medactive oral care for dry mouth conditions

™

© 2012 MedActive, LLC.

Four Brands MedActive - Oral Care Redefined™

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MedActive redefines oral care by prioritizing dry mouth relief as a

critical objective of daily oral hygiene.

MedActive’s integration of continuous dry mouth relief into

comprehensive oral care is based upon clinical recognition that

salivary dysfunction adversely impacts oral and general health,

especially for patients managing chronic illness.

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Causes of dry mouth and other oral conditions:

• Cancer Chemotherapy & Radiation Therapy • Kidney Dialysis • Transplant Surgeries

• Antibiotics • Diuretics • Muscle relaxers • Corticosteroids • Amphetamines

• Anticholinergics • Analgesics • Antipsychotics • Antihistamines • Antidepressants

Health Condtions

Medications

Medical Treatments

• Diabetes • COPD • Heart Disease • Cancer • High Blood Pressure • Rheumatoid Arthritis • Depression

• Anxiety • Lupus/Scleroderma • Pneumonia • Asthma • Allergies • Sjögren’s Syndrome • HIV/AIDS

• Hepatitis • Sleep Disorder • GERD • Obesity • Incontinence

• Antihypertensives • Decongestants • Sedatives • NSAIDS

Lifestyle

• Poor hygiene • Smoking • Drug & alcohol abuse • Infrequent dental visits

MedActive® Brands rely on multiple applications of proprietary ingredients throughout the day. These applications achieve unprecedented relief from dry mouth discomfort.

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Repetitively enhancing saliva flow, with Spilanthes Extract and its unique “tingle”

feature

Repetitively moisturizing soft tissue, with ULTRAMULSION® and its extraordinary

“mouthfeel” and flavor enhancement

Repetitively lubricating and conditioning the mouth, with a mucoprotectant and

its distinct substantivity to soft tissue.

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Caries

Cascade Effects of

Dry Mouth

Immune System

Compromise

Bacterial Overgrowth

Viral & Fungal Overgrowth

Pathogenic Biofilm

Gingivitis

Periodontitis

Stomatititis

Mucositis

Inflammation

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Health Impacts of Dry Mouth

Dysphagia Immuno-

compromise

Kidney disease

Migration of biofilm into

bloodstream

Ingestion of bacteria, virus

& fungi

Depression

Pulmonary Infections

Stroke

Diminished quality of

life

Heart disease

Malnutrition

Bacteremia

Cancer

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Patient Populations

Sjögren’s Syndrome

Denture Discomfort

Hyper-tension

Allergies

Kidney Dialysis

Alzheimer's & Dementia

COPD

Diabetes Palliative

Care

Gastro-intestinal problems

Drug Dependency

Sleep Apnea

Obesity

Depression & Anxiety

Parkinson’s

Arthritis

MS, Scleroderma

& Lupus

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Integration of Dry Mouth Management into Patient Centered Care Pathways Reduces Costs

Downstream Medical Costs

Increased dental care

Nosocomial infections

Regulatory risk

Litigative risk

Reduced HVBP

Incentives

Increased drug costs

Empty bed losses

Longer & more frequent

hospitalizations

Increased care costs

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Dry mouth leads to and exacerbates the following conditions:

• Oral thrush • Sensitivity • Sores & lesions • Hoarsness • Caries

• Gingivitis/Periodontitis • Bleeding gums • Inflammation • Burning mouth • Throat irritation • Difficulty swallowing

Percentage of Adults who have had problems involving the mouth

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“QuickStats: Percentage of Adults* Aged 18-64 Years Who Have Had Problems Involving the Mouth, by Race/Ethnicity and Type of Problem ---National Health Interview Survey, United States, 2008.” Centers for Disease Control and Prevention. Morbidity and Mortality Weekly Report (MMWR). http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6022a7.htm?s_cid=mm6022a7_w

MedActive provides comprehensive oral care which includes continuous oral relief for patient-centered integrated care pathways.

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Taking the appropriate efforts to improve oral and dental care for nursing home

residents could have a significant impact not only on quality of life for nursing

facility residents, but also a meaningful impact on downstream medical costs for

the health care system by preventing hospitalizations and death resulting from

medical care needs arising out of poor oral and dental care.

“

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Dentition problems can result in malnutrition

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Patients with painful dentition eat less, and if the patient is demented at baseline, the communication of the painful condition is often missed by care providers.

Dentition problems along with the normal loss of the sense of smell accompanied with aging can result in signficantly reduced caloric intakes. Malnutrition frequently

leads to immunocompromise and this puts individuals at risk for a whole host of opportunistic infections such as urinary tract infections and pneumonia, both of

which are common primary diagnoses for nursing home patients admitted to acute care centers.

“

”

MedActive protocol encourages and promotes ongoing self-care and independence.

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Senior citizens fear moving into a nursing home and losing their

independence more than death, according to a research study that

examines the attitudes and anxieties of the nation’s elderly population.

“Aging in Place in America,” commissioned by Clarity

and The EAR Foundation ”

Four Brands Facts

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Approximately 300,000 cases of ventilator-associated pneumonia (VAP) are reported annually, associated

with increased morbidity and mortality, and costs up to $50,000 per case.1 In a 2008 study in an acute care facility with 4 critical care units, the implementation of a q4

oral care protocol costing $21.35/day resulted in an annual savings of more than $7,722.1

The January 2012 issue of the JADA reported that patients with diabetes were one third less likely to visit an

emergency department or be hospitalized for the disease when regular dental care was received.2

1 Killer, Harriet S., RN, BSA, CIC, CPA & Tara Haines, RN, BSN. Simple & Cost-Effective Strategies to Reduce the Occurrence of Ventilator-Associated Pneumonia. Ocala Regional Medical Center, Ocala, FL. 2008. 2 The Journal of the American Dental Association. January 1, 2012. Vol 143, No. 1, 20-30. 3 Bad teeth cause malnutrition in elderly. BBC News Health. May 21, 1999. 4The National Kidney Foundation. http://www.kidney.org/.

Undiagnosed dental and oral problems could be a leading cause of malnutrition in elderly people – the

problem may be exacerbated by a failure of residential and nursing homes to ensure residents receive

proper basic oral care. 3

Patients on dialysis often feel thirsty, but are instructed to control their fluid intake. These patients are

constantly looking for a way to relieve their dry mouth and satisfy their thirst.4

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Physical Removal of Pathogenic Biofilm

Inhibition of Bacterial Migration

Remineralization of Tooth Surfaces

Saliva Enhancement

Soft Tissue Conditioning

Ongoing Immune System Support

Comprehensive

Continuous

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The CONTINUUM

™ Continuous, Comprehensive Oral Care & Relief

The Interactive Relationship of Saliva & Mucosal Soft Tissue Supports a Healthy Mouth

MedActive’s Proprietary Formulation: Spilanthes Extract & ULTRAMULSION® Enhances saliva and coats/soothes the soft tissues of the mouth

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Nighttime Care Daytime Relief

Rinse PROPHY TAPE® (Floss)

Gel Spray Lozenges

Four Brands

2

Summary of the

Physical removal of plaque biofilms

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Continuous conditioning of soft tissue

Continuous remineralization of teeth

Continuous enhancement of saliva flow

Continuous cleansing of oral biofilm

Continuous relief of oral discomfort

Oral Professionals and Pharmacists Recognize Medication-Induced Dry Mouth Risk

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WhiteHill Oral Technologies Stafford, TX

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• All MedActive Brands are proprietary patented technology • ULTRAMULSION® and Spilanthes Extract are exclusively licensed by WhiteHill to MedActive for healthcare • WhiteHill provides MedActive with:

o Manufacturing (GMP) o Quality Control o Quality Assurance o Research & Development o FDA Label Claims Guidance

Licensed Intellectual Property

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Pending U.S. Patent Applications:

10/331,800 11/149,597 11/331,513 11/349,042 11/549,668 11/671,075

Issued U.S. Patents:

5,711,936 6,609,527 5,057,310 6,575,176 6,138,314 6,907,889 6,086,373 6,916,880 6,545,077 7,017,591

Pending U.S. Trademark Applications:

HI-IMPACT™

feel it working™

feel ‘m working™

Patient-Friendly™

Oral Relief CONTINNUM™

PROPHYLAXIS ESSENTIALS™

Clean, Lubricate, Moisten & Protect™

Biofilm Targeting™

Biofilm Management™

Registered U.S. Trademark:

MedActive®

ULTRAMULSION®

PROPHY TAPE®

SOFT ABRASIVES®

MedActive Oral Pharmaceuticals, LLC.

Headquarters:

8364 Forest Oaks Blvd. Spring Hill, FL 34606 U.S.A.

Phone: 352-293-2164 Fax: 352-835-7180

© 2011 MedActive, LLC.

Contact

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medactive oral care for dry mouth conditions

Health & Medicine