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The Cleveland Clinic Foundation 9500 Euclid Avenue, TR204 Cleveland, OH 44195 NON-PROFIT ORG. U.S. POSTAGE PAID CLEVELAND OH PERMIT NO. 1918 Mastering the Management of Aortic Valve Disease: Im- aging, Intervention and Inno- vation December 3-4, 2021 JW Marriott Essex House, New York, NY Register to attend in person in NYC or live stream www.ccfcme.org/aorticvalve21 Mastering the Management of Aortic Valve Disease: Imaging, Intervention and Innovation December 3-4, 2021 Course Description The management of patients with aortic valve disease is constantly evolving, highlighted by innovations in devices, surgical techniques, and imaging. In addition, guidelines, research studies and clinical trials are continually expanding the evidence base related to both management decisions and treatment outcomes from valve interventions, both transcatheter and surgical-implanted devices. These developments, in turn, have altered the clinical practice framework for approaching aortic valve disease quantification and treatments, resulting in some confusion regarding the optimal management strategies. This program is designed to bring together cardiologists, surgeons, and other healthcare providers to address the contemporary and future management of aortic valve disease and better define the role of transcatheter and surgical therapies. The course will emphasize case-based learning designed to engage learners in discussions, debates, and critical decision-making for this condition. Learning Objectives After participating in this educational activity, practitioners will be able to do the following: Describe the best practices for the management of patients with aortic valve disease. Discuss the role of basic and advanced imaging techniques to assess patients with aortic valve disease. Accurately assess options for treating difficult scenarios associated with aortic valve disease including transcatheter valve failure, minimally invasive valve replacement, and evaluation of surgical risks in shared decision making. Discuss the pros and cons associated with transcatheter aortic valve replacement (TAVR) in various patient populations and review the management of potential complications. Summarize the emerging innovations in technologies for TAVR along with results in clinical trials and describe their potential implications for clinical practice. Target Audience This course is intended for cardiothoracic surgeons, cardiologists, interventional cardiologists, internists, nurses, physician assistants and all health care professionals involved in the evaluation, diagnosis and/or management of patients with aortic valve disease. Course Directors Lars G. Svensson, MD, PhD Chairman, Heart, Vascular & Thoracic Institute Cleveland Clinic Katherine Hoercher, RN Senior Director, Heart, Vascular & Thoracic Institute Cleveland Clinic Guest Faculty Robert O. Bonow, MD Northwestern University Feinberg School of Medicine Susheel Kumar Kodali, MD NewYork-Presbyterian/Columbia University Medical Center Patrick T. O’Gara, MD Brigham & Women’s Hospital Cleveland Clinic Heart, Vascular & Thoracic Institute Faculty Eugene Blackstone, MD Section Head, Clinical Investigations Department of Thoracic and Cardiovascular Surgery Milind Desai, MD, MBA Director, Clinical Operations Department of Cardiovascular Medicine Brian Griffin, MD Section Head, Cardiovascular Imaging Department of Cardiovascular Medicine Wael Jaber, MD Section of Cardiovascular Imaging Department of Cardiovascular Medicine Douglas Johnston, MD Vice Chairman, Department of Thoracic and Cardiovascular Surgery Samir Kapadia, MD Chairman Department of Cardiovascular Medicine Amar Krishnaswamy, MD Section Head, Invasive & Interventional Cardiology Department of Cardiovascular Medicine L. Leonardo Rodriguez, MD Section of Cardiovascular Imaging Department of Cardiovascular Medicine Shinya Unai, MD Department of Thoracic and Cardiovascular Surgery James Yun, MD, PhD Department of Thoracic and Cardiovascular Surgery Mastering the Management of Aortic Valve Disease: Imaging, Intervention and Innovation December 3-4, 2021 JW Marriott Essex House, New York, NY Register to attend in person in NYC or live stream www.ccfcme.org/aorticvalve21

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Page 1: Mastering the Management Mastering the Management of

The Cleveland Clinic Foundation 9500 Euclid Avenue, TR204 Cleveland, OH 44195

NON-PROFIT ORG. U.S. POSTAGE PAID

CLEVELAND OH PERMIT NO. 1918

Mastering the Management of Aortic Valve Disease: Im-aging, Intervention and Inno-vationDecember 3-4, 2021JW Marriott Essex House, New York, NYRegister to attend in person in NYC or live streamwww.ccfcme.org/aorticvalve21

Mastering the Management of Aortic Valve Disease: Imaging, Intervention and InnovationDecember 3-4, 2021

Course Description

The management of patients with aortic valve disease is constantly evolving, highlighted by innovations in devices, surgical techniques, and imaging. In addition, guidelines, research studies and clinical trials are continually expanding the evidence base related to both management decisions and treatment outcomes from valve interventions, both transcatheter and surgical-implanted devices. These developments, in turn, have altered the clinical practice framework for approaching aortic valve disease quantification and treatments, resulting in some confusion regarding the optimal management strategies. This program is designed to bring together cardiologists, surgeons, and other healthcare providers to address the contemporary and future management of aortic valve disease and better define the role of transcatheter and surgical therapies. The course will emphasize case-based learning designed to engage learners in discussions, debates, and critical decision-making for this condition.

Learning Objectives

After participating in this educational activity, practitioners will be able to do the following:

• Describe the best practices for the management of patients with aortic valve disease.

• Discuss the role of basic and advanced imaging techniques to assess patients with aortic valve disease.

• Accurately assess options for treating difficult scenarios associated with aortic valve disease including transcatheter valve failure, minimally invasive valve replacement, and evaluation of surgical risks in shared decision making.

• Discuss the pros and cons associated with transcatheter aortic valve replacement (TAVR) in various patient populations and review the management of potential complications.

• Summarize the emerging innovations in technologies for TAVR along with results in clinical trials and describe their potential implications for clinical practice.

Target AudienceThis course is intended for cardiothoracic surgeons, cardiologists, interventional cardiologists, internists, nurses, physician assistants and all health care professionals involved in the evaluation, diagnosis and/or management of patients with aortic valve disease.

Course DirectorsLars G. Svensson, MD, PhDChairman, Heart, Vascular & Thoracic Institute Cleveland Clinic

Katherine Hoercher, RNSenior Director, Heart, Vascular & Thoracic Institute Cleveland Clinic

Guest FacultyRobert O. Bonow, MD Northwestern University Feinberg School of Medicine

Susheel Kumar Kodali, MD NewYork-Presbyterian/Columbia University Medical Center

Patrick T. O’Gara, MD Brigham & Women’s Hospital

Cleveland Clinic Heart, Vascular & Thoracic Institute Faculty Eugene Blackstone, MDSection Head, Clinical InvestigationsDepartment of Thoracic and Cardiovascular Surgery

Milind Desai, MD, MBADirector, Clinical OperationsDepartment of Cardiovascular Medicine

Brian Griffin, MDSection Head, Cardiovascular ImagingDepartment of Cardiovascular Medicine

Wael Jaber, MDSection of Cardiovascular ImagingDepartment of Cardiovascular Medicine

Douglas Johnston, MDVice Chairman, Department of Thoracic and Cardiovascular Surgery

Samir Kapadia, MDChairmanDepartment of Cardiovascular Medicine

Amar Krishnaswamy, MDSection Head, Invasive & Interventional CardiologyDepartment of Cardiovascular Medicine

L. Leonardo Rodriguez, MDSection of Cardiovascular ImagingDepartment of Cardiovascular Medicine

Shinya Unai, MDDepartment of Thoracic and Cardiovascular Surgery

James Yun, MD, PhDDepartment of Thoracic and Cardiovascular Surgery

Mastering the Management of Aortic Valve Disease: Imaging, Intervention and InnovationDecember 3-4, 2021JW Marriott Essex House, New York, NYRegister to attend in person in NYC or live stream

www.ccfcme.org/aorticvalve21

Page 2: Mastering the Management Mastering the Management of

Friday, December 3, 20217:00 am Registration and Breakfast7:55 am Welcome and Announcements

Lars G. Svensson, MD, PhDSession I: A Contemporary Framework for Approaching Aortic Valve Disease

in 2021Moderators: Robert O. Bonow, MD, and Eugene Blackstone, MD

8:00 am The Evolving Management of Aortic Valve Disease: Trends in SAVR, TAVR, and Medical TherapyRobert O. Bonow, MD

8:15 am Case: Patient With Asymptomatic AS Early Intervention to Slow ASBrian Griffin, MD

8:30 am Cleveland Clinic Approach to Transcatheter Management of ASSamir Kapadia, MD

8:45 am Current Valve Guidelines: Key Points and Take Home MessagesPatrick T. O’Gara, MD

9:00 am STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement: Current Findings in 2021Amar Krishnaswamy, MD

9:15 am What Did the Low Risk TAVR Trials Miss?Lars G. Svensson, MD, PhD

9:30 am Long Term Trends in SAVR versus TAVREugene Blackstone, MD

9:45 am Panel Discussion and Q&A10:05 am BreakSession II: Imaging of the Aortic Valve from Basic to Advanced TechniquesModerators: Milind Desai, MD, MBA, and L. Leonardo Rodriguez, MD

10:30 am Case of Standard Severe AS: Utilization of Basic EchoWael Jaber, MD

10:40 am Case of Symptomatic AS: The Modern Role of MDCT for Annular Sizing and Transcatheter Valve SelectionMilind Desai, MD, MBA

10:50 am Case of Low Flow, Low EF and Paradoxic AS: Using Dobutamine Echo Contractile ReserveL. Leonardo Rodriguez, MD

11:00 am Case of Severe AR With Imaging Work-up: Quantification of AR and Surgical TimingBrian Griffin, MD

11:10 am Case of BAV With AortopathyMilind Desai, MD, MBA

11:20 am Bicuspid Valve With Aortic Valve RepairLars G. Svensson, MD, PhD

11:30 am Lifetime Management of AS: Imaging Considerations Wael Jaber, MD

11:40 am Panel Discussion and Q&A12:00 pm LunchSession III: Controversies and Difficult Scenarios in Aortic Valve Disease Moderators: Douglas Johnston, MD, and Patrick T. O’Gara, MD

1:00 pm Evaluation of Surgical and Interventional Risk: Key Points for Shared Decision MakingSamir Kapadia, MD

1:15 pm Low Surgical Risk Patients - Intervention (Surgery or TAVR) in Severe Aortic StenosisDouglas Johnston, MD

1:30 pm Mixed Aortic Disease vs. Pure AS: Decision and Predictors of Adverse OutcomesPatrick T. O’Gara, MD

1:45 pm Valve Reimplantation and Aortic Valve Repair Lars G. Svensson, MD, PhD

2:00 pm Coronary Access and Commissural Alignment After TAVR: Clinical Relevance and Procedural ConsiderationsAmar Krishnaswamy, MD

2:15 pm Anticoagulation After Bioprosthetic AV Replacement or TAVR (including off label use of DOACS) Samir Kapadia, MD

2:30 pm Transcatheter Valve in Valve vs. Redo Surgical AV Replacement Douglas Johnston, MD

2:45 pm Break

3:00 pm Endocarditis Requiring Surgery Shinya Unai, MD

3:15 pm TAVR in Aortic Bioprosthetic Valve Failure Susheel Kumar Kodali, MD

3:30 pm Outcomes of Transcatheter Aortic Valve Replacement in Patients with Mitral Valve DiseaseAmar Krishnaswamy, MD

3:45 pm Minimally Invasive AV Replacement: J-Incision, Right Chest, or Both?Douglas Johnston, MD

4:00 pm Panel Discussion and Q&A4:15 pm Adjourn

Ranked Among the BestCleveland Clinic has been ranked the nation’s No. 1 heart care program for 27 consecutive years by U.S. News & World Report.

General InformationLocationJW Marriott Essex House New York160 Central Park South, New York, NY 10019

Register to attend in person in NYC or live stream

Hotel AccommodationsA block of guest rooms has been reserved at the JW Marriott Essex House at a reduced holiday rate of $569.00 plus tax per night. Rooms can be booked by calling 800-228-9290 and identifying yourself as a conference attendee or online at https://book.passkey.com/go/CMEMeeting2021 The hotel block will close on November 12, 2021.

AccreditationThe Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The Cleveland Clinic Foundation Center for Continuing Education designates this live activity for a maximum of 10.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

American Board of Internal Medicine MOC Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 10.75 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Please see our website for our faculty disclosure and Americans with Disabilities Act policies

Registration and CancellationPreregistrations are accepted until November 29, 2021 or until atten-dance has reached capacity. In case of cancellation, email notification is required to process your refund. In order to ensure that attendee, faculty, and staff health is priority, full refunds will be issued if can-celed by the start of the course on December 3, 2021. No refunds will be issued if attendees are not able to meet attendance requirements upon Activity check-in.

In case of cancellation for live stream attendees, an email notification is required to process your refund. No refunds will be issued after November 22, 2021 or once access instructions are sent.

Registration

Register online at www.ccfcme.org/aorticvalve21

All applicable Centers for Disease Control (CDC) and state safety protocols will be enforced for this event. In keeping with New York City public health guidelines, attendees at the in-person course will need to show proof of vaccination (dated two weeks prior to the event) against COVID-19 before entering the meeting space. Additional attendance requirements may be implemented to ensure attendee health and safety. The use of masks by all participants at this event are required except when eating and drinking.

Onsite registration fee includes continental breakfasts, refreshment breaks, lunch and faculty presentations available in PDF format post course.

Early Bird (ends November 1) Regular

Physician (MD, PhD) $595.00 $695.00

Allied Health $300.00 $400.00

Student/Resident/Fellow* $300.00 $400.00

Non-exhibiting Industry $1,000.00 $1,000.00

Live stream registration fee includes access to the live stream and faculty presentations available in PDF format post course

Early Bird (ends November 1) Regular

Physician (MD, PhD) $495.00 $595.00

Allied Health $200.00 $300.00

Student/Resident/Fellow* $200.00 $300.00

Non-exhibiting Industry $900.00 $900.00

* Letter from program director is required to receive the discounted fee. If letter is not received two weeks prior to the activity, the full physician fee will be charged.

Cleveland Clinic Center for Continuing Education reserves the right to cancel or postpone an activity at our sole discretion. In the unlikely event that this occurs, any registration fee(s) paid will be refunded. Be advised that Cleveland Clinic is not responsible for related costs including airline tickets, hotel costs, or any similar fee penalties incurred as a result of any trip cancellations or changes.

Saturday, December 4, 20217:00 am Registration and Breakfast

Session IV: TAVR Moderators: Samir Kapadia, MD, and James Yun, MD, PhD

8:00 am Evolving Directions for TAVR (new trial results, low risk patients) Samir Kapadia, MD

8:10 am Outcomes of Urgent/Emergency Transcatheter Aortic Valve Replacement in Aortic Valve Stenosis vs. Balloon DilatationAmar Krishnaswamy, MD

8:20 am Stroke and Cerebral Protection – Case Based ApproachSamir Kapadia, MD

8:30 am Complications During and After TAVR (Tamponade, Embolization, PPM, VSD)James Yun, MD, PhD

8:40 am Management of Structural Valve Deterioration After TAVRSamir Kapadia, MD

8:50 am Importance of Prosthesis-Patient Mismatch After TAVR: Definitions, Incidence, and Clinical Relevance Wael Jaber, MD

9:00 am Selection of Devices for TAVRAmar Krishnaswamy, MD

9:10 am Alternative Access Options for TAVRJames Yun, MD, PhD

9:20 am What Are the Current Limitations of TAVRSusheel Kumar Kodali, MD

9:30 am Treatment of Paravalaular Leak After TAVR – VIV or Plug Amar Krishnaswamy, MD

9:40 am Endocarditis after TAVR Shinya Unai, MD

9:50 am Invasive vs. Echocardiographic Gradients Post Valve-in-Valve TAVR Milind Desai, MD, MBA

10:00 am Panel Discussion and Q&A10:15 am BreakSession V: Emerging TechnologiesModerators: Douglas Johnston, MD, and Susheel Kumar Kodali, MD

10:35 am New TAVR TechnologiesSusheel Kumar Kodali, MD

10:45 am How to Make a More Durable TAVR Valve?Samir Kapadia, MD

10:55 am New Data on S3 UltraAmar Krishnaswamy, MD

11:05 am Use of Support Devices in ASJames Yun, MD, PhD

11:15 am The COMMENCE Trial at 5 Years Douglas Johnston, MD

11:25 am Optimal Hemodynamics After TAVRSamir Kapadia, MD

11:35 am Transcatheter Aortic Valve Replacement With the Accurate NEOAmar Krishnaswamy, MD

11:45 am PROACT XA Trial Douglas Johnston, MD

12:00 pm Panel Discussion and Q&A12:15 pm Adjourn