mineral nutrition ruminant
DESCRIPTION
PeternakanTRANSCRIPT
Mineral Nutrition for Ruminants
Major Minerals
Major (macro) mineralsCa, P, K, Mg, Na, Cl, S Included as % in diet
FunctionsStructuralNerveElectrolytesOsmotic balanceBuffer in the rumen
Trace Minerals
Trace (micro) mineralsCobalt, copper, iodine, iron, manganese,
molybdenum, selenium and zinc all requiredChromium-no established requirement Included as ppm or ppb in diet
FunctionEnzyme co-factor or component
Mineral Deficiencies
Milk Fever
Metabolic disease at/after parturition in dairy cows
Rapid decrease in serum Ca because Ca is lost to colostrum secretion
Symptoms included lack of appetite and paralysis
Treatment is intravenous Ca borogluconate
Milk Fever Prevention Include anionic salts in diet for 3-5 wks prior to
parturitionmEq(Na+ + K+) – mEq(Cl- + SO4
-)
Normal diet: +20 to +30 mEq/100g diet (electrolyte balance)
Anionic diet: -7 to -25 mEq/100g diet Induces mild acidosis, which increases tissue
responsiveness to PTHCa release from bone to serum
Grass Tetany
Hypomagnesemia in ruminants Usually following lush spring growth Fertilizing with K or N make it worse Symptoms include muscular twitching,
collapse, convulsionTreatment is Intravenous injection (IV) Mg
gluconatePrevent with high Mag mineral (MagOx)
Copper, sulfur and molybdenum
High sulfur & molybdenum thiomolybdates Cu + thiomolybdates insoluble complexes Thiomolybdates can result in reduced Cu absorption and
systemic metabolism
NRC, 1996
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
1.8
0 114 183 241 297 422 459 490
Pla
sma
Cu
, mg
/L
Calf day of age
Cu Adequate Cu Def icient Cu Def icient + Mn
Mineral Toxicosis
Maximum Tolerable Levels for Ruminants
Copper Toxicosis
Sheep particularly sensitive to copper5 ppm CuExcessive Cu builds up in Red Blood Cells,
causing Heinz-body formation and methemoglobin production
Can’t bind oxygen-chocolate bloodRelease of hemoglobin damages kidneys
Avoid feeding cattle mineral
Copper Toxicosis Treatment
IV methylene blue to control metHb Copper chelators
D-penicillamine Ammonium tetrathiomolybdate
Cu:Mo ratio of 10:1 or less
Sulfur Toxicity in Ruminants
Dietary sulfate reduced to H2S (gas) Eructate-reinhale Toxic in high amounts
Polioencephalomalacia (PEM, brainers)
Brain lesions due to S toxicity
Polioencephalomalacia (PEM) Terminology
Polio = gray matter Encephalo = brain Malacia = tissue death
Clinical signs Subacute – head pressing, circling, ataxia, staggering,
blindness, depression, stupor Acute – blindness, seizures, comatose
Can be caused by thiamine deficiency, lead or salt poisoning and high sulfur diets
S induced PEM
Does not appear to be caused by thiamine or copper deficiency No alterations of thiamine or its mono- and diphosphate esters in
whole blood, brain, cerebrospinal fluid, or liver (Sager et al., 1990; Gould et al.,1991)
Thiamine treatment can help reduce symptoms Increase energy availability to the brain
plays a key role in the tri-carboxcylic acid cycle and pentose shunt Thiamine-supplemented groups also manifested PEM, even
though clinical signs were not observed (Olkowski et al., 1992).
Pka of HS- = 7.04
60% of ruminal gas that is eructated is inhaled
S Induced PEM
Oxidative Stress
Reactive oxygen compoundByproduct of cellular respirationRoles in cell signallingDangerous in excess
Oxygen CompoundHydroxylSuperoxideHydrogen peroxide
Oxidative Stress
EffectsDNA damageLipid peroxidation (oxidation of
polyunsaturated fatty acids) Inactivation of some enzymes (oxidation of
metal cofactors)
Antioxidant Capacity
Superoxide dismutaseSuperoxide anion to hydrogen peroxideCopper-Zinc SOD-cytosolManganese SOD-mitochondria
http://en.wikipedia.org/wiki/Superoxide_dismutase
Antioxidant Capacity
CatalaseHydrogen peroxide to water and oxygenConsists of 4 parts, each containing a heme
(iron) group
Antioxidant Capacity
Glutathione peroxidaseHydrogen peroxide to waterSelenium dependent enzyme-4 selenium
atoms per molecule
Iodine
Function- part of thyroid hormone (metabolism rate)70-80% of body I- is in thyroidT4 (thyroxine)T3 (triiodothyronine)-3 times more active than
T4Controls rate of energy metabolism in cells
Iodine
Deficiency “goiter” enlarged thyroid gland
Plants have “goitrogens” (goiter creating), block use of iodine
Reduced growth Impaired reproduction-dead, weak or
hairless young
Goiter in lamb
Selenium
Regulated by the FDA, because relatively low levels toxic (i.e. 10x requirement)
Function Glutathione peroxidase (antioxidant) Iodothyronine 5’-deiodinase-1 (T4 conversion to T3)
Selenium
Deficiency Deficient in many areas of U.S. Muscular dystrophy
Sheep-white muscle disease Reproductive problems such as retained placenta and
low fertility, weak newborns
Cobalt
Essential component of B12 Required by ruminants Rumen microorganisms synthesize B12
from cobalt B12 dependent enzymes
Methylmalonyl-CoA mutaseMethionine synthetase