medical implication of developmental biology
TRANSCRIPT
![Page 1: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/1.jpg)
Medical Implication of Developmental Biology
![Page 2: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/2.jpg)
ContentsInfertility
◦Assisted Reproduction Technology (ART) In Vitro Fertilization Intracytoplasmic sperm injection (ICSI) Ovary transfer
Developmental cancer therapyGene therapyStem cells and therapeutic
cloning
![Page 3: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/3.jpg)
Infertility• Inability to achieve or sustain
pregnancy. • Not a disease.
• 80% by 1.5 years, beyond 2 years.
• Failure of ovulation, physical blockage, sperm defects.
![Page 4: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/4.jpg)
In Vitro FertilizationAssisted reproductive technology
(ART).
Four steps◦Ovarian stimulation◦Eggs retrieval, aspiration◦Fertilization, sperm collection and
“washing”.◦Embryo transfer.
![Page 5: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/5.jpg)
![Page 6: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/6.jpg)
Intracytoplasmic Sperm InjectionProcedure in which a single sperm is injected
directly into an egg. In vitro fertilization.
![Page 7: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/7.jpg)
Ovary Transfer
![Page 8: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/8.jpg)
Developmental Cancer Therapy
Cancer can be seen as a result of altered development.
![Page 9: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/9.jpg)
Cancer Therapy- Angiogenesis Inhibition
Angiogenesis◦The formation of new blood vessels.◦Is utilized to provide blood supply to
a tumor◦Tumor cells secrete molecules such
as VEGF(Vascular Endothelial Growth Factor)
![Page 10: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/10.jpg)
![Page 11: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/11.jpg)
Angiogenesis InhibitionAngiogenesis inhibitors are drugs that
prevent angiogenesis and hence prevent vascularization from occurring.
Natural and synthetic inhibitors of angiogenesis have been characterized by several groups.
Some angiogenesis inhibitors have been FDA approved for humans
![Page 12: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/12.jpg)
Gene TherapyThe insertion of normal or genetically altered
genes into cells usually to replace defective genes especially in the treatment of genetic disorders.
Somatic cell gene therapy◦ (e.g. through blood or liver stem cells)
Germ line gene therapy◦ by modifying a germ cell or fertilized egg and
transferring to next generation.◦ by modifying embryonic stem cells and making a
body )
![Page 13: Medical implication of developmental biology](https://reader035.vdocument.in/reader035/viewer/2022062319/55572155d8b42a320c8b47c6/html5/thumbnails/13.jpg)
Stem Cell - MedicineThe human stem cells can be
used to produce new cells or organs (neurons, blood cells, pancreas etc.) for people with diseases or failing organs.