microbivores-the future of nanomedicines
TRANSCRIPT
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MICROBIVORES - NISHANT YADAV
SHRI RAM MURTI SMARAK COLLEGE OF ENGG. & TECHNOLOGY
PRESENTATION ON
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OUTLINE Nanorobots Types of Nanorobots Microbivores Applications Advantages Challenges Conclusion
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NANOROBOTS
Integrated and embedded system Consists of nanosensors, processors
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NANOROBOTS
Picowatts of power required
Transmission Antenna of 200nm size
Sonar communication
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TYPES OF NANOROBOTS
Concept proposed by Dr. Robert A Freitas Basic 3 types- Respirocytes Microbivores Clottocytes
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RESPIROCYTES artificial mechanical red blood cells carry oxygen and carbon dioxide molecules constructed of 18 billion atoms deliever 236 times more oxygen to the body
tissues when compared to natural red blood cells
spherical 1 µm diameter sized
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MICROBIVORE artificial white blood cell or nanorobotic
phagocytes spheroid device 3.4 µm in diameter consist of 610 billion precisely arranged atoms Traps blood pathogens & breaks them 1000 times faster than white blood cells
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CLOTTOCYTES artificial platelets powered by serum-oxyglucose reduces the clotting time & blood loss performs clotting in approximately 1 sec while the natural time is 4-5
mins
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MICROBIVORE
STRUCTURE Programmed spheroid device 3.4 µm diameter along MAJOR axis and 2 µm
diameter along MINOR axis 610 billion arranged carbon atoms in diamond
structure
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MICROBIVORE
COMPONENTS Four basic components - Binding sites Grapples Morcellation chamber Digestion chamber
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MICROBIVORE
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MICROBIVORE WORKING target bacterium binds to the microbivore
surface via binding sites telescopic robotic grapples rise up from the
surface and attach to the trapped bacterium grapple’s handoff motion can transport the
bacterium from binding site to the ingestion port
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MICROBIVORE the bacterium is internalized into the
morcellation chamber bacterium is minced into nanoscale pieces remains are pistoned into the digestion
chamber which consists of a pre-programmed set of digestive enzymes
These enzymes are injected and extracted 6 times during a single digestion cycle
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MICROBIVORE Morcellate is progressively reduced into amino
acids, free fatty acid and simple sugars by specifically selected sequence of 40 enzymes
These small molecules are then discharged into the blood stream through the exhaust port
After the destruction of pathogens the microbivores exits the body through the kidneys and are then excreted in urine
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MICROBIVORE Consumes 200 pW power during the operation metabolizes local glucose and oxygen for
power or may be externally supplied with acoustic power
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APPLICATIONS
Drug delivery
Body surveillance
Surgery
Cancer detection and treatment
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APPLICATIONS
Gene therapy
Diabetes treatment
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ADVANTAGES
Most animal cells are 10,000 to 20,000 nm in diameter so microbivores are easy to inject
Glucose or natural body sugars and oxygen might be a source for propulsion
1000 times faster & 80 times more efficient than natural phagocytes
completely destroy one pathogen in just 30 seconds
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DISADVANTAGES
Change in behaviour at nano level,may not be suitable for body
High cost
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CHALLENGES
Larger nanoparticles may accumulate in vital organs
Nanorobots of larger size will block capillary flow
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CONCLUSION
The concept of microbivores is just a theoritical justification till now
But the recent advancement in the field of nanotechnology gives the hope of the effective use of this technology in medical field
Diseases like AIDs,cancer can be treated permanently at any stage using these technologies
It can be a great replacement for the existing medical technology in terms of fast results and efficiency