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TRANSCRIPT
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Memória
&Aprendizagem
Teorias e modelos
id662322 pdfMachine by Broadgun Software - a great PDF writer! - a great PDF creator! - http://www.pdfmachine.com http://www.broadgun.com
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Rejection [of the idea that mental events have no locus] by common sense,
for whatever reason, proves nothing. Other fields of science are built on propositions
that may seem absurd but in fact are true. (Air is heavy, has weight? Water is
made up of two gases? The continents are adrift in the oceans?)
Donald O. Hebb, 1980
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Tipos de memória
Recordadainconscientemente
Recordadaconscientemente
Episódica(autobiográfica)
Semântica(conhecimentosobjetivos)
Lesões na amígdala: não afeta M. Explícita, apenas componentes emocionais
Lesões no HPC e Cx temporal: défict na M. Explícita
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Penfield :� cirurgia para ressecção lobo temporal > 1000 pacientes
� �resposta vivencial�� 8% dos casos
Brenda Milner :� HM� ressecção bilateral do hipocampo, amígdala e córtex temporal
� controle das crises epilépticas.... Mas,
� amnésia - memória de longo prazo preservada... Mas,
� incapaz de transformar MCP em MLP� capaz de aprender habilidades motoras... Mas,� incapaz de lembrar que as havia aprendido
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Apesar das lesões extensas no córtex temporal,
A retenção para eventos pregressos é mantida....
Como isso ocorre?
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Isso sugere que o hipocampo seja apenas uma estação
temporária para a memória de longo prazo
Apesar das lesões extensas no córtex temporal,
A retenção para eventos pregressos é mantida....
Como isso ocorre?
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Isso sugere que o hipocampo seja apenas uma estação
temporária para a memória de longo prazo
Apesar das lesões extensas no córtex temporal,
A retenção para eventos pregressos é mantida....
Como isso ocorre?
As memórias de longo prazo tanto de eventos episódicos
Quanto semânticos ficam retidas em áreas associativas
Unimodais ou multimodais do córtex sensorial que inicialmente
Processam a informação sensorial
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Condicionamento clássico � aprendizagem associativa
Estimulo condicionado : inócuo Estimulo condicionado : reforço
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Memória Operacional
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J.M.Fuster (1980). The Prefrontal Cortex.
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Memória
&Aprendizagem
Aspectos celulares e moleculares
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Aplysia californica
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Memória implícita
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Habituação
Mecanismos pré-sinápticos
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Sensibilização
Mecanismos pré-sinápticos
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Condicionamento
clássico
Mecanismos pré-e pós-sinápticos
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Sensibilização de Longo Prazo
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Sensibilização de Longo Prazo
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Memória explícita
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Hipocampo (circuito tri-sináptico)
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Potenciação duradoura (LTP)
�Pós-sináptica
�Pré-sináptica
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LTP
CA1� pré-sináptica
� independe de NMDA� Ca++ ativa AMPc e PKA
CA3� pré- e pós-sináptica
� depende de NMDA� Ca++ ativa AMPc e PKC
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CA1
CA1
CA3
CA3
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LTP precoce
LTP tardia
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Treino e
representação
cortical