mclean immunology questions

8/10/2019 McLean Immunology Questions

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Dental Immunology Questions for students with highlighted answers

1. B and T lymphocytes are derived from

A. Erythroid progenitors

B. Myeloid progenitors

C. Common lymphoid progenitors

2. Which of the following does not involve innate immunity

A. !esponse time is a few hours

B. Ma"or components include physical and chemical #arriers

C. $pecificity is limited and fi%ed

&. $econdary response is faster than primary response

'. ()* selectively infects

A. C&+ T cells

B. C&, T cells

C. -atural iller cells

&. Macrophages

,. Which of the following is a primary lymphoid tissue

A. /ymph node

B. $pleen

C. Bone marrow

&. Tonsils

0. Which of the following is the ma"or lymphoid organ that filters pathogens from the #lood



A. Thymus

B. Appendi%

C. $pleen

&. Bone marrow

. (ematopoiesis in the adult occurs in

A. /iver

B. $pleen

C. Bone marrow

&. ol sac

3. Which of the following #est descri#es an immunogen

A. Any agent capa#le of #inding specifically to components of the immune system such as

the BC! or TC!

B. Any agent capa#le of inducing an immune response

C. Antigens called haptens

&. A su#stance that can #e identified #y the B cell receptor or #y the T cell receptor when

they com#ine and form comple%es with M(C in antigen presenting cells

+. 444444444444444 are e%cellent immunogens

A. (aptens

B. /ipids

C. -ucleic acids

&. 5roteins



6. The part of an antigen to which an anti#ody #inds is termed the

A. 5aratope

B. Epitope

C. 5attern recognition receptors

&. *aria#le region

17. The two types of light chains found in immunoglo#ulins are

A. 8 and 9

B. : and ;

C. < and =

11. The predominant anti#ody in saliva and tears

A. )gM

B. )gA

C. )g&

&. )g>

12. The ma"or anti#ody that can pass through the placenta from mother to fetus

A. )gM

B. )gA

C. )gE

&. )g> ?brambell receptor takes it out of blood – mast cells & basophils – kills worms@

1'. The most common T cell receptor is composed of two polypeptide chains

A. 8 and 9



B. : and ;

C. < and =

1,. TC! gene rearrangement occurs during T cell development in the

A. Bone marrow

B. Thymus

C. /ymph node

&. $pleen

10. M(C class ) molecules present antigens of

A. )ntracellular origins to C&+ T cells

B. E%tracellular origins to C&+ T cells

C. )ntracellular origins to C&, T cells

&. E%tracellular origins to C&, T cells

1. M(C class 44444 8 genes are e%pressed #y all cell types e%cept erythrocytes while M(C

class 44448 and 9 genes are e%pressed #y antigens presenting cells

A. )) and ) respectively

B. ) and )) respectively

C. ) and ))) respectively

&. )) and ))) respectively

13. 444444 is due to an alloreaction

A. )sotype switching

B. Transplant re"ection



C. Bare lymphocyte syndrome

&. $evere Com#ined )mmunodeficiency &isease ?$C)&@

1+. The greatest danger for #one marrow transplant is

A. >raft re"ection

B. >raft versus host disease

16. The education of B lymphocytes occurs in the

A. Thymus

B. Bone marrow

C. /ymph node

& $pleen

27. *preB and :0 are components of the BC!s

A. (eavy chain

B. /ight chain

C. $urrogate heavy chain

&. $urrogate light chain

21. An immature B cell has the following immunoglo#ulin on its surface

A. )gA

B. )g&

C. )g>

&. )gM



22. Memory B cells

A. (ave a life span of a#out four wees

B. Become highly specialied toward anti#ody secretion

C. Allow a much uicer and stronger response to antigen than in the primary response

&. -o longer e%press surface )g or M(C class )) and therefore are unresponsive to antigen

or T cells

2'. The earliest stage in T cell development is

A. single positive

B. dou#le positive

C. dou#le negative

&. single negative

24. The development of mature T cells that recognie antigen only when it is presented #y M(C

molecules in the surface of an antigen presenting cell is termed

A. Acuisition of tolerance

B. -egative selection

C. M(C restriction

&. 5ositive selection

20. Three types of professional antigen presenting cells

A. T cellsD natural iller cells and B cells

B. -eutrophilsD #asophils and eosinophils

C. &endritic cellsD macrophages and B cells

&. &endritic cellsD macrophages and T cells



2. When viruses infect cellsD helper T cells differentiate into 44444444444 cells

A. T(2

B. T(1

C. T(7

23. T(1 cells preferentially secrete the cytoine 444444while T(2 preferentially secrete 4444444

A. )/' and )/2 respectively

B. >MC$F and )/' respectively

C. )/2 and )/, respectively

&. )/' and )/, respectively

2+. The effector molecules of cytoto%ic T cells are mainly

A. )/, and )/0

B. )/2 and )/'

C. 5erforin and >ranymes

&. C&,7 ligand and eota%in

26. 5rofessional antigen presenting cells are distinguished from other cells #y the presence of the

costimulatory molecule4444444 on their surface which #inds to the receptor protein444444 on

the surface of the T cell

A. C&, and C&+ respectively

B. B3 and C&2+ respectively

C. C&16 and C&,7 respectively

&. C!2 and C'& respectively



'7. /epromatous leprosy is dominated #y444444 which are not effective against the intracellular

pathogen

A. T(1 cells

B. Cytoto%ic T cells

C. Anti#odies

&. -atural iller cells

'1. The smaller fragment of a cleaved complement molecule has

A. )nflammatory activity

B. Enymatic activity

'2. )g>s are lowest in children

A. 017 years old

B. adolescent years

C. ' months old

&. 10 years old

''. -eutraliation and opsoniation ?pathogen mared for ingestion@ are functions of

A. Cytoto%ic T cells

B. (elper T cells

C. Anti#odies

&. Macrophages

',. )gA and )g> are transported across epithelial #arriers #y specific receptor proteins

44444444444and 44444444

A. B cell receptor and T cell receptorD respectively



B. Bram#ell receptor and poly)greceptor D respectively

C. M(C class ) and M(C class ))D respectively

&. 5olylgreceptor and Bram#ell receptorD respectively

'0. )gE preferentially #inds to high affinity Fc receptors on

A. Macrophages

B. -eutrophils

C. Mast cells

&. B cells

'. The complement classical pathway is triggered

A. &irectly #y components of #acterial cell surfaces

B. By anti#odies #ound to the surface of the pathogen

C. By mannose #inding proteins that are #ound to molecules on the surface of pathogens

&. By lactose #inding proteins that are #ound to molecules on the surface of pathogens

'3. Which of the following #est descri#es Tcell dependent antigens

A. $imple polysaccharides

B. Comple% proteins

C. /ess common than Tcell independent antigens

&. )nduce B cells to predominantly secrete )gM

'+. Which of the following mitogens tend activate #oth B and T cells

A. plant glycoproteins

B. 5oeweed



C. Bacterial polysaccharides

,7. The hypervaria#le region is also termed

A. Framewor region

B. Complementarity determining region ?C&!@

C. (inge region

&. Constant region

,1. )sotype switching produces )gs with

A. different * regions #ut identical C regions

B. different C regions and different antigen specificities

C. different C regions #ut identical antigen specificities

&. same * regions and identical C regions

,2. Which of the following anti#odies 1@ has the shortest half life 2@ is present on surfaces of

#asophils and mast cells and '@ is involved in allergic reactions

A. )gA

B. )g>

C. )gM

&. )gE

,'. Which of the following anti#odies 1@ can form a pentamer 2@ when it is #ound to B cells it

forms the B cell receptor '@ it functions in complement activation with high activity and ,@

has high agglutination a#ility

A. )gA



C. !edundancy?when multiple cytoines can #e specific to one target@

&. Antagonism

,+. Beside cytoto%insD cytoto%ic T lymphocytes also secrete the cytoine 44444444 thatD inhi#its

viral replicationD increases processing and presentation of viral antigens #y M(C class ) and

activates macrophages to get rid of dying cells.

A. )/,

B. )/0

C. )/17

&. )nterferongamma

,6. 444444 syndrome is caused #y a failure to isotype switch due to the a#sence of C&,7 ligand

on T cells.

A. (yper)gA

B. (yper)gM

C. (yper)g>

&. (yper)g E

07. These immune components 1@ are called ymogens in their inactive form 2@ aids in

phagocytosis and '@ there terminal proteins lyse pathogens #y forming a Hmem#raneattac

comple%I ?MAC@ pore.

A. cytoines

B. complement

C. cytoto%ins

mclean immunology questions

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