matrikulasi tulang sendi angktn 2012
DESCRIPTION
UKAI Materi matrikulasiTRANSCRIPT
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Dita Maria Virginia
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Osteoarthritis
Rheumatoid arthritis
Osteoporosis
Gout / hiperuricemia
ARTHRITIS
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common condition that causes pain and
inflammation within a joint
Klasifikasi:
Rheumatoid-arthritis (RA)
Osteo-arthritis (OA)
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Genetik/family history HLA class II
Wanita
Merokok
Usia
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Rheumatoid factor (RF) detectable in 60% to
70%.
Anticyclic citrullinated peptide (anti-CCP)
antibodies have similar sensitivity to RF (50%
to 85%) but are more specific (90% to 95%)
and are present earlier in the disease.
Elevated erythrocyte sedimentation rate
and C-reactive protein
Normocytic normochromic anemia is
common as is thrombocytosis.
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Patofisiologi:
body's immune system attacks and destroys
the affected joints, causing pain and swelling
to occur. This can lead to a reduction in
movement and the breakdown of bone and
cartilage.
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Rheumatoid nodules Vasculitis
Ocular manifestation
Pulmonary complication
Cardiac involvement
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Exercises: walking, swimming
Weight reduction
Surgery
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DMARD
Methotrexat
Sulfasalazine
Biologic agent
Anti TNF : infliximab
Antagonis receptor IL-1 : Antakira
NSAIDs
Corticosteroid
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Menurunkan faktor-
faktor proinflamasi
Pembentuk panus
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Obesitas
Umur
Hormonal
Genetik
Injury,overloading of joints, muscle
weakness, or joint deformity
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Primary
Secondary
Errosive
reflects a failure of the chondrocyte to maintain
proper balance between cartilage formation and
destruction.
This leads to loss of cartilage in the joint, local
inflammation, pathologic changes in underlying
bone, and further damage to cartilage triggered
by the affected bone
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Cold or warm
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There is no cure for osteoarthritis, but the
symptoms can be eased with several
different treatments.
Treatment options may include: non-drug treatments, such as physiotherapy and weight
loss
medications, such as painkillers
surgery in a small number of cases, such as a knee or hip
replacement
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patah tulang punggung
Rasa sakit dari sisi belakang tubuh. Setelah bertahun-tahun, patah tulang belakang yang berulangkali dapat menyebabkan nyeri punggung kronis dan tulang belakang tidak tegak lagi /melengkung, yang menyebabkan bungkuk pada punggung.
patah karena tekanan
Patah tulang yang terjadi selama aktivitas normal
patah tulang pinggul
Patah tulang panggul biasanya terjadi sebagai akibat jatuh atau kecelakaan yang tidak parah. Patah tulang pinggul juga akan sulit untuk disembuhkan setelah bedah karena kualitas tulang yang buruk.
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Inhibisi resorbsi
Agonis Estrogen/ Selective Estrogen Receptor Modulators
(SERMs) raloxifene
Bisfosfonat - alendronate
Estrogen
RANK-L inhibitor denoxumab
Meningkatkan formasi tulang - Teriparatide
Mineralisasi:
Kalsitonin
Kalsium
Vitamin D
Tujuan utama manajemen osteoporosis adalah pencegahan, dengan mengoptimasi
perkembangan skeletal dan massa tulang puncak akrual saat masa kanak-kanak,
remaja dan awal dewasa akan menurunkan insiden osteoporosis di masa mendatang.
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Akut gout monoarticular
Tophaceus gout ada tophy
Intercritical gout asimptomatik
Nefrolitiasis
Nefropati
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Tujuan terapi untuk menghilangkan rasa nyeri serangan akut, mencegah
serangan berulang dari arthritis gout, mencegah terjadinya komplikasi,
dan mengurangi kadar serum uric acid
NSAIDs
Colchicine
Corticosteroid
Uric Acid Lowering Therapy
Xantin oxidase Inhibitor = Allopurinol
Uricosuric agents = Probenesid
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phar.uokufa.edu.iq
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www.cram.com
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DiPiro, J.T., et al., 2009, Pharmacotherapy Handbook, Seventh edition, McGraw-Hill,
New York, pp.1516-1581.
Khanna, D., et al., 2012, 2012 American College of Rheumatology Guidelines for
Management of Gout. Part 1: Systematic Nonpharmacologic and Pharmacologic
Therapeutic Approaches to Hyperuricemia, Arthritis Care & Research, Vol. 64, No.
10, pp 14311446 DOI 10.1002/acr.21772
Mazzioti, G., Canalis, E., Giustina, A., 2010, Drug induced osteoporosis: mechanism and
clinical implication, The American Journal of Medicine, pp. 877-884.
McAlindon, T.E., 2014, OARSI guidelines for the non-surgical management of knee
osteoarthritis, Osteoarthritis and Cartilage, 22,pp363-388,
http://oarsi.org/sites/default/files/docs/2014/non_surgical_treatment_of_knee_oa
_march_2014.pdf
Singh, J.A., et al., 2015, 2015 American College of Rheumatology Guideline for the
Treatment of Rheumatoid Arthritis, Arthritis Care & Research, DOI
10.1002/acr.22783
Beberapa slide merupakan hasil translasi yang diambil dari makalah/tugas
Farmakoterapi 2 angkatan 2012