longer life, better life
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Longer Life, Better Life. ——Current research progress on Alzheimer Disease. The third group 陈昊. 21 st century--time for the aged. Number of the aged is so huge!. 0.7 billion is the old! Almost 1 in 10 on the world is over 60!. VS. October 31st, 2011 7 billion people on the world?. - PowerPoint PPT PresentationTRANSCRIPT
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LOGO Longer Life, Better Life
The third group 陈昊
——Current research progress on Alzheimer Disease
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21st century--time for the aged
Number of the aged is so huge!
October 31st, 2011
7 billion people on the world?
0.7 billion is the old!Almost 1 in 10 on the world
is over 60!
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Aging is everywhere
Number of the aged (current and predicted) of some continent
4-5 times increasing in 50 years, just like a
rocket!
What about China?
The pace is faster.
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The Result: Enjoy a longer life
Life expectancy worldwide on 2007
From Wikipedia
CIA World Fact book 2007 :Over 100 nations or regions enjoy the life expectancy over 70!
Quality
of life?
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Living quality---A better life as well?
Economic influence
Social problems
Health and diseases
Aging is good Aging is good or not? This is or not? This is
a question.a question.
The tragedy of aging:
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Diseases of the aged
diabetes
CHF Stroke
Neurodegenerativedisease hypertension
Aged diseases
When we become old……
Cancer
Alzheimer
The position of Alzheimer
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Contents
1 The characters of Alzheimer
2 Alzheimer----the killer of life quality
3 Research on Mechanism of Alzheimer
4 Current drug and therapy
5 Can Alzheimer be prevented?
Fight against
Alzheimer!
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1 Alzheimer--- four stages characters
Early Middle Severe Final
1. slow, progressive loss of intellectual ability
2. difficulty learning
3. mild depression
1. an increase in memory loss
2. Decrease losing of daily living ability
1. unable to recognize objects and family members
1. cannot speak or walk, even breathe
2. has profound memory loss
Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30
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Epidemiology from a point: a large market in AD therapy
•Drugs for AD have a large market.
•AD is very popular in the aged.
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2. Alzheimer destroys the quality of life
Danger of the patients
1. They can’t remember what they have done.
2. They can’t remember their family members.
3. Finally, they will not know who they are.
4. They will die because of breath problem!
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Alzheimer destroys the quality of life
Social problems
TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661
Have you remembered or not? !
Mercy killing!
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3.The mechanism of Alzheimer—so many hypothesis
Cholinergic hypothesis
The mechanismOf Alzheimer
Amyloid hypothesis
imbalance
Acetylcholine (ACh)
production elimination
11C-PIB PET images characteristicChristiane Reitz. Epidemiology of Alzheimer disease. Nat.
Rev. Neurol. 7, 137–152 (2011)
amyloid deposits
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New research: The interaction between these hypothesis
MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111
Amyloid hypothesis to Cholinergic hypothesis
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New research: The interaction between these hypothesis
MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111
Cholinergic hypothesis to Amyloid hypothesis
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4.Current Drug and therapy
CurrentDrug H3
antagonist
5-HTreceptor
ACEIs
NewACEIs
Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210
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5. Can Alzheimer be prevented?
EmotionalTherapy?
AntibodyTherapy?
DietTherapy?
Anti-oxidation?
Virus-likeVaccine?
PreventionOf AD
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---Longer life, better lifeConclusion
Our loveTo the old?
Better prevention
More drugs
Mechanismclearer
live longer, live better.
It’s not only for the old, but also for our
future!