Magnitude of the problemEpilepsy afects:approximately 1 in 50 children and 1 in 100 adults.PHARMACOTHERAPY OF EPILEPSY The i!!ue!Is treatment justifed?When to start treatment?o! to start dru" treatment?Which #E$? Which dosa"e?When should #E$ com%inations %e used?&is's associated #E$ treatment?o! lon" should treatment %e continued?PHARMACOTHERAPY OF EPILEPSY The i!!ue!Is treatment justifed?When to start treatment?o! to start dru" treatment? Which #E$?Which dosa"e?When should #E$ com%inations %e used?o! lon" should treatment %e continued?1()0 1(*0 1((0 1+00 1+,0 1+)0 1+*0 1+(0 ,000051015,0-romide.heno%ar%ital.henytoin.rimidoneEthosuximide/odium 0alproate-en1odia1epines2ar%ama1epine3i"a%atrin4onisamide5amotri"ine6el%amate7a%apentin8opiramate6osphenytoin9xcar%a1epine8ia"a%ine5e0etiracetam:ore;ear#E$s Antiepilepti" drug Antiepilepti" drug de#elopmentde#elopmentMa$or "on!ideration! in "hoo!ing an AE%8ype o< sei1ure8ype o< epileptic syndrome#d0erse efect profle#"e = "enderEase o< use > ,(P 0ersus *P?:ode o< action: un'no!nEDcacy = tolera%ility data are limitedEmerging ne) AE%S Eslicar6a9epine acetate. # 0olta"e@"ated sodium channel action %loc'erEa prodru" that is structurally similar to car%ama1epine and oxcar%a1epine. It has impro0ed tolera%ilityE&esponder rate )1P 0ersus ,(P9nce daily dosin" is enou"hEmerging ne) AE%S Lacosamide. #ppro0ed %y 6$##djuncti0e therapy ,H F 1enign rolandic epilepsy - /H %&'(N')*) '+ E%*,E%)- G&&D *R&G0&($( $0; +. #e6rile sei9ure >. 1enign rolandic epilepsy .. "6sence sei9ures J. $diopathic gen. tonic clonic sei9ure2 /it onset bet/een 1 7 18 yrs9%&'(N')*) '+ E%*,E%)- *&&R *R&G0&($( $0; +. 'omple: partial sei9ure >. (ymptomatic partial epilepsy .. "ll forms of minor motor sei9ures J. Generalised tonic clonic sei9ures : ;it onset in infancy or p!berty9!han" #ou