mechanism of arrhythmia fellow school lecture series mahmoud houmsse, md. july 11 th, 2014
TRANSCRIPT
Mechanism of ArrhythmiaFellow School Lecture Series
Mahmoud Houmsse, MD.July 11th, 2014
Cardiac Action Potential
Transmembrane Potential
-90 mV
+30 mV
0 mV
Protocol for RFA:
1. Catheters introduced via the femoral vein
2. Try to induce arrhythmia by pacing – defined protocol
3. Confirm diagnosis of type of arrhythmia
4. Map and RFA
5. Retest to assess if RFA was successful
Basic Catheter Positions
His and RightBundle Potentials
Right Atrium
His Bundle –Junction betwn. RA and RV
Right Ventricle
Surface ECG I
Surface ECG III
Mechanisms
Disorder of Impulse Formation◦ Automaticity ◦ Triggered activity
Two major causes of Impulse initiation (used to indicate an electrical impulse that can arise in a single cell or closely coupled cells through depolarization of the cell membrane and rest of myocardium)
Each has own unique cellular mechanism
Disorders of Impulse Conduction◦ Reentry
65 y/o Female Presented with Severe Near Syncope and Palpitations
Fast, Regular and Narrow: PSVT
Mechanisms of Arrhythmias
Reentry Dog chasing his tail or a Race Track
Scar – tissue that does not conduct
AV Node Re-Entrant Tachycardia
1 AV node pathway conducts rapidly Known as the “fast pathway” takes a long time to recover to conduct again
2nd AV node pathway conducts slowly Known as the “slow pathway” takes a short time to conduct another beat
AV Node Re-Entrant Tachycardia
Typically, PAC blocks in the “fast” pathway,
conducts down the “slow” pathway,
then back up the “fast” pathway
Slow pathway
Fast pathway
Compact AV node
Timed PAC to initiate AVNRT
12
13
Retrograde P wave
Atrio-Ventricular PreexcitationWPW
Accessory pathway that conducts from atrium to ventricle (and usually from V to A too)
Simultaneous conduction creates fusion beat with a delta wave
delta wave
Atrio-Ventricular PreexcitationWPW
May proceed up or down the accessory pathway Down = antidromic
wide complex not common
antidromic
Atrio-Ventricular PreexcitationWPW
May proceed up or down the accessory pathway Up = orthodromic
narrow complex common
orthodromic
Atrio-Ventricular PreexcitationWPW
Atrio-Ventricular Re-Entry due to a Concealed Bypass Tract Atrium and ventricle are needed to sustain the
tachycardia Lack of antegrade conduction “conceals” the
presence of this pathway on the ECG There is NO delta wave
X
Atrio-Ventricular Re-EntryConcealed Accessory PathwayAtrio-Ventricular Re-EntryConcealed Accessory Pathway
Up the accessory pathway, Up the accessory pathway, Down the AV nodeDown the AV node
orthodromic
Atrial Tachycardia
Automatic Atrial Tachycardia Intra-Atrial Re-Entrant Tachycardia Triggered Automaticity
Digitalis Toxicity
PSVT Types
Atrial Tachycardia AVNRT AVRT/WPW
Atrial Flutter Circuit
Reentrant Circuit Around Anatomical
Barriers
Slow Conduction between tricuspid
valve & inferior vena cava
Isthmus
Slow Conduction
52 y/o M with H/O HTN and Recurrent Palpitations
Atrial Flutter: Catheter LyingAlong Tricuspid Valve
Tri. Valve
Inf Vena Cava
Typical AFL: Intracardiac ECG Recording catheter along tricuspid valve
Reentrant VT
scar
scar
“Squeezed by Scar”
Catheter Ablation Procedure:
1. Induce the VT
*The QRS of the VT begins here
*
2. Map the VT circuit, ie, find the zone of slow conduction squeezed by scar3. Deliver RF energy to destroy the zone of slow conduction and thus eliminate reentry and VT
Step #1 of a VT Ablation Procedure EP Study: Induce VT
V1
aVF
RA
RV
* * * * * * VT
Early Electrical Signal Recorded at Zone of Slow Conduction………Squeezed by Scar
scar
scar
*The QRS of the VT begins here
*
* ***Successful
Ablation Site
QRS from Pacing During VT = QRS of the VT
scar
scar
*
*QRS of the VT begins here
** * * * * * * * * ** * * * * * * *
Concealed entrainment
Pace here
Spontaneous impulse initiation is a process whereby cardiac cells undergo spontaneous diastolic depolarization (phase 4) and initiate electrical impulse in the absence of external stimulation.
Enhanced Normal Automaticity – refers to accelerated generation of Action Potential (AP) by normal pacemaker tissue
Abnormal Automaticityoccurs in cardiac cells when there are major abnormalities in transmembrane potentials Drugs, (digoxin) Cardiac disease, CAD, Electrolytes Change in autonomic nervous
Normal Cardiac Automaticity
Normal Automatcity-Intrinsic Rate determined by Diastolic potential Threshold potential Slope of phase 4
Change in any above will alter rate of impulse formation
Above factors influenced by sympathetic / parasympathetic systems
Automaticity
Parasympathetic Reduces spontaneous discharge of SN
Sympathetic Increase slope of diastolic depolarization Enhances pacemaker activity
Automaticity
SA node 60 to 100 bpm
AV node 40 to 60 bpm
Ventricular specialized conduction tissue 20-30 bpm
Tissues with Intrinsic Automaticity
Automatcity & Overdrive Suppression
Triggered activity
After-depolarizations are depolarizing oscillations in membrane potential that follow the upstroke of a preceding action potential.◦ Can occur early during repolarization phase of
(Early afterdepolarization) or
◦ After completion of repolarization phase (Delayed afterdepolarization)
Triggered activity is not a self-generating rhythm. But occurs as a response to a preceding impulse (the trigger)
Automatic rhythms can arrive de novo in the absence of prior electrical activity
Triggered Activity
DADs
DADs usually occur when Calcium Overload develops in
the Myoplasm and Sarcoplasmic Reticulum
Possible Therapeutic meds include CCB and BB
DADs
During repolarization Calcium influx can rise to critical level and cause secondary spontaneous release of Calcium DADs of Low Amplitude, usually not significant However, during pathological conditions
Ischemia, Acidosis, Low Mg, Digitalis toxicity, Rapid Atrial Pacing, Increased Catecholamines Amplitude of oscillations is increased.
If process continues, tachycardia will ensue (RVOT)
Other causes, geneteic (Ryanodine receptor aka RYR2)
Calcium Influx Pathways
Earlier DADs with increasing amplitude
DAD earlier
DAD even earlier
DADs
Duration of AP Decrease in Cycle Length
(sinus tachycardia or paced rhythm) Triggered activity is influenced markedly by
overdrive pacing (both rate and duration) Overdrive acceleration obsereved with triggered
rhythm Overdrive suppression observed with automatic
rhythms
EADs Occur at phase 2 and 3 More likely to propagate when membrane
potential is more negative. Fundamental condition that underlies the
development of EADS is AP prolongation which is manifested by polonged QT. Hypokalemia, Hypomagnesemia, Bradycardia and Drugs
predispose to formation of EADs (Antibiotics, Non-sedating Antihistamines)
EAD mediated triggered activity likely underlies initiation of characteristic PMVT
DADs Vs. EADs
DADs are dependent on a rise in intracellular Calcium.
EADs are dependent on AP prolongation.
Pacing induced increases in heart rate shorten the AP duration and reduce EAD amplitude Initiation of single premature depolarization will reduces
the magnitude of EADs Exception is long compensatrory pause followed by
PVC.
Questions??