Medication

2BLEOMYCIN

3CYCLOPHOSPHAMIDE (Endoxan )

4CYTARABINE (Ara-c ), Alexan)

5DACTINOMYCIN (ACTINOMYCIN)

6DOCETAXEL (Taxotere)

7DOXORUBICIN (Adriamycin)

85 FU, FLUOROURACIL

9IDARUBICIN

10L-ASPARAGINASE (Leunase)

11MTX, METHOTREXATE

12OXALIPLATIN (Eloxatin, Oxalip, Oxitan)

13PACLITAXEL (Intaxel, Taxol)

14VINBLASTINE

15VINCRISTINE

BLEOMYCIN

Anaphylaxis

V/S 15

CBC

CXR Pulmonary function tests 1

Renal function tests 400 units

SBP 120 / ,RR > 20 / , T > 38.5 C

ANC < 1500 cells/mm3

BUN ,Creatinine

Slow IV push > 10 , IV infusion 10-60

2-3

( pulmonary fibrosis)

CYCLOPHOSPHAMIDE (Endoxan )

CBC ,Platelet

Renal function tests

Acute haemorrhagic cystitis

ANC < 1500 cells / mm3

platelet count < 100,000 / mm3

UA , BUN, Creatinine

Slow IV push 20-30 , IV infusion 1-24 hrs

1.5-2 gm / m2 2 haemorrhagic cystitis

CYTARABINE (Ara-c ), Alexan)

CBC ,Platelet

Renal function test

Liver function tests

Cerebellar toxicity

Conjunctivitis

ANC 2.5

BUN, Creatinine

IV infusion only 1 hr

prophylactic G-CSF

> 38.5 c

DOXORUBICIN (Adriamycin)

Extravasation

CBC, Platelet

Cardiotoxicity

( )

ANC 60 , , CHF, 450 mg/m2, ejection fraction 30-40 %

4-12

2-4

()

Echo

5 FU, FLUOROURACIL

CBC ,Platelet

renal function tests

Liver function tests

ANC 10-15

( )

1 2

, , ( 3 - 10 )

L-ASPARAGINASE (Leunase)

Anaphylaxis

CBC

V/S 15 X 4

Pancreatitis ( Enz. Amylase 3 )

Renal function test

Prothrombin time

Allergic reaction ( , , )

ANC < 1500 cells / mm3

SBP < 90 mmHg , HR < 60 120 / , RR > 20 / , T > 38.5 C

Enz. Amylase ( 44-128 IU/L)

BUN, Creatinine

Prothrombin time (10-13 )

IM , slow IV push , IV infusion 30 - 60

Hypersensitivity reaction intradermal test dose dose asparaginase test dose dose 1 (Test dose 0.1 ml of a dilute 20 unit/ml solution )

MTX, METHOTREXATE

CBC

Liver function tests

Renal function tests

ANC 1 , IV infusion - 4 hrs

High dose ( > 1 gm / m2 ) Hydration Alkalinization

dose > 500 mg /m2 Leucovorin (Rescue dose)

Preservative 1 mg/ml (max 2 mg/ml) IT

OXALIPLATIN (Eloxatin, Oxalip, Oxitan)

CBC

Liver function tests

Renal function tests

signs of neuropathy

respiratory effects

ANC 38.5 C

IV infusion only 2-3 hrs

Premedication

Carboplatin , Cisplatin Paclitaxel

infusion set ( Non PVC tube)

VINBLASTINE

Extravasation

CBC

Renal function test

( )

ANC