metabolismo 1
TRANSCRIPT
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Principles of BiochemistryFourth Edition
Chapter 10Introduction to Metabolism
Copyright © 2006 Pearson Prentice Hall, Inc.
Horton • Moran • Scrimgeour • Perry • Rawn
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CatabolismoUtilización de energía
AnabolismoSíntesis
Metabolismo20-30% de los genes
130/900 E. coli
1200/5300 S. cerevisiae
5300/19100 C. elegans
2400/14100 D. melanogaster
5000/22000 H. sapiens
Variabilidad metabólica
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Rutas metabólicas
Linear
Circular
Espiral
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Catabolismo
Las rutas metabólicas pueden tener ramificaciones
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Anabolismo
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Reacciones metabólicasen multipasos
Flujo metabólico
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El metabolismo o flujo metabólico es regulado por:
•concentración de la enzimas•concentración del sustrato•modulaciones alostéricas•modificaciones covalentes
Retroalimentación negativa
Feedback inhibition or Negative feedback
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Alimentación positiva
Feed-forward activation
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AutotrophsPhotoautrotophs & Chemoautrotophs
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HeterototrophsChemoheterotrotophs
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Catabolismo
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Anabolismo
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Compartimentos celulares
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ATP y NADH
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* Fosfocreatina 5X más que ATP en músculo en reposo
Creatine kinase
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Principles of BiochemistryFourth Edition
Chapter 11Glycolysis
Copyright © 2006 Pearson Prentice Hall, Inc.
Horton • Moran • Scrimgeour • Perry • Rawn
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DisaccharidesDisaccharides
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PolysaccharidesPolysaccharides StarchStarch
Glycogen
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StarchStarch • Glycogen
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Aerobic RespirationAerobic RespirationBacterias and Bacterias and
EukaryotsEukaryots
Glycolysis occurs in the Glycolysis occurs in the cytosolcytosol All other stages in the All other stages in the mitochondriamitochondria
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Dehidrogenasas NAD+ -- NADH2
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Bacteria Gram -
Glucolysis + Citric Cycle
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En el hígado las hexocinasas I, II y III son inhibidaalostéricamente por glucosa 6-P
Glucocinasa en hígado (hexocinasa IV) no es inhibida por glucosa 6-P
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5
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2,3 BPGeritrocitoscuando bajapH
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-2 ATP +4 ATP
2 ATP + 2NADH
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2 ATP + 2NADH
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RegulaciónSGLT1, Na+ ->GLUT1, GLUT3 ->GLUT2 <->GLUT4 -> (insulin dep)GLUT7 -> G-P -> ERGLUT5-> fructosa
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Glucose 6-phosphate is at a pivotal position in carbohydrate metabolism in the liver
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En el hígado las hexocinasas I, II y III son inhibida alostéricamente por glucosa 6-P
Glucocinasa en hígado(hexocinasa IV) no es inhibida por glucosa 6-PEs inhibida por fructosa 6-P y una proteína reguladora.
incubated with glucagon, pyruvate kinase is phosphorylated
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glucokinase
&(Fructose 6P)
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pyruvate kinase isphosphorylated by protein kinase A