Meeting Program June 5, 2019

Medical Sciences Building, University of Toronto http://www.neuroscience.utoronto.ca/events/CPIN_Research_Day.htm

Collaborative Program in Neuroscience (CPIN)

2019 Research Day Next Generation of Neurotechnology Symposium

Wednesday June 5, 2019 Medical Sciences Building, University of Toronto

Program Schedule

9:00–9:30 a.m. Registration Opens (Medical Sciences Building Stone Lobby) Trainee Poster Set-up 9:30–9:40 a.m. Welcome and opening remarks (Room 2172, Medical Sciences Building)

Dr. Zhong-Ping Feng, Director, Collaborative Program In Neuroscience (CPIN); Professor, Department of Physiology, U of T

Section I. Oral Presentations by CPIN PhD Trainees (Room 2172, Medical Sciences Building) 9:40–11:30 p.m. Chaired by CPIN Graduate Executives, Joe Steinman (PhD Candidate, Medical Biophysics) and Raymond

Wong (PhD Candidate, Physiology) 9:40–9:55 a.m. Afif Aqrabawi, PhD candidate, Cell and Systems Biology, OLFACTORY MEMORY REPRESENTATIONS ARE STORED IN THE ANTERIOR OLFACTORY NUCLEUS

10:00–10:15 a.m. Jonathon Chio, PhD candidate, Institute of Medical Science, DRUG RE-

PURPOSING: HIGH DOSE HUMAN IMMUNOGLOBULIN G FOR TREATMENT OF TRAUMATIC CERVICAL SPINAL CORD INJURY

10:20–10:35 a.m. Jennifer Lepock, PhD candidate, Institute of Medical Science, ASSOCIATION

OF SEMANTIC PRIMING DEFICITS WITH ROLE FUNCTIONING IN PERSONS AT CLINICAL HIGH RISK FOR SCHIZOPHRENIA: EVIDENCE FROM EVENT-RELATED BRAIN POTENTIALS

10:40–10:55 a.m. Natalia Moskal, PhD candidate, Biochemistry, MITOPHAGY ENHANCERS

IDENTIFIED USING IBM WATSON IMPROVE PHENOTYPES ARISING FROM MITOCHONDRIAL DYSFUNCTION IN DROSOPHILA

11:00–11:15a.m. Kristiana Xhima, PhD candidate, Laboratory Medicine and Pathobiology,

MODULATION OF TRKA RECEPTOR SIGNALING AS A THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE

Section II. Lunch and CPIN Trainee Poster Presentations (Medical Sciences Building Stone Lobby) 11:30–1:10 p.m. Lunch and Poster Presentation/Evaluation

Section III. Next Generation of Neurotechnology Symposium (Room 3154, Medical Sciences Building) 1:10– 3:30 p.m. Chaired by Dr. Zhong-Ping Feng, Director, CPIN; Professor, Department of Physiology

1:10–1:20 p.m. Opening remarks Dr. Christopher Yip, Incoming Dean Faculty of Applied Science and Engineering, Associate Vice President – International Partnerships, & Professor, Institute of Biomaterials and Biomedical Engineering, Departments of Chemical Engineering and Applied Chemistry, and Biochemistry, U of T

Dr. Allan Kaplan, Vice Dean - Graduate and Life Science Education, Faculty of Medicine; Senior Clinician/Scientist, Chief of Research, CAMH; Professor, Department of Psychiatry, U of T

1:20–1:50 p.m. Dr. Sheena Josselyn, Senior Scientist, Neurosciences & Mental Health, SickKids;

Professor, Departments of Psychology and Physiology, U of T

“Making Memories”

1:50–2:20 p.m. Dr. Joyce Poon, Director, Max Planck Institute for Microstructure Physics; Professor, Electrical

and Computer Engineering, U of T; Honorary Professor, Faculty of Electrical Engineering and

Computer Science, Technical University of Berlin, Germany

“ Light, Communications, and Computing”

2:20–2:50 p.m. Dr. Taufik Valiante, Associate Professor, Departments of Surgery (Neurosurgery), IMS, IBBME, and ECE, U of T; Scientist, Krembil Research Institute, TWH; Director, Surgical Epilepsy Program, TWH; Co-Director, CRANIA “CRANIA – Center for Advancing Neurotechnological Innovation to Application"

2:50–3:40 p.m. Keynote Lecture (Introduced by Dr. Joyce Poon)

Julius Axelrod Distinguished Visiting Neuroscientist Dr. Euisik Yoon, Professor, Electrical Engineering & Computer Science and Biomedical Engineering Departments, Director of NSF International Program for Advancement of Neurotechnology (IPAN), University of Michigan, USA “Brain Interface: High-Density Neural Recording and Optical Stimulation”

Section IV. Awards Ceremony, Closing Remarks, and Reception (Medical Sciences Building)

3:40–4:00 p.m. Awards Ceremony (MSB 3154) Chaired by Dr. Jeffrey Henderson, CPIN Faculty Executives; Associate Professor, Department of Pharmaceutical Science, U of T

Jonathan Dostrovsky Awards in Neuroscience Poster and Oral presentation awards

Closing

4:00–5:00 p.m. Light Reception (MSB Stone Lobby)

Event Organizers

Trainee Presentation Judges Dr. Zhong-Ping Feng Dr. Leon French Dr. Jennifer Griffin Dr. Bill Ju Dr. Aras Kayvanrad Dr. Junchul Kim Dr. Evelyn Lambe Dr. Thulasi Thiruvallur Madanagopal Dr. Loren Martin Dr. Kei Masani Dr. Peter Mastrangelo Dr. Massieh Moayedi Dr. Howard Mount Dr. Scott Rich Dr. Azadeh Sabetghadam Dr. Shuzo Sugita Dr. Hong-Shuo Sun Dr. Carmela Tartaglia Dr. Arun Tiwari Dr. Alexander Velumian Dr. Paul Yoo Dr. Karl Zabjek

Symposium Speakers Dr. Euisik Yoon (keynote) Dr. Sheena Josselyn Dr. Joyce Poon Dr. Taufik Valiante Event Program Design Julia Bandura Jonathon Chio Ann Gong Joseph Steinman Raymond Wong Trainee Volunteers Tameem Al-Ozzi Sarah Eide Emilio Garcia Flores Manroop Khroud Joie Luo Amir Reza Peimani Siyuan Shu Stephanie Tran

CPIN Research Day Organizing Committee Julia Bandura (Student Organizer) Jonathon Chio (Student Organizer) Dr. Zhong-Ping Feng (Chair, CPIN Director) Dr. Roman Genov Haifan Gong (Student Organizer) Dr. Jeffrey Henderson Iulia Park (CPIN Administrator) Dr. Joyce Poon Joseph Steinman (Student Organizer) Dr. Kaori Takehara-Nishiuchi Raymond Wong (Student Organizer) Award Committee Dr. Oliver Ernst Dr. Zhong-Ping Feng Dr. Jeffrey Henderson Dr. Cindi Morshead Dr. Amy Ramsey Dr. Kaori Takehara-Nishiuchi Dr. Vincent Tropepe Dr. Karl Zabjek CPIN Academic/Executive Committees; Board of Directors Applied Psychology and Human Development | Kang Lee; Earl Woodruff Biochemistry | Angus McQuibban/Oliver Ernst; Justin Nodwell Institute of Biomaterials & Biomedical Engineering | Warren Chan Cell and Systems Biology | Melanie Woodin/John Peever; Les Buck, Vincent Tropepe Computer Science | Richard Zemel; Ravin Balakrishnan Dalla Lana School of Public Health | Geoff Anderson; Adalsteinn Brown Dentistry | Ze'ev Seltzer; Morris Manolson Laboratory Medicine and Pathobiology | Janice Robertson/Lili-Naz Hazrati; Harry Elsholtz Institute of Medical Science | Cindi Morshead/Albert Wong; Mingyao Liu Medical Biophysics | Bojana Stefanovic; Thomas Kislinger Music | Michael Thaut Pharmaceutical Sciences | Jeffrey Henderson, David R. Hampson (Honorary member) Pharmacology | Amy Ramsey; Ruth Ross Physiology | Jonathan Dostrovsky (Honorary member)/Doug Tweet; Graham Collingridge Physiology | Zhong-Ping Feng (CPN Director; Chair of Committees) Psychology | John S. Yeomans/Kaori Takehara-Nishiuchi; Morris Moscovitch Rehabilitation Science Institute | Karl Zabjek; Angela Colantonio

2019 Next Generation of Neurotechnology Symposium

Dr. Euisik Yoon Professor, Department of Electrical Engineering and Computer Science Professor, Department of Biomedical Engineering Director, NSF International Program for Advancement of Neurotechnology University of Michigan, Ann Arbor Talk title: Brain Interface: High-Density Neural Recording and Optical Stimulation

Euisik Yoon received the B.S. and M.S. degrees in electronics engineering from Seoul National University in 1982 and 1984, respectively, and the Ph.D. degree in electrical engineering from the University of Michigan, Ann Arbor, in 1990.

He worked for industries for six years including the Fairchild Research Center of the National Semiconductor Corp. in Santa Clara, CA and for Silicon Graphics Inc. in Mountain View, CA, before he returned to academia. He took faculty positions in the Department of Electrical Engineering at Korea Advanced Institute of Science and Technology (KAIST) in Daejon, Korea (1996-2005) and in the Department of Electrical and Computer Engineering at the University of Minnesota, Minneapolis, MN (2005-2008), respectively. During the academic year of 2000-2001, he was a Visiting Faculty at Agilent Laboratory, Palo Alto, CA. In 2008, he joined the Department of Electrical Engineering and Computer Science at the University of Michigan, Ann Arbor, MI, where he is a Professor. He served as the Director of Lurie Nanofabrication Facility at the University of Michigan from 2011 to 2016. His research interests are in MEMS, integrated microsystems, and VLSI circuit design.

Dr. Yoon has served on various Technical Program Committees including the Microprocesses and Nanotechnology Conference (1998), the International Sensor Conference (2001), the IEEE Asia-Pacific Conference on Advanced System Integrated Circuits (2001-2002), the International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers) (2003, 2005), the IEEE International Electron Device Meeting (2006-2008) and the IEEE International Conference on Micro Electro Mechanical Systems (2006, 2009-2010). He also served on the IEEE International Solid-State Circuit Conference program committee (2003-2007) and was a general chair of International Symposium on Bio Micro & Nanosystems (2005). Currently, he serves as an associate editor for IEEE Solid-State Circuits Letters.

Dr. Sheena Josselyn Senior Scientist, Neurosciences and Mental Health, Hospital for Sick Children Professor, Departments of Psychology and Physiology University of Toronto Talk title: Making Memories

Dr. Sheena Josselyn is a Senior Scientist at the Hospital for Sick Children and a professor in the departments of psychology and physiology at the University of Toronto. She holds a Canada Research Chair in Brain Mechanisms underlying Memory and is a Fellow of the Royal Society of Canada. Dr. Josselyn’s research focuses on understanding how information is encoded, stored and used in the brain, using a variety of different tools to examine memory in mice.

In her talk, Dr. Josselyn will provide an overview of recent research focusing on how a memory is physically or functionally represented in the brain (the memory trace or “engram”). An engram is thought to be sparsely distributed over a distributed memory network. Dr. Josselyn will describe the studies from her lab investigating how engrams supporting both fearful and rewarding memories are formed, stored and changed with time or further experience. Memory impairments are a hallmark of aging, major mental illnesses (e.g., schizophrenia and depression) as well as neurological disorders (e.g., Alzheimer's and Parkinson's diseases). Therefore, understanding how the brain encodes and stores information is highly relevant to both mental health and mental illness.

Dr. Joyce Poon Professor, Electrical and Computer Engineering, U of T Director, Max Planck Institute for Microstructure Physics

Honorary Professor, Faculty of Electrical Engineering and Computer Science, Technical University of Berlin, Germany Joyce Poon is a Director of the Max Planck Institute of Microstructure Physics, Professor of Electrical and Computer Engineering at University of Toronto, and an Honorary Professor in the Faculty of Electrical Engineering and Computer Science at the Technical University of Berlin. At the University of Toronto, she holds the Canada Research Chair in Integrated Photonic Devices. She and her team specialize in integrated photonics on silicon.

Prof. Poon obtained the Ph.D. and M.S. in Electrical Engineering from Caltech in 2007 and 2003 respectively, and the B.A.Sc. in Engineering Science (physics option) from the University of Toronto in 2002. Recognitions she has received include an ECE Department Teaching Award (2017), OFC Top-Scored Paper (2017), the McCharles Prize for Early Research Career Distinction (2013), MIT TR35 (2012), and the IBM Faculty Award (2010, 2011). She is a Fellow of the Optical Society.

Dr. Taufik Valiante Scientist, Krembil Research Institute, TWH; Surgical Director, Epilepsy Program, TWH Associate Professor, Department of Surgery (Neurosurgery), IMS, IBBME and ECE, U of T Co-Director, Center for Advancing Neurotechnological Innovation to Application (CRANIA)

Taufik Valiante completed his residency in the Neurosurgery Training Program at the University of Toronto in 2002, and an Epilepsy Surgery Fellowship at the University of Washington, Seattle, under the mentorship of Dr. George Ojemann in 2003. In 2007 he established a state of the art five-bed Epilepsy Monitoring Unit at the Toronto Western Hospital, significantly increasing surgical services to those with medically refractory epilepsy throughout the Province of Ontario. Through his involvement with professional and not-for profit epilepsy organizations, he is a strident advocate for the standardization of epilepsy care. His CIHR-funded research focuses on in vivo and in vitro electrophysiological recordings of brain activity. His particular interest is in the association of such activity with cognitive processes, and the cellular mechanisms that underlie them. He studies the pathological disruption of such activity using optogenetics, and computational techniques. He is currently the Director of the Surgical Epilepsy Program at the Krembil Neuroscience Center, a Scientist at the Krembil Research Institute, and has a cross-appointment at the Institute of Biomaterials and Biomedical Engineering. His neurosurgical staff appointment is at the Toronto Western Hospital. He is currently Associate Professor of Surgery, Institute of Medical Science (IMS), Institute of Biomaterials and Biomedical Engineering (IBBME), and Electrical & Computer Engineering (ECE), at the University of Toronto.

Jonathan Dostrovsky Award in Neuroscience

Dr. Jonathan Dostrovsky completed his undergraduate studies in physics and mathematics at the Israel Institute of Technology in 1969 and then proceeded to graduate studies in the Department of Physiology at University College London where he obtained his M.Sc. degree in 1971 under the supervision of John O’Keefe. His master’s research project with O’Keefe led to the important discovery of ‘place cells’ in the hippocampus, and their seminal paper describing their findings has become a cornerstone in the field of spatial navigation and hippocampal function. Dr. Dostrovsky moved to Toronto where he obtained his PhD degree in the Zoology Dept. in 1974 for studies on pain processing in the spinal cord. Following 3-years of postdoctoral research in London on the somatosensory system with special emphasis on plasticity, with Pat Wall, he returned to the University of Toronto to take up a position in the Department of Physiology. He was promoted full professor in 1989 and is currently a Professor Emeritus in the Department of Physiology and Faculty of Dentistry.

Throughout his career Dr. Dostrovsky has made significant advances in our understanding of the neurophysiological basis of pain perception, somatosensory information processing, brain plasticity and basal-ganglia related movement disorders. A hallmark of these studies is the elegant combination of experiments executed in various animal models and in humans. For example, data from the Dostrovsky lab shed light on how thermal and noxious information is processed at the level of the thalamus in humans and in a rat model of allodynia. In a publication in Nature, Dr. Dostrovsky demonstrated how thalamic networks could contribute to phantom sensations in amputees. He also studied this question in animal models, where the plasticity of the sensory map in thalamic networks was demonstrated in rats after the removal of the hind-limb input. In a series of elegant studies he has unveiled the relationship between movement disorders and altered basal ganglia oscillatory activity. These studies have significantly contributed to our current understanding of central physiological mechanisms in the somatosensory and motor networks which underlie our perception of tactile, thermal and painful stimuli and the pathophysiological alterations that occur following certain traumatic or disease-induced injuries to the nervous system.

Dr. Dostrovsky was also very actively involved in neuroscience education at the University at the undergraduate, graduate and postdoctoral levels, and has served on many committees at all levels. In particular he served as Director of CPIN from 1993 to 2008, and as the President /Vice President of the Canadian Association for Neuroscience from 2003 to 2007. Selection Criteria: The recipients of the awards will be selected by a committee appointed by the Collaborative Program in Neuroscience for this purpose. The committee will make their decision based on, but not limited to, the following criteria: intellect, originality and judgement, research skills, independent research potential, motivation, and progress in research towards their graduate degrees. Results: All applicants will be notified of the results of the competition at the 2019 CPIN Research Day.

Established in 2016 by the generosity of Dr. Jonathan Dostrovsky, this annual award recognizes and supports excellence amongst graduate students enrolled in the Collaborative Program in Neuroscience and will be selected based on academic merit.

Effective 2019, there will be two Jonathan Dostrovsky Awards in Neuroscience for outstanding achievement in graduate neuroscience research towards a Ph.D. degree.

1 Junior Award: Outstanding achievement in initial graduate neuroscience research (<2 years in Ph.D. program)

1 Senior Award: Outstanding achievement in graduate neuroscience research towards a Ph.D. degree (< 4 years in Ph.D. program)

TRAINEE POSTER PRESENTATIONS

1. Sally Abudiab; Rehabilitation Sciences Institute Supervisor: Robin Green UNEXPECTED PATTERN OF LONGITUDINAL RECOVERY IN MODERATE-SEVERE TRAUMATIC BRAIN INJURY USING MEASURES OF REACTION TIME INCONSISTENCY Abudiab S, 1; Green R, 1,2 1 Rehabilitation Sciences Institute, University of Toronto; 2 Toronto Rehabilitation Institute, University Health Network 2. Silviu Agotici; Institute of Biomaterials and Biomedical Engineering Supervisor: Paul Yoo COMPUTATIONAL STUDY ON SPATIALLY DISTRIBUTED SEQUENTIAL STIMULATION FOR FATIGUE RESISTANT NEUROMUSCULAR ELECTRICAL STIMULATION Agotici S, 1; Masani K, 1,3; Yoo PB, 1,2 1 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 2 Department of Electrical & Computer Engineering, University of Toronto; 3 Toronto Rehabilitation Institute, University Health Network 3. Sarah Ahmed; Institute of Medical Science Supervisor: Romina Mizrahi EXAMINING AN EVENT-RELATED BRAIN POTENTIAL INDEX OF SEMANTIC PRIMING IN CANNABIS-USING INDIVIDUALS AT CLINICAL HIGH-RISK FOR PSYCHOSIS Ahmed S, 1; Lepock JR, 1; Maheandiran M, 2; George TP, 1, 2; Mizrahi R, 1,2; Kiang M, 1,2 1 Institute of Medical Science, University of Toronto; 2 Centre for Addiction & Mental Health 4. Frhan Alanazi; Department of Physiology Supervisor: William D. Hutchison GLOBUS PALLIDUS AND AUDITORY ODDBALL TASK IN PARKINSON’S DISEASE PATIENTS Alanazi FI, 1,3; Al-Ozzi TM, 1,3; Cheung K 3; Hodaie M, 3,4; Kalia S, 3,4; Lozano AM, 2,3,4; Hutchison WD, 1,2,3,4 1 Department of Physiology and 2 Surgery, University of Toronto; 3 Krembil Research Institute, 4 Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada 5. Tameem Al-Ozzi; Department of Physiology Supervisor: William D. Hutchison SUBTHALAMIC NUCLEUS NEURONAL ACTIVITY DURING A CHOICE-PREFERENCE DECISION-MAKING TASK IN PARKINSON’S DISEASE PATIENTS DECISION-MAKING TASK IN PARKINSON’S DISEASE PATIENTS Alozzi TM 1,3*; Botero PLF, 5; Lopez Rios AL, 5; Hutchison WD, 1,2,3,4,5 1 Department of Physiology and 2Surgery, University of Toronto; 3 Krembil Research Institute, 4 Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada; 5 Hospital Universitario De San Vicente Fundación, MedellÍn, Antioquia, Colombia

6. Afif Aqrabawi; Cell and Systems Biology* Supervisor: Dr. Junchul Kim OLFACTORY MEMORY REPRESENTATIONS ARE STORED IN THE ANTERIOR OLFACTORY NUCLEUS Aqrabawi AA, 1; Kim JC, 1,2 1 Cell & Systems Biology, University of Toronto, 2 Psychology, University of Toronto 7. Mark Aquilino; Institute of Biomaterials and Biomedical Engineering; Supervisor: Peter Carlen CHARACTERISTICS OF SEIZURE-LIKE EVENTS DURING A FUNCTIONAL LACK OF PANNEXIN-1 ACTIVITY Aquilino MS,1,2; Whyte-Fagundes P, 3; Lukewich MK 2,4; Zhang L, 2; Bardakjian BL,1; Zoidl G, 3; Carlen, PL, 1,2,4 1 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 2 Krembil Research Institute, University Health Network; 3 York University; 4 University of Toronto, Departments of Medicine and Physiology 8. Julianne Baarbé; Institute of Medical Science Supervisor: Robert Chen SENSORIMOTOR OSCILLATIONS DURING VIRTUALLY-INDUCED FREEZING IN PATIENTS WITH PARKINSON’S DISEASE AND FREEZING OF GAIT Baarbé JK, 1,2; Lizarraga KJ, 1,2; Brown MJN, 3; Saha U, 2; Drummond N, 1,2; Saravanamuttu J, 1,2; Chen R, 1,2 1 Division of Neurology, Department of Medicine, University of Toronto; 2 Krembil Research Institute, University Health Network; 3 Department of Kinesiology and Health Science, California State University 9. M. Amin Banihashemi; Institute of Medical Science Supervisor: Sandra Black WHAT IS THE ASSOCIATION OF BIRTH YEAR WITH NEURODEGENERATION ATER IN LIFE? Banihashemi MA, 1,2; Sapkota S, 3; Kiss A, 4,5; Stuss DT, 6,7,8; Bronskill SE, 4,5; Swartz RH, 1,2,7; Black SE, 1,2,7 1 Institute of Medical Sciences, University of Toronto; 2 LC Campbell Cognitive Neurology, Sunnybrook Health Sciences Center; 3 Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre; 4 Institute for Clinical Evaluative Sciences; 5 Dalla Lana School of Public Health, University of Toronto; 6 Rotman Research Institute, Baycrest Centre; 7 Department of Medicine (Neurology), University of Toronto; 8 Department of Psychology, University of Toronto 10. Nadia Boachie; Psychiatry Supervisor: Isabelle Boileau PLASMA N-ACYLETHANOLAMINES AND ENDOCANNABINOIDS CONCENTRATIONS IN CHRONIC FREQUENT CANNABIS USERS DURING EARLY ABSTINENCE Boachie N, 1,5; Gaudette, E 1,5; Bazinet, R 1,2,3,5; Lin, L1,5; Mansouri, E 1,5; Huestis, M 6; Tong, J 1,2; Kish, S 1,2, 3,5; George T, 1-3,5; Boileau I, 1,2,3,5.

* = indicates oral presentation

1 Research Imaging Centre, Centre for Addiction and Mental Health; 2 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health; 3 Department of Psychiatry, University of Toronto; 4 Department of Pharmacology and Toxicology, University of Toronto; 5 Institute of Medical Science, University of Toronto; 6 Lambert Center for the Study of Medicinal Cannabis and Health, Thomas Jefferson University, Philadelphia, PA 11. Mary Boulos; Rehabilitation Sciences Institute Supervisor: Robin Green FEASIBILITY OF GROUP-BASED TELEREHABILITATION FOR PATIENTS WITH CHRONIC ACQUIRED BRAIN INJURY Boulos M, 1,2; Colella B, 2; Meusel L, 2; Miguel-Jaimes L, 2; Panozo M, 2; Dabek M, 2; Worthington,T, 2; Green REA, 1,2 1 Rehabilitation Sciences Institute, University of Toronto; 2 Toronto Rehabilitation Institute, University Health Network 12. Analyssa Cardenas; Rehabilitation Sciences Institute Supervisor: Darcy Fehlings INPATIENT REHABILITATION EXERGAMES IN CHILDREN WITH CEREBRAL PALSY AFTER LOWER EXTREMITY ORTHOPEDIC SURGERY: A PROTOCOL Cardenas A, 1,2; Warner D, 2; Switzer L, 2; Rumbolt S, 2; Graham N, 3; Narayanan U, 4; Camp M, 4; Yeung KK, 2; Champagne M, 2; Fehlings D, 1,2 1 Rehabilitation Science Institute, University of Toronto, Toronto, Ontario; 2 Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario; 3 Queen's University, Kingston, Ontario; 4 The Hospital for Sick Children, Toronto, Ontario 13. Carly Cermak; Rehabilitation Sciences Institute Supervisor: Deryk Beal CHARACTERIZATION OF LANGUAGE PROFILES IN SUBACUTE PRESCHOOL TRAUMATIC BRAIN INJURY: A RETROSPECTIVE CHART REVIEW Cermak CA, 1,2; Scratch SE, 1,2,4; Beal DS, 1,2,3 1 Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital; 2 Rehabilitation Sciences Institute, University of Toronto; 3 Department of Speech-Language Pathology, Faculty of Medicine, University of Toronto; 4 Department of Pediatrics, Faculty of Medicine, University of Toronto 14. Jordan Chad; Medical Biophysics Supervisor: Jean Chen ENHANCING THE SPECIFICITY OF DIFFUSION MRI TO BRAIN MICROSTRUCTURE Chad JA, 1,2; Pasternak O, 3; Chen JJ, 1,2 1 Medical Biophysics, University of Toronto; 2 Rotman Research Institute, Baycrest Health Sciences; 3 Brigham and Women's Hospital, Harvard Medical School 15. Nathan Chan; Institute of Medical Science Supervisor: Ariel Graff-Guerrero STRUCTURAL BRAIN DIFFERENCES BETWEEN COGNITIVELY IMPAIRED PATIENTS WITH AND WITHOUT APATHY

Chan NK, 1,2; Plitman E, 4,5; Gerretsen P, 1,2,3; Blumberger DM, 1,2,3; Caravaggio F, 1,3; Brown E, 1,2; Graff-Guerrero A, 1,2,3 1 Centre for Addiction and Mental Health, Toronto, Ontario; 2 Institute of Medical Science, University of Toronto, Toronto, Ontario; 3 Department of Psychiatry, University of Toronto, Toronto, Ontario; 4 Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Montreal, Quebec; 5 Department of Psychiatry, McGill University, Montreal, Quebec 16. Dipa Chatterjee; Department of Pharmacology & Toxicology Supervisor: Etienne Sibille CHRONIC STRESS INDUCES SPECIFIC CELLULAR AND MORPHOLOGICAL ASTROGLIAL CHANGES ASSOCIATED WITH DEPRESSIVE-LIKE PHENOTYPES. Chatterjee D, 1,2; Prevot TD, 1,2; Gali P, 2; Sibille E, 1,2; Banasr M, 1,2 1 University of Toronto; 2 Centre for Addiction & Mental Health 17. Alexandra Chatzikalymniou; Department of Physiology Supervisor: Frances Skinner TOWARDS A CELLULAR-BASED UNDERSTANDING OF THETA/GAMMA RHYTHMS AND THEIR CROSS-FREQUENCY COUPLING IN THE HIPPOCAMPUS Chatzikalymniou AP, 1,2; Skinner FK,1,3 1 Krembil Research Institute, University Health Network, Toronto ON CA; 2 Department of Physiology, University of Toronto, Toronto ON, CA; 3 Department of Medicine (Neurology), University of Toronto, Toronto ON CA 18. Stephanie Cheung; Institute of Biomaterials and Biomedical Engineering Supervisor: Deryk Beal COMPARING RESPONSES TO REAL-TIME VOWEL PERTURBATION IN YOUNGER AND OLDER CHILDREN Cheung S, 1, 2; Thompson K, 1; Yunusova Y, 3, 4, 5; Chen J, 3, 6; Beal D, 1, 2, 4, 5 1 Holland Bloorview Kids Rehabilitation Hospital; 2 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 3 Sunnybrook Health Sciences Centre; 4 Rehabilitation Sciences Institute, University of Toronto; 5 Department of Speech Language Pathology, University of Toronto; 6 Faculty of Kinesiology and Physical Education, University of Toronto 19. Jonathon Chio; Institute of Medical Science* Supervisor: Dr. Michael Fehlings DRUG RE-PURPOSING: HIGH DOSE HUMAN IMMUNOGLOBULIN G FOR TREATMENT OF TRAUMATIC CERVICAL SPINAL CORD INJURY Chio J, 1,3; Wang J, 1; Badner A, 2; Hong J, 1,3; Surendran V, 1; Fehlings MG, 1,3,4 1 Department of Genetics and Development, Krembil Research Institute, University Health Network; 2 Sue and Bill Gross Stem Cell Research Centre, University of California, Irvine; 3 Institute of Medical Science, University of Toronto; 4 Faculty of Medicine, University of Toronto

* = indicates oral presentation

20. Kenya Costa-Dookhan; Institute of Medical Science Supervisor: Margaret Hahn INVESTIGATING THE ASSOCIATION BETWEEN PLASMA CLOZAPINE TO N-DESMETHYLCLOZAPINE RATIO IN PATIENTS WITH OBESITY AND ULTRA-TREATMENT REFRACTORY SCHIZOPHRENIA Costa-Dookhan, KA, 1, 2; Agarwal, SM, 1,3; Chintoh, A, 1,3; Mackenzie, N, 1; Borlido, C, 1; Bowden, S,1; Colucci, L,1; Lo, L, 1; Casuccio-Treen, Q, 1;Tran, V, 1; McIntyre, W, 1; Remington, G, 1,2,3; Hahn, M, 1,2,3 1 Centre for Addiction and Mental Health; 2 University of Toronto Institute of Medical Science; 3 Department of Psychiatry, University of Toronto 21. Marie-Eve Di Raddo; Department of Pharmacology and Toxicology Supervisor: Susan George DOPAMINE D1-D2 RECEPTOR HETEROMER EXPRESSION IN REWARD CIRCUITRY FOLLOWING CHRONIC Δ9-TETRAHYDROCANNABINOL (THC) AND CANNABIDIOL (CBD) IN ADULT AND ADOLESCENT RATS Di Raddo M, 1; Sun Y,1; Milenkovic M,1; Sivasubramanian M, 1; Hasbi A, 1; George S,1 1 Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto 22. Rebecca Earnshaw; Department of Laboratory Medicine and Pathobiology Supervisor: Suneil Kalia INVESTIGATING THE IMPACT OF CHIP PHOSPHORYLATION ON MITOCHONDRIAL AUTOPHAGY Rebecca Earnshaw1,2, Lorraine Kalia1,2, Suneil Kalia1,2 1 Department of Laboratory Medicine & Pathobiology, University of Toronto; 2 Krembil Research Institute, University Health Network 23. Azin Ebrahim Amini; Institute of Biomaterials and Biomedical Engineering Supervisor: Peter Carlen NEOCORTICAL POTASSIUM REDISTRIBUTION IN VIVO IS INFLUENCED BY ASTROCYTIC GAP JUNCTIONAL COMMUNICATION AND ASTROCYTIC MEMBRANE POTENTIAL Ebrahim Amini AA, 1,2; Bazzigoloupi PB, 3; Stefanovic BS, 3,4; Carlen PC, 1,2 1 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 2 Krembil, Toronto Western Hospital; 3 Sunnybrook Research Institute; 4 Medical Biophysics, University of Toronto 24. Aeen Ebrahim Amini; Department of Physiology Supervisor: Graham Collingridge THE ROLE OF ENDOGENOUS CELLULAR PRION PROTEIN IN BRAIN SYNAPTIC FUNCTION Ebrahim Amini AA,1,3; Georgiou JG, 1; Taghibiglou CT, 2; Collingridge GC,1,3 1 Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital; 2 Department of Pharmacology, University of Saskatchewan; 3 Department of Physiology, University of Toronto

25. Sarah Eide; Department of Physiology Supervisor: Zhong-Ping Feng DOXORUBICIN CHEMOTHERAPY-INDUCED 'CHEMO-BRAIN': META-ANALYSIS Eide S, 1,2; Feng ZP, 1,2 1 Physiology, University of Toronto; 2 Collaborative Program in Neuroscience, University of Toronto 26. Laurel Etkin-Spigelman; Institute of Medical Science Supervisor: Maru Barrera PSYCHOSOCIAL RISK SCREENING AND INTERVENTION RATES IN PEDIATRIC ONCOLOGY: FROM DIAGNOSIS TO 6 MONTHS Etkin-Spigelman L 1,2; Barrera M, 1,2 1 Institute of Medical Science, University of Toronto; 2 Department of Psychology, The Hospital for Sick Children 27. Erin Gaudette; Institute of Medical Science Supervisor: Isabelle Boileau CONCENTRATIONS OF THE FATTY ACID ETHANOLAMIDE N-DOCOSAHEXAENOYLETHANOLAMINE ARE CORRELATED WITH INTRUSION SYMPTOMS IN POST-TRAUMATIC STRESS DISORDER: A PRELIMINARY REPORT Erin Gaudette, Junchao Tong, Jerry Warsh, Tina McCluskey, Shawn Rhind, Richard Bazinet, Rachel F. Tyndale, Don Richardson, Lin Lin, Stephen Kish, Sylvain Houle, Matt N. Hill, Isabelle Boileau 1 Research Imaging Centre and 2 Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada 3 Department of Psychiatry, 4 Pharmacology and Toxicology and 5Institute of Medical Sciences, 6 Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada 7 Defense Research and Development Canada, Toronto Research Centre, Toronto, Ontario, Canada 8 Parkwood Operational Stress Injury Clinic, London, Ontario, Canada 9 Department of Psychiatry 28. Shahrzad Ghazisaeidi; Department of Physiology Supervisor: Michael Salter SEX DIFFERENCE IN SPINAL CORD TRANSCRIPTION AND GENE REGULATION AFTER PERIPHERAL NERVE INJURY Ghazisaeidi S, 1,2; Ramani A, 3; Shooshtari P, 3; Tu Y, 2; Halievski K, 2; Finn D, 4; Assi S, 1,2; Muley M, 2; Wang V, 2; Sengar A, 2; Weksberg R, 5; Brudno M, 2,6; Salter MWS, 1,2 1 Department of Physiology, University of Toronto; 2 Neurosciences and Mental Health, Hospital for Sick Children; 3 Centre for Computational Medicine, Hospital for Sick Children; 4 Department of Pharmacology & Therapeutics, National University of Ireland; 5 Genetics & Genome Biology, Hospital for Sick Children; 6 Dept. of Computer Science, Hospital for Sick Children 29. Haifan Gong; Department of Physiology Supervisor: Hong-Shuo Sun THE REGULATING EFFECTS OF TRPM7 CHANNEL IN GLIOBLASTOMA THROUGH CALCINEURIN Gong H, 1; Bandura J, 1; Zhang H,1; Feng ZP, 1; Sun HS, 1,2,3,4 1 Department of Physiology, University of Toronto; 2 Department of Surgery, University of Toronto; 3 Department of Pharmacology and

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Toxicology, University of Toronto; 4 Institute of Medical Science, University of Toronto 30. Duncan Green; Institute of Medical Science Supervisor: Isabelle Boileau ENDOCANNABINOID MODULATION OF AMYGDALA FUNCTIONAL CONNECTIVITY: A COMBINED POSITRON EMISSION TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING STUDY Green DGJ, 1,2,9; Kish SJ, 2,3,4,5,6,7; Tyndale RF, 4,6,7,8,9; Hill MN, 10; Strafella AP, 4,5,9; Tong JC, 2,3,4,5,6,7; McCluskey T, 1,2,3,4,5; Westwood DJ, 1; Lobaugh N, 5; Boileau I 1,2,4,5,6,9; Kim J 5. 1 Addiction Imaging Research Group, 2 Human Brain Lab, 3 Translational Addiction Research Laboratory, 4 Campbell Family Mental Health Research Institute and 5 Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada; 6 Departments of Psychiatry, 7 Pharmacology & Toxicology, 8 Family and Community Medicine, 9 Institute of Medical Sciences, University of Toronto, Toronto, Canada and 10 Hotchkiss Brain Institute and Mathison Centre for Mental Health Research 31. Sarah Gregor; Rehabilitation Sciences Institute Supervisor: Kara Patterson CHARACTERIZATION OF NOVEL CENTER OF PRESSURE CYCLOGRAM MEASURES DURING DOUBLE SUPPORT PHASE OF GAIT IN PEOPLE WITH STROKE Gregor S, 1,2; Vaughan-Graham J, 2,3; Patterson KK, 2,3 1 Rehabilitation Sciences Institute, University of Toronto; 2 KITE-Toronto Rehab, University Health Network; 3 Department of Physical Therapy, University of Toronto 32. Alexandre Guet-McCreight; Department of Physiology Supervisor: Frances Skinner SYNAPTIC MECHANISMS UNDERLYING THE NETWORK STATE-DEPENDENT RECRUITMENT OF THE INTERNEURON-SPECIFIC INTERNEURONS IN THE MOUSE CA1 HIPPOCAMPUS Luo X, 1,2,*; Guet-McCreight A, 3,4*; Villette V, 1,2; Francavilla R, 1,2; Chamberland S, 2; Skinner FK, 3,5,4; Topolnik L, 1,2 1 Neuroscience Axis, CHU de Québec Research Center (CHUL); 2 Department of Biochemistry, Microbiology and Bio-informatics, Laval University; 3 Krembil Research Institute, University Health Network; 4 Department of Physiology, University of Toronto; 5 Department of Medicine (Neurology), University of Toronto; *equal contribution 33. Melisa Gumus; Institute of Medical Science Supervisor: Carmela Tartaglia EVALUATING THE RELATIONSHIP BETWEEN SUBJECT SPECIFIC CONNECTOMES AND COGNITIVE MEASURES IN PATIENTS WITH POST-CONCUSSION SYNDROME Gumus M, 1,2; Mack ML, 3; Green R 1,4; Tartaglia CM 1,2,5,6 1 Institute of Medical Science, University of Toronto; 2 Tanz Centre for Research in Neurodegenerative Diseases; 3 Department of Psychology, University of Toronto; 4 Rehabilitation Sciences Institute, University of Toronto; 5 Canadian Concussion Center, Toronto Western Hospital; 6 Division of Neurology, Krembil Neuroscience Centre

34. Kim Haffey; Faculty of Music, Music and Health Research Collaboratory Supervisor: Michael Thaut DIFFERENCES IN PROPRIOCEPTION IN CHILDREN WITH AUTISM SPECTRUM DISORDER: A LITERATURE REVIEW Kimberly Haffey, 1,2 1 University of Toronto; 2 Music and Health Research Collaboratory 35. Irene Harmsen; Institute of Medical Science Supervisor: Andres Lozano ULTRA-HIGH FREQUENCY DEEP BRAIN STIMULATION AT 10,000 HZ IMPROVES MOTOR FUNCTION Harmsen IE, 1,2; Lee DJ, 1; Dallapiazza RF, 1; De Vloo P, 1; Chen R, 2,3; Fasano A, 2,3; Kalia SK, 1,2; Hodaie M, 1; Lozano AM, 1,2 1 Division of Neurosurgery, Toronto Western Hospital, University of Toronto; 2 Krembil Research Institute, University Health Network; 3 Division of Neurology, University of Toronto 36. Tara Henechowicz; Music and Health Sciences Research Collaboratory, Faculty of Music Supervisor: Michael Thaut PREVALENCE OF BDNF POLYMORPHISM IN MUSICIANS: EVIDENCE FOR COMPENSATORY MOTOR LEARNING STRATEGIES IN MUSIC? Henechowicz TL,1,2; Chen JL, 3; Cohen LG, 4; Thaut, MH.1,2 1 Music and Health Science Research Collaboratory (MaHRC); 2 Faculty of Music, University of Toronto; 3 Faculty of Kinesiology, University of Toronto; 4 3NIH/NINDS, Bethesda, MD 37. Louise Ho; Faculty of Music Supervisor: Corene Thaut FORMATION OF NEW LONG-TERM MUSICAL MEMORY FOR PATIENTS WITH MIDDLE TO LATE STAGE ALZHEIMER'S DISEASE: ASSESSING POTENTIAL FOR A PROSPECTIVE STUDY Ho, L 1,2; Karpazis, A 1,2; Thaut, C 1,2 1 Music and Health Research Collaboratory (MaHRC), University of Toronto; 2 Faculty of Music 38. David Houston; Rehabilitation Sciences Institute Supervisor: Kristin Musselman CHANGES IN STANDING BALANCE PERFORMANCE AMONG INDIVIDUALS WITH INCOMPLETE SPINAL CORD INJURY FOLLOWING VISUAL FEEDBACK BALANCE TRAINING WITH FUNCTIONAL ELECTRICAL STIMULATION Houston DJ, 1,2; Lee JW, 1,3; Grabke E, 1,3; Masani K, 1,3; Musselman KE, 1,2,4 1 KITE, Toronto Rehab-University Health Network; 2 Rehabilitation Sciences Institute, University of Toronto; 3 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 4 Department of Physical Therapy, University of Toronto 39. Seyed Mohammad Amin Kamaleddin Ezabadi; Institute of Biomaterials and Biomedical Engineering Supervisor: Steven Prescott

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SPIKE INITIATION PROPERTIES OF PYRAMIDAL NEURON AXONS REVEALED BY CHANNELRHODOPSIN-BASED PHOTOSTIMULATION Kamaleddin MA, 1,2; Ratté S, 1,3; Prescott SA, 1,2,3 1 Neurosciences and Mental Health, The Hospital for Sick Children; 2 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 3 Department of Physiology, University of Toronto 40. Kyurim Kang; Faculty of Music Supervisor: Michael Thaut MUSICAL NEGLECT TRAINING FOR UNILATERAL VISUAL NEGLECT IN RIGHT HEMISPHERIC STROKE PATIENTS Kang K, 1,2; Thaut MH, 1,2,3 1 Music and Health Science Research Collaboratory (MaHRC), Faculty of Music, University of Toronto; 2 Collaborative Programs in Neuroscience (CPIN), University of Toronto; 3 Rehabilitation Science Institute, University of Toronto 41. Zahra Khan; Institute of Medical Science Supervisor: Ori Rotstein REMOTE ISCHEMIC CONDITIONING AS A TREATMENT FOR TRAUMATIC BRAIN INJURY: A PROSPECTIVE RANDOMIZED TRIAL Khan ZK 1; Ziesmann M 2; Rhind SR 3; Schweizer TS 1,2; Rotstein OR 1,2 1 Institute of Medical Science, University of Toronto; 2 St. Michaels Hospital; 3 Defence Research and Development Canada 42. Julia Kim; Institute of Medical Science Supervisor: Ariel Graff-Guerrero, Philip Gerretsen IMPROVING INSIGHT WITH TRANSCRANIAL DIRECT CURRENT STIMULATION IN SCHIZOPHRENIA: A PILOT STUDY Kim J, 1,2; Iwata Y, 1,3; Plitman E 1,2; Caravaggio F, 1,3; Shah P, 1,2; De Luca V, 2,3,4,5,6; Remington G, 2,3,5,6; Graff-Guerrero A, 1,2,3,4,6; Gerretsen P, 1,2,3,4,6 1 Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health (CAMH); 2 Institute of Medical Science, University of Toronto; 3 Department of Psychiatry, University of Toronto. 4 Geriatric Mental Health Division, CAMH, University of Toronto; 5 Schizophrenia Division, CAMH; 6 Campbell Institute Research Program, CAMH 43. Vincent Lam; Department of Pharmacology & Toxicology Supervisor: Ruth Ross A NOVEL NEGATIVE ALLOSTERIC MODULATOR (NAM) OF THE CANNABINOID RECEPTOR 1 (CB1) AS A POTENTIAL THERAPEUTIC LIGAND FOR THE TREATMENT OF PYSCHIATRIC DISORDERS ARISING FROM DOPAMINE DYSREGULATION Lam VM,1; Baillie G 1,3; Greig I 2, Abdelrahman MH; Trembleau LA; Ross R 1 1 University of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology; 2 University of Aberdeen, UK, institute of Medical Sciences; 3 University of Dundee, UK 44. Shiron Lee; Pharmaceutical Sciences Supervisor: David Hampson

DEVELOPING GENE THERAPY FOR TREATING INTRACTABLE EPILEPSY IN DRAVET SYNDROME Lee SJ, 1; Niibori Y, 1; Hampson DR, 1,2 1 Pharmaceutical Sciences, University of Toronto; 2 Pharmacology & Toxicology, University of Toronto 45. Jennifer Lepock; Institute of Medical Science* Supervisor: Michael Kiang ASSOCIATION OF SEMANTIC PRIMING DEFICITS WITH ROLE FUNCTIONING IN PERSONS AT CLINICAL HIGH RISK FOR SCHIZOPHRENIA: EVIDENCE FROM EVENT-RELATED BRAIN POTENTIALS Lepock JR, 1; Mizrahi R, 1,2,3; Maheandiran M, 2; Ahmed S, 1; Korostil M, 3; Bagby M, 1,2,4; Kiang M, 1,2,3 1 Institute of Medical Sciences, University of Toronto; 2 Centre for Addiction and Mental Health; 3 Department of Psychiatry, University of Toronto; 4 Department of Psychology, University of Toronto 46. Bing Li; Music and Health Research Collaboratory Supervisor: Michael Thaut A CROSS-CULTURAL INVESTIGATION OF NEUROLOGIC MUSIC THERAPY (NMT) INTERVENTIONS ON COGNITIVE IMPROVEMENT IN PATIENTS WITH MILD-TO-MODERATE ALZHEIMER'S DISEASE AND MCI: A PERSPECTIVE STUDY Li, B 1; Thaut M 1 1 Music and Health Research Collaboratory 47. Yuqi Lin; Institute of Medical Science Supervisor: Aylin Reid THE EFFECT OF INFLAMMATION IN COGNITIVE AND MOTOR FUNCTION AFTER TRAUMATIC BRAIN INJURY Lin Y, 1; Wu C, 2; Liu J, 2; Reid AY, 1,2 1 Institute of Medical Science, University of Toronto; 2 Krembil Research Institute, Toronto Western Hospital 48. Eileen Liu; Institute of Medical Science Supervisor: Andrew Baker EFFECTS OF HUMAN UMBILICAL CORD PERIVASCULAR CELL-CONDITIONED MEDIA IN AN ADULT ZEBRAFISH MODEL OF TRAUMATIC BRAIN INJURY Liu E 1; Park E 2; Barretto T 1; Liu E 2; Ferrier GA 3; Tavakkoli J 3,4; Baker AJ 1, 2, 5, 6 1 Institute of Medical Science, University of Toronto; 2 Keenan Research Centre, Li Ka Shing Knowledge Institute; 3 Department of Physics, Ryerson University; 4 Institute for Biomedical Engineering, Science and Technology (iBEST), Keenan Research Centre for Biomedical Science, St. Michael’s Hospital; 5 Departments of Critical Care and Anesthesia, St. Michael's Hospital; 6 6. Departments of Anesthesia and Surgery, University of Toronto 49. Catharine Mielnik; Department of Pharmacology and Toxicology Supervisor: Ruth Ross NOVEL NEGATIVE ALLOSTERIC MODULATOR (NAM) OF CANNABINOID RECEPTOR 1 (CB1) AMELIORATES SYMPTOMS

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DUE TO DOPAMINE DYSREGULATION IN PSYCHIATRIC DISORDERS Mielnik C, 1; Li CK, 1; Greig IR, 2; Abdelrahman MH, 2; Trembleau LA,2; Burnham WM, 1; Salahpour A, 1; Ramsey AJ, 1; Ross RA, 1 1 University of Toronto, Faculty of Medicine, Department of Pharmacology & Toxicology; 2 University of Aberdeen, UK. 50. Kelly Mo; Institute of Medical Science Supervisor: Meng-Chuan Lai NEURO-BIOLOGICAL SEX DIFFERENCES IN THE AUTISTIC BRAIN: A SYSTEMATIC REVIEW Mo K, 1,2; Bonato S, 2; Ameis S, 1,2; Anagnostou E, 1,3; Lerch J, 1,4,5; Taylor M, 1,4; Lai M-C, 1,2 1 University of Toronto; 2 Centre for Addiction & Mental Health; 3 Holland Bloorview Kids Rehabilitation Hospital; 4 Hospital for Sick Children; 5 University of Oxford 51. Natalia Moskal; Biochemistry* Supervisor: Angus McQuibban Moskal N, 1; Visanji N, 2; Lewis PN, 1; McQuibban GA, 1 1 Department of Biochemistry, University of Toronto; 2 Morton and Gloria Shulman Movement Disorders Centre and Edmund J. Saffra Program in Parkinson’s disease, Toronto Western Hospital 52. Hajer Nakua; Institute of Medical Science Supervisor: Stephanie Ameis TO EXCLUDE OR NOT TO EXCLUDE: SYSTEMATIC BIAS INTRODUCED BY QUALITY CONTROL IN PEDIATRIC IMAGING RESEARCH Nakua HN, 1; Hawco CH, 1; Forde NF, 1; Voineskos AV, 1; Wheeler ALW, 2; Lai ML, 1; Stazmari PS, 1; Schachar RS, 2; Taylor MT, 2; Anagnostou EA, 2; Arnold PA, 3; Lerch JL, 2; Ameis SA, 1 1 Centre of Addiction and Mental Health, University of Toronto; 2 SickKids Hospital, University of Toronto; 3 Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary 53. Alborz Noorani; Institute of Medical Science Supervisor: Mojgan Hodaie TN PAIN RELIEF LEADS TO BILATERAL VOLUMETRIC INCREASE IN HIPPOCAMPAL SUBFIELDS Noorani A, 1,2,3; Hung PSP, 1,2,3; Zhang JY, 1,3; Hodaie M,1,2,3 1 Krembil Research Institute, University Health Network; 2 Institute of Medical Science, University of Toronto; 3 Division of Neurosurgery, Toronto Western Hospital 54. Rabiya Noori; Institute of Biomaterials and Biomedical Engineering Supervisor: Jeremie Lefebvre INFERRING WHITE MATTER STRUCTURE FROM NEURAL POPULATION ACTIVITY Noori R, 1,2; Lefebvre J, 1,2,3 1 Fundamental Neurobiology, Krembil Research Institute; 2 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 3 Department of Mathematics, University of Toronto

55. Nadine Parker; Institute of Medical Science Supervisor: Tomas Paus HUMAN CEREBROCORTICAL MATURATION: THE NEUROBIOLOGICAL CORRELATES OF CORTICAL THINNING Parker N, 1,2; Patel Y, 1,2; Schumman G, 3; Salum G, 4,5; Pausova Z, 6; Paus T 1,2,7 1 Institute of Medical Science, University of Toronto; 2 Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital; 3 MRC-Social Genetic and Developmental Psychiatry Centre, Kings College London; 4 Department of Psychiatry, Federal University of Rio Grande do Sul; 5 National Institute of Developmental Psychiatry for Children and Adolescents (INCT-CNPq); 6 The Hospital for Sick Children, University of Toronto; 7 Department of Psychiatry, University of Toronto 56. Sandra Poulson; Department of Psyhology Supervisor: Loren Martin CHARACTERIZING NEUROPATHIC AND NOCICEPTIVE PAIN IN THE AFRICAN NAKED MOLE-RAT Poulson, SJ, 1; Holmes, MM, 1,2; Martin, LJ, 12 1 Department of Psychology, University of Toronto; 2 Cell & Systems Biology, University of Toronto 57. Saige Power; Department of Physiology Supervisor: Evelyn Lambe PREFRONTAL CHOLINERGIC SIGNALLING DYSREGULATION IN THE TGF344 RAT MODEL OF ALZHEIMER'S DISEASE Power SK, 1; Venkatesan S, 1; McNabb J, 1; McLaurin J, 2,3; Lambe EK, 1,4,5 1 Department of Physiology, University of Toronto; 2 Dept of Laboratory Medicine & Pathobiology, University of Toronto; 3 Biological Sciences at Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute; 4 Department of OBGYN, University of Toronto; 5 Department of Psychiatry, University of Toronto 58. Nicole Richard; Faculty of Music Supervisor: Michael Thaut A NEW ROADMAP FOR RESEARCH IN NEUROLOGIC MUSIC THERAPY REGARDING INDIVIDUALS WITH AUTISM SPECTRUM DISORDERS Richard, NM, 1,2; Thaut, MH, 1,2 1 Music and Health Research Collaboratory, University of Toronto; 2 Faculty of Music, University of Toronto 59. Julia Rybkina; Rehabilitation Sciences Institute Supervisor: Robin Green REMOTELY DELIVERED SPATIAL NAVIGATION INTERVENTION FOR INDIVIDUALS LIVING WITH MULTIPLE SCLEROSIS Rybkina J, 1,4; Gilboa A, 2,3,4; Bruno TR, 4; Srivastava A, 4; Belchev Z, 2,3; Jeffay E, 4; Boulos ME, 1; Johns K, 4; Green REA, 1,2,4 1 Rehabilitation Sciences Institute, University of Toronto; 2 Department of Psychology, University of Toronto; 3 Baycrest Health Sciences; 4 Toronto Rehabilitation Institute, University Health Network

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60. Kate Rzadki; Department of Laboratory Medicine and Pathology Supervisor: Sunit Das IDENTIFYING BARRIERS TO COMPLETION OF ADJUVANT THERAPY IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME: AN EXPLORATORY STUDY Rzadki K 1; Das S 1,2 1 Laboratory Medicine & Pathobiology, University of Toronto; 2 Division of Neurosurgery, St. Michael's Hospital 61. Parisa Sabetian; Institute of Biomaterials and Biomedical Engineering Supervisor: Paul Yoo OPTIMIZING A NOVEL NERVE CUFF ELECTRODE TO RECORD BIDIRECTIONAL NEURAL ACTIVITY Sabetian, P, 1; Yoo, PB,1,2,3 1 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 2 Department of Electrical and Computer Engineering, University of Toronto; 3 Toronto Rehabilitation Institute, University Health Network 62. Julie Sato; Hospital for Sick Children Suprvisor: Margot Taylor THE IMPACT OF PRETERM BIRTH ON WHITE MATTER MICROSTRUCTURE IN FIVE-YEAR-OLD CHILDREN Sato J, 1,2,3; Vandewouw MM, 1,3; O'Connor D, 4,5,6; Taylor MJ, 1,2,3,7 1 Department of Diagnostic Imaging, The Hospital for Sick Children; 2 Department of Psychology, University of Toronto; 3 Neuroscience & Mental Health Program, The Hospital for Sick Children Research Institute; 4 Nutritional Sciences, University of Toronto; 5 Translational Medicine, The Hospital for Sick Children; 6 Paediatrics, Mount Sinai Hospital; 7 Department of Medical Imaging, University of Toronto 63. Parita Shah; Institute of Medical Science Supervisor: Ariel Graff-Guerrero, Philip Gerretsen CLINICAL PREDICTORS OF CLOZAPINE NON-RESPONSE IN TREATMENT-RESISTANT SCHIZOPHRENIA: A CHART REVIEW STUDY Shah, P, 1,2; Iwata, Y, 1,3; Brown, EE, 1,2,3; Kim, J, 1,2; Sanches, M, 1,4; Takeuchi, H, 5; Nakajima, S, 1,5; Hahn, M, 1,2,3,6; Remington, G, 1,2,3; Gerretsen, P, 1,2,3; Graff-Guerrero, A, 1,2,3 1 Centre for Addiction & Mental Health; 2 Institute of Medical Science, University of Toronto; 3 Department of Psychiatry, University of Toronto; 4 Biostatistics Department, Dalla Lana School of Public Health, University of Toronto; 5 Department of Neuropsychiatry, Keio University; 6 Banting and Best Diabetes Centre, University of Toronto 64. Vivek Sharma; Faculty of Music Supervisor: Michael Thaut ABSOLUTE PITCH AND MUSICAL EXPERTISE MODULATE NEURO-ELECTRIC AND BEHAVIORAL RESPONSES IN AN AUDITORY STROOP PARADIGM Sharma VV, 1,2; Thaut M, 1; Russo F, 3; Alain C, 1,2,4 1 Music & Health Sciences, University of Toronto; 2 Rotman Research Institute, Baycrest Health Sciences; 3 Department of Psychology,

Ryerson University; 4 Department of Psychology, University of Toronto 65. Max Shcherbina; Human Biology Program NEXT GENERATION NEUROSCIENCE EDUCATION: OPEN EDUCATIONAL RESOURCES Shcherbina M 1; Bello SJ 1; Chenmi Y 1; Chow CY 1; Ho S 1; Liu J 1; Tajbakhsh P 1; Teymori S 1; Ju W 1 1 Neuroscience Program, Human Biology, University of Toronto 66. Marc Shenouda; Department of Laboratory Medicine and Pathology Supervisor: Janice Robertson VALIDATION OF SMALL MOLECULES PREVENTING TDP-35 AGGREGATION AS THERAPEUTICS FOR AMYOTROPHIC LATERAL SCLEROSIS Shenouda M 1,2; Mancini RS 3; Hadley KC 4; Reed M 5; Barden C 5; Chakrabartty A 4,6,7; Weaver DF 3 8 9; Robertson J 1 1 Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto , Toronto, ON, Canada; 2 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; 3 Department of Fundamental Neurobiology, Krembil Research Institute, University Health Network, Toronto, ON, Canada; 4 Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; 5 Treventis Corporation, Toronto, ON, Canada; 6 Department of Medical Biophysics, Princess Margaret Hospital 67. Sanghavy Sivakumaran; Department of Physiology Supervisor: Evelyn Lambe IMPACT OF CHRNA5 DELETION ON HABENULOPEDUNCULAR NEUROTRANSMISSION Sivakumaran S 1; Liu Y 1; Chen T 1; Sparks DW 1; Lambe EK 1, 2, 3 1 Department of Physiology, University of Toronto; 2 Department of OBGYN, University of Toronto; 3 Department of Psychiatry, University of Toronto 68. Maximilian Strauss; Department of Laboratory Medicine and Pathology Supervisor: Janice Robertson IDENTIFYING PATHOLOGICAL INTERACTORS OF TDP-43 Strauss M, 1,2; Williams D, 2; Schmitt-Ulms, 1,2; Robertson J, 1,2 1 Department of Laboratory Medicine and Pathobiology, University of Toronto; 2 Tanz Centre for Research in Neurodegenerative Disease, University of Toronto 69. Yalin Sun; Department of Pharmacology and Toxicology Supervisor: Susan George CHRONIC UNPREDICTABLE STRESS ASSOCIATED CHANGES IN RAT BRAIN: REGION-SPECIFIC DOPAMINE D1-D2 HETEROMER EXPRESSION AND SIGNALLING Sun Y, 1; Sivasubramanian M, 1; Di Raddo ME, 1; Hasbi A, 1; Milenkovic M, 1; George SR, 1 1 Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto

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70. Prathima Sundaram; Department of Electrical and Computer Engineering Supervisor: Willy Wong RESPONSE OF RETINAL GANGLION CELLS TO ELECTRICAL STIMULATION: FROM PROSTHESIS TO “SEEING” Sundaram P, 1; Yamashita K, 2; Yoo P 1,3; Wong W 1,3 1 Department of Electrical & Computer Engineering, University of Toronto; 2 Graduate School of Natural Science and Technology, Okayama University; 3 Institute of Biomaterials and Biomedical Engineering, University of Toronto 71. Zara Szigeti; Rehabilitation Sciences Institute Supervisor: Emily Nalder, Gillian King A NARRATIVE INQUIRY INTO THE MEANING RELATED PROCESSES OF RESILIENCY IN PRIMARY CAREGIVERS OF CHILDREN WITH TBI Szigeti Z 1,2; Nalder E 1,3; Trentham B, 3; King G, 1,2,3,4 1 Rehabilitation Sciences Institute, University of Toronto; 2 Bloorview Research Institute; 3 Department of Occupational Science and Occupational Therapy, University of Toronto; 4 Holland Bloorview Kids Rehabilitation Hospital 72. Abanti Tagore; Institute of Medical Science Supervisor: Romina Mizrahi CORTICAL DOPAMINE RELEASE IN RESPONSE TO A COGNITIVE CHALLENGE: RESULTS IN FIRST EPISODE AND CLINICAL HIGH RISK FOR SCHIZOPHRENIA Tagore A, 1, 2; Rao N, 1; Schifani C, 1; Mizrahi R, 1, 2 1 Centre for Addiction and Mental Health; 2 Institute of Medical Science, University of Toronto 73. Theresa Tam; Department of Physiology Supervisor: Michael Salter THE ROLE OF AUTOPHAGY IN NEUROPATHIC PAIN Tam TH, 1,2; Salter MW 1,2 1 Neuroscience and Mental Health Program, The Hospital for Sick Children; 2 Department of Physiology, University for Toronto 74. Lindsey Thurston; Department of Psychology Supervisor: Doug VanderLaan MENTAL ROTATION TASK PERFORMANCE INFLUENCED BY MENSTRUAL CYCLE PHASE IN A GENDER EXPANSIVE THAI SAMPLE Thurston LT, 1; Skorska MN, 2; Peragine DE, 1; Coome LA, 1; VanderLaan DP, 2 1 Department of Psychology, University of Toronto; 2 Department of Psychology University of Toronto Mississauga 75. Sarasa Tohyama; Institute of Medical Science Supervisor: Mojgan Hodaie LESIONAL TRIGEMINAL NEURALGIA: CLINICAL AND NEUROIMAGING DEFINITION OF A NEW SYNDROME Tohyama S, 1,2; Hung PS, 1,2; Cheng JC, 3; Zhang JY, 1; Hodaie M, 1,2,4

1 Division of Brain, Imaging, and Behaviour - Systems Neuroscience, Krembil Research Institute; 2 Institute of Medical Science, University of Toronto; 3 Stony Brook University School of Medicine; 4 Division of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network 76. Sai Vemula; Institute of Biomaterials and Biomedical Engineering Supervisor: Willy Wong HOW MUCH INFORMATION IS NEEDED TO NOTICE A DIFFERENCE IN SENSORY SIGNALS? Vemula S, 1; Norwich K, 1; Wong W, 1,2 1 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 2 Department of Electrical and Computer Engineering, University of Toronto 77. Sridevi Venkatesan; Department of Physiology Supervisor: Evelyn Lambe CHOLINERGIC MODULATION IN THE PREFRONTAL CORTEX: A ROLE FOR THE α5 NICOTINIC RECEPTOR SUBUNIT Venkatesan S, 1; Turner EE, 2; Lambe EK, 1,3 1 Department of Physiology, University of Toronto; 2 Ctr. for Integrative Brain Res., Seattle Children's Res. Inst., Seattle, WA; 3 Department of Obstetrics and Gynaecology, University of Toronto 78. Chantelle Whiteside; Music and Health Research Collaboratory Supervisor: Michael Thaut THE EFFECT OF TRANSCRANIAL DIRECT CURRENT STIMULATION ON RHYTHMIC AUDITORY STIMULATION IN POST-STROKE GAIT REHABILITATION: A PROPOSED STUDY Whiteside CC 1,2; Thaut, M 1,2 1 Music and Health Research Collaboratory (MaHRC), University of Toronto; 2 Music and Health Sciences, Faculty of Music, University of Toronto 79. Jordan Winberg; Department of Pharmacology and Toxicology Supervisor: Jane Mitchell SEX DIFFERENCES IN THE EFFECT OF OSTEOCALCIN AND EXERCISE ON MEMORY AND COGNITION Winberg JW, 1; Rentz J 1; Darwish L, 1, 2; Swardfager W, 1,2; Mitchell, J, 1 1 Department of Pharmacology & Toxicology, University of Toronto; 2 Sunnybrook Health Sciences Centre 80. Wennie Wu; Institute of Medical Science Supervisor: Leon French, Etienne Sibille DIFFERENTIAL EXPRESSION META-ANALYSIS OF GENES IDENTIFIED IN GENOME-WIDE ASSOCIATION STUDIES OF DEPRESSION Wu W 1; Sibille E 1,3,4,5; French L 1,2,3,4 1 Institute of Medical Science, University of Toronto; 2 Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health; 3 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health; 4 Department of Psychiatry, University of Toronto; 5 Departments of Pharmacology and Toxicology, University of Toronto

* = indicates oral presentation

81. Kristiana Xhima; Laboratory Medicine and Pathobiology* Supervisor: Dr. Isabelle Aubert MODULATION OF TRKA RECEPTOR SIGNALING AS A THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE Xhima K, 1,2; Markham-Coultes K, 1; Nedev H, 4; Saragovi HU, 4; Hynynen, 3; Aubert I, 1,2 1 Department of Laboratory Medicine and Pathobiology, University of Toronto; 2 Biological Sciences, Sunnybrook Research Institute; 3 Physical Sciences, Sunnybrook Research Institute; 4 Pharmacology & Therapeutics, McGill University 82. Koichiro Yamashita; Department of Electrical and Computer Engineering Supervisor: Willy Wong DEVELOPMENT OF RETINAL PROSTHESIS USING PHOTOELECTRIC DYES COUPLED TO A POLYETHYLENE FILM (OUREP) Yamashita K, 1,2; Sundaram P, 1; Uchida T, 2; Matsuo T, 3; Wong W, 1,4 1 Department of Electrical and Computer Engineering, University of Toronto; 2 Graduate School of Natural Science and Technology, Okayama University; 3 Graduate School of Medicine Dentistry and Pharmaceutical Science, Okayama University; 4 Institute of Biomaterials and Biomedical Engineering, University of Toronto 83. Jane Yang; Institute of Biomaterials and Biomedical Engineering Supervisor: Steven Prescott ION CHANNEL CORRELATIONS EMERGE FROM THE SIMULTANEOUS REGULATION OF MULTIPLE NEURONAL PROPERTIES Yang J, 1,2; Prescott SA, 1,2,3 1 Neurosciences and Mental Health, The Hospital for Sick Children; 2 Institute of Biomaterials and Biomedical Engineering, University of Toronto; 3 Department of Physiology, University of Toronto 84. Shirley Zhang; Department of Laboratory Medicine and Pathobiology Supervisor: Suneil Kalia BCL-2 ASSOCIATED ATHANOGENE 5 PHOSPHORYLATION REGULATES MITOCHONDRIAL QUALITY CONTROL FOLLOWING MITOCHONDRIAL STRESS Zhang S, 1,2; Friesen E, 1,2; de Snoo M, 1,2; Chau H, 2; Kalia L, 1,2; Kalia S, 1,2 1 Department of Laboratory Medicine and Pathobiology, University of Toronto; 2 Krembil Research Institute, University Health Network

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Julius Axelrod Distinguished Visiting Neuroscientist