methodological issues in outcome research
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Methodological Issues in Outcome Research. Effective Healthcare AHRQ 2008 Conference September 7-10, 2008. Purpose. To discuss state of the art analytical approaches to adjust for confounding in observational research within the Effective Health Care Program - PowerPoint PPT PresentationTRANSCRIPT
Agency for Healthcare Research and QualityAgency for Healthcare Research and QualityAdvancing Excellence in Health CareAdvancing Excellence in Health Care • • www.ahrq.govwww.ahrq.gov
Methodological Issues in Methodological Issues in Outcome ResearchOutcome Research
Effective Healthcare Effective Healthcare
AHRQ 2008 ConferenceAHRQ 2008 Conference
September 7-10, 2008 September 7-10, 2008
Advancing Advancing Excellence in Excellence in Health CareHealth Care PurposePurpose
To discuss state of the art analytical approaches to To discuss state of the art analytical approaches to adjust for confounding in observational research adjust for confounding in observational research within the Effective Health Care Programwithin the Effective Health Care Program– Measured confounders: Propensity scoreMeasured confounders: Propensity score
– Unmeasured confounders:Unmeasured confounders: Sensitivity analysisSensitivity analysis Instrumental variablesInstrumental variables
Advancing Advancing Excellence in Excellence in Health CareHealth Care PanelistsPanelists
John D. Seeger, PharmD., DrPH.John D. Seeger, PharmD., DrPH.– Senior scientist, Ingenix/i3 Drug SafetySenior scientist, Ingenix/i3 Drug Safety– Transparency in the Use of Propensity Score MethodsTransparency in the Use of Propensity Score Methods
Sebastian Schneeweiss, M.D., ScD Sebastian Schneeweiss, M.D., ScD – Department of Medicine, Harvard Medical SchoolDepartment of Medicine, Harvard Medical School– Principal Investigator of Brigham and Women’s Hospital Principal Investigator of Brigham and Women’s Hospital
DEcIDE CenterDEcIDE Center– Sensitivity Analysis for Residual ConfoundingSensitivity Analysis for Residual Confounding
Alan M. Brookhart, Ph.D.Alan M. Brookhart, Ph.D.– Brigham and Women’s Hospital, Harvard medical SchoolBrigham and Women’s Hospital, Harvard medical School– Instrumental variable analysis for comparative Instrumental variable analysis for comparative
effectiveness researcheffectiveness research
Advancing Advancing Excellence in Excellence in Health CareHealth Care Ground RulesGround Rules
Each panelist will present for ~20-25 minutesEach panelist will present for ~20-25 minutes Questions and comments should be made at Questions and comments should be made at
the end of session. the end of session. If you have a question, please come to the If you have a question, please come to the
microphone if possible.microphone if possible. Please identify the panelist to whom the Please identify the panelist to whom the
question is addressed.question is addressed.