malaria medicines and diagnostics
DESCRIPTION
Malaria Medicines and Diagnostics. WHO/UNICEF Technical Briefing Seminar on Essential Medicines Policies 30 October 2012, WHO Headquarters, Geneva - Salle A. A. Bosman, MD PhD Coordinator, Diagnosis Treatment and Vaccines. Malaria positivity rate in African health facilities. - PowerPoint PPT PresentationTRANSCRIPT
Malaria Medicines and Diagnostics
A. Bosman, MD PhDCoordinator, Diagnosis Treatment and Vaccines
WHO/UNICEF Technical Briefing Seminar on Essential Medicines Policies30 October 2012, WHO Headquarters, Geneva - Salle A
0
10
20
30
40
50
60
70
80
90
100
PR
(%
)
Age groups
<5y 5-15y >15y
Malaria positivity rate in African health facilities
20%27%
13%
Age groups
<5y 5-15y >15y
56%50%
31%
<year 2000 >year 2000
7686 5372 7785 2118 700 2376
D’Acremont et al, Malaria J 2010
39 studies conducted between 1986 and 2007 in 16 African countries
Interactions in malaria between medicines, diagnostics and vector control
RDT ACT
non-ACTs
Severe malaria treatment
LLIN/IRS
-
--
--
+
Product interactions more complex in private sector (order of entry, perseverance etc.)
+
Medicines for NMFI
Deployment of RDTs in Livingstone (Zambia): impact on malaria cases and ACT consumption
Source: NMCC, Zambia MoH
Reported malaria cases, Zambia Livingstone District, 2004 - 2008
0
2000
4000
6000
8000
10000
12000
14000
IRS
Introduction of RDTs
Bednet introduction
ACT
RDTs
From over 25'000 ACTs in 2007 to less than 5'000 in 2008
ACTs
The example of Senegal: ~ 0.5 million less ACT consumed in 2008-2009
World malaria report 2010
Suspected cases
Tested cases
Treated cases
Positive cases
ACT procurement with international funds
2005 2006 2007 2008 2009 2010 20110
50,000,000
100,000,000
150,000,000
200,000,000
250,000,000
300,000,000
Public sector AMFm public sector AMFm private sector
data provided by 8 companies eligible for procurement by WHO/UNICEF
RDT performance in Phase 2 of Rounds 1 – 3 against wild type (clinical) samples containing P. falciparum at low (200 parasites/μl) and
high (2000 or 5000 parasites/μl) parasite densities and clean-negative samples
Invalid RateFalse Positive
Rate
PDS at 200 parasites/μl
PDS at 2000 parasites/μl
Malaria RDT sales
Sales to public and private sectors
Sales by panel detection score (PDS)
RDT Product Testing: Rounds 1 - 4
Infographic disponible: http://www.youtube.com/watch?v=vnsoTPE_PUc&feature=youtu.be
T3 – Test. Treat. Track.Scaling up diagnostic testing, treatment and surveillance