1. MarkFx CreamNatural pathway for prevention andtreatment of stretch marks

2. Skin Anatomy and physiology Largest organ in the body Varies in thickness at different parts (< 0.5 mm at eyelids to > 5 mm on middle of upper back) 3. Anatomy Of The SkinSkin Dermis EpidermisBeneath epidermisOutermost layerThicker layerEpithelial tissueConnective tissue 4. Epidermis Stratified squamous epithelium No blood vessels In palms of hand and soles of feet, epidermis isthicker Composed of five layers:[1] Stratum corneum[2] Stratum lucidum[3] Stratum granulosum[4] Stratum spinosum[5] Stratum basale 5. Dermis True skin Highly elastic, tough and flexible tissue Meshwork of collagenous, reticular and elasticfibresCollagenous FibresProvide support for skinReticular FibresThinner, yet still provide supportElastic FibresSkin flexibility 6. Cells Of The Dermisa) Fibroblastsb) Fat cellsc) MacrophagesDermis subdivided into two main layers:{1} Upper papillary layer{2} Reticular layer 7. [1] Upper Papillary Layer- Loose connective tissue- Contain protrusions into epidermis calledPAPILLAE- Fine capillaries to carry waste away + providenourishment and oxygen- Nerve endings for heat, pain, cold, pressure andtouch (Meissners corpuscles)- Double row of papillae better gripping by handsand feet + distinctive fingerprint patterns 8. [2] Reticular Layer- Elastic network of tough collagen fibres interwoven with elastic fibres- Collagenous fibres arranged in special pattern- Incisions made parallel to these lines during surgery wound heals faster- Contains sebaceous and sweat glands, arrector pili muscle and hair follicle- Pacinian corpuscles are distributed through the dermis and function as pressure receptors- Stretch marks and pregnancy due to breaks in collagen and elastic fibres 9. HypodermisSubcutaneous layer- Thicker than dermis- Thicker in females- Ducts of sweat glands and bases of hair folliclesArea for formation and storage of fat due to:@Adipose tissue containing fat cells@Areolar tissue tissue elasticity 10. Functions Of The Skin[1] Protection- Anatomical barrier against infection- Melanin = screen out excess UV rays- When melanin is darkened by the tantransferred to outer skin layers (suntan) skinless sensitive to sunrays- Dark skin due to wider distribution of melaninbeyond stratum basale into higher levels ofepidermis 11. Thermoregulation [2] Skin temperaturePeripheral Thermoreceptors (Skin) Hypothalamic thermoregulatory integrating centre Motor neurons Sympathetic nervous system Sympathetic nervous system Skeletal muscleSkin blood vessels Sweat glandsShiveringSkin vasocontriction and vasodilation SweatingControl of heat production Control of heat loss Control of heat loss 12. [3] Sensory Perception- Millions of nerve endings- Receptor for pain, heat and pressure- Therefore, maintain homeostasis[4] Excretion- Excretion of lactic acid and sodium chloride- Urea (1 g nitrogenous waste eliminated throughskin per hour) 13. [5] Vitamin D SynthesisVitamin D precursor (in skin) Vitamin D3 (Cholecalciferol) Modification by liver and kidney enzymes Active vitamin DPromotes absorption of calcium and phosphate through intestine 14. Stretch MarksStretch marks (also known as striae distensae) arewhite, smooth, linear lesions can be foundanywhere on the body and are related tostretching of the skin. The most common sites tobe affected by stretch marks include thebreasts, buttocks, thighs and lateral abdomen.Stretch marks appear to be a type of scarring thatoccurs in the dermal layer of the skin, as a resultof an altered healing response and replacementof collagen. They are separated from the normalskin by dense collagen bundles. 15. The cause of stretch marks appears to be adecrease in elastin fibers and fibrillin in thedermal layer of the skin. This is closely related tohormonal and physical factors. Stretch marks arecommonly found to affect many people, especiallywith conditions such as Cushingssyndrome, pregnancy and prolonged use ofsteroid medications. Common predisposingcircumstances for the devlopment of stretchmarks include; those which involve a physicalstretching of the skin, such as rapid weight gainor adolescent growth spurts, and others thatinvolve hormonal changes, such as chronic 16. MarkFx Cream Pharmacological overview Ingredient Active substance ActionVitamins, minerals,plant sterols, salcylicacid, amino acids,enzymes, sugar, ligninsAloe vera helps toand more. Thedeliver oxygen moreAloe Barbadensis Leaf vitamins in aloe consist efficiently to the skinJuice of antioxidants A, C and thereby aidand E, as well assynthesis and strengththiamine, riboflavin and of the skin tissues. AloeB12, choline and folic vera enhances skinacid. Aloe consists aregeneration andvariety of minerals as prevents the stretchwell including iron, marks from appearing.chromium, zinc,copper, manganese,magnesium, sodium,potassium and calcium.It contains also 17. Ingredient Active substanceAction Squalene oil is a natural part of olive oil that is extracted. It has a very strongSqualane OilSqualane regenerative property when you use it on the skin. It protects and stimulates the surface of the skin. As you probably understand this ingredient is one of the most important since it aids in the healing of the scars. 18. IngredientActive substanceActionFlavonoids,ascorbic Grapefruit seeds helpacid (commonly knownto promote the skinas vitamin C),health and the elastinCitrus Grandistocopherols, citric acid, production, which(Grapefruit) Seed limonoids,sterols, andstrengthens the skin.Extract minerals. So not only does thiscompound improve thecondition of yourstretching skin, afterthe delivery it will alsoaid in the contraction ofyour skin to its previousappearance. 19. IngredientActive substance ActionPolyphenols whichclassified as catechins.Camellia Sinensis Green tea contains six Polyphenols are very(Green Tea) Leafprimary catechin potent anti-oxidantsExtract compounds: catechin, and likely to slow downgallaogatechin,the development ofepicatechin, some signs of skinepigallocatechin,aging and reducing theepicatechin gallate, and appearance of stretchapigallocatechin marks.gallate. Green tea alsocontains alkaloidsincluding caffeine,theobromine, andtheophylline 20. IngredientActive substanceAction Centella Asiatica contains actives knownCentella asiatica Glycosides:to assist theExtract indocentelloside,development andbrahmoside,metabolism of thebrahminoside,connective tissue andasiaticoside,stimulate collagenthankuniside and production. Alsoisothankuniside. has anti-oxidant properties and can increase wound healing, improve skin tone and smoothness. 21. IngredientActive substance ActionTocopherols as a Calendula significantlyCalendula Officinalis healing agent. lower tissue damageFlower ExtractFlavonoids, sterols ,marker enzymes-Triterpenoids (oleanolic alkaline phosphatase,acid) as anti- alanine and aspartateinflammatory.transaminases . 22. IngredientActive substanceActionVitamin A palmitate Vitamin AVitamin A promotes repair and maintenance of the skin 23. Ingredient Active substance ActionIt is known as powerfulantioxidant and anessential ingredientsTocopherol (Vitamin E) Vitamin Efor skin regeneration.Topical use of VitaminE over a certain periodof time can show alessening of wrinklesand lines, and it helpsto reduce theappearance of stretchmarks. 24. MarkFx Cream Why?! MarkFx Cream increase the syntheses andregeneration of the skin tissues. MarkFx Cream Promote collagen and elastinproduction and strengthens the skin. MarkFx Cream formula has a potent anti-oxidantsubstances. MarkFx Cream Diminishes discoloration, improvestexture, enhances softness and reduces theappearance of stretch marks.MarkFx Cream is a natural clinically approved formulafor preventing and treating stretch marks.MarkFx Cream is patented and well-studied formula.MarkFx Cream is completely safe and cost effectiveproduct. 25. Great ThanksFromKena Roots for therapeutic cosmetics Amman Jordanwww.kenaroots.webs.com