membrane structure and function chapter 7. plasma membrane of cell selectively permeable (allows...
TRANSCRIPT
Membrane Structure and Function
Chapter 7
• Plasma membrane of cell selectively permeable (allows some substances to cross more easily than others)
• Made mostly of proteins and lipids (phospholipids).
• Phospholipids and proteins create unique physical environment (fluid mosaic model)
Phospholipid
• Membrane - bilayer - hydrophilic (water loving) heads pointing outwards, hydrophobic (water fearing) tails pointing inwards.
• Proteins help membrane to stick to water.
• Fluid because lipids and proteins can move laterally.
• As temperatures drop, liquid membrane can solidify.
• Cholesterol found in membrane helps with fluidity of membrane.
• Membranes need to be fluid to work properly.
• Two different types of proteins are found in membrane.
• 1Peripheral proteins not in membrane, bound to surface of protein.
• 2Integral proteins in membrane often spanning entire membrane.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/MembraneProteins.gif
• Also aids in cell-to-cell recognition (ability of a cell to distinguish one type of neighboring cell from another)
Pass through Membrane Easily
• Some substances move steadily across membrane (sugars, ions, and wastes like CO2)
• Hydrophobic molecules (i.e. hydrocarbons, CO2, and O2) can dissolve in lipid bilayer and cross easily.
• Charged particles and polar molecules have more difficulty passing.
• Diffusion - tendency for substance to spread out in open area.
• Move from an area of Most concentrated to Least concentrated.
• No force acting upon it - substance will tend to move down it’s concentration gradient (passive transport).
• Diffusion of molecules with limited permeability through lipid bilayer may be assisted by transport proteins.
http://library.thinkquest.org/27819/media/protein_channel.gif
• Difference in concentration - ions move from one area to other.
• Solution with higher [ ] solutes - hypertonic. (water moves out)
• Solution with lower [ ] solutes -hypotonic. (water moves in)
• [ ] equal - isotonic.
http://www.biologycorner.com/resources/hypertonic.gif
http://www.biologycorner.com/resources/hypotonic.gif
• Movement of H2O across selectively permeable membrane - osmosis.
• Organism does not have rigid walls must have ability to osmoregulate and maintain internal environment.
• Allows plant to stand up against gravity (turgid cell); not watered, plant will begin to wilt (flaccid cell).
• Plant loses enough water, plasma membrane will pull away from cell (plasmolysis).
http://faculty.southwest.tn.edu/jiwilliams/plasmolysis.gif
• facilitated diffusion - diffusion of substance down it’s [ ] gradient with help of transport protein.
• Some channel proteins (gated channels) open/close depending on presence/absence of physical or chemical stimulus.
In this case, the protein actually rotates to dump the materials to the inside of the cell.
• Active transport- materials need to be moved against [ ] gradient
• Requires energy of cell to move substances from an area of low [ ] to an area of high [ ] (i.e. sodium-potassium pump in animal cells)
http://www.sp.uconn.edu/~terry/images/anim/antiport.gif
• Sodium-potassium pump actively maintains gradient of sodium (Na+) and potassium ions (K+) across membrane.
• Sodium-potassium pump uses energy of 1 ATP to pump 3 Na+ ions out and 2 K+ ions in.
http://bioweb.wku.edu/courses/Biol131/images/neuronions.GIF
• Some organisms have proton pumps that actively pump H+ out of cell (i.e. plants, bacteria, and fungi)
More Active Transport
• Exocytosis - When membranes meet - fuse - material is let out to outside of cell.
• Endocytosis - Membrane is inwardly pinched off and vesicle carries material to inside of cell.
http://www.kscience.co.uk/as/module1/pictures/endoexo.jpg
• 1Phagocytosis (“cell eating”) - cell engulfs particle by extending pseudopodia around it, packaging it in a large vacuole.
• Contents of vacuole are digested when vacuole fuses with lysosome.
• 2Pinocytosis (cell drinking) - cell creates vesicle around droplet of extracellular fluid.
• 3Receptor-mediated endocytosis - specific in transported substances.
• Extracellular materials bind ligands (receptors) - causes vesicle to form.
• Allows materials to be engulfed in bulk (i.e. cholesterol in humans)