1

Longevity and Tea Longevity and Tea

2

Tegreen 97Tegreen 97

Second most popular beverage

Tremendous positive press Top 20 in health food sales Thousands of studies

worldwide Including National Cancer

Institute Dose: 250 mg capsule; 1

capsule/day with food

Tea is HOT!

3

Proprietary processingProprietary processing

Only finest leaf buds and young leaves used

Cultivated in Zhejiang province (number one tea-producing region in China)

Proprietary extraction process Achieves 97% polyphenols

65% Catechins• 38% EGCg

4

Green tea vs. Black teaGreen tea vs. Black tea

Green tea Camellia sinensis Non-fermented

Lightly steamed and dried

Benefit of process Preservation

polyphenols (similar to fresh leaves)

Black tea Camellia sinensis Fermented and

dried. Benefit of process

Flavor enhancing Disadvantage

Destroys polyphenols

5

Green tea researchGreen tea research

Epidemiological studies on green tea drinkers

Polyphenol Research Proven antioxidants Cell protection Inhibition of abnormal cell proliferation

6

What are Polyphenols?What are Polyphenols?

Powerful antioxidants High concentrations in green tea Tegreen enriched for polyphenol anti-

oxidants, particularly Epigallocatechin gallate (EGCg)

7

TeGreen

0

20

40

60

80

10 20 30 400

Dose (µM)

Vitamin C

Vitamin E

Antioxidant potency

Example of Pharmanex research Example of Pharmanex research on Tegreen on Tegreen

EGCG

8

3 glasses ofred wine

4 cups ofgreen tea

4 glasses oficed tea

Based on EGCg levels

Anti-oxidant equivalency to Anti-oxidant equivalency to other beverages without caffeine other beverages without caffeine or alcoholor alcohol

9

New Research by Pharmanex New Research by Pharmanex collaboratorscollaborators

Abnormal cells proliferate and live longer than normal cells

The life of a normal cell is regulated by a natural regulatory mechanism called programmed cell death (apoptosis)

Apoptosis is severely limited in abnormal cells Pharmanex collaborators discovered unique

enzyme (tNOX) in abnormal cells associated with this defect

10

Inhibition of enzyme (tNOX) Inhibition of enzyme (tNOX) activity in cancer cells activity in cancer cells

0

0.5

1

1.5

2

2.5

3

3.5

4

Control 10 nM 1000nM

100000nM

EGCg

Tegreen

Cancer cell enzyme activity

Source: Morre et al.

11

Tegreen Vs EGCg in promoting Tegreen Vs EGCg in promoting cancer drug activitycancer drug activity

0

1

2

3

4

5

0 1 10 100 1000 10000

Anti-cancer drugalone

Tegreen+ Anti-cancer drug

Anti-cancer drug, glaucarubolone, nM

Cancer cell killing

12

Tegreen 97 AttributesTegreen 97 Attributes

Highest levels of polyphenols in industry 97% polyphenols Most competitors: 50-65% polyphenols

Once per day dose Equivalent to 4 cups of green tea beverage

Caffeine free