microneedle patch technology for long-acting...
TRANSCRIPT
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Microneedle patch technology for long-acting contraception
Mark R. Prausnitz Georgia Institute of Technology
© Mark Prausnitz, Georgia Tech .
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Disclosure
Mark Prausnitz is a co-founder and has a significant financial interest in Micron Biomedical. This conflict of interest is managed by the Georgia Institute of Technolgy.
© Mark Prausnitz, Georgia Tech
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Introduction to microneedle patches
Long-acting contraception
Outline
© Mark Prausnitz, Georgia Tech
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Microneedle patch ©
Mark Prausnitz, G
eorgia Tech
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Microneedle patch ©
Mark Prausnitz, G
eorgia Tech
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Microneedle patch
© Mark Prausnitz, Georgia Tech
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Microneedle patch meets public health needs
Patient administration Minimally-trained personnel No applicator, no reconstitution Painless delivery, no fear of needle
Manufacturing Low-cost, scalable fabrication
Transportation and storage Small package size Improved thermostability
Waste disposal No sharps waste Difficult or impossible reuse © Mark Prausnitz, Georgia Tech
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Microneedle clinical trials
Microneedle patch vaccination
• Influenza vaccine o Phase 1 (Lancet 2017)
• Measles-rubella vaccine o Phase 1 (summer 2020)
• Others, Phase 1 and 2 o (2020, 2021)
© M
ark Prausnitz, Georgia Tech
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Outline
Long-acting contraception
This abstract is made possible by the generous support of the American people through USAID, provided to FHI 360 through cooperative agreement number AID-OAA-A-15-00045. The contents of this abstract are the responsibility of the authors and do not reflect the views of the U.S. Agency for International Development (USAID) or the United States Government.
© M
ark Prausnitz, Georgia Tech
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Need for long-acting contraception
Provide increased access to family planning resources
Every year there are
• 212 million pregnancies
• 56 million (27%) abortions
• 85 million (40%) pregnancies unintended
© Mark Prausnitz, Georgia Tech
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Design of separable microneedle patch for long-acting contraception
B
skin
microneedle patch
A
release layer
© Mark Prausnitz, Georgia Tech
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Separable microneedles for long-acting contraception
fluid from skin Goal:
Approach: water-soluble air bubble effervescent
material © Mark Prausnitz, Georgia Tech
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Design and fabrication of rapidly separable MNPs
Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech
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Incorporation of bubble in rapidly separable MNPs
Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech
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Mechanical performance of rapidly separable MNPs
Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech
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Application of MNPs to porcine skin ex vivo
Wei Li et al., Nature Biomedical Engineering, 2019
© M
ark Prausnitz, Georgia Tech
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Histological image of MNs in porcine skin ex vivo
Wei Li et al., Nature Biomedical Engineering, 2019 © Mark Prausnitz, Georgia Tech
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Release kinetics of LNG from MNPs
Wei Li et al., Nature Biomedical Engineering, 2019 LNG = levonorgestrel
© M
ark Prausnitz, Georgia Tech
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Imaging of dye release from MNPs in rats
Wei Li et al., Nature Biomedical Engineering, 2019
© M
ark Prausnitz, Georgia Tech
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Release of LNG from MNPs in rats
Wei Li et al., Nature Biomedical Engineering, 2019
LNG = levonorgestrel
© Mark Prausnitz, Georgia Tech
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Wei Li et al., Scientific Reports, 2019
Design and fabrication of rapidly separable effervescent MNPs
© Mark Prausnitz, Georgia Tech
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Microneedles rapidly separate by effervescence
Wei Li et al., Scientific Reports, 2019 © Mark Prausnitz, Georgia Tech
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Pharmacokinetics of LNG from MNPs in rats
Wei Li et al., Scientific Reports, 2019 © Mark Prausnitz, Georgia Tech
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Tolerability of placebo effervescent patch in humans (n = 10)
Wei Li et al., Scientific Reports, 2019 © Mark Prausnitz, Georgia Tech
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Preferences of human participants (n = 10)
Wei Li et al., Scientific Reports, 2019
Monthly patch vs. monthly injection Monthly patch vs. daily pill
© Mark Prausnitz, Georgia Tech
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Microneedle patch with larger dose
Microneedle patch with longer-acting contraception
Future work
© Mark Prausnitz, Georgia Tech
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Acknowldegements ©
Mark Prausnitz, G
eorgia Tech
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Questions?
© Mark Prausnitz, Georgia Tech .