mathematical neuroscience m394c

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Mathematical neuroscience M394C Topics in neural dynamics, information theory, and machine learning

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Page 1: Mathematical neuroscience M394C

Mathematical neuroscience M394C

Topics in neural dynamics, information theory, and machine learning

Page 2: Mathematical neuroscience M394C

Mathematical theory

Page 3: Mathematical neuroscience M394C

Network complexity

100 billion neurons 100 trillion synapses

Page 4: Mathematical neuroscience M394C

Coding ambiguity

Page 5: Mathematical neuroscience M394C

Noise

Page 6: Mathematical neuroscience M394C

Heterogeneity

Page 7: Mathematical neuroscience M394C

Sloppinessin

form

atio

n

coding strategies

codi

ng s

trate

gies

info

rmatio

n

coding strategies

codi

ng s

trate

gies

info

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coding strategies

codi

ng s

trate

gies

Tractable landscape Higly non-convex landscape Sloppy landscape

Page 8: Mathematical neuroscience M394C

Course content

Neural dynamics

Information theory

Machine learning Theoretical Neuroscience P. Dayan and L. Abbott

Background in neuroscience

Page 9: Mathematical neuroscience M394C

Neural dynamics

Page 10: Mathematical neuroscience M394C

Biophysical modeling via dynamical systems

Dynamical Systems in Neuroscience

E. Izhikevich

Hodgkin-Huxley model

Reduced dynamical systems

Spiking in excitable systems

Page 11: Mathematical neuroscience M394C

Bifurcation theory in single neurons

Nonlinear oscillations, dynamical systems and

bifurcation of vector fields J. Guckenheimer and P. Holmes

Center manifold reduction

Normal form theory

Two-dimensional bifurcations

Page 12: Mathematical neuroscience M394C

Stochastic modeling of neural variability

Spiking neuron models W. Gerstner and W. Kistler

Intensity-based models

Integrate-and-fire models

Simulation and inference methods

Page 13: Mathematical neuroscience M394C

Simplifying mean-field limits for neural networks

Topics in Propagation of chaos

A. Sznitman

Networks in the thermodynamic limit

Propagation of chaos

Replica mean-field limit

Page 14: Mathematical neuroscience M394C

Information theory

Page 15: Mathematical neuroscience M394C

Statistical inference

Probability theory E. Jaynes

Maximum entropy methods

Exponential family of distributions

Application to inference in neuroscience

Page 16: Mathematical neuroscience M394C

Information geometry

Methods of information geometry

S. Amari

Probabilistic models as manifolds

Fisher metric and information divergence

Dual structure of information geometry

Page 17: Mathematical neuroscience M394C

Basics of information theory

Elements of Information theory

T. Cover and J. Thomas

Mutual information

Information capacity

Rate-distortion theory

Page 18: Mathematical neuroscience M394C

Efficient coding hypothesis

Optimization under constraints of relevance: information bottleneck

Variational optimization of the Fisher information

Page 19: Mathematical neuroscience M394C

Machine learning

Page 20: Mathematical neuroscience M394C

Basics of machine learning

Linear separability and complexity

Learning via perceptron algorithm

Linear separability and neural code

Page 21: Mathematical neuroscience M394C

Support-vector machines

Learning with kernels B. Scholkopf and A. Smola

Nonlinear separability

Reproducing-kernel Hilbert space

Page 22: Mathematical neuroscience M394C

Reinforcement learning

Reinforcement learning

R. Sutton and A. Barto

Dynamic programming

and optimal control

D. Bertsekas

Markov decision process

Dynamic programming

Q-learning algorithm

Page 23: Mathematical neuroscience M394C

Unsupervised learning methods

Autoencoder networks

Generative adversarial networks