MBS Seminar Announcement

June 5th, 2014College of Veterinary MedicineResearch Building, Room 101

12:15 PM

Research abstract: In regenerative medicine, a critical hurdle for the development of clinically relevant applications is the lack of appropriate large animal models. Two species, dog and swine, provide di�erent, yet unique opportunities. Swine are physiologically similar to humans and can be genetically manipulated at high e�ciency. Our work in this area has allowed us to generate complex transgenic lines including the generation of a severe combined immune de�cient (SCID) pig that can be used to host xenogeneic cells. The dog, in contrast, is an excellent model of naturally occurring diseases and as such is a great translational model for developing cell-based therapies in a clinical setting. Our work in this area focuses on identi�cation of ideal conditions for the isolation and maintenance of stem cells. This seminar will summarize some of our work in these areas.

Web site: http://www.cvm.ncsu.edu/mbs/personnel/piedrahita_jorge.html

“Large Animal Models in Regenerative Medicine: A Tale of Two Species”

Jorge Piedrahita, PhDDirector, Center for Comparative Medicine and Translational

ResearchProfessor, Dept. of Molecular Biomedical Sciences

North Carolina State University