1 MA’ 1971

VOLUME3 NO. 2 OFFICIALPUBLICATIONOF THE MEDICALSOCIETY,H.K.U.S.U. 15THFEBRUARY1971

EDITORIALThenewmedicsweaterthatwasoutrecentlyhasseemingly

inedgeneralacclamation.

Beforethis,medicalstudentsweremerelymarkedby -besidesthebooksin theirhands. themedictieandblazer.Andnowit seemsthatthereissuddenlyanewpopulationofmedicalstudentswalkingaboutintheirbrandnewnavybluesweaters.

Thesepeopleconstitutedpartof the”out”crowdof thefirstandsecondyearmedicswhohavesofarbeendeniedoftheprivilegeofwearingamedictie,letalonebuyingone.

Thefactis:althoughthereisnohard-and-fastregulationwhatsoevergoverningtheexhibitionofthisarticle,membersoftheMedicalSocietywhoarenotthrou yetwiththe1stMBexaminationarejustrefrainedfromdoingsobya traditionthathasbeenhanded-downforalltheseyears.

Perhapsonemayarguethatthemedictie hasbecomesomeformof a rewardforthe1stMBcandidates.Butthatjuststartedonerememberingthecutelittlewhitepigonegotinthegoodoldkindergardendayswhenoneshouldpresentacleanepidermis.

Thepointis: the medictie, withits presentstatus,stigmatiseda barrierbetweenseniorsandjuniorsamongmembersmembersoftheMedicalSociety—-confe!ringasenseofinferiorityaridinsecuritytothelatter.

Whilefraternisingthefreshmen(aswealwaysdoeveryyearwhena newacademicyearstarts),withbarrierandthestigmataofit,mustbeabolished.. - —

Thesweateris a goodstart.Let’swiththetie.

seewhatwillhappen

MEDIC-ARTS-SOCIALBARNDANCE

TheMedicbarndancewasheldin theeveningof 15thJan.,1971at ourMedicCanteen.Over40 ladiesanda fewgentlemenfromtheFacultiesof ArtsandSocialScienceshonouredtheoccasionbytheirpresence.ThiswasthefirsttimethatOurja handswereextendedto theSocialSciencesfellowundergiads.Thefunctionwaswellsupportedbymore

•thana hundredstudentsfromthevariousclasses.Manywereonlytooreluctantto gowhenthegatheringendedbymidnight.midnight.

Seudae:Decreasein thepopulationof theMedicallibraryWitflacorrespondingincreaseintheUnionLibrary.WHERECAN ALL THE MOBILESGO?

Whilethetrafficconditionin HongKongisdeterioratingdaybmday,theMedicalstudentshavealsostartedappreciatingitsmaunancylately.Withthecar-parkinfrontoftheCanteengone,mecar-ownersalreadyfelt theinadequacyof parkingSpaces;andarsareseenscatteredallalongSassoonRoad.AndasfromJan.,5,carsofmedicalstudentsareprohibitedtopark111QueenMaryHospitalCompounduntilfurthernotice.Soredy,wherecanallthemobilesgo?

PROFESSORFREQUENTER-OF-LIBRARYMinya time,prof.Robertscanbeseensittingin the7, wellabsorbedinhisbooks.HeistheprofessorI comem ofteninthelibrary.ThosewhohaveattendedhisI mustadmitthattheyareconcise,fullofconceptsand

: HisefforttopreventcerebralindigestionamongI to becomplimentedandI thinkhispresencein‘helpstomaketheplacelessnoisytoo.

AS THEY SEE US

EXCELLENTTEACHINGFACILITIES

Ontheirarrivaltheywereagreeablysurprisedto findtheplacecleanerthanexpectedexpectedandeverythingverywellorganised.Most impressivewasthe“excellentteachingfacilities”,especiallyat theoutpatients’department.Asyet,languageposednoproblem,problem,andpatientswerenotuncooperative.In addition,everyonearoundthewardsweremosthelpful.Theysuspectsuspectthhis hqpystatefaffairsprobai...xistsonlyforthem.

Their MedicalSocietybackhomedoesmuchaboutthesamethingsmostmedicalsocietiesdo. Amongotherthingslikerunninga cheapbookstore,producinga newspaper,newspaper,printingnotes,sponsoringsponsoringa varietyof sports,andtakingcareof allpoliticalpoliticalmanoeuvers,theSocietyoccupiestwo seatsin theFacultyBoardthusdirectlyparticipatingin criticisingtheircourses,andalsoorganisesorganisesmedicalconventions.STUDIOUS,CONSCIENTIOUS

STUDENTSWhenaskedwhatthey

thoughtofthestudents’attitude,attitude,they were of theopinionthatlocalstudents,atleastthosetheyhavecomeacrossinthehostels,areverystudious,veryconscientious,butsomewhatdisinterestedinextracurricularthings.Theybelievethat thisconditioncouldbedueto theimportanceimportanceof the degreetostudentsin HongKong,somuchsothatnothingwouldbedonetojeopardiseitsrealisation.realisation.

LAfENTE STUENTSTAFFSTUENTSTAFFR ATjHIP -Astothestudent-staffrelationship,

relationship,theyfoundthisbeingkeptattooprofessionala level,resultinginalamentablelamentablelackofdialoguebetweenthetwo.Whattheymostdeplore

deploreis thewayin whichstudentsareopenlycriticisedinfrontofthepatients.Theyhavesofarneverencounteredsuchtreatmentabroad.Theysuggestedthatamoreacceptableacceptablemethodof settingrighterrorscouldconsistofsimplyinformingor demonstratingto thestudentsthecorrectwayhowthingsshouldbedone.

Theirtightschedulehasnotallowedthemmanyopportunitiesopportunitiesto taketimeoutto seethecity.Theyhavecome withoutpreformedideas.However,theywouldliketo havea lookat theunique resettlementareasbeforeleavingfor home.Theywouldrecommendmorestudentsto cometo HongKongfortheirelectives,butthatthenecessityto fmancethe wholeenterprisefromtheirownpocketscouldseriouslyseriouslydetera greatmanyfromcoming.Theyhopethatclosercooperationbetweenthemedicalsocietiesofbothuniversitives,somesponsorsandsparebedsinthehomesof localstudentswouldhelpeasethesituation.

TheirSpecialtyClerkshipendsbytheendofFebruary.Let us wishthemeverysuccess.

EXCHNtiEPUBL1ATIONINTHELIBRARYNOWIn reviewin...thatjn the

past,therewasa confusionin the exchangeofpublications,it waspassedinthefirstCouncilMeetingoftheMedicalSocietythattheExternalAffairsSecretarywill takecareof all theexchangedpublicationswithother Universitiesororganisations.In ordertofacilitatethereadingoftheseexchangedpublications,itwas arrangedwith theLibrariantoprovidea cornerin the librarywheretheabovementionedpublicationscouldbeplaced.

MissJ. ThompsonandMr.D.J.Hodgkinson,twoof thestudentsfromtheUniversityof SydneywhoarehereatpresentdoingtheirSpecialtyClerkshipinMedicine,werekindenoughto letushavesomeideasastowhatotherpeopledo,andalsohowothersseeus.

Theyhavecomespecificallyto HongKongon severalgrounds.Oneof theseis thattheircurriculumincludesanelectiveperiod.Anotheristhatthematerialsavailableandtheteachingstandardaremoreor lesscomparable.in bothuniversities.Moreover,thegreatnumberof casesin HongKong,concentratedintoa fewhospitals,provideamplepracticalpracticalexperienceandincreasedopportunitiestoseerarecases.

vvaniLUnecome“AWFUL’ VISITORS WELCOMED

THEfollowingprofessorsfromabroadwillvisitourMedicalSchooltoactasExternalExaminersintheirrespectivesubjectsinthedatesindicated:

Prof.R.Warwick,B.Sc.,Ph.D.,M.D.,Headof theDepartmentDepartmentof Anatomy,Guy’sHospitalMedicalSchool,London,fromFebruary,28toMarch,8,1971.

Prof.Williams,M.D.,F.R.C.P.,F.R.C.Path.,ProfessorofBacteriology,TheWright-FlemingInstituteofMicrobiology,St.Mary’sHospital,London,fromApril,14toApril,25,1971.

Prof. EleanorZaimisM.D., B.Sc.,ProfessorofPharmacology,RoyalFreeHospitalMedicalSchool,London,fromApril,18toApril,28,1971.

Prof.Fairweather,M.D.,F.R.C.O.G.,ProfessorofObstetricsand Gymaecology,HonoraryConsultantObstetricianandGynaecologist,ObstetricHospital,HuntlyStreet,l.ondon,fromMay,10toMay24,1971.

a C.D. or 0.0. ?The5thGeneralAssemblyofARMSA willbe heldinSydneyfrom10thAug.,1971to15thAug.,1971.The20thGeneralAssembleof IFMSAwillbeheldinNewZealandfrom16thAugust,1971to27thAugust,1971.ApplicationsApplicationsaxenowopenedtoallFULL MEMBERSof theMedicalSocietyfor- aChiefDelegate,andOfficialObserverObservertothetwoGeneralAssembliesAssembliesmentionedabove.Forfurtherdetails,pleaseconsulttheExternalAffairsSecretaryortheposterthatwillbeputup in Medic Centre.ApplicationformsareavailableavailablefromtheGeneralSecretary.Secretary.Deadlineofentryis26thFeb.,71.

MEDICALsTUDENTS’CENTRE.SASSOONROAD,

HONGKONG.

Page2 CADUCEUS

CADUCEUSEDITORIALBOARD

Hon.Adviser: Dr.PaulC.K.YueEditor-in-Chief: RobertLawGeneralEditors:

Hon.SecretaryShamTakCheongJohnHon.TreasurerYeungKwokWai

PidbnagingEditor: NgHinKwongAcademicEditor: RebeccaWangArt&PhotographyEditors:j NaiHae

JulietLauChineseEditors:

NgaiLoiCheungChowSzeFu,Joseph

ExternalAffairsEditor: TsangchiuWahFeatures&CorrespondenceEditor:RoseMakInternalAffairsEditor: ShekSluLamSportsEditor: PongPingSumRepresentativeofpreviousEditorialBoard

LaurenceChanChiefEditorofElixir: HoChungPing-

———a e ———-Sub-Editor: LiChunSang

Theviewsexpressedby ourcontributorsarenotnecessarilythoseof the EditorialBoard.

TheEditorialBoardwishesto thankthespecialsupportof theGlaxoLab.Ltd.

Where topical antifungals

cannot penetrate

Grisovin

acts from within

,

Grisovin is available in 125mg. and 500mg. tablets.

GlaxoGlaxoLaboratoriesLtd.Greenford.Middlesex.UKAgentsfortheGlaxodivisionofGlaxoAllenburys(Export)LtdDodwell&CoLtd,P0Box5849,HongKong

A

CAR PARK

BECAUSEOFtheconstructionworkinQMHandtheMedicalStudents’Centrecar-parksinthesetwoplacesbecomelimited. The prohibitionofstudentsfromparkinginQMHhasnodoubtcreatedmuchinconvenienceinconvenienceto clinicalmedicalmedicalstudents.

Thisproblemwasbroughtupduringthe Dean-Undergradmeetingon 5th February,1971again.Thosepresentwereinformedthattheprin.cipalofNorthcoteCollegeofEducationhadkindlyagreedtopermitmedicalstudentstouseeightparkingspaces(ontherightinfrontofthemainentrance)whentheyarenotneededforcollegepurposes.Itis importantthat studentsusingthecar-parkshouldacceptanydirectionsgivenbythecollegestaff.

Thepossibilityof obtainingStudentParkingPermitsinQMHwasalsotouchedupon.It wasdecidedthata surveybecarriedoutby theclass-representivesclass-representivesof 3rdand4th

It isunderstandablethatthisparkingproblemhasbecomeaheadacheto all thoseCon.cerned.Evenso,it mustbeemphasizedthatthereisnoroomforforgedparkingper.mits. AnybodyfoundusingforgedparkingpermitswillbereportedtothePoliceandthecentralauthorityof theUniversity.University.Pleasebepatient,andshouldyouhaveanysuggestionsorpossiblesolutionto thepro.blem,donothesitatetoforwardforwardit to eitherMr.A.P.Walker,theFacultySecretary,oranyoneoftheex-codirectlydirectlyor throughyourcLass-representatives.

(M.C.)

So you think you know love now! No!

BernardLau

“Whenpeoplehavesomestrange,pleasantfeelingtowardsothers,especiallyoftheoppositesex,whichmightbebeyondtheirdescriptionor understanding,theywill naturallyandimmediatelyattributethisto love;hencetheabuseof theword.”

“If lovedoesexistandif loveisreallyrespected,eventhesparklesof it canenlightena newpathof life,thedrivingforceofwhichbecomesdependentonlove.”

“Loveislikeechoes.Themoreyougive,themoretheywillreturnuntoyou.”

“If yourejoicebecauseyourbelovedhasgainedwhatyouhavelongedformadly,yourloveistrue.”

“Nolovecanbesaidtobecompleteif thereisnosharingof joy andsorrows,problemsandsolutions,pleasureandsuffering,comfortandhardship,praiseandcontempt.”

“If youarefaithful,LOVE=Like+Opportunity÷Valour+Equality

Andif youarereallyluckyenough,LOVE= Life÷Offer+Volatility÷ Eternity

However,astimegoesby,LOVE= Lie+Overindulgence+Voracity+ Exclusion.”

“Thebeginnersareoftendepressedbecausetheyfearthatall thefeelingtheyhaveofferedsoreadilyandunreservedlymightbe lostintotheairall of a suddenwhentheyarerejected.”

“Fallingrainplaysmusicforthoseinlove,butthesamenoisesarecursedbythemelancholyandthelonely.”

“Lovecanbelikea game;therearewinnersandlosers,tearsandlaughters,joy andsorrow,sweetandhauntingexperience.”

“Themoreyouareconsciousof probabilityof love,theless likelyyou will experiencetrue love,becauseofhypersensitivityandmisinterpretation.”

“Themostbeautifulsunsetis oneby yourbelovedtogether.”

“Youngstersoftenfeeldisappointedin theirloveaffairsbecausetheyalwayswishtogain,ratherthanoffer,andtheirdesirestobesatisfied,ratherthansacrifice.”

“Platonicloveislikenaturalspringwater;it isnottastybutit flourishesthefloweroflove.”

“Howharshis thesee-sawtypeof love:Whenyouaregoingto offeryourself,youfindyourselfnotaccepted;butwhenyouaretoogrievousandscaredtostayon,yourbelovedwavesherhandtoyou.”

“Hatredis nottheoppositeof love,butdisconcernisoppositetoboth.”

“Thedeeperyoulovea person,themoreyouwillallofasuddenhateher.”

“Anounceof lovecanmorethancancela tonofhatred.”

“Thedilemmaofdecidingwhethertoacceptorrejectyourproposerislikethebreaking-and-closingpotentialinn electriccircuit,whichcausesmoredisturbancesthanthenonnalflow.”

yearstofindoutif therewereunoccupiedparkingspacesattimeswhenmedicalstudentsarein needof them.Thisisessential,accordingto theSeniorHospitalSecretary,while the constructioninQMHisgoingon.It wassuggestedsuggestedthatthesurveybecarriedoutfora numberofconsecutivedaysat regulartime intervals,say,8:30a.m., ):3Oa.m.etc.It ishopedthatafavourablereportofthesurveywillfacilitatenegotiationnegotiationwiththeSeniorHospitalHospitalSecretary.

CADUCEUS Page3

ImmUnOSUPPreSSiVeAgents

Theantiproliferativeagentsappeartoactprimarilybyirnpairingirnpairingcellreproductiveintegrity.integrity.Thismeansthattheaffectedcellsmayremainaliveandmaycontinueto carryoutmanyof theirfunctions,butareunableto reproducesuccessfully.SynthesisofDNA,RNAandothercellconstituentsmaycontinueatthenormalratebutthecelleitherfailstodivide,formingagiantcell,oritcommencesadivisionthatit cannotcomplete,complete,orit dividesunsuccessfully,unsuccessfully,withchromosomesunequallyunequallysharedbetweenthedaughtercellsordamagedinsomeway.Theselesionsmayeventuallyleadto celldeathbut,evenwhentheydonot,theaffectedcellsare‘dead’sofarastheirreproluctiveabilitiesabilitiesareconcerned.

Thereasonsforbelievingthatimpairmentof cellreproductivereproductiveintegrityis thebasicmodeof actionof theantiproliferativeagentsareasfollows:I. Correlation of immunosuppressiveimmunosuppressiveandantitumourantitumouractivity:Almostalleffectiveeffectiveantitumouragentsareimmunosuppressive.immunosuppressive.Not onlythis;whereoneandthesameagentisusedclinicallyorexperimentallyexperimentallyeitherto treatneoplasmsorasanimmunosuppressive,immunosuppressive,thedogethathasbeenfoundto bethemostusefulisvirtuallythesameforeitherpurpose.2. Time-dependenteffectsofimmunosuppressiveagents:Mostagentsthatimpaircellreproductiveintegritydosomosteffectivelyif thecellsconcernedaremultiplyingrapidlyrapidlyatthetimetheyareexposedexposedto the agent.Thisappliestosuchagentsasmethotrexate,methotrexate,6-mercaptopurine,5-fluorouracil,vincaleukoblastincvincaleukoblastincandactinomycin.Timingexperimentshaveclearlyshownthatagentsofthissortinterferemaximallywithimmuneimmuneresponsesif theyaregivenduringthefewdaysfollowingfollowingadministrationof antigen,antigen,whenthecellsconcernedconcernedareproliferatingmostrapidly.rapidly.Administrationbeforetheantigen,whenimmunocyteaimmunocyteaarenotrapidlymultiplyingIsineffective.

Radiation,on the otherband,Isableto Impaircellreproductiveintegritywhetherthecellsaremultiplyingornot.If theyarenotproliferatipgproliferatipgat thetimeof irradiation,irradiation,thedamageis stored,sometimesfor monthsoryears,untilproliferationIsIn-

duced.If the immunosuppressiveimmunosuppressiveeffectsof radiationareduetoimpairmentofcellreproductiveintegrity,wewouldexpectradiationtobeeffectiveif givenbeforetheantigenanditseffectstobelong-lasting.Boththeseexpectationsexpectationsareborneoutinpractice.

Theconclusionisinescapableinescapablethatthemainmodeofactionof immunosuppressiveagentsof theantiproliferativeclassisimpairmentofthereproductivereproductiveintegrityof cellsthatmediatetheimmuneresponse.response.

Interferencewithcellreproductivereproductiveintegrityis, ofcourse,notthewholestory,evenfortheknownantiproliferativeantiproliferativeagents,X-rays,forexample,example,probablyimpairmacrophagemacrophagefunction.MechanismsofImpairmentofCellReproductiveIntegrityThereare two principal

knownwaysbywhichantip.roliferativeagentsaffecttheabilityof cellstoreproduce:(a)byinhibitingtheenzymesmediatingthesynthesesessentialessentialforcellreproduction,and(b) by interferingwiththetemplatesusedby someoftheseenzymesfortheassemblyassemblyof complexmacromolecules.macromolecules.

Enzymeinhibitionis aprincipalfeatureof antimetaboliteantimetaboliteaction.It maybebroughtabouteitherbycompetitioncompetitionbetweensubstrateandantimetabolitefor thesamebindingsiteontheenzymemolecule,orbytheantimetaboliteantimetabolitemimickingnormalproduct-inhibition.product-inhibition.

ThetemplatesconcernedincellreproductionaretheDNAandmessengerRNAmolecules.AssociatedwiththesearethetransferRNAmoleculesandribosomesthatenablemessengermessengerRNAtemplatestoactinproteinsynthesis.Therearemanywaysinwhichimmunosuppressivesimmunosuppressivescaninterferewiththefunctioningof thiscomplexcomplexsystem.TheDNAchainmaybesplitbyX-raysormitomycin.mitomycin.ThecomplementarystrandsoftheDNAhelixmaybechemicallycross-linkedbyalkylatingagentsormitomycm.mitomycm.Theinformationencodedin the sequencesof nucleicacidbasesmaybealteredbysubstitutionof abnormalpurineor pyrimidinebases,suchas 6-thioguanineor5-fluorouracil,for normalones.TheabilityofDNAtoactasa templateforRNAsynthesismaybereducedbyagentssuchastheactinomycins,actinomycins,whichbindtightlytotheminorgrooveon theDNAdoublehelixandsopreventaccessof RNApolymerase.Theattachmentof messengerRNAtotheribosomesmaybepreventedbychioramphenicol.Theaminonuclcosideantibioticsantibiotics(streptomycin,neomycin)alsoattachto ribosomesandcausea‘misreading’oftheinformationinformationinattachedmessengermessengerRNA.TheproblemofToxicity

Thedifficultiesinusingantiproliferativeantiproliferativeagentsstemlargelyfromthefactthattheyimpairthereproductiveintegrityintegritynotonlyof lymphoidcellsbutofanyproliferatingcells,includingthoseofbonemarrow,intestinalepitheliumandskin.Withtheseagentsthereisalwayslikelytobeaproblemin steeringbetweentherapeuticeffectandintolerableintolerabletoxicity.TheSearchforNewDrugs

It is obviousthatvariousagentsdifferverymuchintheratiobetweentherapeuticallyeffectiveandtoxicdoses.Withdrugslikeazathioprineandcyclophospharnidethisratioishighandit isoftenpossibleto

obtain highlysatisfactoryeffectswithnegligibleoronlymoderatetoxicity.It wouldbedifficultto dothiswith,say,nitrogenmustardoractinomycinactinomycinD,andpracticallyimpossibleimpossiblewith whole-bodyirradiation.Thesedifferencesintherapeuticratioareduetothe differencesbetweenvariouscell typesin thefactorsthataffecttheirsensitivitysensitivitytodrugs.

It is exceedinglyunlikelythattheagentswefindmostusefulnowhappento havetheoptimumcombinationofall thesefactors.Therefore,thesearchforbetteragentsisneeded.Sucha searchcanbecarriedonbythemoreorlessblindtechniqueof screening,butit wouldhemoreeconomicaleconomicalin thelongrun,andmoreinteresting,to studyindetailthefactorsthatdeterminedetermineselectivityof actionofdrugsandto usethisinformationinformationtodesignnewdrugmoleculesmoleculesona rationalbasis.

CombinedTherapy

Whilewecanusesynergisticsynergisticcombinationsofdrugs,thiswouldbeof littleuseif asynergisticeffectinimmunosuppressionimmunosuppressionwereaccompaniedbyanequalorgreatersynergywithregardto bonemarrowtoxicity.Thetypeofsynergywearelookingforissynergywith regardto therapeuticratio,andtherapeuticeffect29dtoxicitycannotbeconsideredconsideredaparthere.Agoodexampleexampleofsuchsynergyisprovidedprovidedby theuseof agentswhicharenotin themselvesimmunosuppressivebut areabletoprotectnon-lymphoidtissuesfromthetoxiceffectsof immunosuppressiveagents.Folinicacid,forinstance,doesnot alter the immunosuppressiveimmunosuppressiveeffectofmethotrexatemethotrexateintheguinea-pig,butitgreatlyreducesits toxiceffects,sothata considerableincreasein therapeuticratioresultsfromadministeringbothagents.

DesignofselectiveDose

Regimens

CORRECTION

SOFTBALLSQUASHTABLE-TENNIS

theproblemof toxicityistoadaptthe therapeuticschedule,schedule,i.e. dosesizeandfrequency,soastoexploitdifferencesdifferencesin drugsensitivityandproliferativeorrecuperativerecuperativeratebetweenvariouscellpopulations.Letusartificiallysimplifythisproblemto thepointwhereweareconsideringconsideringonlytwocellpopulations,oneofimmunocyteswhichwewishto damageasmuchaspossible,andtheotherof avitalandvulnerablecellpopulation,population,suchasbonemarrow,whichwewishtoconserveasmuchaspossible.Boththesecellpopulationsexistin thesameindividual,sothatwecannotproducethewidelydivergentdivergenteffectsweareaimingatbyusingywodifferentdoseregimens;theoneregimenhastoachievebothpurposes.

Relativetoeachother,thetwocellpopulationsmaybeeithersensitiveor insensitiveto thedrug,i.e.agivendoeswillproduceeithera largerorsmallerdepletion.Further,therecoveryfromdepletionofeachpopulationwillberelativelyrelativelyeitherfastorslow.Nowit isevidentthatsensitivecellswillbedamagedbyonlysmalldosesof drugandinsensitivecellswillrequirelargedoses.Similarly,a cellpopulationthatrecoversrapidlyfromdepletiondepletionwillrequirefrequentdosesof drugtokeepit depleteddepletedwhereasa populationthatrecoversslowlywouldrequirerequireonlyinfrequentdoses.Supposeoneofthecellpopulationspopulationsweareconsideringissensitiveandrapidlygrowingandtheotheris insensitiveandslowlygrow.Theop.timumregimenforeliminatingtheformerwhileconservingthelatterwillbeoneofsmallfrequentdoses,whilethereversereverseeffectwillfollowsfroma

regimenofmassive,infrequentdoses.If we knewwhatcategoriesour immunocyteandbonemarrowpopulationsbelongedto,wecouldchoosethe typeof regimenthatwouldachievethe desired

Thiswouldseemsto be apromisingfieldforclinicalreMr.

reMr.ClementHO(2ndYear)Mr.WANHoYue(3rdYear)Mr.LAUKaiChiu(4thYear)

ANTIPROLIERATIVE AGENTS AS

IMMUNOSUPPRESSIVE DRUGS

Agentsknowntobeantiproliferative:X-rathatiofl

Alkylatingagents(cyclophosphamide,nitrogenmustard)A.ntimetabolites:Antipurines(6-mercaptopurine,azathioprine),

antipyrimidines(cytosinearabinoside),antifolics(methotrexate),antiglutamines(azaserine,DON)

Antibiotics(actinomycin,mitomycin)

Alkaloids(vincaleukoblastine,colchicine)

result.

Anotherwayof tacklingsearch.

withtheSportsSecretary’sapologiesThenamesof thefollowingTeamCaptains,whichweremisrepresentedinthelastissueofCaduceus,shouldread:

MINI-SEMINAR ON ABORTION

A mini-seminaronABORTIONhasbeenorganizedbyTHEGUILDOF ST’ LUKE,SS.COSMAS& DAMIAN,HONGKONGin associationwiththeCatholicMarriageAdvisoryCouncil.

Date:Thursday,25thFebruary,1971Time:8:30p.m.Place:RuttonjeeSanatorium,Queen’sRd.East,H.K.

Principalspeakers:JudgeSimonLiMr.LeoF.Goodstadt,deputyeditoroftheFarEasternEconomicReviewRev.Fr.PeterBrady,S.J.,WahYanCollegeDr.GeorgeOu,Psychiatricspecialist,aridmedicalsuperintendentofCastlePeakHospitalDr.RamonC.Ruiz,MasteroftheGuild(Convenor)

AllCatholicmedicalstudentsandmembersof theMedicalprofessionarecordiallyinvitedtotakepartinthediscussions.

HERE’SAN EXCUSETO STARVE

YOURSELFAND GET SLIMConsideringtherisein priceof foodarticlesandwages,

it is decidedby theCouncilthata smallincreasein priceof foodsuppliedbytheMedicCanteenbeallowed.

Startingfromthe21stFeb.,1971,thechangesareasfollow:

Forbreakfast variousvarietiesof friednoodlesfrom50.80to $1.00

Forlunchanddinner. . . . variousvarietiesof friednoodlesfrom$1.50to $1.80usualricedishesfrom$1.80to $2.00

Lightrefreshmentswillbeprovidedatabout10:00p.m. Thepricesfortherestwillremainunchanged.

妒攤• ‘

香港大學學生會

醫

學

會

月

刊

第

三

巷

第

二

期

一儿七一手二月十五日

（一）連卡佛大減價，東西好便宜l·

考試嘛，誰

才有心情去擠！

滿街都是中庸和密實裝，配上靴子，甚好看！

管他呢，考完試才算！·

喲，今年的暑假一個月，要好好的玩一陣，不

然，以後一年沒有假期，要扯啦！我想到美國一遊，

看看幾年沒見的老友，不過，這要用很多錢，退一步

嘛，到東南亞及日本一行，也是樂事，只是，只是，

我要考試考得好，才可以去！唉t·

考試，考試，似乎我以後的生活方針，喜怒哀樂

·都維繫在這個考試。畢業嘛，當然大件事，從××

小姐先生，榮陞為××醫生，多少羨慕的眼光向你射

過來，只要你合格！

畢業，興奮是當然。但老實說，我不想畢業，也

不想韶斑，做學生多暢快，除了考試之外，輕鬆自在

，無責任可言，考完試之後，又可以藉口狂玩一頓·

畢業了呢？前面鋪的是什慶路我不知道，可能庸碌一

生而毫無成就。

畢業雖說前途未卜，但畢不了業更慘。同學說，

帝斑蛟大的問題是面子。並不是浪費金錢和時問．很

多人說，女孩子怕什麼·一定不會肥的，我認為

·這是絕大的看不起女孩子們·合格，即是說被人開

恩·不合格嘛，便是精透f扶不起的阿斗·事實是這

樣嗎？不過，考試時不免汗顏慚愧，自覺無面目見老師

，因為他問的東西·教過的，也吶吶不知所答，老師

，希望你明白考試時是慌得魂飛魄散，六神無主，我

或許原本是懂得的嘛。誰不想做個好學生？

考試像個無影的籠，困得好苦，但想起考完後可

以去旅遊。心中不禁大樂，遊地方是我般大的愛好；

到別處短衍地換．下環境，欣賞完別地的風土文物人

悄，回家後會特別覺得它親切。只可惜，廿多年來未

能回中國內陸，因為我怕毛叔叔忽然帝我長住，台視

，去過雨次，手續之煩，前所未有，為什慶中國人不

能自由出入自己的地方”

（二）哎地，NlJ完了一個試，這麼快又唸書？好訝

異的口氣。何必假猩猩作態呢？誰不知你是對人狂玩背人狂

唸的人，說什麼假話，唸書不是犯伕，多唸也不見得

表示比別人蠢，你說不用讀書，別人也不會信，多虛

偽的人。有一些人，看見自己眼中釘，卻上前親熱招呼一

番，笑襄藏刀；看見別人衣服古怪，卻要特意去稱讀

，背轉身卻又作嘔狀，何苦呢？多虛偽的人！

你會懷疑四周的人都是對你虛情假意嗎？

（三）

今天一早回校，瑪麗的斜坡上橫架了一條黑白相

間的木條，請回吧I·這裹沒有你泊車的地方！

李樹芬樓附近擠滿了備塵的車，醫生住所旁的空

地水洩不通，何處是吾車的家？在中區受薛璞大人措

施之苦不少，想不到回到自家的地方，也不外如

是。好容易在牛奶公司附近的草地泊了個位，徒步走

上教授樓，經過停車場，疏疏落落的放了幾輛車，佔

據了偌大地方，在陽光下向我嘲笑，像是在說：你是

什麼東西，想在這兒泊車？

我遠沒有責格做東西，比人家說醫院最低

動物的實習醫生還不如，四個月、四個月，天才知

道我會不會榮陞為一點的東西默

（四）

那輛j.t厭的鏟地皮工具又在開動了，好好的草地

，好好的石塊，都統統被翻轉，為什麼一下子四周都

在改建？那兒才有塊淨土？

正如我唸書一樣，考試一個月前還在遊遊蕩蕩，

電視機前永遠有我的影子，明天才算·反正時問還多

！到了審判的口子·書給我翻得東歪西倒。凌亂不堪

。真是沒有遠見的人嘩；為什麼不懂未雨網繆？

一百五十個學生；二百個學生；二百五十個··⋯州州州州．..,、戶、j' . •．•．'，•••、’. ••• ,．、.，戶鳥，．、•，州•．'k 邊、'，尸,‘、．',

我不能忘記她。我真的

不能忘記她•不是因為我嘗

試了多次都失敗，而是我本

來不想忘記她·我和她過去

的一切，還歷歷在目，好像

發生在昨天似的。每次遇到

有關愛、生命或快樂等事物

時，我便不禁埋沒在一股洶

湧的回憶洪流與。這洪流，

找不知是從那裹開始，也不

知它會在何處停止，祇是永

遠，永遠的滾滾地流。

我是三年前在一個偶然的場

認識她的。事實上也不特別的，祇是我對她的印象

深RlJ了。我望她第一眼時，我便深深的被吸引了。

心而論，她不算太美，我曾見過比她美麗得多的少

，但不知怎的，我毫不猶豫地在心中對自己說：

了，這就是了·從那時開始·別的女子已失去了

引我的力量。當我坐在她的對面時，我真的目不轉

地看著她，我自己一點也不感覺到這是多慶的失態

呢。尤令我迷醉的是她的笑容·她笑起來是那樣甜悅

可愛，毫不讓人有反抗的餘地；又是來得那麼的自然

，半點也沒有矯飾的份兒。在我的眼底中，她還是一

個純潔率直的女孩子，我真的想從她身上，找尋出過

去年青的我。她的一舉一動，都足以使我回憶我以前

的一切。很奇怪。我平日應付少女的社交手腕，都不

知走到了那裊去。每次想說一句話時，都要鼓起萬二

分的勇氣，和在心中默念了多次才敢放肌說出來，但

說時又常常口吃吃似的，惹得她屢次怡然而笑，而我

，則滿面通紅。

愛，往往是從一點小小的火星，尋到合適的燃料

後，而慢慢燃燒起來的。根本上，愛就是生命的火花

；畢竟也是生命所不能缺少的原動力·我倆的愛，不

久已到了不能分開的地步。

不幸，人有悲歡離合，月有陰晴圓缺，上天

竟然嫉妒我們，死神的手把她從我的懷中搶走了。她

含笑而逝的那一剎那。我真的不敢再復回想。當時，

我曾悲痛得不欲倫生，哭泣不知凡幾。正是春蠶到

死絲方盡，蠟炬成灰淚始乾。然而，冗長的時問，

漸漸沖淡了我心中的創傷。

至今，兩年多了。我倆所留下在公園野郊的足跡

可能已被擦抹無遺，但她的倩影·甚至她的一切。卻

永不能從我的腦海中洗去。平日事務繁忙，那就沒有

怎樣，但當我獨自靜靜的坐著閒思，或在舊地重遊時

，她的笑容，便再次呈現出來。

最近，我竟埋頭於酒杯中，可能在酒醉時·迷矇

中，能重返舊夢，我的摯友文曾多次苦勸我自愛健康

，努力戒除這惡習，但我怎能怪他，他還祇是一個不

知天高地厚的小伙子呢．近日，對狂歡玩樂甚惑興趣

，每每不盡興不歸，藉以麻醉自己的思想，暫時拋開

心中的憂鬱，可惜回到家中時，無形的空虛，又再次

佔有我的心靈了。

案頭上相架中的少女，就是日夕不能忘懷的她。

媽時常罵我為何痴痴的凝望看而至寢食不思。唉！她

又怎知失去了的已不能再彌補了，又有誰能了解我的

心音）呢。她現在在何處？快樂不？她知不知這世界上

還有一個痴心人想念著她呢？她知不知道因為她離開

了我，我已喪失了生命的活力呢？昨日的歡樂的果子

，已成為今日的苦惱；明日生涯，何去何從呢？這一

切的一切，不斷在我的腦海中環繞著。

現時，在說不出的苦悶中，唯一的希望就是忘卻

過去的事物，拋棄現在的自己，而再次建立自己未來

新的世界，但是·。這一段遙遠的愛，又要到何時何日

才得以補償呢？兩條不同方向的線，

交叉於一點；

是快樂與快樂的起點，

點是沒有長潤，

沒有時分，

只在心靈深處，;

隨著命運的軌跡，

兩線各自向前·

是痛苦與痛苦的起點；

帶著似甜又酸的回憶，

負著懊悔的重袒，

直至永遠。

也許，線要不是直的，

始終，還有再交叉的一點髡