Monday, 4 June 2018

Auditorium I

09:00Early Career Symposium (ECS)Chairs:Sarah ChappleKing´s College London, UK

Consuelo BorrásUniversidad de Valencia, Spain

Bárbara RochaUniversity of Coimbra, Portugal

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09:0009:20 Keynote 1

The Decline of Adaptive Homeostasis & AdaptiveProteostasis in AgeingKelvin J. A. DaviesUniversity of Southern California, Los Angeles, USA

09:2009:35 Iodide modulates oxidative protein modication

induced by myeloperoxidaseLuke Gamon, Marta Ignasiak, Simon Dieterich, MaxSauerland, Michael DaviesUniversity of Copenhagen, Denmark

09:3509:50 Mitochondrial hydrogen peroxide levels in

healthy peripheral nerves and peripheralneuropathiesGerben van Hameren, Nicolas TricaudInstitute for Neurosciences Montpellier, France

09:5010:05 Boost of vitamin E metabolism as a novel

treatment strategy for myocardial infarctionMaria Wallert, Melanie Ziegler, Xiaowei Wang, AnaMaluenda, Stefan Lorkowski, Karlheinz PeterBaker Heart and Diabetes Institute, Melbourne, Australia;University of Jena, Germany; Competence Cluster forNutrition and Cardiovascular Health (nutriCARD),Germany; Monash University, Australia

10:0510:20 Deregulation of small intestine permeability by

miRNA-21 in liver diseaseAndré Anastácio Santos, Marta Bento Afonso,Pedro Miguel Rodrigues, Rui Eduardo Castro,Cecília Maria Pereira RodriguesUniversity of Lisbon, Portugal

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10:2010:35 High-fat and high cholesterol diet induces

Alzheimer’s like disease in miceGianni Mancini, Cândida Dias, Cátia Lourenço, RuiM. Barbosa, João Laranjinha, Andreza F. de Bem,Ana LedoUniversidade Federal de Santa Catarina, Florianópolis,Brazil; Center for Neuroscience and Cell Biology, Coimbra,Portugal; University of Coimbra, Portugal

10:3510:50 Improving arterial surgery outcomes: Combating

restenosis with nanotechnology and redoxmodulationNicholas Buglak, Wulin Jiang, Samuel Stupp,Melina Kibbe, Edward Moreira BahnsonUniversity of North Carolina at Chapel Hill andNorthwestern University, USA

10:5011:05 Redox regulation in human endothelial

cells: a critical role for the glycocalyx inmechanotransduction of fluid shear stressParaskevi-Maria Psefteli, Mark Fowler, Giovanni E.Mann, Richard C. SiowKing’s College London, UK; Strategic Science Group,Unilever R&D, Colworth, UK

11:0511:25 Keynote 2

The nitrate-nitrite-NO pathway in health and diseaseJon O. LundbergKarolinska Institutet, Stockholm, Sweden

11:2512:00 Coffee Break

Auditorium I12:0012:05 Symposium YIA 2017

Chairs:Daniela CaporossiForo Italico University of Rome, Italy

Giuseppe ValacchiUniversity of Ferrara, Italy

12:0512:20 Synthesis and separation of peptide-oxidized

phospholipid adducts, a potential lipoxidationmarkerCatarina B. Afonso, Andrew R. Pitt, Corinne M. SpickettAston University, Birmingham, UK

12:2012:35 Scavenger receptor B1 as a new target for

pollution-induced oxidative skin damageXimena Maria Muresan, Giuseppe Belmonte, ClaudiaSticozzi, Franco Cervellati, Florian Gruber, GiuseppeValacchiUniversity of Ferrara, Italy; Medical University of Vienna,Austria; Christian Doppler Laboratory for Biotechnologyof Skin Aging, Vienna, Austria; NC State University, USA

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12:3512:50 Transcription factor NRF2 modulates chaperone

mediated autophagy through the regulation ofLAMP2AMarta Pajares, Ana I. Rojo, Esperanza Arias, AntonioDiaz-Carretero, Ana Maria Cuervo, Antonio CuadradoUniversity of Madrid, Spain; CIBERNED, ISCIII, Madrid,Spain; Albert Einstein College of Medicine, NY, USA

12:5013:05 Molecular mechanisms of HO-1 up-regulation in

neuroblastoma cell response to oxidative stressSabrina Piras, Anna Lisa Furfaro, Rocco Caggiano,Lorenzo Brondolo, Umberto Maria Marinari, MariaAdelaide Pronzato, Raaella Faraonio, Mariapaola NittiUniversity of Genoa, Italy; University of Naples “FedericoII”, Italy

13:0513:20 Novel redox-targets of NADPH oxidase 4

Oliver Löwe, Juliana Heidler, Ilka Wittig, Katrin Schröder,Flavia Rezende, Ralf P. BrandesGoethe University Frankfurt, Germany

13:2014:00 ECS/YIA delegates lunch

Auditorium I 14:0016:00 Workshop Elsevier

Chair:Ana LedoCenter for Neurosciences and Cell Biology, Coimbra, Portugal

How to write a great research paper, and get itaccepted by a good journalAnthony NewmanLife Sciences Department, Elsevier, Amsterdam, The Netherlands

16:0017:30 Welcome address

Auditorium I16:3017:30

Trevor Slater Award LectureChairs:Shinya ToyokuniNagoya University, Japan

Josiane CillardUniversité de Rennes, France

Metabolism and Redox Signaling in Brain AgingEnrique CadenasUniversity of Southern California, Los Angeles, USA

17:3018:00 Catherine Pasquier lecture

Chairs:Michael J. DaviesUniversity of Copenhagen, Denmark

Analysis of oxidised lipids; validation and applicationIrundika DiasAston University, Birmingham, UK

18:0019:30 Welcome Cocktail

Tuesday, 5 June 2018

Auditorium I Auditorium III+IV Pavilion 508:3010:30 Symposium I - The biology

of H2O2 after 200 years of itsdiscovery by ThenardSponsored by:

Chairs:Helmut SiesHeinrich-Heine-UniversityDüsseldorf, Germany

Enrique CadenasUniversity of SouthernCalifornia, Los Angeles, USA

Symposium II - Ferroptosis:A Program or a Free RadicalCatastrophe?Chairs:Marcus ConradHelmholtz Zentrum Muenchen,Germany

Valerian E. KaganUniversity of Pittsburgh, USA

Symposium III - Oxidativestress and signaling byreactive oxygen andnitrogen species in plantsChairs:Gary J. LoakeEdinburgh University, UK

Frank Van BreusegemGhent University – VIB, Gent,Belgium

08:3009:00 H2O2 as a central redox

signaling molecule inphysiological oxidativestressHelmut SiesHeinrich-Heine-University,Düsseldorf, Germany

Ferroptosis: Death by lipidperoxidationBrent StockwellColumbia University, New York,USA

Nitric oxide signalling indeconvolutionGary J. LoakeEdinburgh University, UK

09:0009:30 Genetically encoded

molecular tools for H2O2imaging and manipulationVsevolod V. BelousovShemyakin-OvchinnikovInstitute of Bioorganic Chemistry, Moscow, Russian Federation

Molecular underpinningscontrolling ferroptotic celldeathMarcus ConradHelmholtz Zentrum Munich,Germany

Plant oxidative stresssignaling: towards theproteome and beyondFrank Van BreusegemGhent University – VIB, Gent,Belgium

09:3010:00 Control of AQP8- dependent

H2O2 transport across the plasma membrane: Implications for cell signalingRoberto SitiaIRCCS Ospedale San Raaeleand Università Vita-Salute,Milan, Italy

Oxidation ofphosphatidylethanolaminesas ferroptotic signals:control by lipoxygenasesValerian E. KaganUniversity of Pittsburgh, USA

Reactive oxygen species,nitric oxide and hydrogensulfide in plant cellregulationJohn T. HancockUniversity of the West ofEngland, Bristol, UK

10:0010:30 Role of NOX-generated

reactive oxygen species inhealth and diseaseKarl-Heinz KrauseUniversity of Geneva, Switzerland

Iron and ferroptosis inthe pathogenesis ofAlzheimer´s diseaseJames DuceUniversity of Cambridge, UK

Interaction betweenantioxidants and reactivenitrogen species duringpepper fruit ripeningJosé M. PalmaEstación Experimental delZaidín, Granada, Spain

10:3011:00 Poster Viewing, Coffee Break and Commercial Exhibit

Auditorium I11:0011:30 Leopold Flohe Award Lecture

Chairs:Leopold FloheOtto von Guericke University, Germany

José ViñaUniversity of Valencia, Spain

Pathways of myeloperoxidase-induced cellular damage in atherosclerosisClare HawkinsUniversity of Copenhagen,Denmark

11:30 12:15 SFRRE Annual Lecture

Chairs:Giovanni E. MannKing’s College London, UK

Henry Jay FormanLeonard Davis School of Gerontology, CA, USA

New horizons in hypoxia signaling pathways in health and diseasePeter J RatcliffeUniversity of Oxford and The Francis Crick Institute, London, UK

12:15 13:30

Lunch, Poster Viewing, Commercial Exhibits

Pavilion 5

Women in Science SessionChairs:Lin MantellSt. John’s University College of Pharmacy, NY, USA

Mari Carmen Gómez-CabreraUniversity of Valencia, Spain

Mariapaola NittiUniversità degli Studi di Genova, Genoa, Italy

Auditorium I Auditorium III+IV Pavilion 513:3015:30 Symposium IV - Molecular

Oxygen in Health AndDisease: One Tissue’sHypoxia is Another’sHyperoxiaSponsored by:

Chairs:Giovanni E. MannKing’s College London, UK

Thomas P. KeeleyKing’s College London, UK

Symposium V - BiologicalRoles of Heme-Protein RedoxInteractionsChairs:Roland StockerVictor Chang CardiovascularResearch Institute, Australia

Miguel P. SoaresInstituto Gulbenkian de Ciência,Portugal

Symposium VI - CrosstalkBetween OxidativeStress and Inflammationin CerebrovascularDisease: Mechanisms andTherapeutic InterventionsChairs:Saverio Francesco RettaUniversity of Torino, Italy

Kathy GriendlingEmory University, Georgia, USA

13:3014:00 Redox regulation under

physiological oxygen levelsGiovanni E. MannKing’s College London, UK

Heme regulation of glucosemetabolism in bloodstreaminfectionsMiguel P. SoaresInstituto Gulbenkian de Ciência,Portugal

Inflammation and immunemechanisms of braindamage after strokeChristopher G SobeyUniversity of Oxford and The La Trobe University, Melbourne,VIC, Australia

14:0014:30 Substrate selectivity of

prolyl hydroxylasesMichael A. McDonoughUniversity of Oxford, UK

Singlet molecular oxygenregulates vascular toneand blood pressure ininflammationRoland StockerVictor Chang CardiovascularResearch Institute, Australia

Nox4, Poldip2 andvascular functionKathy GriendlingEmory University, Atlanta, USA

14:3015:00 Oxygen in cancer and

neovascularizationSharon GerechtJohns Hopkins University,Baltimore,USA

Heme degradation in Myco-bacterium tuberculosisMasao Ikeda-SaitoTohoku University, Sendai,Japan

ROS-induced ROS releaseorchestrated by Nox4,Nox2 and mitochondriain VEGF signaling drivingendothelial metabolismand angiogenesisMasuko Ushio-FukaiAugusta University, Augusta,USA

15:0015:30 Oxygen homeostasis

in intestinal health andinflammationEric CampbellQueen’s University Belfast, UK

Evolution of structureand function of humanperoxidasesChristian ObingerUniversity of Natural Resourcesand Life Sciences, Vienna,Austria

Oxidative Stressand inflammation incerebral cavernousmalformation diseasepathogenesis: Toward aunifying mechanistic andtherapeutic landscapeSaverio Francesco RettaUniversity of Torino, Italy

15:3016:00 Coffee Break

Auditorium I Auditorium III+IV Pavilion 516:0017:30 Oral presentation 1 -

Cardiovascular RedoxSignalingChair: Maria MonsalveInstituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Spain

John MaguireOCC, USA

Oral presentation 2 - Thiols-Disulfide Exchange in CellSignalingChair: Fabio VirgiliResearch Centre for Foodand Agriculture, Rome, Italy

Cesar FragaUniversity of Davis, USA

Oral presentation 3 - Redox Signaling in Plants and MammalsChair: Bato KoracUniversity of Belgrade, Serbia

Tilman GruneGerman Institute of Human Nutrition, Potsdam, Germany

16:0016:15 Inflammatory mediators

and atmospheric O2exacerbate antioxidantdefences in endothelialcellsThomas Keeley, Giovanni MannKing’s College London, UK

Specific irreversibletargeting of theselenoprotein thioredoxinreductase 1 in cancertherapyElias S.J. ArnérKarolinska Institutet, Sweden

The human Golgi anti-poptotic protein induces cell invasion by an H2O2- dependent mecha-nismNuno Almeida, Guia Carrara,Ana Fernandes, Maddy Parsons, Geoffrey Smith, Nuno SaraivaCBIOS, Universidade Lusófona, Lisboa, Portugal; University of Cambridge, UK; King’s College London, UK

16:1516:30 Mitochondrial Na+

import controls oxidativephosphorylation andhypoxic redox signallingPablo Hernansanz-Agustín,Elena Ramos, Tamara Villa-Piña,Elisa Navarro, Esther Parada,Laura Moreno, Alicia Izquierdo-Álvarez, Tamara Oliva, J. DanielCabrera-García, Ana Cortés, Daniel Tello, Rebeca Acín-Pérez, Izaskun Buendia, Juan Carlos Rodríguez-Aguilera, Plácido Navas, Ángel Cogolludo, Álvaro Martínez-del-Pozo, Javier Egea, Manuela G. López, Anna Bogdanova, José Antonio Enríquez, Antonio Martínez-RuizI. de Investigaciones SanitariasPrincesa, Madrid, Spain; F. Medicina,Univ. Autónoma de Madrid and I. deInvestigaciones Biomédicas AlbertoSols, Madrid, Spain; F. Medicina,Univ. Autónoma de Madrid, I. deInvestigaciones Sanitarias Princesa,Madrid, Spain; Univ. Complutensede Madrid, Spain; Centro deInvestigación Biomédica en Red deEnfermedades Respiratorias, Spain;Univ. Pablo de Olavide-CSIC, Sevilla,Spain; Centro de InvestigaciónBiomédica en Red de EnfermedadesRaras, Spain; I. de InvestigacionesSanitarias Princesa, Madrid, Spain;Centro Nacional de InvestigacionesCardiovasculares Carlos III, Madrid,Spain; Centro de InvestigaciónBiomédica en Red de Fragilidad yEnvejecimiento Saludable, Spain;Univ. Complutense de Madrid, Spain;Univ. of Zurich, Switzerland; Centrode Investigación Biomédica en Redde Enfermedades Cardiovasculares,Spain

Lipid peroxidation andGPx4: the players of theoxygen paradoxFulvio Ursini, Valentina Bosello-Travain, Giorgio Cozza, MariaLuisa Di Paolo, Giovanni Miotto,Monica Rossetto, AntonellaRoveri, Stefano Toppo, RinaVenerando, Ana-Marija VučkovićMattia Zaccarin, MatildeMaiorinoDepartment of MolecularMedicine, University of Padova,Italy

Redox signaling in plantsJoris MessensVIB-VUB Center for StructuralBiology, VIB, Brussels, Belgium;Brussels Center for Redox Biology, Brussels, Belgium; Vrije Universiteit Brussel, Brussels, Belgium

16:3016:45 Regulation of UCP3

expression and function inresponse to hypoxia andoxidative stress in mousecardiomyocytesPatricia Sánchez-Pérez, EliaLópez-Bernardo, AndreaAnedda, Susana CadenasCentro de Biología Molecular“Severo Ochoa” , Madrid, Spain;Instituto de InvestigaciónSanitaria Princesa, Madrid, Spain

Thioredoxin-relatedprotein of 14 kDa maydirectly reduce proteincysteinylation motifsPablo Martí-Andrés, Isabela Finamor, Belén Espinosa, Salvador Pérez, Sergio Rius-Pérez, Raquel Taléns-Visconti, Rafel León, Antonio Martínez-Ruiz, Elias S.J. Arnér, Juan SastreUniversity of Valencia, Burjassot,Spain; Federal University of SantaMaria, Rio Grande do Sul, Brazil;Karolinska Institutet, Stockholm,Sweden; Instituto Teólfilo Hernando, Instituto de Investigación Sanitaria Princesa, Madrid, Spain

Redox responses todenervation in skeletalmuscleMattia Scalabrin, NataliePollock, Anne McArdle,Malcolm J. Jackson,Aphrodite VasilakiUniversity of Liverpool, U.K.

16:45 17:00 Human mercaptalbumin

and nuclear factor kappaB in subjects with mildlyimpaired renal, vascularand metabolic healthcompared to “super-healthy”subjects: the BIOCLAIMS Integration studyBrigitte M. Winklhofer-Roob,Gernot Faustmann, Karl Öttl,Hildegard Hafner-Giessauf,Johanna Grabher, PetraKieslinger, Matteo C. Sattler,Barbara Obermayer-Pietsch,Beate Tiran, Johannes M. RoobUniversity of Graz, Austria

Bicarbonate is requiredfor hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxinMarkus Dagnell, Qing Cheng, Paul E. Pace, Mark B. Hampton, Christine C. Winterbourn, Elias S.J. ArnérKarolinska Institutet,Stockholm, Sweden; Universityof Otago, Christchurch, NewZealand

Peroxidase, holdaseand signaling functionsof Trypanosomacruzi mitochondrialperoxirredoxinGabriela Specker, DamiánEstrada, Carolina Prolo, MaríaNoel Alvarez, Rafael Radi, Lucía PiacenzaUniversidad de la Repúblicaand Center for Free RadicalBiology and Medicine (CEIN-BIO), Montevideo-Uruguay

17:00 17:15 Mechanosensitive miR-320a

and miR-21-3p regulate Bach1 expression in endothelial cellsPhoebe Kitscha, Giovanni E Mann, Richard C SiowFaculty of Life Sciences andMedicine, King’s College LondonUK

Silencing Bach1 mRNA alters the age-related changes in Nrf2-dependent gene regulation in primary human bronchial epithelial cellsHenry Jay Forman, Jiuqi Zhang, Hongqiao ZhangLeonard Davis School of Gerontology, University of Southern California Los Angeles, USA

Oxidation of disulfidebonds: a novel pathway toprotein glutathionylationLuke Carroll, ShuwenJiang, Kasper Engholm-Keller, Adelina Rogowska-Wrzesinska, Michael DaviesUniversity of Copenhagen,Denmark; University ofSouthern, Denmark

17:15 17:30 Kinetic and stoichiometric

constraints determine the pathway of H2O2 consumption by red blood cellsFlorencia Orrico, Matías N. Möller, Adriana Cassina, Ana Denicola, Leonor ThomsonUniversidad de la República, Montevideo, Uruguay

Targeting mitochondria by TrxR2 inhibitionMaria Pia Rigobello, Valeria Scalcon, Federica Tonolo, Alessandra Folda, Anne Vessières, Michèle Salmain, Alberto BindoliUniversità di Padova, Italy; Sorbonne Université, Paris, France; Dipartimento di Scienze Biomediche, Padova, Italy

Glutathione S-transferase P influences the Nrf2-de-pendent control of cellular glutathione metabolismBartolini Desirée, Giustarini Daniela, Pietrella Donatel-la, Marinelli Rita, Torquato Pierangelo, Rossi Ranieri, Galli FrancescoUniversity of Perugia, Italy; University of Siena, Italy

17:30 19:30 Poster Viewing, Refreshments and Commercial Exhibits

Wednesday, 6 June 2018

Auditorium I Auditorium III+IV Pavilion 508:30 10:30 Symposium VII - Nitric

Oxide BiochemistryChair: Thomas MichelHarvard Medical School, Boston,USA

Santiago LamasCentro de Biología Molecular“Severo Ochoa”, Spain

Symposium VIII - ReactiveOxygen Species andMusculoskeletal AgeingChair: Malcolm J. JacksonInstitute Ageing & ChronicDisease, University of Liverpool,UK

Anne McArdleInstitute Ageing & ChronicDisease, University of Liverpool,UK

Symposium IX - A Systems-Oriented Perspective onKey Processes in RedoxStress and RegulationChair: Fernando AntunesUniversidade de Lisboa, Portugal

Armindo SalvadorUniversidade de Coimbra,Portugal

08:30 09:00 Soluble guanylate cyclase

activation by nitric oxideMichael A. MarlettaUniversity of California Berkeley,USA

NADPH oxidase Nox4 inosteoporosisKatrin SchröderGoethe-University Frankfurt,Germany

Superoxide radical-nitricoxide interplay and thefate of peroxynitrite inbiological systemsRafael RadiUniversidad de la República,Montevideo, Uruguay

09:00 09:30 Nitroso-oxidative stress

and cardiovasculardiseaseJoseph LoscalzoHarvard Medical School, Boston,USA

Aberrant redox signalingin age-related muscledeclineAnne McArdleUniversity of Liverpool, UK

Quantitative analysisof cytosolic andmitochondrial H2O2metabolism and toxicityin human epithelial cellsHadley D. SikesMassachusetts Institute ofTechnology, Cambridge, USA

09:30 10:00 Nitric oxide synthases,

oxidant stress and cardiacremodelingJean-Luc BalligandUniversité Catholique deLouvain, Brussels, Belgium

Modelling of the role of re-dox-related mechanisms in decline of musculoskeletal systemAlvaro Martinez GuimeraUniversity of Newcastle, UK

Identification andquantification of proteindamage induced byinflammatory oxidantsMichael J. DaviesUniversity of Copenhagen,Denmark

10:00 10:30 Regulation of nitric oxide

synthases by intracellular oxidantsThomas MichelHarvard Medical School, Boston, USA

Ultra-long-distancerunning and the liver. Interna-tional journal of sports medi-cineZsolt RadakUniversity of Physical Education,Budapest, Hungary

Environmental stressors and cardiovascular risk: Im-pact of environmental noise exposure on vascular oxida-tive stress and damage Andreas DaiberUniversity Medical Center at the Johannes Gutenberg University Mainz, Germany

10:30 11:00 Poster Viewing, Coffee Break and Commercial Exhibits

Auditorium I11:00 11:40 SFRRE Basic Science Award Lecture

Sponsored by: Chairs:Juan SastreUniversity of Valencia, Spain

Brigitte Winklhofer-RoobUniversity of Graz, Austria

Exploring mitochondrial free radical production in health and diseaseMike MurphyMRC Mitochondrial Biology Unit, University of Cambridge, UK

11:40 12:20 SFRRE Clinical Science Award Lecture

Sponsored by:

Chairs:Aphrodite VasilakiUniversity of Liverpool, UK

Antonio Martínez RuizHospital de la Princesa, Madrid, Spain

Taking oxidative stress from the bench to the bedside, exemplified by RNA oxidationHenrik Enghusen PoulsenUniversity of Copenhagen, Denmark

12:20 13:30 Lunch, Poster Viewing, Commercial Exhibits

Auditorium I Auditorium III+IV Pavilion 513:30 15:30 Symposium X - Caloric

Restriction and Mimetics asInterventions in AgingSponsored by:

Chairs:José ViñaUniversity of Valencia, Spain

Mari Carmen Gómez-CabreraUniversity of Valencia, Spain

Symposium XI - SPBSymposium – MolecularMechanisms of DiseaseSponsored by:

Chairs:João LaranjinhaUniversity of Coimbra, Portugal

Leonor CancelaUniversity of Algarve, Portugal

Symposium XII - Advancesin MitochondrialPhysiology and MedicineSponsored by:

Chairs:Danica ChenUniversity of California Berkeley,USA

Lester PackerUniversity of Southern California,Los Angeles, USA

13:30 14:00 A novel nutrient blend

mimics calorie restrictiontranscriptomics inmultiple tissues of miceand increases vitality andlifespan in C. elegansAngela MastaloudisNu Skin Enterprises, Provo, UT,USA

Brain redox bioenergeticsare determined byOXPHOS organization inneurons and astrocytesJuan Pedro BolañosUniversity of Salamanca, Spain

Mitochondria andhematopoietic stem cellMaegan CapitanoIndiana University School ofMedicine, Indianapolis, USA

14:00 14:30 Malnutrition vs calorie

restriction: The effectson maternal nutrientreduction in cardiac fetalmitochondrial functionPaulo J. OliveiraCNC, University of Coimbra,Portugal

Molecular mechanismsregulating gliahomeostasisJoão B. RelvasUniversidade do Porto, Portugal

The mitochondrialmetabolic checkpoint,stem cell aging andrejuvenationDanica ChenUniversity of CaliforniaBerkeley, USA

14:30 15:00 Exercise as a calorie

restriction mimetic.Implications for thetreatment of ageassociated frailtyMari Carmen Gómez-CabreraUniversity of Valencia, CIBERFES,INCLIVA, Valencia, Spain

SIRT3, a modifier ofmitochondrial function inHuntington’s diseaseA. Cristina RegoUniversity of Coimbra, Portugal

Keeping mitochondriain shape: a matter of lifeand deathLuca ScorranoUniversity of Padua, Italy

15:00 15:30 The SPRINTT project:

tackling physical frailtyand sarcopenia to preventdisability in the elderlyEmanuele MarzettiCatholic University of the SacredHeart, Rome, Italy

Molecules and mechanisms inmaladaptative stressNuno SousaUniversidade do Minho, Braga,Portugal

Mitochondria in kidneydisease and recoveryRick G. SchnellmannUniversity of Arizona College ofMedicine, Tucson, USA

15:30 16:00 Coffee break

Auditorium I Auditorium III+IV Pavilion 516:00 17:30 Oral presentation 4 - Brain

Redox Biology, Metabolism,and CognitionChairs: Catarina OliveiraCenter for Neuroscience and CellBiology, University of Coimbra,Portugal

Rui BarbosaUniversity of Coimbra, Portugal

Oral presentation 5 - RedoxSignaling in Health andDiseaseChairs: Paul WittingUniversity of Sydney, Australia

Yuji NaitoKyoto Prefectural University of Medicine, Japan

Oral presentation 6 - RedoxStress in CancerChairs: Regina Brigelius-FlohéUniversity of Potsdam, Germany

Lin MantellSt. John’s University College of Pharmacy, NY, USA

16:00 16:15 BDNF differentially

activates Nrf2 in astrocytesand neuronsTetsuro Ishii, Eiji Warabi,Giovanni E MannUniversity of Tsukuba, Ibaraki,Japan; Faculty of Life Sciences andMedicine, King’s College London,U.K.

Nitric oxide mediated neurovascular coupling is maintained under hypoxia through asorbate-dependent nitrite reduction to NO: An in vivo study in the hippocampusNuno R. Ferreira, Cátia F.Lourenço, Rui M. Barbosa, JoãoLaranjinhaUniversity of Coimbra, Portugal

The role of necroptosisin non-alcoholic fattyliver disease-relatedcarcinogenesisMarta B. Afonso, Pedro M.Rodrigues, André L. Simão,André A. Santos, Maria M.Gaspar, Rui E. Castro, Cecília M.P. RodriguesUniversidade de Lisboa, Portugal

16:15 16:30 The dys-regulation of

anti-oxidant defense viaan impairment of Nrf2response in the pathologyof Friedreich’s ataxiaShannon Chiang, Amy Anzovino,Bronwyn E. Brown, Clare L.Hawkins, Des R. Richardson,Michael L.-H. HuangUniversity of Sydney, Australia;Heart Research Institute,Newtown, Australia; University ofCopenhagen, Denmark

NOX2 is a major ROSsource in exercising muscleregulating glucose uptakeCarlos Henríquez-Olguin, JonasR. Knudsen, Steen H. Raun,Zhencheng Li, Lykke Sylow, ErikA. Richter, Enrique Jaimovich,Thomas E. JensenUniversity of Copenhagen,Denmark

Cellular metalsequestration andredox stress bythiosemicarbazonesinduces endoplasmicreticulum stress in tumorsto suppress cancerprogressionAngelica Merlot, Nurul Shafie,Elizabeth Lim, Amanda Chen,Sumit Sahni, Yu Yu, DesRichardsonUniversity of Sydney, NSW,Australia

16:30 16:45 Intranasal rapamycin

protects against cognitivedecline in a mouse model ofDown syndromeFabio Di Domenico, AntonellaTramutola, Chiara Lanzillotta,Ilaria Zuliani, Andrea Arena,Eugenio Barone, Marzia PerluigiSapienza University of Rome, Italy

ROS regulatedevelopmental andpathological denervation invivoEva Sidlauskaite, Ian L. Megson,Phil D. Whiteld, Ines Batinic-Haberle, Michael P. Murphy,James N. Cobley, Peter R. MoultAbertay University, Dundee,UK; University of Highlandsand Islands, Inverness, UK; DukeUniversity, Durham, USA;University of Cambridge, UK

Myoglobin inducesmitochondrial fusionto inhibit cancer cellproliferation and tumorgrowthAndrea Braganza, KellyQuesnelle, Lisa Arnotti,Shivendra Singh, Sruti ShivaUniversity of Pittsburgh School ofMedicine, USA

16:45 17:00 Amyloid-β peptide

irreversibly blocks mitochondrial biogenesis and dynamics ofself-renewing neural stem cells compromising neurogenesisMaria Filipe Ribeiro, TâniaGenebra, Cecília Rodrigues,Susana SoláUniversidade de Lisboa, Portugal

Alpha-synuclein inducesferroptosis throughgeneration of lipidperoxidation and calciumderegulationPlamena R. Angelova, Minee-Liane Choi, Mathew H. Horrocks, David Klenerman, Sonia Gandhi, Andrey Y. AbramovUCL Institute of Neurology, London, UK

A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipidsMarie-Sophie Narzt, Ionela-Mariana Nagelreiter, Olga Oskolkova, Valery Bochkov, Julie Latreille, Maria Fedorova, Zhixu Ni, Fernando J. Sialana, Gert Lubec, Manuel Filzwieser, Maria Laggner, Martin Bilban, Michael Mildner, Erwin Tschachler, Johannes Grillari, Florian GruberMedical University of Vienna; BOKU University; University of Graz; University of Vienna; Paracelsus University

17:00 17:15 SIRT3 overexpression

in neurons enablesβ-oxidation and preventspalmitate-induced insulinresistanceEugenia Alfine, Kristina Wardelmann, André KleinriddersGerman Institute of Human Nutrition, Potsdam-Rehbrücke, Germany; German Center for Diabetes Research, Neuherberg, Germany

NADPH oxidase is a target for (-)-epicatechin in the prevention of fatty acid-induced insulin resistanceEleonora Cremonini, Patricia I OteizaUniversity of California Davis, USA

Nitroxide radical-containing nanoparticles impairs the tumorigenic potential of triple negative breast cancerBabita Shashni, Yukio Nagasaki University of Tsukuba, Ibaraki, Japan

17:15 17:30 Age-dependent changes of

neurovascular coupling and brain metabolism in Fischer 344 ratsCátia F. Lourenço, Ana Ledo, Miguel Caetano, Rui M. Barbosa, João LaranjinhaUniversity of Coimbra, Portugal

oxSWATH: an integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screeningSandra I. Anjo, Matilde N. Melo, Liliana R. Loureiro, Lúcia Sabala, Pedro Castanheira, Mário Grãos, Bruno ManadasUniversity of Coimbra, Portugal; University of Aveiro, Portugal; Biotechnology Transfer Association, Cantanhede, Portugal

TGF-β1-induced epithelial-to-mesenchymal transition depends on mitochondrial dysfunction and biogenesis impairment in lung cancer cellsJiaxin Zhang, Wei Zhang, QingbiaoZhou, Deqin Kong, Hai Chun-xu, Rui Liu Medical University of the Air Force, Changchun, P.R. China

17:30 19:30 Poster Viewing, Refreshments and Commercial Exhibits

20:30Gala Dinner (venue: Estufa Fria)

Thursday, 7 June 2018

Auditorium I Auditorium III+IV Pavilion 508:30 10:30 Symposium XIII - Redox

Biology Based Preventionand Treatment of Cancerin the Era of PrecisionMedicineChairs:Shinya ToyokuniNagoya University GraduateSchool of Medicine, Japan

Young-Joon SurhSeoul National University,South Korea

Symposium XIV - Autophagy in Pathophysiology (GEIRLI Symposium)

Chairs:Jordi MuntanéInstitute of Biomedicine ofSeville, Spain

Victor Manuel VictorUniversidad de Valencia, Spain

Symposium XV - Regulation of Hydrogen Sulfide Signalling in MammalsChairs:Elias ArnérKarolinska Institutet, Stockholm,Sweden

Péter NagyNational Institute of Oncology,Budapest, Hungary

08:30 09:00 Bright and dark sides of

KEAP1-NRF2 system incarcinogenesisHozumi MotohashiTohoku University, Sendai,Japan

Autophagy and its link tothe endoplasmic reticulumVeit GoderDepartment of Genetics,University of Seville, Spain

Metabolic reprogramming by hydrogen sulfideRuma BanerjeeUniversity of Michigan, Ann Arbor, USA

09:00 09:30 A radical drug

mechanism to inhibittumor growth,metastasis, andresistance: targetinglysosomal P-glycoproteinD. R. RichardsonUniversity of Sydney, NSW,Australia

Free radicals at thecrossroads of autophagyand immunityJennifer MartinezNIEHS, Research Triangle Park,NC, USA

Cysteinyl-tRNA synthetase(CARS) controls endogenous hydropersulfide production and mitochondrial respirationTakaaki AkaikeTohoku University Graduate School of Medicine, Sendai, Japan

09:30 10:00 Differential roles for

the redox sensitivetranscription factor Nrf2in carcinogenesisYoung-Joon SurhSeoul National University,South Korea

Autophagy deficient miceas a model for studyingstress-induced autophagyin vivoGuillermo MariñoUniversity of Oviedo/Principalityof Asturias Sanitary ResearchInstitute (ISPA), Spain

Dynamic redox cyclingof hydrogen sulfide andpolysulfide species couldrepresent an importantregulatory element in sulfurbiologyPéter NagyNational Institute of Oncology,Budapest, Hungary

10:00 10:30 Ferroptosis in

carcinogenesis and tumor biologyShinya ToyokuniNagoya University Graduate School of Medicine, Japan

The role of autophagy andcancerGuillermo VelascoComplutense University andInstituto de InvestigacionesSanitarias San Carlos, Madrid,Spain

TrxR1- and Gsr-double-null mouse livers reveal un-expected mechanisms of redox homeostasis, oxida-tive damage defense, and long-term survivalEdward E. Schmidt Montana State University, USA

Auditorium I10:30 11:30 Forum discussion/debate: Science and Society

Chairs:João LaranjinhaUniversity of Coimbra, Portugal

Enrique CadenasUniversity of Southern California, Los Angeles, USA

Knowledge and dialogue to deal with uncertaintyAlexandre QuintanilhaUniversity of Porto, Portugal

11:30 12:00 Coffee Break

Auditorium I Auditorium III+IV Pavilion 512:00 14:00 Symposium XVI - Defence

and Adaptation – The Critical Role of Reactive Oxygen SpeciesSponsored by:

Chairs:Helen GriffithsUniversity of Surrey, UK

Corinne SpickettAston University, UK

Symposium XVII - SPB Symposium – Molecular structure and FunctionSponsored by:

Chairs:Graça SoveralUniversity of Lisbon, Portugal

Cláudio SoaresNova University of Lisbon, Portugal

Oral presentation 7 - Nitrite,Peroxynitrite, and OxidizedLipidsChairs:Richard SiowKing’s College London, UK

Bertrand FriguetPierre and Marie Curie University, Paris 6, France

12:00 12:30 NOX2-derived ROS in

myeloid cell differentiation:Implications in cancer

Anna MartnerUniversity of Gothenburg,Sweden

CO2 toxicity: Role forredox reactions?

Ohara AugustoUniversidade de São Paulo, Brazil

12:00 - 12:15

Effect of short-chainaldehydes on the enzymaticactivity of pyruvate kinaseBebiana C. Sousa, Jed Ashman,Corinne M. Spickett, Andrew R.PittAston University, Aston Triangle,Birmingham, UK

12:15 - 12:30

Analytical strategies for theidentification of oxidizedlipids from adipose tissueMike Lange, Zhixu Ni,GeorgiaAngelidou, Maria FedorovaUniversität Leipzig, Germany

12:30 13:00 NOX2 NADPH oxidase

controls responses to infection and sterile inflammation

Mary C. DinauerWashington University in StLouis School of Medicine, USA

Structural insights on aldehyde oxidase and xanthine oxidoreductaseand their roles in xenobiotic metabolism

Maria João RomãoNOVA University of Lisbon,Portugal

12:30 - 12:45

Generation of biliverdinreductase-a gene knockoutmice to study the in vivoactivities of bilirubinWeiyu Chen, Ghassan Maghzal,Anita Ayer, Cacang Suarna,Louise Dunn, Roland StockerVictor Chang Cardiac ResearchInstitute, Sydney, Australia;University of New South Wales,Sydney

12:45 - 13:00

Dietary nitrate modulatesgut microbiota profile andprevents the activationof mucosal inflammatorypathways induced by broad-spectrum antibioticsBárbara S. Rocha, AnabelaPereira, Gabriela J. Da Silva, João LaranjinhaUniversity of Coimbra, Portugal

13:00 13:30 Reactive oxygen species

ameliorate the clinicalcourse of murine lupus

Markus HoffmannFriedrich-Alexander- University Erlangen- Nuremberg, UK Erlangen

The diversity of linksbetween the functionaland structural features ofcarboxylate transportersin prokaryotic andeukaryotic cells:Implications in healthand biotechnology

Margarida CasalUniversity of Minho, Braga,Portugal

13:00 - 13:15

Role for neutrophil-derivedmyeloperoxidase in promoting acute colitis; inhibition of disease progression with 4-Methoxy TEMPOBelal Chami, Abigail Vallejo,Stephen KumJew, Nina Dicker-hof, Anthony J. Kettle, Joanne M. Dennis, Paul WittingThe University of Sydney, Austra-lia; University of Otago Christ-church, New Zealand

13:15 - 13:30

A1M-035, an improved human recombinant alpha-1-microglobulin, has therapeutic effects in rhabdomyolysis-induced acute kidney injuryBo Åkerström, Lena Rosenlöf,Anneli Hägerwall, SigurbjörgRutardottir, Jonas Ahlstedt, Maria E Johansson, Lena Erlandsson, Maria Allhorn, Magnus GramLund University, Sweden

13:30 14:00 Oxidative Stress,

‘NObonomics’, sulfur chemistry and the ‘Reactive Species Interactome’ – Lessons from a journey in adaptation to stress

Martin FeelischFaculty of Medicine, University of Southampton, UK

Hidden functions in the capsid protein of Dengue virus: biological relevance and drug development opportunities

Miguel CastanhoUniversity of Lisbon, Portugal

13:30 - 13:45

Declining renal functionand thresholds of estimatedglomerular filtration rate:impact on biomarkersof oxidative stress in theBIOCLAIMS cohortJohannes M. Roob, Gernot Faustmann, Hildegard Hafner-Giessauf, Karl Öttl, WillibaldWonisch , Matteo C. Sattler,Johanna Grabher, Petra Kieslinger, Hans-Jürgen Gruber, Beate Tiran, Brigitte M. Winklhofer-RoobMedical University of Graz, Austria; Karl-Franzens University of Graz, Austria

13:45 - 14:00

Insights into the mechanisms of peroxynitrite-mediated inactivation of human glutamine synthetaseSilvina Bartesaghi, NicolásCampolo, Mauricio Mastrogiovanni, Federico Issoglio, Ari Zeida, Christiane Ott, Tilman Grune, Darío Estrín, Rafael RadiUniversidad de la República,Uruguay; Universidad de BuenosAires, Argentina; German Institute of Human Nutrition, Germany

14:00 14:30 Closing Ceremony