lung cancer for finals
DESCRIPTION
Lung Cancer for Finals. Simple Success. Tim Robbins Academic FY1 UHCW. Ron Ailman : Symptoms. Cough Haempotysis Dyspnoea Chest Pain Recurrent pneumonia Anorexia/weight loss Hoarseness of voice. Patient photo/data from: http://www.macmillan.org.uk. Risk Factors. Cigarette Smoking - PowerPoint PPT PresentationTRANSCRIPT
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Lung Cancer for Finals
Syp RF Signs Comp Inx Histology Rx Surg
Simple Success
Tim RobbinsAcademic FY1
UHCW
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Syp RF Signs Comp Inx Histology Rx Surg
Ron Ailman: Symptoms
Patient photo/data from: http://www.macmillan.org.uk
• Cough• Haempotysis• Dyspnoea• Chest Pain• Recurrent pneumonia• Anorexia/weight loss• Hoarseness of voice
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Risk Factors
• Cigarette Smoking• Industrial contaminants:
Asbestos/arsenic• Radon gas
• Genetic pre-disposition
Syp RF Signs Comp Inx Histology Rx Surg
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Signs
Syp RF Signs Comp Inx Histology Rx Surg
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Pleural Effusion: Atelectasis:
Consolidation:
Chest Signs
Syp RF Signs Comp Inx Histology Rx Surg
-Decreased chest wall movement-Stony dullness-Decreased breath sounds-Decreased vocal fremitus-Pleural Rub (above)-Mediastinal shift away
-Decreased chest wall movement- Dullness to percussion- Decreased breath sounds- Decreased vocal resonance- Mediastinal shift towards
- Crackles - Decreased chest wall movement- Dullness to percussion- Bronchial breathing / increased breath sounds- Increased vocal resonance
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Com
plic
ation
s• Recurrent Laryngeal nerve palsy• Horner's Syndrome (Pancoast’s tumour)• Rib erosion
Local
• Brain, bone, liver, adrenalsMetastases
• SIADH• Excess ACTH secretion• Addisons Syndrome• Gynaecomastia
Endocrine
• Lambert Eaton Syndrome• Proximal MyopathyNeurological
• Pericarditis• SVC obstruction• Venous Thomboembolism
Cardiovascular
Syp RF Signs Comp Inx Histology Rx Surg
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Investigations
Diagnosis Stage Grade
Chest X-ray
CT
Radio-nucleotide uptake scan
SputumPleural fluid
LN aspirationBronchoscopy
Syp RF Signs Comp Inx Histology Rx Surg
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HistologySmall CellNon-Small Cell
AdenocarcinomaSquamous cell
Large-cell
50% 2 year survival if caught before
spread
Neurosecretory cells
3 month median survival if untreated
1/1.5 yrs with Rx
Staging: TNM
Syp RF Signs Comp Inx Histology Rx Surg
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TreatmentSmall CellNon-Small Cell
•Excision if no metastatic spread
•Curative radiotherapy if respiratory reserve poor
•Chemotherapy +/- radiotherapy in advanced disease (likely palliative)
•Almost inevitably disseminated
•Chemotherapy, but relapse
•Radiotherapy for symptomatic relief:
Bronchial ObstructionSVC obstruction
Haemoptysis
•SVC stenting / endobronchial therapy
Syp RF Signs Comp InxHistology Rx Surg
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Surgery – the curve ball OSCELobectomy / pneumonectomy with LN excision
The similarities:Both have thoracotomy scars.Both have reduced chest expansion and reduced AE.
The differences:1. The signs of lobectomy are confined to lobe which is removed.
2. The signs of pneumonectomy are extensive i.e. involve the whole lung. The side involved would be flatten. It is similar to whole lung collapse.
3. Normally, the tracheal is central in lobectomy (except for upper lobe). The tracheal is almost always shifted in pneumonectomy.
Syp RF Signs Comp InxHistology Rx Surg