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MARS SMALL BORE SCANNER MARS SMALL BORE SCANNER MARS Bioimaging Ltd www.marsbioimaging.com X-ray imaging at histology levels Measures the concentration of materials (lipid, water, Au, Gd, Ca, I) in mg/mL Rapid imaging. 30mm diameter by 30mm length in 15 minutes Human-translatable: imaging parameters enable direct translation to human research Intuitive user interface with one click “scan-to-recon” operation Advanced image visualisation and analysis tools

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Page 1: MARS SMALL BORE SCANNERSMALL BORE SCANNER€¦ · MARS SMALL BORE SCANNERSMALL BORE SCANNER MARS Bioimaging Ltd X-ray imaging at histology levels Measures the concentration of materials

MARS SMALL BORE SCANNER MARS SMALL BORE SCANNER

MARS Bioimaging Ltdwww.marsbioimaging.com

● X-ray imaging at histology levels

● Measures the concentration of materials (lipid, water, Au, Gd, Ca, I) in mg/mL

● Rapid imaging. 30mm diameter by 30mm length in 15 minutes

● Human-translatable: imaging parameters enable direct translation to human research

● Intuitive user interface with one click “scan-to-recon” operation

● Advanced image visualisation and analysis tools

Page 2: MARS SMALL BORE SCANNERSMALL BORE SCANNER€¦ · MARS SMALL BORE SCANNERSMALL BORE SCANNER MARS Bioimaging Ltd X-ray imaging at histology levels Measures the concentration of materials

MARS imageGrey scale CT image

Material quantificationMaterial quantification

Page 3: MARS SMALL BORE SCANNERSMALL BORE SCANNER€¦ · MARS SMALL BORE SCANNERSMALL BORE SCANNER MARS Bioimaging Ltd X-ray imaging at histology levels Measures the concentration of materials

Clinical applicationsClinical applications

Cancer imaging

Better characterisation and better drug delivery

The technology opens the door to targeted imaging probes on CT

Gold-nano probes within a murine model of lung cancer, with a 2D magic lens used to enhance the view of the region of interest

Cartilage imaging

Measure glycosoaminoglycanchanges in osteoarthritis

Using routine x-ray contrast agents the gradientof biochemical changes can be quantified

goldiodinegadoliniumcalciumwater

Multiple targeted agents

Many agents have their own spectral signatures

The MARS system can measuremultiple targeting agents simultaneosly

Page 4: MARS SMALL BORE SCANNERSMALL BORE SCANNER€¦ · MARS SMALL BORE SCANNERSMALL BORE SCANNER MARS Bioimaging Ltd X-ray imaging at histology levels Measures the concentration of materials

Multiple targeted agents

Many agents have their own spectral signatures

The MARS system can measuremultiple targeting agents simultaneosly

Clinical applicationsClinical applications

Water Calcium Lipid Combined

Spectral imaging of atherosclerosis

Histological scale imaging of the components of a plaque, including its lipid-rich coreand micro-calcifications Reducing metal artifacts in bone

Streak and beam hardening artifacts caused by metal can be removed

This enables clear visualisationof the bone-metal interface

Page 5: MARS SMALL BORE SCANNERSMALL BORE SCANNER€¦ · MARS SMALL BORE SCANNERSMALL BORE SCANNER MARS Bioimaging Ltd X-ray imaging at histology levels Measures the concentration of materials

● Spectral range: 15-120 keV

● Sample bed ready for gas lines, monitoring inputs

and temperature sensors

● Variable source and detector distances giving variable magnification

● Molecular image visualisation and analysis software

● MARS Vision workstation with HP zVR 3D

interactive virtual reality system

● Radiation dose similar to conventional CT (20-80 mGy)

● LED illumination of the sample. HD webcam

for real-time sample monitoring

● Fully x-ray shielded cabinet on industrial,

locking caster wheels

● Reconstruction, processing and PACS server

rack-mounted inside scanner

● Data acquired and stored in a standard medical format (DICOM)

● Adjustable filters, and x, y automatic tracking collimators

● Small footprint - fits through most doorways: 75 x 140 x 117 cm, 450 kg

MARS scanner speci�cations

Rensselaer Polytechnic Institute

Troy, New York, USA

University of Notre Dame

South Bend, Indiana, USA

University of Otago

Christchurch, New Zealand

University of Canterbury

Christchurch, New Zealand

MARS Bioimaging [email protected]

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