melanoma skin cancer: will the drugs in the pipeline deliver?
TRANSCRIPT
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Ranjith Gopinathan, Industry Analyst
Healthcare Practice
May 25,2010
Melanoma Skin Cancer: Will the Drugs in the Pipeline Deliver?
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Focus Points
Skin Cancer : Melanoma– Key Facts1
Patient Forecasts2
Market Drivers and Restraints3
Current Drug Therapies for Melanoma4
5 Revenue Forecasts
6 Pipeline Analysis - Melanoma
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Skin Cancer : Melanoma– Key Facts
There are two main types of skin cancer:
•Melanoma
•Non-melanoma (Basal cell carcinoma, Squamous cell carcinoma)
Other types of Skin Cancer:
•Kaposi sarcoma (KS)
•Merkel cell carcinoma (MCC)
•Intraocular (Eye) Melanoma
•Dermatofibrosarcoma protuberans (DFSP)
•Sebaceous gland carcinoma (SGC)
• The incidence of melanoma at a global level is increasing faster than the other types of cancer, with an approximate
doubling of rates every 10 to 20 years in countries with Caucasian (light-skinned) populations.
• Melanoma is the second most common cancer in the age group of 15 to 34 years.
• Australia and New Zealand leads the world with world age-standardised rate between 30-40 cases per 100,000
population affected by skin cancer.
•Melanoma is curable when it is detected during the early stages. Surgery is common treatment for early stage melanoma.
•Melanoma is rare in non-white populations.
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Skin Cancer: Incidence and Mortality (World), 2006-2016
Note: The incidence post 2009 has
been calculated based on population statistics. The figures do not take into account changes in diagnosis or other external factors.
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Current Drug Therapies for Melanoma
Intron A (Interferon Alfa - 2B) Schering-PloughTreatment Area: Metastatic Melanoma
Approval Status: Approved in 1987 (US FDA)
Patent Expiry: 2002
Proleukin or Aldesleukin( IL-2, Interleukin 2) NovartisApproval Status: Approved in 1998 (US FDA)
Treatment Area: Metastatic melanoma
Chemotherapy
DTIC-Dome (Dacarbazine) Bayer
Approval Status: Approved in 1975 (US FDA)
Treatment Area: Metastatic melanoma
Generics: Available
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Melanoma Therapeutics Market: Revenue Forecasts (World), 2006-2016
Note:• Future revenue potential of promising drug candidates which are currently in pipeline are also considered in the revenue forecasts.
• Many of the drugs for cancer are indicated for more than one therapeutic indication. Publicly available information tends to combine all indications when sales figures are reported. Therefore, estimations and primary research were used to arrive at the Melanoma therapeutics revenue forecasts. In addition, the revenue estimations have been cross-validated with the market participants.
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Pipeline Analysis - Melanoma
Sheba Medical CenterAdoptive cell transfer (ACT) therapy
AntisomaAS1409
Bayer/ OnyxNexavar
NovartisGleevec (imatinib mesylate)
BioVex
Limited /Symbion Research
InternationalOncoVEX
Avax TechnologiesMvax
Abraxis BioScience/ AstraZenecaAbraxane
Genta / Sanofi-AventisGenasense (oblimersen)
Vical/ AnGesAllovectin-7
Roche/ PlexxikonPLX4032
Bristol-Myers Squibb/ MedarexIpilimumab
DevelopersDrug Name
Note: The above drugs pipeline list includes only, some of the most promising drugs in development and may not necessarily include all (promising) drugs in development for melanoma.
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