage
• Humans store Energy in the form of fats
• Some Energy storage is in the form of the carbohydrate glycogen – fast energy
• Fats produce 50% more energy per gram than carbohydrates
• 9 kcal/gram compared to 4 kcal/gram
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Membrane Components
• Because lipids are insoluble in water, they work well as membranes to separate compartments in the body
• The structure of lipids makes them water repellent or hydrophobic
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Messengers
• Primary messengers like steroids
• Secondary messengers like prostaglandins or thromboxanes
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Classification of Lipids
• Classified into four groups
1) Fats and waxes
2) Complex Lipids
3) Steroids
4) Prostaglandins
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Structure of Fats
• Fats are esters• Alcohol part is always
glycerol
• Acid part varies but is a “Fatty Acid”
glycerolH2C
HC
H2C
OH
OH
OH
palmitic acid
CCH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH3 OH
O
a typical “fatty acid”
also called “glycerin”
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Structure of Fats• Fatty Acids (FA)
1) Practically all straight chain with no branches
2) 10 to 20 C in length
3) Contain an even number of C
The body builds FA from two carbon units
of acetic acid (acetate ion)
4) Those with double bonds are usually in the cis isomer formation
palmitic acid
CCH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH2CH3 OH
O
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Structure of Fats
• Fatty Acids + Glycerol = FAT (an ester)
C (CH2)16 CH3
O
HC
H2C
H2C C (CH2)12 CH3O
O
O
O C (CH2)16 CH3
O
C (CH2)16 CH3
O
HC
H2C
H2C C (CH2)12 CH3O
O
O
O C (CH2)16 CH3
O
glycerol
first FA
second FA
third FA
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Structure of Fats
• FATS– Triglycerides (three FA esterified with
glycerol)• Also called Triacylglycerides
– diglycerides (two FA esterified w/ glycerol)– Monoglycerides (one FA esterified w/
glycerol)– Fats are insoluble in water– Exist as both saturated and unsaturated FA
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Structure of Fats• FATS
– Saturated Fatty Acids• Fit together well - close, parallel alignment• Regular pattern
– Unsaturated Fatty Acids• cis/trans double bonds do not allow regular
packing• LOWER mp and bp lower than the Sat’d. FA
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Properties of Fats
• Physical State - FATS– Animal fats
• generally solids at RT• contain mostly saturated FA
– Plant and Fish oils• generally liquids at RT• contain more unsaturated FA
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Properties of Fats
• PURE Fats – Colorless, odorless, and tasteless– Tastes, odors, colors are caused
by substances dissolved in the fats
From Yahoo Images
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Hydrogenation
• Treatment with hydrogen gas, H2
• Catalyst required
• NOT difficult to convert unsaturated FA to saturated FA
• Called “hardening”
• Margarine contains more unsaturation than hydrogenated shortenings– Crisco, Spry, etc.
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Hydrogenation
• Unsaturated converted to saturated:
HC
H2C
H2C C (CH2)12 CH3O
O
O
O
C (CH2)6 CH2
CH CH
CH2 (CH2)6 CH3
O
C (CH2)6 CH2
CH CH
CH2 (CH2)6 CH3
O
+ H2
catalyst
HC
H2C
H2C C (CH2)12 CH3O
O
O
O
C (CH2)6 CH2
CH2 CH2
CH2 (CH2)6 CH3
O
C (CH2)6 CH2
CH2 CH2
CH2 (CH2)6 CH3
O
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Saponification• Triglycerides are subject to hydrolysis
– Can be hydrolyzed with acid or base– Base hydrolysis is called “saponification”– Result of base hydrolysis is a SOAP
• SOAP– The mixture of sodium salts of Fatty Acids
produced by saponification is called SOAP.
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Saponification
• Triglycerides are subject to hydrolysis– base hydrolysis is called “saponification”
HC
H2C
H2C C (CH2)12 CH3O
O
O
O
C (CH2)6 CH2
CH CH
CH2 (CH2)6 CH3
O
C (CH2)6 CH2
CH CH
CH2 (CH2)6 CH3
O
+ 3 NaOHH2O
H2C
HC
H2C
OH
OH
OHC (CH2)12 CH3O
O
Na+ -
+
O C (CH2)6 CH2
CH CH
CH2 (CH2)6 CH3
O
Na+ -2
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QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
• Pre-18th century soap making… It is said of Queen Elizabeth I that she bathed once a month, "whether she needed to or not". Whether she used soap is not recorded. But soap was a commodity only available to the wealthy before modern times.
• Source of “lye”… A large wooden hopper, which was large at the top and tapered down to a small bottom, was kept in the backyard near the kitchen door. The hopper was made of clapboards, which were arranged as a pyramid turned up side down. Dried grass or cornhusks were put into the bottom of the container to act as a strainer. In this the wood ashes from the hearth were stored. When the hopper was filled, many buckets of water had to be drawn from the well and poured over the ashes. Through a trough from the bottom of the hopper came the drops of strong brown lye, which was put in a large kettle over the fire to boil. As soon as the lye would float an egg, scraps of fat and grease were put in. everyone was careful not to touch the strong lye, for it would have eaten the skin off one’s fingers. (62) The grease was saved by the housewife from cooking during several months. Then it was put in the large round-bottomed iron kettle with the homemade lye. After boiling the mixture became a mass of jelly-like soap. Then it was allowed to cool, and from it were cut bars of brown soap, which were stored for household use. (63)
Soap Making
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Common Fatty Acids To Know
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Classification of LipidsG
lyce
rol
FA
FA
FA
Simple and complex lipids
Simple Complex
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Classification of Lipids
GlycolipidsGlycerophospholipids
Gly
cero
l
FA
FA
FA
Simple and complex lipids
Simple Complex
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Classification of Lipids
GlycolipidsGlycerophospholipids
Gly
cero
l
FA
FA
FA FASphi
ngos
ine
GLUCOSEGALACTOSE
Simple and complex lipids
Simple Complex
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Phosphoglycerides Sphingolipids
Classification of Lipids
GlycolipidsGlycerophospholipids
Gly
cero
l
FA
FA
FA FASphi
ngos
ine
GLUCOSEGALACTOSE
Simple and complex lipids
Simple Complex
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Phosphoglycerides Sphingolipids
Classification of Lipids
GlycolipidsGlycerophospholipids
Gly
cero
l
FA
FA
FA
Gly
cero
l
FA
FA
PO43- ALCOHOL FASp
hing
osin
e
GLUCOSEGALACTOSE
Simple and complex lipids
Simple Complex
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Phosphoglycerides Sphingolipids
Classification of Lipids
GlycolipidsGlycerophospholipids
Gly
cero
l
FA
FA
FA
Gly
cero
l
FA
FA
PO43- ALCOHOL
Sphi
ngos
ine FA
PO43- CHOLINE FASp
hing
osin
e
GLUCOSEGALACTOSE
Sphi
ngos
ine
Simple and complex lipids
Simple Complex
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Membranes
• Complex Lipids make up membranes
• Hydrophilic vs. Hydrophobic
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Cell Membrane
• Lipid layers line up with alaphatic tails inward• Unsaturation allows for liquid like character of the membrane• Intergral and peripheral proteins are a part of the structure• Cholesteral is also a component of membranes
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Transport Through a Membrane
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Membranes• Youtube• http://www.youtube.com/watch?
v=GW0lqf4Fqpg• http://www.youtube.com/watch?
v=ULR79TiUj80• http://www.youtube.com/watch?
v=vh5dhjXzbXc• http://www.youtube.com/watch?
v=ooX9hHu5baM
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Glycerophospholipids
• Glycerol is the alcohol
• Two acids are Fatty Acids
• Third is esterified to PO43- and choline
• The Fatty Acid on carbon 2 is unsaturated
choline
CH2 CH2OHNH3C
CH3
CH3
+
glycerolH2C
HC
H2C
OH
OH
OH
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C (CH2)7 CH
O
HC
H2C
H2C C (CH2)16 CH3O
O
O
O OP
O
O CH2CH2 N CH3
CH3
CH3
CH CH2 CH CH (CH2)4 CH3
-
+
Glycerophospholipids
• Phosphotidylcholines
• Also called “lecithins”
Locate:glycerol portionstearic acidcholinelinoleic acidphosphate
Charged groupsForms lipid bilayer withHydrophobic heads together
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Glycerophospholipids• Cephalins
– another type of glycerophospholipids– alcohol is ethanolamine or serine instead of
choline
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Glycerophospholipids
• Phosphatidylinositols (PI)
• Alcohol is inositol
• Serve as signaling or
Communication sites
inositol
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• Coating of nerve axons (myelin)
• Alcohol portion is sphingosine (not glycerol)– A long chain fatty acid is connected to the NH2
– The End OH group is esterified by phosphorylcholine
Sphingolipids
CH(CH2)12CH3 CH CH CH CH2
OH NH2 OH
sphingosine
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Sphingolipids
Can you find the sphingosine????
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• Glycolipids contain carbohydrates
• They also use sphingosine
• One type is the cerebrosides– occur in the brain (7% of dry weight!)
– present at nerve synapses
Glycolipids
O
OH
OH
HO
CH2OHO
HNO
OH
a glucocerebroside
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Steroids
• A third major class of lipids:
• They are all based on this structure
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H3C CH3
CH3
HO
CH3
CH3
cholesterol
Cholesterol– most abundant steroid in the body– cell membrane component– raw material for other
steroids synthesis
• Exists in both free and esterified forms– Esterifies with FA– Gallstones are almost pure cholesterol– Correlation between HI serum levels and atherosclerosis– Necessary for human life– Manufactured in the liver – body keeps a set amount
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H3C CH3
CH3
HO
CH3
CH3
cholesterol
Lipoproteins
• Transport cholesterol, and fats
• Types of Lipoproteins– HDL = hi density lipoprotein (the good Kind)
• 33% protein and 30% cholesterol
– LDL = lo density lipoprotein (the not good kind)
• 25% protein and 50 % cholesterol
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Steroid HormonesCholesterol is starting material for synthesis
of Progesterone:• Alcohol on C-3 converted
to a ketone• Side chain on D ring modified• Precursor of sex hormones
and adrenocorticoid hormones
C
CH3
O
O
CH3
CH3
progesterone
H3C CH3
CH3
HO
CH3
CH3
cholesterol
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Hormones from Progesterone
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C
CH2OH
O
O
CH3
HCHO
O
aldosterone
Steroid Hormones
• Aldosterone– Product of the adrenal gland– Mineralocorticoid (regulates ion concentration)– Increased secretion
enhances reabsorption of Na+ and Cl- ions in the kidney tubules
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testosteroneO
CH3
CH3OH
Steroid Hormones
• Sex Hormones - Testosterone– Promotes normal growth of male sex organs– Synthesized in testes
from cholesterol– Secretion results in
2nd sex characteristics
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Steroid Hormones
• Sex Hormones - Estradiol– Regulates cyclic changes in the uterus– Synthesized from
testosterone– Menstrual Cycle
• increased estradiolat beginning of cycle
• uterus thickens• Luteinizing hormone
triggers ovulationestradiol
HO
CH3OH
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YouTube
http://www.youtube.com/watch?v=9oaFmKc3ll0
http://www.youtube.com/watch?v=rBBWMRRWOrM
http://www.youtube.com/watch?v=p_ewmP1L7ro
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H3C
HO
CH3
CH3
OH
HOC O
NH
CH2
COO-
glycocholate
Bile Salts
• Bile Salts are oxidation products of Cholesterol – 3 OH’s and an Acid end
• Charged salt is more soluble in solution• Bile salts help disperse dietary lipids in
the small intestine – increase digestion rate• Removes cholesterol
in two ways – they are broken cholesterols and dissolve deposited cholesterol
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Prostaglandins
• Fatty acid-like substances
• Produced in prostate– small amounts produced
in all tissue
• Synthesized fromArachidonic Acid
COOH
CH3
Arachidonic Acid
COOH
O
HO OH
CH3
PGE2 (a prostaglandin)
steps
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Prostaglandins
• PGE2
– induce labor– therapeutic abortion– lowers bp– used to treat asthma
• PGE2 – causes hypertension
• PGE1
– used as a nasal decongestant
COOH
O
HO OH
CH3
PGE2 (a prostaglandin)
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Thromboxanes
O
O
OH
COOH
•Induce Plaelet aggregation
•When a blood vessel is ruptured, platelets congregate and PGH2 causes Them to clot together
Aspirin blocks the effect and acts A blood thinner
PGH2
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Prostaglandins / Leukotriene• Leukotrienes
– Occur mainly in leukocytes (white blood cells)
– Long lasting muscle contractions especially in the lungs where they cause Asthma-like attacks
CH3
OH OHOH
COOH
Leukotriene B4