mike mcevoy, phd, nrp, rn, ccrn sr. staff rn – cardiothoracic surgery chair – resuscitation...
TRANSCRIPT
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Mike McEvoy, PhD, NRP, RN, CCRNSr. Staff RN – Cardiothoracic SurgeryChair – Resuscitation Committee – Albany Med CtrEMS Coordinator – Saratoga County, New YorkEMS Editor – Fire Engineering magazine
Non-Invasive Safety and Wellness Technologies
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Mike McEvoy - Books:
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Disclosures
• I am on the speakers bureau for Masimo Corporation.
• I am the EMS editor for Fire Engineering magazine.
• I do not intend to discuss any unlabeled or unapproved uses of drugs or products.
• Slides at: www.mikemcevoy.com
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Nurses Week 2012 – Albany Medical Center (NY)
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How Good Are You?
•HR
•LOC
•BP
•Resps
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Not As Good As You Might Think:• 50% of physical assessments wrong
• Therapeutic interventions altered with invasive assessment 34 - 56% of the time:• 1980 Del Guercio • 1984 Eisenberg• 1990 Bailey • 1991 Steinberg • 1994 Minoz • 1998 Staudinger • 2002 Jacka, etc, etc…
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How Good Are Your Monitors?
What monitors?
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Pulse Oximetry
Problems:
•Accuracy
•Motion & artifact
•Dyshemoglobins
•Perfusion
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Oxygenation
• Pulse Oximetry
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Oxygenation
• Pulse Oximetry
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Model of Light Absorption At Measurement Site Without Motion
ACAC Variable light absorption due pulsatile volume of arterial blood
DCDC Constant light absorption due to non-pulsatile arterial blood.
DCDC Constant light absorption due to venous blood.
DC Constant light absorption due to tissue, bone, ...
Abs
orpt
ion
TimeTime
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Model of Light Absorption At Measurement Site With Motion
ACAC Variable light absorption due pulsatile volume of arterial blood
DCDC Constant light absorption due to non-pulsatile arterial blood.
AC Variable light absorption due to moving venous blood
DCDC Constant light absorption due to venous blood.
DC Constant light absorption due to tissue, bone ...
TimeTime
Abs
orpt
ion
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Influence of Perfusion on Accuracy of Conventional Pulse Oximetry During Motion
Good Perfusion (Conventional PO)
SpaO2=98
SpvO2=88SpO2=93
Poor Perfusion (Conventional PO)
SpO2=74
SpaO2=98
SpvO2=50
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Post Processor
R & IRDigitized, Filtered &
NormalizedR/IR
MEASUREMENT
CONFIDENCE % Saturation% Saturation
Conventional Pulse Oximetry Algorithm
3 options during motion or low perfusion:
1. Freeze last good value
2. Lengthen averaging cycle
3. Zero out
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Next Generation Pulse Oximetry
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Next Generation Pulse Oximetry
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Masimo SET: Signal Extraction Technology
SET “Parallel Engines”
Masimo SET “Parallel Engines”
R/IR(Conventional Pulse
Oximetry)
Confidence Based
Arbitrator
0 50% 66% 97% 100%SpO2% SpO2%
Post ProcessorDigitized,
Filtered & Normalized
% Saturation
SSTTM
Proprietary Algorithm 4
DST DST SET – 97%SET – 97%
DSTTM
FSTTM
MEASUREMENT
CONFIDENCE
MEASUREMENT
CONFIDENCE
MEASUREMENT
CONFIDENCE
MEASUREMENT
CONFIDENCE
MEASUREMENT
CONFIDENCE
R & IR
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A Solution for Patient Motion Discrete Saturation Transform (DST)
0 50% 66% 86% 97% 100%
SpOSpO2% %
Measure Through Motion Pulse Oximetry
Separating - accurate SpO2
Conventional Pulse Oximetry
0 50% 66% 86% 97% 100%
SpOSpO2% %
Averaging - inaccurate SpO2
Variable
Constant
Variable
Constant
In the presence of motion, SET separates the venous and arterial saturation values resulting in accurate saturation
readings (compared to conventional oximetry that averages the values to produce a reading)
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Certainty…
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Pulse Oximetry
Problems:
Accuracy
Motion & artifact
•Dyshemoglobins
• Perfusion
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Carbon Monoxide (CO)
• Gas:• Colorless• Odorless• Tasteless• Nonirritating
• Leading cause of poisoning deaths worldwide!
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CO: The Leading Cause of Poisoning Deaths
30-50 % of CO-exposed patients presenting to Emergency Departments are misdiagnosed
Barker MD, et al. J Pediatr. 1988;1:233-43
Barret L, et al. Clin Toxicol. 1985;23:309-13
Grace TW, et al. JAMA. 1981;246:1698-700
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Show me the money…Is this real?
104 CCU admissions UAP: 3 CO toxic, 5 others minor exposure (> smoker). Balzan et al, Postgrad Med J, 1994;70:699-702
307 acute neuro admits: 3 CO toxic (all from group of 29 w/ decr. LOC absent focal s/s). Balzan et al, Postgrad Med J, 1996;72:470-3.
168 acute neuro admits: 5 CO toxic (2 from group w/ seizures) Heckerling et al, Clin Toxicol, 1990;28:29-44.
48 h/a pts: 7 COHb > 10% (14.6%, all unrelated to smoking) Heckerling et al, Am J Emer Med, 1987;5:201-4.
146 h/a pts: 4 COHb > 10% (3%, all unrelated to smoking) Heckerling et al, Ann Intern Med, 1987;107:174-6.
Up to 10% of UAP, ACS, seizure, and h/a admits
have CO poisoning
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Limitations of Pulse Oximetry
Barker SJ, Tremper KK. The Effect of Carbon Monoxide Inhalation on Pulse Oximetry and Transcutaneous PO 2. Anesthesiology 1987; 66:677-679
SpCO-SpO2 Gap:
The fractional difference between actual SaO2 and display of SpO2 (2 wavelength oximetry)
in presence of carboxyhemoglobin
SpCO-SpO2 Gap:
The fractional difference between actual SaO2 and display of SpO2 (2 wavelength oximetry)
in presence of carboxyhemoglobin
From Conventional Pulse Oximeter
From invasive CO-Oximeter Blood
Sample
[Blood]
Conventional pulse oximetry can not distinguish between COHb, and O2Hb
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Signs and Symptoms
SpCO% Clinical Manifestations
<5% None
5-10% Mild headache, tire easily
11-20% Moderate headache, exertional SOB
21-30% Throbbing headache, mild nausea, dizziness, fatigue, slightly impaired judgment
31-40% Severe headache, vomiting, vertigo, altered judgment
41-50% Confusion, syncope, tachycardia
51-60% Seizures, unconsciousness
Carbon Monoxide Poisoning Presents Like the Flu!
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Laboratory CO-oximetry
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Pulse CO-oximetry
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Hgb Signatures: Physics of O2 Pathways
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Red
FDA ValidationRainbow SET Compared to Reference Methodology
Noninvasive measurement provides clinically equivalent results for HbCO without invasive blood draw (+ 3% from 0 – 40%)
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14,438 Patient Brown University Study
• Partridge and Jay (Rhode Island Hospital, Brown University Medical School), assessed carbon monoxide (CO) levels of 10,856 ED patients
• 11 unsuspected cases of CO Toxicity (COT) were discovered.Overall mean SpCO was 3.60%
• Occult COT was 4 in 10,000 during cold, 1 in 10,000 during warm months
• They concluded “unsuspected COT may be identified using noninvasive COHb screening and the prevalence of COT may be higher than previously recognized”
Non-Invasive Pulse CO-Oximetry Screening in the Emergency Department Identifies Occult Carbon Monoxide Toxicity. Suner S, Partridge R, Sucov A, Valente J, Chee K, Hughes A, Jay G. J Emerg Med 2008 Department of Emergency Medicine, Rhode Island Hospital, Brown Medical School, Providence, RI.
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Methemoglobinemia
• Cyanotic Chemical Guardian Protocol – Health surveillance for cyanosis causing chemical handlers (pre-placement, routine, high risk assignment clearance and symptomatic workers).
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Causes of Acquired Methemoglobinemia
• Soda and other foods with phenol based preservatives
• Nitrogen based fertilizers
• Nitrate laden preservatives (such as saltpeter used to cure BBQ meats)
• Infantile diarrhea (high intestinal pH promotes gram-negative organism growth, converts dietary nitrates to nitrites)
• Benzocaine & Cetacaine sprays• Dapsone• EMLA Creams• Chloroquine• Flutamide• Lidocaine• Nitrates• Nitric oxide• Nitroglycerin• Nitroprusside
Iatrogenic Causes: Others (community based):
Ash-Bernal R, et al. Acquired Methemoglobinemia A Retrospective Series of 138 Casesat 2 Teaching Hospitals. Medicine Sept 2004;83(5):265-273.
Industrial Causes:
More than 112 chemicals used
in manufacturing and finishing
plants: aniline, dinitrobenzene…
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Symptoms of Methemoglobinemia
Source: David C Lee, MD, Research Director, Assistant Professor, Department of Emergency Medicine, North Shore University Hospital and New York University Medical School
SpMet% Clinical Manifestation
0-3% Normal concentration, no symptoms
3-15% Slight skin discoloration (palor, gray, or blue) may be present
15-20% Patient may be relatively asymptomatic, cyanosis likely
25-50%Headache, dyspnea, lightheadedness, weakness, confusion, palpitations, chest pain
50-70% Altered mental status, delirium
Methemoglobinemia Can Present Like the Flu!
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Traditional Diagnosis of MetHb
Traditional marker: “chocolate brown” color of arterial blood
Laboratory CO-oximeter
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Limitations of Pulse Oximetry
Barker SJ, Tremper KK, Hyatt J. Effects of Methemoglobinemia on Pulse Oximetry and Mixed Venous Oximetry. Anesthesiology 1989;70:112-117
[Blood]
From invasive CO-Oximeter Blood Sample
From Pulse Oximeter
The 85% SpO2 “Push”:
The difference between actual SpO2 (blue) and display
SpO2 (red) (2 wavelength oximetry) in presence of
methemoglobin
The 85% SpO2 “Push”:
The difference between actual SpO2 (blue) and display
SpO2 (red) (2 wavelength oximetry) in presence of
methemoglobin
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Noninvasive Pulse CO-Oximetry
Oxygenated Hb and reduced Hb absorb different amounts of Red (RD) and Infrared (IR) Light(Two-wavelength oximeters cannot measure dyshemoglobins)
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0
2
4
6
8
10
12
14
SpM
et (
%)
0 2 4 6 8 10 12 14
HbMet (%)
FDA ValidationsRainbow SET Compared to Reference Methodology
Noninvasive measurement clinically equivalent results for MetHb without invasive blood draw
Equivalent precision and accuracy (+ 1% from 0-25%)
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Perfusion
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Nellcor Capnoprobe™ US approval Jan 2003.
Research study: Children's Medical Center – Dallas TX.
11 kids infected Burkholderia cepacia, 2 died.
Traced to saline solution packaging of probes.
5,600 units @ 30 centers recalled
FAIL
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Perfusion Index
Infrared
Saturation
Red
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Infrared Signal
0.254-0.253 = 0.001
0.253- 0 = 0.253
0.001/0.253 = 0.4%
AC
DC
• Perfusion index is the ratio of the variable absorption (AC) to the non-variable (DC) of the infrared signal.
• PI display ranges from 0.02% (very weak) to 20% (very strong)
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Perfusion Index
• Perfusion Index is an objective method for measuring a patient’s peripheral perfusion
• Perfusion Index is an early indicator of deterioration
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Datex-Ohmeda PIr®
Range 0.3%-10%
Most Patients >0.7%
Increases the validity of the
SpO2 by locating the strongest pulse signal
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Philips
Range 0.3%-10%
Optimal >1.0%
< 0.3% is marginal
reposition the site
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Masimo
Range 0.02%- 20.0% Select site with highest value
Perfusion Index
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• 108 healthy adults and 37 critically ill patients (finger sensors)
• PI range: 0.3% to 10%, median 1.4%
• ROC used to determine the “cutoff” value
• 1.4% PI best discriminated normal from abnormal
What is the “Normal” PI value?
Lima, et al. CCM 2002
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Photoplethysmography
Abs
orpt
ion
TimeTime
R IR
Photodetector
Pleth Waveform
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Pleth Waveform
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Definition of PVI
• Pleth Variability Index (PVI) is a measure of dynamic changes in PI that occur during the respiratory cycle
• PVI is a percentage from 1 to 100%: 1 = no variability 100 = maximum variability
• PVI: fluid volume status
• High variability (high PVI) = volume depletion
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Research on PI and PVI Ongoing…
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Can we get oximetric hemoglobin?
• SpHb addedin 2008
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Jan 2012: Pronto-7 (for adults > 30 kg)
• Noninvasive, quick, and accurate spot-check hemoglobin testing• Measures (Under 1 Minute)• Total Hemoglobin (g/dL, g/L, mmol/L) – SpHb (±1 g/dL at 1 SD)• Oxygen Saturation - SpO2
• Pulse Rate - PR• Perfusion Index - PI
• Touch Screen Navigation• Multiple Printing Solutions• Blue Tooth• Wireless
• Multiple Patient Reports• Stores Patient Test Information
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Pronto 7 Accuracy
Frasca D et al. Crit Care Med. 39(10); 2011; 2277-2282.
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Ocular Scanner
EyeMarker Systems™
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Retinal imaging
Pattern recognition:•Botulism,
neurotoxins•Nerve Agents•Carbon Monoxide•CyanideFAIL
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Pulse CO-Oximetry Applications
• Screening during routine exams• CO, Met, Hb baseline values• Early detection and prevention
• Urgent screening• Rapid assessment of exposed/injured workers• Triage and assessment (including PI)
• Health and safety tool• Monitoring high risk areas/workers
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Questions?
mikemcevoy.com