Materials and methods

• Design• Open-label, randomized trial, February 2010 to May 2011, avoiding the

summer period

• Participants• recruited from a primary care centre in Sweden, serving a population with a

high proportion of non-European residents

• Inclusion criteria • age 15 years or above and vitamin D deficiency 25(OH)D3 less than 25

nmol /L

• Exclusion criteria• light-sensitive skin• ongoing treatment with vitamin D supplementation• sunny holidays • intake of photosensitive medicine during the study period.

UVB

• The average starting dose was 0.36 J• increments were about 15% every second treatment session• the average maximal (final) dose was 1.20 J.• The mean cumulative dose was 9.0 J /cm2

Results

• Significantly greater increase in 25(OH)D3 levels in the NB-UVB treated group compared with the tablet-treated group after 6 weeks of treatment (P = 0.02)

• in the NB-UVB treated group The 25(OH)D3 levels (mean ± SD) increased from 19.2 ± 6 nmol /L to 75 ± 16.8 nmol/L vs. 23.3 ±4.4 nmol /L to 60.6 ± 16.7 nmol /L in the oral vitamin D3 treated group

Results

• No significant difference regarding PTH, calcium, albumin or HbA1c levels.

• A significant decrease in PTH

• A significant increase in calcium levels

Limitations

• lack of compliance among the group who took vitamin D3 supplements

• high dropout number

• primarily non-European immigrants

Conclusion

• exposure to a small dose of full body NB-UVB radiation three times a week is more efficient in raising vitamin D levels than prescription of a daily oral intake of 1600 IU vitamin D3

Race ?Skin type?

Suscreen?

Winter vs summer

NB UVB vs BB UVB?

Diet?

Screening?

Deficiency?

-Vitamin D deficiency is defined as a 25(OH)D below 20 ng/ml (50 nmol/liter)

- Vitamin D insufficiency is defined as a 25(OH)D of 21–29 ng/ml

Daily requirement?

Treatment